1. Metabolic Enzyme/Protease
  2. Aminoacyl-tRNA Synthetase
    Mitochondrial Metabolism

Asp-AMS 

Cat. No.: HY-112860
Handling Instructions

Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.

For research use only. We do not sell to patients.

Asp-AMS Chemical Structure

Asp-AMS Chemical Structure

CAS No. : 828288-98-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.

IC50 & Target

Aspartyl-tRNA synthetase, Mitochondrial enzyme [1].

In Vitro

Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM). Asp-AMS is a strong inhibitor with Ki in the nanomolar (nM) range. Asp-AMS has also the highest inhibitory effect for the mitochondrial enzyme. Asp-AMS is the most active inhibitor with Ki values in the nanomolar range, with a stronger effect on bacterial AspRSs (E. coli and P. aeruginosa) than on human cytosolic AspRS[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1673 mL 10.8363 mL 21.6727 mL
5 mM 0.4335 mL 2.1673 mL 4.3345 mL
10 mM 0.2167 mL 1.0836 mL 2.1673 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

461.41

Formula

C₁₄H₁₉N₇O₉S

CAS No.

828288-98-8

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3COS(=O)(NC([[email protected]@H](N)CC(O)=O)=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Asp-AMS
Cat. No.:
HY-112860
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Asp-AMS

Cat. No.: HY-112860