1. Neurological Disease

Neurological Disease

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Neurological Disease Related Products (1861):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13027
    DAPT 208255-80-5 99.97%
    DAPT is a γ-secretase inhibitor with IC50s of 115 and 200 nM for total Aβ and Aβ42, respectively.
    DAPT
  • HY-17366
    Clozapine N-oxide 34233-69-7 99.98%
    Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system.
    Clozapine N-oxide
  • HY-B0215
    Acetylcysteine 616-91-1 >98.0%
    Acetylcysteine is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor.
    Acetylcysteine
  • HY-15608
    MPTP hydrochloride 23007-85-4 99.62%
    MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease.
    MPTP hydrochloride
  • HY-B1756
    Rotenone 83-79-4 >98.0%
    Rotenone is an mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone
  • HY-B0075
    Melatonin 73-31-4 98.95%
    Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties.
    Melatonin
  • HY-B2176
    ATP 56-65-5 99.18%
    ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells.
    ATP
  • HY-B0726
    Pilocarpine Hydrochloride 54-71-7 99.92%
    Pilocarpine Hydrochloride is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
    Pilocarpine Hydrochloride
  • HY-B0150
    Nicotinamide 98-92-0 >98.0%
    Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
    Nicotinamide
  • HY-B0407A
    Chlorpromazine hydrochloride 69-09-0 99.83%
    Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel and sodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.
    Chlorpromazine hydrochloride
  • HY-100229
    Aloxistatin 88321-09-9 98.22%
    Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor.
    Aloxistatin
  • HY-P0128
    Amyloid beta-peptide(25-35) 131602-53-4 98.03%
    Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells.
    Amyloid beta-peptide(25-35)
  • HY-100347A
    SRI-011381 hydrochloride 99.78%
    SRI-011381 (hydrochloride) is a TGF-beta signaling agonist, with neuroprotective.
    SRI-011381 hydrochloride
  • HY-100965
    Diphenyleneiodonium chloride 4673-26-1 99.87%
    Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM.
    Diphenyleneiodonium chloride
  • HY-12012
    SB 216763 280744-09-4
    SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC50s of 34.3 nM for both GSK-3α and GSK-3β.
    SB 216763
  • HY-15084
    Dizocilpine Maleate 77086-22-7 99.98%
    Dizocilpine ((+)-MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
    Dizocilpine Maleate
  • HY-B0617
    Ademetionine 29908-03-0 >98.0%
    Ademetionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood.
    Ademetionine
  • HY-13951
    ICI 118,551 hydrochloride 72795-01-8 98.50%
    ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
    ICI 118,551 hydrochloride
  • HY-B0573
    Propranolol hydrochloride 318-98-9 99.92%
    Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist with an IC50 of 12 nM.
    Propranolol hydrochloride
  • HY-B1618
    Corticosterone 50-22-6 99.70%
    Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
    Corticosterone