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FB23-2 

Cat. No.: HY-127103 Purity: 98.82%
Handling Instructions

FB23-2 is a potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO, with an IC50 of 2.6 μM.

For research use only. We do not sell to patients.

FB23-2 Chemical Structure

FB23-2 Chemical Structure

CAS No. : 2243736-45-8

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5 mg USD 650 Get quote

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Description

FB23-2 is a potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO, with an IC50 of 2.6 μM[1].

IC50 & Target

IC50: 2.6 μM (FTO)[1]

In Vitro

FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells[1].
FB23 inhibits the proliferation of NB4 and MONOMAC6 cells, with IC50 values of 0.8 μM and 1.5 μM[1].

In Vivo

FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice[1].

Molecular Weight

392.24

Formula

C₁₈H₁₅Cl₂N₃O₃

CAS No.

2243736-45-8

SMILES

O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (159.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5495 mL 12.7473 mL 25.4946 mL
5 mM 0.5099 mL 2.5495 mL 5.0989 mL
10 mM 0.2549 mL 1.2747 mL 2.5495 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
FB23-2
Cat. No.:
HY-127103
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