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RSL3 1S,3R- (Synonyms: 1S,3R-RSL3)

Cat. No.: HY-100218A Purity: 99.87%
Handling Instructions

RSL3 is the inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system that blocks GSH synthesis with an IC50 of 100 nM.

For research use only. We do not sell to patients.

RSL3 1S,3R- Chemical Structure

RSL3 1S,3R- Chemical Structure

CAS No. : 1219810-16-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 175 In-stock
Estimated Time of Arrival: December 31
2 mg USD 114 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 660 In-stock
Estimated Time of Arrival: December 31
50 mg USD 960 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1560 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

RSL3 is the inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system that blocks GSH synthesis with an IC50 of 100 nM.[1] [2] RSL3, that are synthetically lethal with cell lines expressing mutant HRAS and KRAS.1. Cells transformed with oncogenic RAS have increased iron content relative to their normal cell counterparts through up-regulation of transferrin receptor 1 and downregulation of ferritin heavy chain 1 and ferritin light chain.[3]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (70.31 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2682 mL 11.3410 mL 22.6819 mL
5 mM 0.4536 mL 2.2682 mL 4.5364 mL
10 mM 0.2268 mL 1.1341 mL 2.2682 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

440.88

Formula

C₂₃H₂₁ClN₂O₅

CAS No.

1219810-16-8

SMILES

O=C([[email protected]]1CC2=C([[email protected]](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
RSL3 1S,3R-
Cat. No.:
HY-100218A
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RSL3 1S,3R-

Cat. No.: HY-100218A