1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. PAK

KPT-9274 

Cat. No.: HY-12793 Purity: 99.28%
Data Sheet SDS Handling Instructions

KPT-9274 is an inhibitor of p21-activated kinase (PAK) extracted from patent WO 2015003166 A1; has an IC50 of less than 100 nM in MTT assay.

For research use only. We do not sell to patients.
KPT-9274 Chemical Structure

KPT-9274 Chemical Structure

CAS No. : 1643913-93-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO $403 In-stock
5 mg $300 In-stock
10 mg $450 In-stock
50 mg $1300 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

KPT-9274 is an inhibitor of p21-activated kinase (PAK) extracted from patent WO 2015003166 A1; has an IC50 of less than 100 nM in MTT assay.

IC50 & Target

IC50: less than 100 nM (PAK)

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02702492 Karyopharm Therapeutics Inc NHL|Solid Tumors|Sarcoma June 2016 Phase 1
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.6377 mL 8.1883 mL 16.3765 mL
5 mM 0.3275 mL 1.6377 mL 3.2753 mL
10 mM 0.1638 mL 0.8188 mL 1.6377 mL
References
Molecular Weight

610.63

Formula

C₃₅H₂₉F₃N₄O₃

CAS No.

1643913-93-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.28%

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Product Name:
KPT-9274
Cat. No.:
HY-12793
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