107910-75-8
Chemical Structure
Ganciclovir sodium
Synonym(s): BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium
- CAS No.: 107910-75-8
- Formula:C9H12N5NaO4
- Molecular Weight:277.21
IUPAC Name: sodium 2-amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-9H-purin-6-olate
InChIKey: JJICLMJFIKGAAU-UHFFFAOYSA-M
SMILES: OCC(OCN1C=NC2=C1N=C(N)N=C2O[Na])CO
Biological Activity: Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].
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Ganciclovir sodium | 99.92% | Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain. | ||||||||||||||||||||
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Ganciclovir sodium (Standard) | ≥98% | Ganciclovir (sodium) (Standard) is the analytical standard of Ganciclovir (sodium). This product is intended for research and analytical applications. Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain. | ||||||||||||||||||||
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Similarity Score 0.76
HY-162069Antiviral agent 47 -
Similarity Score 0.74
HY-13637Ganciclovir -
Similarity Score 0.71
HY-13637BGanciclovir hydrate -
Similarity Score 0.65
HY-41344RGanciclovir mono-O-acetate (Standard) -
Similarity Score 0.64
HY-159737Rociclovir -
Similarity Score 0.63
HY-17422RAcyclovir (Standard) -
Similarity Score 0.62
HY-106175Detiviciclovir -
Similarity Score 0.61
HY-Z44836-Deoxypenciclovir -
Similarity Score 0.61
HY-1371819-Carboxymethoxymethylguanine -
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References
- [1]. Faulds D, et al. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 1990;39(4):597-638. [Content Brief]
- [2]. Maggs DJ, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. [Content Brief]
- [3]. Boujemla I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016;132:111-115. [Content Brief]
