Signaling Pathway

CMV

CMV

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Cytomegalovirus(CMV) is a viral genus of the viral family known as Herpesviridae or herpesviruses. Within Herpesviridae, CMV belongs to the Betaherpesvirinae subfamily, which also includes the genera Muromegalovirus and Roseolovirus (HHV-6 and HHV-7). All herpesviruses share a characteristic ability to remain latent within the body over long periods. Although they may be found throughout the body, CMV infections are frequently associated with the salivary glands in humans and other mammals. Several species of Cytomegalovirus have been identified and classified for different mammals. Such as Human cytomegalovirus (HCMV), Chimpanzee cytomegalovirus (CCMV), Simian cytomegalovirus (SCCMV) and Rhesus cytomegalovirus(RhCMV) etc..

CMV Inhibitors & Modulators (8)

Product Name Catalog No. Brief Description
Brivudine

HY-13578

Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.

Cidofovir

HY-17438

Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.

Cidofovir dihydrate

HY-17438A

Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis.

CMX001

HY-14532

CMX001 (Brincidofovir; HDP-CDV) was developed as an orally active, lipophilic form of cidofovir (CDV); has enhanced activity in vitro and in vivo compared to CDV against certain herpesviruses, adenoviruses and orthopoxviruses.

Letermovir

HY-15233

AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.

Maribavir

HY-16305

Maribavir(GW257406X; BW1263W94; 1263W94) inhibits HCMV replication is by inhibition of an HCMV encoded protein kinase enzyme called UL97 or pUL97.

Valganciclovir

HY-A0032

Valganciclovir, the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir.

Valganciclovir hydrochloride

HY-A0032A

Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir.