1. Others
  2. Others

RSL3 1S,3R- (Synonyms: 1S,3R-RSL3)

Cat. No.: HY-100218A Purity: 99.59%
Data Sheet SDS Handling Instructions

RSL3 is the inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system that blocks GSH synthesis with an IC50 of 100 nM.

For research use only. We do not sell to patients.
RSL3 1S,3R- Chemical Structure

RSL3 1S,3R- Chemical Structure

CAS No. : 1219810-16-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $145 In-stock
2 mg $95 In-stock
5 mg $150 In-stock
10 mg $250 In-stock
25 mg $550 In-stock
50 mg $800 In-stock
100 mg $1300 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Featured Recommendations

Related Screening Libraries:

View More Collapse
  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

RSL3 is the inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system that blocks GSH synthesis with an IC50 of 100 nM.[1] [2] RSL3, that are synthetically lethal with cell lines expressing mutant HRAS and KRAS.1. Cells transformed with oncogenic RAS have increased iron content relative to their normal cell counterparts through up-regulation of transferrin receptor 1 and downregulation of ferritin heavy chain 1 and ferritin light chain.[3]

References
Molecular Weight

440.88

Formula

C₂₃H₂₁ClN₂O₅

CAS No.

1219810-16-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
RSL3 1S,3R-
Cat. No.:
HY-100218A
Quantity: