1. Anti-infection
    Cell Cycle/DNA Damage
  2. CMV
    HSV
    Antibiotic
    Nucleoside Antimetabolite/Analog
  3. Ganciclovir sodium

Ganciclovir sodium  (Synonyms: BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium)

Cat. No.: HY-13637A Purity: 99.85%
COA Handling Instructions

Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.

For research use only. We do not sell to patients.

Ganciclovir sodium Chemical Structure

Ganciclovir sodium Chemical Structure

CAS No. : 107910-75-8

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 80 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 80 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 73 In-stock
Estimated Time of Arrival: December 31
1 g USD 117 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Ganciclovir sodium:

Top Publications Citing Use of Products

    Ganciclovir sodium purchased from MCE. Usage Cited in: Eur J Pharm Sci. 2019 Jan 15;127:29-37.  [Abstract]

    Viral reporter GFP expression after inoculation and compound treatment. Infected cells treated with DMSO control, BIO, Ganciclovir (GCV) or Letermovir (LTR)
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].

    IC50 & Target[1][2][3]

    CMV

     

    HSV-1

     

    HSV-2

     

    FHV-1

    5.2 μM (IC50)

    In Vitro

    Ganciclovir (BW 759) is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median Ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 μM versus 72 μM for acyclovir[4].
    The primary mechanism of Ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Ganciclovir (BW 759) (50 mg/kg; i.p.; twice a day for five injections) significantly decreases white blood cells, red blood cells and platelets in newborn mice, and can diffuse into the brain and the perilymphatic space of the inner ear[3].
    Ganciclovir (1-80 mg/kg; i.h.; daily for 5 days) delays murine cytomegalovirus (MCMV)-induced wasting syndrome and mortality[6].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Non-inbred Oncins France 1 (OF1) mice and albino rats non-immunized for MCMV[3]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, twice a day for five injections (mice) or 3 days (adult rats) (Pharmacokinetic Study)
    Result: In adult rats, the intracochlear diffusion of Ganciclovir was shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion was observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of Ganciclovir showed a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but became undetectable by 2 h after injection.
    Significantly decreased white blood cells, red blood cells and platelets in newborn mice.
    Animal Model: Female SCID mice inoculated with MCMV[6]
    Dosage: 0, 1, 10, 80 and 160 mg/kg
    Administration: Subcutaneous injection, once daily for 5 days
    Result: Dose dependently delayed the wasting syndrome and mortality in a dose range up to 80 mg/kg per day, whereas a dose of 160 mg/kg per day induced reversible side-effects.
    Clinical Trial
    Molecular Weight

    277.21

    Formula

    C9H12N5NaO4

    CAS No.
    SMILES

    OCC(OCN1C=NC2=C1N=C(N)N=C2O[Na])CO

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (180.37 mM; Need ultrasonic)

    DMSO : 5 mg/mL (18.04 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6074 mL 18.0369 mL 36.0737 mL
    5 mM 0.7215 mL 3.6074 mL 7.2147 mL
    10 mM 0.3607 mL 1.8037 mL 3.6074 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (90.18 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.85%

    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Ganciclovir sodium
    Cat. No.:
    HY-13637A
    Quantity:
    MCE Japan Authorized Agent: