1. Metabolic Enzyme/Protease
  2. Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetases (AARSs) are ubiquitous and evolutionarily conserved enzymes that catalyze the highly specific acylation of amino acids to cognate tRNAs. Aminoacyl-tRNA Synthetases are essential for accurate decoding of the triplet genetic code and for sustenance of all domains of life, including bacteria, archaea, and eukarya.

Aminoacyl-tRNA Synthetases also perform critical cellular activities unrelated to their primary function in aminoacylation. These noncanonical activities include regulation of gene transcription, mRNA translational control, angiogenesis, apoptosis, amino acid sensing, and cell signaling.

Aminoacyl-tRNA Synthetase Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-108900
    Leu-AMS Inhibitor 99.14%
    Leu-AMS is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM and inhibits the growth of bacteria.
  • HY-108939
    Aminoacyl tRNA synthetase-IN-1 Inhibitor 99.61%
    Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor.
  • HY-112860
    Asp-AMS Inhibitor >98.0%
    Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.
  • HY-112862
    Arg-AMS Inhibitor 99.80%
    Arg-AMS is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes.
  • HY-112861A
    Gln-AMS TFA Inhibitor 99.50%
    Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 µM.
  • HY-108900A
    Leu-AMS R enantiomer
    Leu-AMS R enantiomer is the R enatiomer of Leu-AMS. Leu-AMS is a potent inhibitor of leucyl-tRNA synthetase (LRS) and inhibits the growth of bacteria.
  • HY-112861
    Gln-AMS Inhibitor
    Gln-AMS is an aminoacyl-tRNA synthetases (AARS) inhibitor, which binds the A-domain within the NRPS enzymes.
  • HY-108940
    GlyRS-IN-1 Inhibitor
    GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1 can also inhibit the growth of bacteria.
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