1. Anti-infection
    Cell Cycle/DNA Damage
  2. CMV
    HSV
    Antibiotic
    Nucleoside Antimetabolite/Analog
  3. Ganciclovir sodium

Ganciclovir sodium (Synonyms: BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium)

Cat. No.: HY-13637A Purity: 98.46%
Handling Instructions

Ganciclovir (BW 759) sodium, a nucleoside analogue and an orally active antiviral agent, shows activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).

For research use only. We do not sell to patients.

Ganciclovir sodium Chemical Structure

Ganciclovir sodium Chemical Structure

CAS No. : 107910-75-8

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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Ganciclovir sodium:

Top Publications Citing Use of Products

    Ganciclovir sodium purchased from MCE. Usage Cited in: Eur J Pharm Sci. 2019 Jan 15;127:29-37.

    Viral reporter GFP expression after inoculation and compound treatment. Infected cells treated with DMSO control, BIO, Ganciclovir (GCV) or Letermovir (LTR)
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    • Customer Review

    Description

    Ganciclovir (BW 759) sodium, a nucleoside analogue and an orally active antiviral agent, shows activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].

    IC50 & Target

    CMV

     

    HSV-1

     

    HSV-2

     

    FHV-1

    5.2 μM (IC50)

    In Vitro

    Ganciclovir sodium is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir[4].The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir sodium is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Ganciclovir sodium (1-80 mg/kg; i.h.; daily for 5 days) delays MCMV-induced wasting syndrome and mortality[6].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Severe combined immunodeficiency (SCID) mice (MCMV infection)[6]
    Dosage: 1-80 mg/kg
    Administration: I.h.; daily for 5 days
    Result: Dose dependently delayed MCMV-induced wasting syndrome and mortality.
    Clinical Trial
    Molecular Weight

    279.23

    Formula

    C₉H₁₄N₅NaO₄

    CAS No.

    107910-75-8

    SMILES

    OCC(OCN1C=NC2=C1NC(N)N=C2O[Na])CO

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (179.06 mM; Need ultrasonic)

    DMSO : 5 mg/mL (17.91 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5813 mL 17.9064 mL 35.8128 mL
    5 mM 0.7163 mL 3.5813 mL 7.1626 mL
    10 mM 0.3581 mL 1.7906 mL 3.5813 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    GanciclovirBW 7592'-Nor-2'-deoxyguanosineBW759BW-759CMVHSVAntibioticNucleoside Antimetabolite/AnalogCytomegalovirusHerpes simplex virusDNAviruseherpesgroupinfectionserotypepolymerasereplicationInhibitorinhibitorinhibit

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    Product Name:
    Ganciclovir sodium
    Cat. No.:
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