1. Metabolic Enzyme/Protease
  2. Nampt

Nampt

Nampt (Nicotinamide phosphoribosyl transferase) has been reported to be a cytokine that promotes B cell maturation and inhibits neutrophil apoptosis. NAmPRTase catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

Nampt Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-50876
    FK866 Inhibitor 99.91%
    FK866 is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM.
  • HY-10079
    GMX1778 Inhibitor 99.72%
    GMX1778(CHS-828) is a potent inhibitor of NAD+ biosynthesis enzyme NAMPT with IC50 <25 nM.
  • HY-15976
    P7C3 Activator 98.00%
    P7C3 is a NAMPT activator.
  • HY-15766A
    GNE-617 hydrochloride Inhibitor 98.83%
    GNE-617 hydrochloride is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer.
  • HY-12808
    STF-118804 Inhibitor 98.55%
    STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.
  • HY-12971
    Nampt-IN-1 Inhibitor 99.12%
    Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
  • HY-15766
    GNE-617 Inhibitor 99.46%
    GNE-617 is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer.
  • HY-14375
    CB 300919 Inhibitor 99.01%
    CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.
  • HY-14373
    CB30865 Inhibitor 98.33%
    CB30865(ZM 242421) is a potent inhibitor of Nampt , an enzyme present in the NAD biosynthetic pathway.
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