2. Cytoskeleton Metabolic Enzyme/Protease
  3. Gap Junction Protein Endogenous Metabolite
  4. Meclofenamic acid sodium

Meclofenamic acid sodium  (Synonyms: Meclofenamate sodium)

Cat. No.: HY-B1320 Purity: 99.00%
COA Handling Instructions

Meclofenamic acid (Meclofenamate) sodium is a nonsteroidal anti-inflammatory agent (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.

For research use only. We do not sell to patients.

Meclofenamic acid sodium Chemical Structure

Meclofenamic acid sodium Chemical Structure

CAS No. : 6385-02-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 61 In-stock
Solid
50 mg USD 55 In-stock
100 mg USD 99 In-stock
200 mg USD 165 In-stock
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Meclofenamic acid sodium:

Meclofenamic acid sodium Related Antibodies

Top Publications Citing Use of Products

    Meclofenamic acid sodium purchased from MCE. Usage Cited in: Theranostics. 2021 Jul 25;11(17):8464-8479.  [Abstract]

    The effect of FTO inhibitor Meclofenamate sodium (MS) (80 μM and 120 μM) on ATF4 protein expression and mTORC1 activity during 968 treatment is detected by western blotting. MS efficiently reduces ATF4 expression and rescues the mTOR downregulation induced by compound 968.

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    Description

    Meclofenamic acid (Meclofenamate) sodium is a nonsteroidal anti-inflammatory agent (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3].

    Clinical Trial
    Molecular Weight

    318.13

    Appearance

    Solid

    Formula

    C14H10Cl2NNaO2
    CAS No.
    SMILES

    O=C(O[Na])C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (392.92 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1434 mL 15.7168 mL 31.4337 mL
    5 mM 0.6287 mL 3.1434 mL 6.2867 mL
    10 mM 0.3143 mL 1.5717 mL 3.1434 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.86%

    COA (251 KB) HNMR (264 KB) LCMS (129 KB)

    Handling Instructions (2659 KB)
    References
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    Meclofenamic acid sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Meclofenamic acid6385-02-0MeclofenamateGap Junction ProteinEndogenous MetaboliteInhibitorinhibitorinhibit

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