1. Neurological Disease

Neurological Disease

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Neurological Disease Related Products (1576):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-17366
    Clozapine N-oxide 34233-69-7 99.63%
    Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system.
    Clozapine N-oxide
  • HY-13027
    DAPT 208255-80-5 99.97%
    DAPT is a γ-secretase inhibitor with IC50s of 115 and 200 nM for total Aβ and Aβ42, respectively.
    DAPT
  • HY-15608
    MPTP hydrochloride 23007-85-4 99.62%
    MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’S Disease.
    MPTP hydrochloride
  • HY-B0215
    Acetylcysteine 616-91-1 >98.0%
    Acetylcysteine is used mainly as a mucolytic, which protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.
    Acetylcysteine
  • HY-B1756
    Rotenone 83-79-4 >98.0%
    Rotenone is an inhibitor of mitochondrial electron transport at NADH:ubiquinone oxidoreductase, and is used to induce a Parkinson-like syndrome as an experimental model in rats.
    Rotenone
  • HY-B0726
    Pilocarpine Hydrochloride 54-71-7 99.92%
    Pilocarpine Hydrochloride is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
    Pilocarpine Hydrochloride
  • HY-B0075
    Melatonin 73-31-4 >98.0%
    Melatonin, a hormone produced in the brain, is a potent melatonin receptor activator, and possesses important antioxidative and anti-inflammatory properties.
    Melatonin
  • HY-15084
    (+)-MK 801 Maleate 77086-22-7 99.98%
    (+)-MK 801 (Maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
    (+)-MK 801 Maleate
  • HY-100229
    Aloxistatin 88321-09-9 98.22%
    Aloxistatin (E64d) is a broad-spectrum cell-permeable cysteine protease inhibitor.
    Aloxistatin
  • HY-B0407A
    Chlorpromazine hydrochloride 69-09-0 99.83%
    Chlorpromazine Hydrochloride is an antagonist of the dopamine D2 receptors, 5-HT2A receptors, potassium channel, sodium channel, with Ki of 363 nM and 8.3 nM for dopamine D2 receptor and serotonin 5-HT2A receptor, respectively.
    Chlorpromazine hydrochloride
  • HY-B0617
    Ademetionine 29908-03-0 >98.0%
    Ademetionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood.
    Ademetionine
  • HY-B0150
    Nicotinamide 98-92-0 >98.0%
    Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
    Nicotinamide
  • HY-B2176
    ATP 56-65-5 99.18%
    ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells.
    ATP
  • HY-12012
    SB 216763 280744-09-4
    SB 216763 is potent and selective and ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor, with an IC50 value of 34.3 nM for GSK-3α and GSK-3β, respectively.
    SB 216763
  • HY-16759
    Verubecestat 1286770-55-5 99.79%
    Verubecestat (MK-8931) is a beta-secretase 1 (BACE1) inhibitor under investigation for the treatment of Alzheimer's Disease.
    Verubecestat
  • HY-B0573
    Propranolol hydrochloride 318-98-9 99.92%
    Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist with an IC50 of 12 nM.
    Propranolol hydrochloride
  • HY-16900
    Rolipram 61413-54-5 99.56%
    Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
    Rolipram
  • HY-100347A
    SRI-011381 hydrochloride 99.66%
    SRI-011381 hydrochloride is a TGF-beta signaling agonist.
    SRI-011381 hydrochloride
  • HY-13291
    WIN 55,212-2 Mesylate 131543-23-2 99.01%
    WIN 55,212-2 Mesylate is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.
    WIN 55,212-2 Mesylate
  • HY-13951
    ICI 118,551 hydrochloride 72795-01-8 98.50%
    ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
    ICI 118,551 hydrochloride