1. Signaling Pathways
  2. Cytoskeleton
  3. Gap Junction Protein

Gap Junction Protein

Gap junction channels are essential in normal heart function and they assist in the mediated spread of electrical impulses that stimulate synchronized contraction (via an electrical syncytium) of cardiac tissues.

Gap junction (GJ) proteins play an important role in direct communication between cells of many tissue types. GJs are specialised intercellular membrane-spanning domains that allow the passage of small molecules including second messenger (e.g. c-AMP, inositol triphosphate) or ionic signals from one cell to another. GJ proteins and their long evolutionary history have permitted adaptation of gap junction intercellular communication (GJIC) with several important functions and multiple regulatory processes. Formation of GJIC is an essential mechanism in coordinating growth and development and tissue compartmentalization during embryonic development.

Gap Junction Protein Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-106268A
    Larazotide acetate Inhibitor 99.68%
    Larazotide acetate is a synthetic peptide that functions as a tight junction regulator and reverses leaky junctions to their normally closed state.
  • HY-15204
    Tonabersat Modulator 99.68%
    Tonabersat is a gap-junction modulator.
  • HY-10913A
    Danegaptide Hydrochloride Modulator 99.20%
    Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.
  • HY-P0139
    Gap 27 Inhibitor 98.34%
    Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor.
  • HY-P1082
    Gap 26 Inhibitor 99.30%
    Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
  • HY-B1320
    Meclofenamate sodium Inhibitor 98.62%
    Meclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
  • HY-117275
    Meclofenamic acid Inhibitor
    Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
  • HY-114426A
    AT-1002 TFA Modulator 99.84%
    AT-1002 TFA, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.
  • HY-10913
    Danegaptide Modulator
    Danegaptide (GAP-134), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.
  • HY-114426
    AT-1002 Modulator
    AT-1002, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.
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