Janus kinase
Every Janus kinase contains two tandem kinase-like modules: the active C-terminal kinase domain (JH1) and the N-terminal pseudokinase domain (JH2) that gives this family its place in pseudokinase catalogs. JH2 lacks residues for full catalytic activity but is far from inert; it folds as a genuine pseudokinase, binds ATP, and allosterically restrains JH1. The JAK2 JH2 V617F mutation disables this brake, causing constitutive JAK-STAT signaling and myeloproliferative neoplasms such as polycythemia vera. Recombinant JH2 domains and full-length JAKs are used to dissect autoinhibition, screen allosteric modulators, and support cytokine-receptor signaling research.
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Janus kinase Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
