Cat. No.: HY-100218A

RSL3

Name: RSL3
Brand: MedChemExpress
SKU: HY-100218A
Price: 60.00 USD
Availability: InStock
Rating: 5 (551 reviews)

(Synonyms: (1S,3R)-RSL3)

551 Cited Publications

Customer Review

Based on 551 publication(s) in Google Scholar

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.

For research use only. We do not sell to patients.

Purity: 99.85%
CAS No.: 1219810-16-8
Formula: C₂₃H₂₁ClN₂O₅
Molecular Weight:440.88

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

RSL3 Chemical Structure

CAS No.: 1219810-16-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (551)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

GPX4

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	3.69 μM Compound: RSL3	Cytotoxicity against human 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34506134]
4T1	IC₅₀	3.69 μM Compound: RSL3	Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34506134]
786-0	IC₅₀	0.047 μM Compound: 1; RSL3	Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 39094276]
BT-549	IC₅₀	0.89 μM Compound: RSL3	Antiproliferative activity against human BT-549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human BT-549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 37452764]
Calu-1	IC₅₀	0.02 μM Compound: 94	Anti-ferroptotic activity against human Calu-1 cells assessed as cell growth inhibition Anti-ferroptotic activity against human Calu-1 cells assessed as cell growth inhibition	[PMID: 33684825]
Calu-1	IC₅₀	50 nM Compound: RSL3	Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 36603510]
HT-1080	CC₅₀	0.14 μM Compound: RSL3	Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
HT-1080	EC₅₀	0.06 μM Compound: RSL3	Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 6 hrs by time-course cell viability assay Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 6 hrs by time-course cell viability assay	[PMID: 36877935]
HT-1080	EC₅₀	0.08 μM Compound: RSL3	Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 3 hrs by time-course cell viability assay Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 3 hrs by time-course cell viability assay	[PMID: 36877935]
HT-1080	EC₅₀	0.16 μM Compound: RSL3	Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 1.5 hrs by time-course cell viability assay Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 1.5 hrs by time-course cell viability assay	[PMID: 36877935]
HT-1080	EC₅₀	0.59 μM Compound: RSL3	Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability measured immediately after addition of compound by time-course cell viability assay Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability measured immediately after addition of compound by time-course cell viability assay	[PMID: 36877935]
HT-1080	EC₅₀	0.75 μM Compound: RSL3	Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 6 hrs in presence of 40% human plasma by time-course cell viability assay Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 6 hrs in presence of 40% human plasma by time-course cell viability assay	[PMID: 36877935]
HT-1080	EC₅₀	0.88 μM Compound: RSL3	Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 24 hrs in presence of 40% human plasma by time-course cell viability assay Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 24 hrs in presence of 40% human plasma by time-course cell viability assay	[PMID: 36877935]
HT-1080	EC₅₀	1.01 μM Compound: RSL3	Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 3 hrs in presence of 40% human plasma by time-course cell viability assay Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 3 hrs in presence of 40% human plasma by time-course cell viability assay	[PMID: 36877935]
HT-1080	EC₅₀	1.42 μM Compound: RSL3	Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 1.5 hrs in presence of 40% human plasma by time-course cell viability assay Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 1.5 hrs in presence of 40% human plasma by time-course cell viability assay	[PMID: 36877935]
HT-1080	IC₅₀	0.09 μM Compound: 1; RSL3	Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 39094276]
HT-1080	IC₅₀	0.1 μM Compound: 17; (1S, 3R)-RSL3	Induction of ferroptosis in human HT-1080 cells assessed as inhibition of (cystine-glutamate antiporter) system Xc- mediated cystine transport Induction of ferroptosis in human HT-1080 cells assessed as inhibition of (cystine-glutamate antiporter) system Xc- mediated cystine transport	[PMID: 36332549]
HT-1080	IC₅₀	1.2 μM Compound: RSL3	Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34506134]
HT-1080	IC₅₀	130 nM Compound: RSL3	Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 36603510]
HT-1080	IC₅₀	3.7 μM Compound: RSL3	Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs in presence of Fer-1 by MTT assay Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs in presence of Fer-1 by MTT assay	[PMID: 34506134]
HT-29	IC₅₀	3.25 μM Compound: RSL3	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
MCF7	IC₅₀	13.57 μM Compound: RSL3	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34506134]
MDA-MB-231	CC₅₀	0.22 μM Compound: RSL3	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
MDA-MB-231	IC₅₀	0.129 μM Compound: 1; RSL3	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 39094276]
MDA-MB-231	IC₅₀	0.28 μM Compound: RSL3	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 37452764]
MDA-MB-231	IC₅₀	3.12 μM Compound: RSL3	Induction of ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 72 hrs in presence of ferroptosis inhibitor, ferrostatin-1 by MTT assay Induction of ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 72 hrs in presence of ferroptosis inhibitor, ferrostatin-1 by MTT assay	[PMID: 37452764]
MDA-MB-468	IC₅₀	0.14 μM Compound: RSL3	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 37452764]
MEF	CC₅₀	0.04 μM Compound: RSL3	Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H1650	IC₅₀	7.75 μM Compound: RSL3	Antiproliferative activity against human NCI-H1650 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 36603510]
NCI-H1703	EC₅₀	0.08 μM Compound: RSL3	Induction of ferroptosis in human NCI-H1703 cells assessed as cell viability incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay Induction of ferroptosis in human NCI-H1703 cells assessed as cell viability incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 36877935]
NCI-H522	CC₅₀	0.31 μM Compound: RSL3	Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H522	CC₅₀	1.1 μM Compound: RSL3	Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H522	CC₅₀	2.84 μM Compound: RSL3	Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
OS-RC-2	IC₅₀	0.082 μM Compound: 1; RSL3	Antiproliferative activity against human OS-RC-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human OS-RC-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 39094276]
U2OS	CC₅₀	2.46 μM Compound: RSL3	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
WI-38	CC₅₀	0.05 μM Compound: RSL3	Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]

In Vitro

RSL3 (0-8 μM, 72 hours) potently reduces the viability of HN3 cells, with IC₅₀s of 0.48 μM in HN3 and 5.8 μM in HN3-rslR cells, respectively^[1].
RSL3 (0-8 μM, 24 hours) reduces the expression of GPX4 protein, increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells^[1].

Ferroptosis-sensitive Cell Lines

Ferroptosis-sensitive Cells	Test Conditions
MCF10A-RAS^[2]	0-10 μM; 48 h
MDA-MB-468^[3]	0.1-1 μM; 24 h
PC-3^[3]	0.01-1 μM; 24 h
Huh-7^[3]	0.01-1 μM; 24 h
Raji^[3]	0.01-1 μM; 24 h
MEF^[3]	0.1-100 nM; 24 h
HT-22 neuron^[4]	200 nM; 16 h
NCI-H508^[5]	0.1-10 μM; 48 h
LoVo^[5]	0.1-10 μM; 48 h
LS513^[5]	0.1-10 μM; 48 h
SW480^[5]	0.1-10 μM; 48 h
SW620^[5]	0.1-10 μM; 48 h
SW1116^[5]	0.1-10 μM; 48 h
DLD-1^[5]	0.1-10 μM; 48 h
Caco-2^[5]	0.1-10 μM; 48 h
HT-1080^[6]	0-10 μM; 48 h; IC₅₀ 1.55 μM
MDA-MB-436^[7]	0.1-2 μM; 24 h
HT-29^[7]	0.1-2 μM; 24 h
U-373^[7]	0.1-2 μM; 24 h
A549^[8]	1 nM-100 μM; 24 h; IC₅₀ 0.5 μM
H1975^[8]	1 nM-100 μM; 24 h; IC₅₀ 150 nM
MAD-MB-231^[9]	0-10 μM; 96 h; IC₅₀ 0.71 μM
HCC1937^[9]	0-10 μM; 96 h; IC₅₀ 0.85 μM

Ferroptosis-insensitive Cell Lines

Ferroptosis-insensitive Cells	Test Conditions
HS578T^[10]	0-2.5 μM; 24 h
MCF10A^[10]	0-2.5 μM; 24 h

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HN3 cells, HN3-rslR cells
Concentration:

0-8 μM
Incubation Time:

72 hours
Result:

Showed IC₅₀s of 0.48 µM in HN3 and 5.8 µM in HN3-rslR cells, respectively^[1].

Western Blot Analysis^[1]

Cell Line:

HN3-rslR cells
Concentration:

0-8 μM
Incubation Time:

24 hours
Result:

Inhibited GPX4 expression, increased p62 and Nrf2 levels, and decreased Keap1 levels.

In Vivo

RSL3 (100 mg/kg, Intratumorally twice per week for 20 days) significantly inhibits the growth of tumor in combination with Trigonelline (HY-N0414) in mice bearing HN3R cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ten-week-old athymic BALB/c male nude mice (nu/nu) bearing HN3R cells^[1]
Dosage:

100 mg/kg in combination with trigonelline (50 mg/kg)
Administration:

Intratumorally twice per week for 20 days
Result:

Significantly reduced the volume of tumor combined with trigonelline in mice.

Chemical Information

CAS No. 1219810-16-8
Appearance Solid
Molecular Weight 440.88
Formula C₂₃H₂₁ClN₂O₅
Color White to off-white
SMILES

O=C([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC
Synonyms

(1S,3R)-RSL3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

Publications (551)

All Flow CytometryRT-PCRHistological Imaging/StainingELISAIn Vivo Efficacy StudyBio/Physico-chemical AssayCell Imaging/Staining2D/3D Cell Culture and DifferentiationIHCIFCell Proliferation/Viability AssayWBIP

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Journal Impact Factor

Nature

Catabolism of extracellular glutathione supplies cysteine to support tumours. [Abstract]

2026 May;653(8115):933-941. PMID: 41851454

RSL3 purchased from MedChemExpress. Usage Cited in: Nature. 2026 May;653(8115):933-941. [Abstract]

Ferroptosis-sensitive HT-1080 cell line and ferroptosis-resistant HCC-1806 cell line were grown in control (208 µM cystine; Cys2) and cystine-free (Cys2-free) medium with vehicle (DMSO) or RSL3 (250 nM), alone or with Fer-1 (10 µM) or Trolox (100 µM). After 24 h, cells were stained with C11-BODIPY, and relative green and red fluorescence was determined.
Nature

Lymph node environment drives FSP1 targetability in metastasizing melanoma. [Abstract]

2026 Jan;649(8096):477-486. PMID: 41193799

RSL3 purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jan;649(8096):477-486. [Abstract]

Cell death assays using Sytox Green in B16-F0, LN7, and LN9 cells treated with RSL3 (0.5 or 1 μM) for 16 h.

RSL3 purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jan;649(8096):477-486. [Abstract]

Cell viability of B16-F0 and LN metastatic lines treated with RSL3 (0.5 μM) for 48 h.
Nature

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer. [Abstract]

2025 Jul;643(8074):1381-1390. PMID: 40399683

RSL3 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jul;643(8074):1381-1390. [Abstract]

SYTOXgreen images (left) and quantification (right) of HPAC cell death (green fluorescence) following knock-out of PCSK9 and treatment with RSL3 (1 μM) for 24 hrs.

RSL3 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jul;643(8074):1381-1390. [Abstract]

Measurement of HPAC cell growth following knockout of SC5D and treatment with increasing doses of RSL3 (left) and ML210 (right) for 96 hrs.
Nature

Emergence of large-scale cell death through ferroptotic trigger waves. [Abstract]

2024 Jul;631(8021):654-662. PMID: 38987590

RSL3 purchased from MedChemExpress. Usage Cited in: Nature. 2024 Jul;631(8021):654-662. [Abstract]

RSL3 (0.15 uM; 1-5 h) induces ferroptosis in U-2 0S and A549 cells.
J Hematol Oncol

METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma. [Abstract]

2024 Sep 2;17(1):78. PMID: 39218945

RSL3 purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2024 Sep 2;17(1):78. [Abstract]

RSL3 (1-2 μM; 24 h) treatment induced a dose‑dependent decrease in both mRNA and protein expression levels of METTL16 in HCC cells.

RSL3 purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2024 Sep 2;17(1):78. [Abstract]

Representative images of HE staining and METTL16, 4-HNE IHC staining of xenografts. Scale bar, 100 μm. Immunohistochemistry (IHC) staining demonstrated that the RSL3 (5 mg/kg; i.p.; every other day)-induced expression of 4-hydroxynonenal (4-HNE), a lipid peroxidation product of ferroptosis, was further amplified by METTL16 knockdown, revealing enhanced ferroptotic activity.

RSL3 purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2024 Sep 2;17(1):78. [Abstract]

Representative images and statistical data of weights and volumes of xenografts from HCCLM3 with or without the treatment of RSL3 (5 mg/kg; i.p.; every other day) (n = 6 mice per group).
J Hematol Oncol

Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis. [Abstract]

2023 May 3;16(1):46. PMID: 37138326

RSL3 purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2023 May 3;16(1):46. [Abstract]

Viability of RM1 cells and hybrid cells after RSL3 (0.05-10 μM; 24 h) treatment.
Cell

Stabilizing MARCH7 as a ferro-guardian against ferroptosis. [Abstract]

2026 Jun 11;189(12):3553-3570.e30. PMID: 42049018

RSL3 purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jun 11;189(12):3553-3570.e30. [Abstract]

Western blot analysis of the indicated proteins in HeLa cells transfected with FLAG-MARCH7 and HA-Ub for 36 h and then treated with RSL3 (0.30 μM) and MG132 (50 μM) for 4 h. RSL3 treatment significantly upregulated the degree of ubiquitination of MARCH7.

RSL3 purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jun 11;189(12):3553-3570.e30. [Abstract]

Viability of the indicated HT-1080 cells and HeLa cells pretreated with Fer-1 (5 μM), DFO (80 μM), Z-VAD (20 μM), Nec-1 (20 μM), and TTM (20 μM) for 12 h, and then treated with RSL3 (0.25 μM) for 12 h. The results showed that the cell viability of RSL3-treated MARCHF7-KD cells was recovered by treatment with DFO or Fer-1, but not by inhibitors of other types of cell death.

RSL3 purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jun 11;189(12):3553-3570.e30. [Abstract]

Levels of lipid ROS in the control and MARCHF7-KD HeLa cells with or without RSL3 (0.25 μM) treatment for 12 h.
Cell

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease. [Abstract]

2026 Apr 30;189(9):2648-2662.e19. PMID: 41747729
Cell Metab

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages. [Abstract]

2026 May 5;38(5):963-980.e12. PMID: 41856104

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2026 May 5;38(5):963-980.e12. [Abstract]

Cell viability of HCT116 or MC38 cells treated with various concentrations of RSL3 for 24 hours, where cells were pretreated with 200 μM oleic acid (OA) for 16 hours or pretreated with 100 ng/mL IL-1β for 6 hours, followed by 200 μM OA for 16 hours. The results showed that IL-1β pretreatment sensitized IEC lines (HCT116 and MC38) to RSL3-induced ferroptosis, resulting in reduced cell viability.
Cell Metab

Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via suppressing ferroptosis. [Abstract]

2025 Jan 7;37(1):169-186.e9. PMID: 39510074
Cancer Discov

C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia. [Abstract]

2023 Jul 7;13(7):1720-1747. PMID: 37012202

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2023 Jul 7;13(7):1720-1747. [Abstract]

MOLM-14 or MV4-11 cells supplemented with or without oleate were incubated with vehicle (veh.) or 250 nM RSL3. cell viability was measured by propidiumiodide (PI) staining after 24-hour treatment.
Adv Mater

Lipid Droplet-Targeted Biomimetic Liposomes Potentiate Chemo-Ferroptosis Therapy in Leukemia. [Abstract]

2026 Apr;38(20):e15716. PMID: 41814941

RSL3 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2026 Apr;38(20):e15716. [Abstract]

Cell viability of OCI-AML2 cells treated with varying concentrations of RSL3 (0.5-2.0 µM; 24 h) under normoxic and hypoxic conditions, with or without Met (50 µM). CCK-8 analysis revealed that RSL3-induced ferroptosis was significantly attenuated under hypoxic conditions, exhibiting a 1.6-fold reduction in cytotoxicity compared to normoxia at 1 µM RSL3.

RSL3 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2026 Apr;38(20):e15716. [Abstract]

Representative flow cytometry plots and quantitative analysis of apoptosis in OCI-AML2 cells treated with RSL3 (1 µM; 24 h) and/or Met (50 µM) under hypoxic conditions. The results showed that apoptosis was significantly increased in the group treated with the combination of RSL3 and Met compared to the group treated with RSL3 alone, confirming the Met-mediated sensitization to ferroptosis
Adv Mater

Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke. [Abstract]

2025 Jan;37(3):e2409176. PMID: 39600046

RSL3 purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Jan;37(3):e2409176. [Abstract]

Cell viability of M0, M1 and M2-type BV2 cells under stimulation of RSL3 at different concentrations (n = 4). The cell viability of M2-type BV2 cells was significantly lower than that of M0 and M1-type BV2 cells after incubation with RSL3 (0.1-2 µM; 10 h), suggesting heightened sensitivity to ferroptosis in M2-type BV2 cells.
Adv Mater

A T-cell Inspired Sonoporation System Enhances Low-dose X-ray-mediated Pyroptosis and Radioimmunotherapy Efficacy by Restoring Gasdermin-E Expression. [Abstract]

2024 Mar 24:e2401384. PMID: 38521987
Cancer Commun (Lond)

Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction. [Abstract]

2024 Nov;44(11):1261-1286. PMID: 39221971

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2024 Nov;44(11):1261-1286. [Abstract]

RSL3 (0.2, 1, 2 µM; 48 h) induced cell death (ferroptosis) in both 4T1-LM3 and E0771-LM3 cells.
Nat Cancer

Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity. [Abstract]

2025 May;6(5):768-785. PMID: 40108413

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2025 May;6(5):768-785. [Abstract]

Immunoblotting analysis of GPX4 palmitoylation by ABE assay in HEK293T cells transfected with plasmids encoding GPX4-HA, together with or without zDHHC8-Flag for 36 h, followed with treatment of RSL3 (1 μM) or IKE (5 μM) for 10 h.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2025 May;6(5):768-785. [Abstract]

HT-1080 cells were treated with RSL3 (0.1 μM) or IKE (1 μM) for 10 h, followed by immunoprecipitation using IgG or anti-GPX4 antibody.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2025 May;6(5):768-785. [Abstract]

The cell viability of mock or ZDHHC8-KO HT-1080 cells treated with the indicated concentrations of RSL3 for 24 h.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2025 May;6(5):768-785. [Abstract]

The cell viability of mock or ZDHHC8-KO HT-1080 cells treated with DMSO, RSL3 (0.1 μM), ML162 (0.1 μM), IKE (1 μM) or IFNγ (20 ng/mL) plus AA (20 μM) together with or without Fer-1 (2 μM). For RSL3, ML162 and IKE, cells were treated for 24 h, and for IFNγ plus AA, cells were treated for 48 h.
Nat Cancer

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis. [Abstract]

2022 Apr;3(4):471-485. PMID: 35484422

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2022 Apr;3(4):471-485. [Abstract]

Cellular responses of neuroblastoma cell lines to 72 h of RSL3 treatment: cells with MYCN amplification (black symbols), moderate MYCN expression (white circle) and lack thereof (white triangle).
Nat Cell Biol

Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability. [Abstract]

2026 May;28(5):915-929. PMID: 42032311

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2026 May;28(5):915-929. [Abstract]

SK-MEL-103 were treated for 2 h with RSL3 (1 μM) or SCLA2 (7 μM). Cells were then stained with BODIPY 581/591 C11.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2026 May;28(5):915-929. [Abstract]

Intracellular glutathione levels in SK-MEL103 treated with BSO overnight or 4 h with RSL3 (1-10 μM) or SCLA2.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2026 May;28(5):915-929. [Abstract]

Tumour weight (mg) of mice treated with vehicle (V), RSL3 (R) (50 mg/kg; i.p.; twice a week for 2 weeks) , palbociclib (P) and palbociclib + RSL3 (P+R). Measurements at the end point. Statistical test used: unpaired t-test (two-tailed) comparing V versus R groups and P versus P+R groups.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2026 May;28(5):915-929. [Abstract]

Mice were treated with vehicle, RSL3 (50 mg/kg; i.p.; twice a week for 2 weeks), palbociclib, and palbociclib + RSL3. Representative images of p21^Cip1 IHC staining in SK-MEL-103 tumours. Scale bar, 200 μm.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2026 May;28(5):915-929. [Abstract]

Representative IF images of GFL16 in PC3 tumours. Scale bar, 25 μm in both figures and mags (n = 7 mice for V, n = 6 mice for RSL3 (R) (50 mg/kg; i.p.; twice a week for 2 weeks), palbociclib (P) and palbociclib + RSL3 (P+R)).
Nat Cell Biol

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer. [Abstract]

2025 Apr;27(4):641-653. PMID: 40033101

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Apr;27(4):641-653. [Abstract]

Parental HeLa cells and the indicated clones with knock-in expression of GPX4-R152K mutant, were treated with or without cystine deprivation, Erastin (20 μM) and RSL3 (2 μM) for 6 h in the absence or presence of pretreated with Fer-1 (2 μM) for 2 h. Basal ROS levels were measured.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Apr;27(4):641-653. [Abstract]

Parental HeLa cells and the indicated clones with knock-in expression of GPX4-R152K mutant, were treated with or without cystine deprivation, Erastin (20 μM) and RSL3 (2 μM) for 6 h in the absence or presence of pretreated with Fer-1 (2 μM) for 2 h. Lipid ROS levels were measured.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Apr;27(4):641-653. [Abstract]

Parental HeLa cells and the indicated clones with knock-in expression of GPX4-R152K mutant, were treated with or without cystine deprivation, Erastin (20 μM) and RSL3 (2 μM) for 6 h in the absence or presence of pretreated with Fer-1 (2 μM) for 2 h. Relative MDA levels were measured.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Apr;27(4):641-653. [Abstract]

C4-2 cells were subjected to mouse xenograft assays, When the tumor reached 50 mm3, the mice were assigned randomly into different treatment groups treat with RSL3 (100 mg/kg; i.p.; once daily) combined with or without GSK3326595 (40 mg/kg). Tumor sizes were monitored until the endpoint at day 30, and dissected tumors were weighed.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Apr;27(4):641-653. [Abstract]

C4-2 cells were subjected to mouse xenograft assays, When the tumor reached 50 mm3, the mice were assigned randomly into different treatment groups treat with RSL3 (100 mg/kg; i.p.; once daily) combined with or without GSK3326595 (40 mg/kg). Representative image and statistical analysis of IHC staining with the indicated antibodies of xenograft tumors from l. Scale bar, 100 μm.
Cancer Res

TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. [Abstract]

2026 Jul 15;86(14):3436-3458. PMID: 41974002

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jul 15;86(14):3436-3458. [Abstract]

Representative mitochondrial morphology images after treatment with 4 µmol/L RSL3 for 12 hours. Scale bars, 500 nm. Transmission electron microscopy revealed severe mitochondrial damage in TRAPPC4-deficient cells following RSL3 exposure.

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jul 15;86(14):3436-3458. [Abstract]

Cell viability of indicated cells following treatment with RSL3 (4 µmol/L) in the absence or presence of Fer-1 (1 µmol/L), Z-VAD (20 µmol/L), or Nec-1 (20 µmol/L) for 12 hours. RSL3-induced cell death in sgTRAPPC4 and control cells was fully rescued by the ferroptosis inhibitor Fer-1 but not by the apoptosis inhibitor Z-VAD or the necroptosis inhibitor Nec-1, excluding contributions from apoptosis or necroptosis.

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jul 15;86(14):3436-3458. [Abstract]

Tumor images at the endpoint, tumor growth curves, and tumor weight and relative MDA levels in the indicated groups. Scale bars, 1 cm. The results showed that in this CDX model, both TRAPPC4 knockout and RSL3 (40 mg/kg; i.p.; once every other day for 8 times) monotherapy suppressed tumor growth, whereas the combination of TRAPPC4 depletion and RSL3 treatment led to a significantly greater inhibition of tumor progression.

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jul 15;86(14):3436-3458. [Abstract]

Representative IHC images of TRA, Ki-67, and 4-HNE proteins in the indicated xenograft tumors (E), along with quantification of Ki-67 (F, left) and 4-HNE (F, right) expression. Scale bars, 40 μm. IHC demonstrated that RSL3-treated sgTRAPPC4-1 tumors had a substantial decrease in Ki-67–positive cells and a significant increase in 4-HNE levels compared with other groups.

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jul 15;86(14):3436-3458. [Abstract]

PDOs with TRA knockdown or control were treated with DMSO or RSL3 (10 µmol/L) for 48 hours. Shown are representative images. Scale bars: 200 μm.

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jul 15;86(14):3436-3458. [Abstract]

PDOs with TRA knockdown or control were treated with DMSO or RSL3 (10 µmol/L) for 48 hours. Shown are relative cell viability.
Cancer Res

MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer. [Abstract]

2025 Sep 24. PMID: 40991294

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

ROS levels in shNC and shMEN1 A549 cells treated with erastin or RSL3 (2 μmol/L; 24 hours) or RosUP (0.5 hours). The results showed that MEN1 knockdown effectively blocked ferroptosis inducers (erastin and RSL3) and the ROS inducer ROSUP-induced cytosolic ROS generation.
Cancer Res

PRODH2-Mediated Metabolism in the Bone Microenvironment Promotes Breast Cancer Metastasis. [Abstract]

2025 Aug 1. PMID: 40749014

RSL3 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1. [Abstract]

Cell viability assay of indicated cells treated for 48 hours with ferroptosis inducers (erastin or RSL3, 10 μmol/L each), with or without Hyp treatment.
Drug Resist Updat

DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. [Abstract]

2025 Jul:81:101224. PMID: 40058099

RSL3 purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2025 Jul:81:101224. [Abstract]

Cell viability curves for Huh7 and Huh7-LR cells treated with the indicated concentrations of Lenvatinib or RSL3 for 48 h. The results showed that Huh7-LR cells exhibited resistance to both lenvatinib and RSL3.
Adv Funct Mater

2023 Apr 28.
Autophagy

Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 axis. [Abstract]

2026 Feb 15:1-19. PMID: 41612599

RSL3 purchased from MedChemExpress. Usage Cited in: Autophagy. 2026 Feb 15:1-19. [Abstract]

Representative images showing cell death by PI staining in A375 and HT1080 cells treated with 1 μM and 0.1 μM RSL3, respectively, with or without 20 μM kitasamycin for 6 h.

RSL3 purchased from MedChemExpress. Usage Cited in: Autophagy. 2026 Feb 15:1-19. [Abstract]

Cell death measurement in A375 and HT1080 cells treated with 1 μM and 0.1 μM RSL3, respectively, with or without 20 μM kitasamycin for 6 h.

RSL3 purchased from MedChemExpress. Usage Cited in: Autophagy. 2026 Feb 15:1-19. [Abstract]

Lipid peroxidation measurement in A375 and HT1080 cells treated with RSL3, 20 μM kitasamycin, and 10 μM Lip-1 for 1 h.

RSL3 purchased from MedChemExpress. Usage Cited in: Autophagy. 2026 Feb 15:1-19. [Abstract]

Representative images of three-dimensional tumor spheroids using A375 cells, HT1080 cells, and HeLa cells by PI staining treated with respectively with 1 μM RSL3 (A375), 0.1 μM RSL3 (HT1080), 5 μM RSL3 (HeLa), in combination with 20 μM kitasamycin and/or 10 μM Lip-1 for 8 h. The results showed that kitasamycin markedly enhanced RSL3-induced ferroptosis in these 3D spheroids, as evidenced by the significantly rescued effect of Lip-1.
Nat Commun

Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia. [Abstract]

2024 Dec 30;15(1):10878. PMID: 39738118

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Dec 30;15(1):10878. [Abstract]

gMFI for ThiolTracker of AML CD34⁺ cells treated for 24 h with vehicle (PBS), RSL3 (1 µM; p = 0.02), EV^AML (p = 0.0003) or after pre-treatment with RSL3 (1 µM) for 6 h before adding EV^AML (p = 0.0004 versus EV^AML). The results showed that RSL3 significantly reduced the GSH levels detected in AML CD34⁺ cells.
Nat Commun

SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis. [Abstract]

2024 Aug 30;15(1):7522. PMID: 39215042

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 30;15(1):7522. [Abstract]

Cell viability of HepG2 and SNU398-shNC, sh#1 and sh#2 cells in the presence of different compound at theindicated concentrations (0.025, 0.05, 0.1, 0.2 μM for RSL3) for 48 h (shNC, gray curve; sh#1, blue curve; sh#2, dark blue curve). The results showed that SLC13A3 knockdown increased the vulnerability of cells to ferroptosis modulators of the GSH-GPX4 axis (RSL3).
Exp Mol Med

Transferrin receptor 1 shedding by the pro-inflammatory iRhom-ADAM17 complex and ADAM10 regulates cellular iron uptake and ferroptosis. [Abstract]

2026 Jun;58(6):1824-1837. PMID: 42243530

RSL3 purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2026 Jun;58(6):1824-1837. [Abstract]

Cell viability was assessed by live cell imaging in combination with cell death staining. Representative pictures of HEK293 cells after 24 h RSL3 (10 µM) treatment (scale bar, 100 µm).
Exp Mol Med

RNA-binding protein HnRNPU regulates proliferation and ferroptosis in colon adenocarcinoma by stabilizing the mRNA of system xc. [Abstract]

2025 Nov;57(11):2686-2698. PMID: 41310105

RSL3 purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2025 Nov;57(11):2686-2698. [Abstract]

Cell viability was determined using CCK-8 in SW620 and SW480 cells expressing sh-con or sh-HnRNPU treated with different concentrations of RSL3 (2.5-10 μM) for 24 h. The results showed that the HnRNPU depletion facilitated RSL3-induced ferroptosis.

RSL3 purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2025 Nov;57(11):2686-2698. [Abstract]

MDA assay kit was used to detect the level of MDA treated with RSL3 (SW620: RSL3 5 μM; SW480: RSL3 7.5 μM). The results showed that HnRNPU depletion facilitated RSL3-induced ferroptosis, as indicated by increased malondialdehyde (MDA) levels.
ACS Nano

Targeted Knockdown of Epithelial Estrogen Receptor α to Mitigate Ferroptosis and Epithelial-Mesenchymal Transition in Eosinophilic Asthma. [Abstract]

2025 Jun 10;19(22):21105-21117. PMID: 40424612
ACS Nano

Biomineralization-Tuned Nanounits Reprogram the Signal Transducer and Activator of Transcription 3 Signaling for Ferroptosis-Immunotherapy in Cancer Stem Cells. [Abstract]

2024 Aug 13;18(32):21268-21287. PMID: 39083438
ACS Nano

Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation. [Abstract]

2023 Nov 28;17(22):22240-22258. PMID: 37966480

RSL3 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2023 Nov 28;17(22):22240-22258. [Abstract]

Percentage of cell viability in HCC samples (paired sorafenib-sensitive and sorafenib-resistant HepG2, PLC/PRF/5, and PDO) treated with 3 μM RSL3.
J Adv Res

Renal tubular Nfe2l1 protect cisplatin-induced acute kidney injury via suppressing ACSL4-dependent ferroptosis. [Abstract]

2026 May 3:S2090-1232(26)00381-4. PMID: 42086188
J Adv Res

MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis. [Abstract]

2025 Oct 10:S2090-1232(25)00764-7. PMID: 41077348
J Adv Res

Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis. [Abstract]

2024 Dec 6:S2090-1232(24)00554-X. PMID: 39647633

RSL3 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Dec 6:S2090-1232(24)00554-X. [Abstract]

Representative images of primary osteoblasts and osteoclasts treated with HGPA (HG 25.5 mM; PA 100 μM) or RSL3 (0.3 μM) with or without AVI (10 μM) for 36 h, and then assayed by TUNEL staining (the upper two panels, positively-stained cells were indicated by arrows). Osteoblasts treated as above were examined by C11-BODIPY (the lower three panels). The results showed that both HGPA and RSL3 induced an increase in TUNEL‑positive cells in osteoblasts, but not in osteoclasts, while AVI reduced TUNEL‑positive cell counts induced by HGPA, but not those induced by RSL3 (the upper two panels). To validate these results, C11‑BODIPY staining was performed, and control osteoblasts overwhelmingly displayed non‑oxidized (N‑) BODIPY (red), whereas both HGPA and RSL3 caused a pronounced increase in oxidized (O‑) BODIPY (green) (the lower three panels).

RSL3 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Dec 6:S2090-1232(24)00554-X. [Abstract]

Western blotting analysis of GPX4, 4-HNE, and MDA of primary osteoblasts treated with RSL3 (0.3 μM), and/or HGPA (HG 25.5 mM; PA 100 μM) in presence or absence of AVI (10 μM) for 36 h.

RSL3 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Dec 6:S2090-1232(24)00554-X. [Abstract]

Control (Ctrl) and RSL3 (100 mg/kg;i.p.; twice a week)-treated mice, as well as Gpx4^fl/fl and Gpx4^Ob-/+ mice, were subjected to vehicle control (Ctrl), STZ/HFD, or AVI/ STZ/HFD treatment as before (n = 6). Representative microphotographs of the μ-CT-scanned distal femurs (the left panel) and TUNEL-stained femur sections (the right panel, Arrows indicated the positive cells).
J Adv Res

Quercetin alleviates acute kidney injury by inhibiting ferroptosis. [Abstract]

2020 Jul 22:28:231-243. PMID: 33364059
Neuron

Protective ApoE variants support neuronal function by effluxing oxidized phospholipids. [Abstract]

2025 Dec 2:S0896-6273(25)00847-5. PMID: 41338186

RSL3 purchased from MedChemExpress. Usage Cited in: Neuron. 2025 Dec 2:S0896-6273(25)00847-5. [Abstract]

Airyscan maximum intensity projection images of WT neurons following RSL3 (0.5-1 μM; 4 h) treatment in media, labeled with DQ Red BSA and normalized to untreated control neurons. Scale bars are 10 µm.
Cell Discov

Genetic tracing uncovers the importance of epithelial-to-mesenchymal transition in small cell lung cancer chemotherapy resistance but not metastasis. [Abstract]

2024 Jun 4;10(1):60. PMID: 38834595
Cell Discov

Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis. [Abstract]

2022 May 3;8(1):40. PMID: 35504898

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 May 3;8(1):40. [Abstract]

U2OS cells are treated with DMSO (Control) or OSMI-1 for 12 h, and then treated with RSL3 (10 μM) for different time as indicated. Cells are then subjected to immunofluorescence microscopy with antibodies against TfR1 and GM130.

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 May 3;8(1):40. [Abstract]

U2OS cells are treated with OSMI-1 (30 μM) or TMG (10 μM) for 12 h, and then induced with or without RSL3 (10 μM) for 6 h.

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 May 3;8(1):40. [Abstract]

U2OS cells are treated with DMSO (Control) or OSMI-1 for 12 h, and then treated with RSL3 (10 μM) for different time as indicated. The levels of cellular ferrous iron are assessed by flow cytometry using FerroOrange.
Redox Biol

CL-316243 facilitates stable atherosclerotic plaque phenotypes in association with suppression of perivascular adipose tissue ferroptosis via upregulating C/EBPβ. [Abstract]

2026 Jun 13:95:104259. PMID: 42289168

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun 13:95:104259. [Abstract]

Measurement of normalized Fe²⁺ content, MDA, and GSH/GSSG ratio in PVAT explants treated by vehicle (DMSO) or RSL3 (5 μM) for 24 h, n = 6. The results showed that RSL3 treatment significantly enhanced key markers of ferroptosis, including elevated intracellular Fe²⁺ and MDA levels, as well as a markedly reduced GSH/GSSG ratio.

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun 13:95:104259. [Abstract]

mRNA levels of genes associated with ferroptosis and PVAT dysfunction in in PVAT explants treated by vehicle (DMSO) or RSL3 (5 μM) for 24 h, n = 6. The results showed that mRNA levels of pro-inflammatory cytokines were significantly elevated in RSL3-treated PVAT, and adipokine expression was aberrant.

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Jun 13:95:104259. [Abstract]

ELISA analysis of TNF-α, IL-1β and IL-6 levels in the conditioned medium of PVAT explants treated by vehicle (DMSO) or RSL3 (5 μM) for 24 h, n = 6. ELISA analysis of conditioned media showed substantially higher secretion of proinflammatory cytokines from RSL3-treated PVAT compared to vehicle (DMSO)-treated controls.
Redox Biol

Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer. [Abstract]

2026 Apr:91:104099. PMID: 41723905

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Apr:91:104099. [Abstract]

The dose-response curve and IC₅₀ of RSL3 (5-20 μM) in H1299 cells were determined after 24 h (CCK-8 assay, n = 3), and cell viability of H1299 cells treated with Pinostilbene (100 μM), RSL3 (5 μM), or their combination for 24 h was assessed (n = 4). The CCK-8 assay showed that Pinostilbene significantly enhanced RSL3-induced reduction of cell viability in H1299 cells.

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Apr:91:104099. [Abstract]

Cell death assessed by Annexin V/PI staining (n = 3). The Annexin V⁻/PI⁻ population was defined as live cells, while cells in the other three quadrants were defined as dead cells. Annexin V/PI staining showed that Pinostilbene (100 μM; 24 h) markedly increased the sensitivity of H1299 cells to RSL3 (5 μM; 24 h)-mediated ferroptosis.

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Apr:91:104099. [Abstract]

H1299 cells were treated with Pinostilbene (100 μM), RSL3 (5 μM), or their combination for 24 h. Mitochondrial morphology by TEM (n = 3). The results showed that the ferroptosis-like mitochondrial damage in H1299 cells caused by the combined treatment of Pinostilbene and RSL3 was more severe than that in the RSL3 single-agent group.

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Apr:91:104099. [Abstract]

H1299 cells were treated with Pinostilbene (100 μM), RSL3 (5 μM), or their combination for 24 h. qPCR of Tfrc, FTH1, GPX4, and ACSL4 mRNA (n = 3). The results showed that Pinostilbene significantly increased the mRNA expression of the iron-storage protein FTH1 at baseline levels. However, under RSL3-induced ferroptotic stress, Pinostilbene downregulated the mRNA expression of the iron-uptake protein Tfrc and the lipid peroxidation-promoting protein ACSL4. Meanwhile, Pinostilbene did not affect the transcription of the key ferroptosis-inhibiting gene GPX4 either in the absence or in the presence of RSL3 treatment.

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Apr:91:104099. [Abstract]

H1299 cells were treated with Pinostilbene (100 μM), RSL3 (5 μM), or their combination for 24 h. Western blot of Tfrc FTH1, LC3B, NCOA4, ACSL4, and GPX4 protein. The results showed that Pinostilbene substantially reversed the RSL3-induced upregulation of FTH1 protein levels.
Redox Biol

Apolipoprotein C3 exacerbates vascular calcification by promoting ferroptosis via the TLR2/AMPK pathway in vascular smooth muscle cells. [Abstract]

2026 Apr:91:104088. PMID: 41734579
Redox Biol

USP20 governs tyrosine kinase inhibitors resistance through ferroptosis evasion by targeting GPX4 in cancers. [Abstract]

2026 May:92:104086. PMID: 41844497

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 May:92:104086. [Abstract]

Parental and Sora-R cells were treated with indicated concentration of RSL3 for 48 h, cell viability was measured via MTT assay.
Redox Biol

Methylation reader MBD2-mediated GPX4 transcriptional repression drives ovarian granulosa cell ferroptosis in PCOS. [Abstract]

2026 Mar:90:104034. PMID: 41576700

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Mar:90:104034. [Abstract]

Control and RSL3 (5 mg/kg; i.p.; the last 10 days)-treated mice were grouped into oil vehicle control (Ctrl), DHEA (60 mg/kg, 21 days)-treated (DHEA), and DHEA-treated with KCC-07 (KCC, 10 mg/kg) treatment (KCC/DHEA) mice (n = 10). Representative photomicrographs of ovarian sections. Ovarian sections were stained with hematoxylin-eosin (HE; upper panels), Masson trichrome (middle panels), and TUNEL assay (lower panels). Asterisks indicate corpora lutea; black arrows indicate preantral follicles; yellow arrows indicate collagen deposits; white arrows indicate TUNEL-positive cells. RSL3-treated mice exhibited marked ovarian damage characterized by reduced ovary size, decreased corpora lutea, increased preantral follicles and enhanced collagen deposition and apoptosis, which were aggravated by DHEA treatment. KCC-07 ameliorated these pathological alterations; however, co-administration of RSL3 effectively abrogated the protective effects of KCC-07 on ovarian function.

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Mar:90:104034. [Abstract]

Control and RSL3 (5 mg/kg; i.p.; the last 10 days)-treated mice were grouped into oil vehicle control (Ctrl), DHEA (60 mg/kg, 21 days)-treated (DHEA), and DHEA-treated with KCC-07 (KCC, 10 mg/kg) treatment (KCC/DHEA) mice (n = 10). Western blot analysis of GPX4, 4-HNE, Collagen I (Col1α) and α-SMA protein expression in ovarian tissues. GAPDH served as a loading control. Blots are representative of two samples per group. The results showed that RSL3 treatment largely abrogated the improvements in GPX4, 4‑HNE, Col1α, and α‑SMA abnormal expression that were significantly reversed by KCC‑07 in DHEA‑induced PCOS ovaries.
Redox Biol

p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer. [Abstract]

2026 Mar:90:104043. PMID: 41604941

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2026 Mar:90:104043. [Abstract]

HCT116 ^p53+/+ and RKO cells stably expressing shNC or shFABP5 were exposed to different doses of RSL3 for 24 h, followed by the cell viability assay.
Redox Biol

ATF7IP inhibits Sorafenib-induced ferroptosis in hepatocellular carcinoma cells by inhibiting CYB5R2 transcription and stabilizing PARK7 protein. [Abstract]

2025 Sep:85:103786. PMID: 40716153
Redox Biol

Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors. [Abstract]

2024 Dec:78:103419. PMID: 39527862

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec:78:103419. [Abstract]

Representative phase-contrast images of the indicated cells treated with the indicated compounds. NCI–H358 cells were treated with 5 μM erastin (18 h), 2 μM RSL3 (12 h) or 1 mM SAS (24 h), while Calu-1 cells were treated with 1 μM Erastin (18 h), 0.5 μM RSL3 (12 h) or 0.5 mM SAS (24 h). Scale bar, 50 μm.
Redox Biol

SLC7A11 protects luminal A breast cancer cells against ferroptosis induced by CDK4/6 inhibitors. [Abstract]

2024 Oct:76:103304. PMID: 39153252

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Oct:76:103304. [Abstract]

Clonogenic survival assay and representative images in MCF-7 cell lines treated with DMSO, abemaciclib(1 μM), RSL3 (3 μM; 24 h) or abemaciclib in combination with RSL3. The survival data were normalized to those of control cells treated with DMSO.
Redox Biol

Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis. [Abstract]

2024 Jun:72:103157. PMID: 38631119
Redox Biol

IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11. [Abstract]

2024 May:71:103100. PMID: 38484644
Redox Biol

DNAJC12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of AKT. [Abstract]

2024 Apr:70:103035. PMID: 38306757
Redox Biol

Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury. [Abstract]

2023 Oct:66:102857. PMID: 37611494
Redox Biol

Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression. [Abstract]

2023 Jun:62:102661. PMID: 36906952
Redox Biol

Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing. [Abstract]

2022 Jul 31;55:102408. PMID: 35944469

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jul 31;55:102408. [Abstract]

Immune blot detection of FSP1, GCLC, GCLM, and GPX4 in total protein extracts from the cell lines exposed to RSL3 or L-BSO for 24 h. The concentrations used are 0.25 and 1 μM RSL3 for CTV-1, Jurkat, K562 and HCT-116. For MOLT-16 RSL3 is used at 0.05 and 0.25 μM.
Redox Biol

ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury. [Abstract]

2022 Feb 9;51:102262. PMID: 35180475
Redox Biol

Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin. [Abstract]

2021 Nov;47:102174. PMID: 34700146

RSL3 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2021 Nov;47:102174. [Abstract]

HT1080 fibrosarcoma cells are exposed to RSL3 (10 μM, 24 h), and phorbol myristate acetate (PMA)-primed THP1 macrophage cells were exposed to crocidolite in the presence of absence of ferric ammonium citrate (Fe, 100 μg/ml) up to 96 h. Membrane-catch transmission electronmicroscopy (TEM) images of EVs on carbon grids.
Mol Cell

The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer. [Abstract]

2026 Apr 2;86(7):1260-1274.e4. PMID: 41932308

RSL3 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2026 Apr 2;86(7):1260-1274.e4. [Abstract]

A panel of human PDAC cell lines were exposed to the indicated doses of RSL3 under normoxic (21% O2) or hypoxic (1% O2) conditions after 24 hours pre-treatment exposure to either normoxia or hypoxia. After 72 hrs of treatment, cell viability was measured with the Cell-Titer Glo assay.
Mol Cell

EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma. [Abstract]

2023 Dec 7;83(23):4334-4351.e7. PMID: 37979586
Nat Chem Biol

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation. [Abstract]

2025 Apr 25. PMID: 40281343

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Apr 25. [Abstract]

MDA-MB-231 cells expressing PSAT1 and GPX4 shRNA with reconstituted expression of the indicated PSAT1 and GPX4 proteins were treated with RSL3 (0.5 μM) in the absence or presence of Fer1 (10 μM) for 24 h. Lipid ROS-positive cells were measured.

RSL3 purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Apr 25. [Abstract]

MDA-MB-231 and BT549 cells with reconstituted expression of the indicated proteins were treated with different doses of RSL3 for 24 h, and cell viability was measured.
Nat Chem Biol

CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes. [Abstract]

2024 Jun;20(6):699-709. PMID: 38212578
J Nanobiotechnology

CXCR4-engineered fibroblast membrane nanovesicles for Photothermal-enhanced ferroptotic therapy through chemokine-navigated tumor homing. [Abstract]

2025 Dec 30;24(1):102. PMID: 41462305

RSL3 purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Dec 30;24(1):102. [Abstract]

Cell viability of MDA-MB-468 cells and KYSE-30 cells after 24 h of incubation with different treatments (NC, RSL3 (1 µg/mL for MDA-MB-468 cells; 0.8 µg/mL for KYSE-30 cells), FbM@IR NPs and FbM@IR/RSL3 NPs) with or without NIR laser (n = 3).

RSL3 purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Dec 30;24(1):102. [Abstract]

Tumor volume changes of MDA-MB-468-bearing mice during 21 days of treatment with different formulations (PBS, RSL3, FbM@IR NPs and FbM@IR/RSL3 NPs) with or without NIR irradiation (808 nm, 0.8 W/cm²). The treatment doses were 1.2 mg/kg for RSL3 (i.v.; once every other day for a total of five times) and 1.6 mg/kg for IR780-DSPE-PEG, with five mice per group (n = 5).

RSL3 purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Dec 30;24(1):102. [Abstract]

H&E staining of MDA-MB-468 tumor tissues after the observation period (scale bar = 200 μm). The treatment doses were 1.2 mg/kg for RSL3 (i.v.; once every other day for a total of five times) and 1.6 mg/kg for IR780-DSPE-PEG, with five MDA-MB-468-bearing mice per group (n = 5).
J Nanobiotechnology

Active-targeting biomimetic nanosystem for prostate cancer enhances radiotherapy efficacy by inducing ferroptosis. [Abstract]

2025 Nov 30;24(1):9. PMID: 41318491
Theranostics

Hypoxia inducible factor (HIF) 3α prevents COPD by inhibiting alveolar epithelial cell ferroptosis via the HIF-3α-GPx4 axis. [Abstract]

2024 Aug 28;14(14):5512-5527. PMID: 39310101
Theranostics

PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis. [Abstract]

2024 Jul 2;14(10):4090-4106. PMID: 38994016
Microbiome

The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis. [Abstract]

2023 Sep 27;11(1):212. PMID: 37752615
Genes Dis

2026 Mar 19.
Acta Pharm Sin B

Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer. [Abstract]

2025 Apr;15(4):2095-2113. PMID: 40486852
Biomark Res

ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2. [Abstract]

2025 Jan 23;13(1):17. PMID: 39849645
Acta Pharm Sin B

The suppression of cervical cancer ferroptosis by macrophages: The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes. [Abstract]

2023 Jun;13(6):2645-2662. PMID: 37425043
Acta Pharm Sin B

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer. [Abstract]

2021 Jun;11(6):1513-1525. PMID: 34221865
J Exp Clin Cancer Res

TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation. [Abstract]

2025 Dec 29;44(1):329. PMID: 41462308
J Clin Invest

4-1BB stimulation with concomitant inactivation of adenosine A2B receptors enhances CD8+ T cell antitumor response. [Abstract]

2025 Apr 3;135(11):e190841. PMID: 40178905
J Exp Clin Cancer Res

OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway. [Abstract]

2024 Dec 26;43(1):330. PMID: 39721999
J Exp Clin Cancer Res

CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. [Abstract]

2022 Oct 20;41(1):307. PMID: 36266731
Adv Sci (Weinh)

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3-IFI6 Circuit in Breast Cancer. [Abstract]

2026 May 25:e75818. PMID: 42183833
Adv Sci (Weinh)

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy. [Abstract]

2026 Apr;13(22):e21997. PMID: 41704008
Adv Sci (Weinh)

Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis. [Abstract]

2026 Apr;13(19):e15768. PMID: 41589658
Adv Sci (Weinh)

GPX4 Inhibitor Resistance and Metastatic Features in Triple-Negative Breast Cancer. [Abstract]

2026 Feb 17:e23198. PMID: 41704007
Adv Sci (Weinh)

Obesity-Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis. [Abstract]

2025 Nov 14:e17330. PMID: 41237333
Adv Sci (Weinh)

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype. [Abstract]

2025 Jul 29:e05436. PMID: 40726407
Adv Sci (Weinh)

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer. [Abstract]

2025 Mar;12(12):e2408845. PMID: 39888307
Adv Sci (Weinh)

Genetically Engineered Membrane-Coated Nanoparticles for Enhanced Prostate-Specific Membrane Antigen Targeting and Ferroptosis Treatment of Castration-Resistant Prostate Cancer. [Abstract]

2024 Sep;11(33):e2401095. PMID: 38946578
Adv Sci (Weinh)

Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer. [Abstract]

2023 Dec;10(36):e2303484. PMID: 37946697
Adv Sci (Weinh)

STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity. [Abstract]

2023 Jan;10(3):e2203718. PMID: 36445063
Cell Rep Med

HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer. [Abstract]

2026 Feb 18:102630. PMID: 41713410
Cell Rep Med

Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis. [Abstract]

2025 Sep 25:102371. PMID: 41005298
Cell Rep Med

Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation. [Abstract]

2024 Sep 17;5(9):101711. PMID: 39232498
Cell Death Differ

The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma. [Abstract]

2025 Mar;32(3):506-520. PMID: 39478199
Cell Death Differ

The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma. [Abstract]

2023 Jul;30(7):1757-1770. PMID: 37173391
Cell Death Differ

Adaptor protein HIP-55-mediated signalosome protects against ferroptosis in myocardial infarction. [Abstract]

2023 Mar;30(3):825-838. PMID: 36639542
Cell Death Differ

SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. [Abstract]

2023 Jan;30(1):137-151. PMID: 35995846
Carbohydr Polym

A sulfated pectin polysaccharide from Chrysanthemum morifolium induces ferroptosis in pancreatic cancer by stabilizing TFRC. [Abstract]

2026 Jun 1:381:125224. PMID: 41943328
Chem Eng J

2023 Jun 15, 466, 143104.
Pharmacol Res

AXL prevents amyloid-β-induced microglial ferroptosis by sustaining SLC2A3-mediated mitochondrial respiration. [Abstract]

2026 Jun:228:108203. PMID: 42025825
Cell Death Dis

Liver kinase B1 maintains natural killer cell survival by regulating redox homeostasis. [Abstract]

2026 Mar 27;17(1):413. PMID: 41896546
Cell Death Dis

Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity. [Abstract]

2026 Feb 14;17(1):224. PMID: 41688429
Cell Death Dis

Targeting the SMAD3/CISD2 axis suppresses bladder cancer progression by promoting ferroptosis in mesenchymal-like bladder cancer cells. [Abstract]

2025 Dec 18. PMID: 41413023
Cell Death Dis

SETD7-mediated H3K4me1 activates ALDH1A3 to drive ferroptosis resistance in esophageal squamous cell carcinoma. [Abstract]

2025 Nov 7;16(1):810. PMID: 41203594
Cell Death Dis

BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP. [Abstract]

2025 Nov 17;16(1):843. PMID: 41249136
Cell Mol Biol Lett

RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis. [Abstract]

2025 Oct 2;30(1):109. PMID: 41039223
Environ Sci Technol

Revealing Ferroptosis Induction by Bisphenol A and Bisphenol S through Distinct Protein Targets. [Abstract]

2025 Oct 21;59(41):21898-21909. PMID: 41068997
Cell Death Dis

DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis. [Abstract]

2025 Aug 28;16(1):654. PMID: 40877242
Cell Death Dis

ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA. [Abstract]

2025 Jul 23;16(1):549. PMID: 40695795
Cell Death Dis

ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease. [Abstract]

2025 Apr 9;16(1):266. PMID: 40204709
Cell Death Dis

Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer. [Abstract]

2025 Apr 5;16(1):254. PMID: 40185704
Cell Death Dis

Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis. [Abstract]

2025 Apr 6;16(1):257. PMID: 40189563
Cell Death Dis

Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis. [Abstract]

2025 Mar 20;16(1):193. PMID: 40113760
Cell Death Dis

Enhanced ferroptosis sensitivity promotes the formation of highly myopic cataract via the DDR2-Hippo pathway. [Abstract]

2025 Feb 3;16(1):64. PMID: 39900894
Cell Death Dis

MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression. [Abstract]

2024 Nov 14;15(11):825. PMID: 39543140
Cell Death Dis

Phosphatase LHPP confers prostate cancer ferroptosis activation by modulating the AKT-SKP2-ACSL4 pathway. [Abstract]

2024 Sep 11;15(9):665. PMID: 39261475
Cell Mol Biol Lett

High-content image screening to identify chemical modulators for peroxisome and ferroptosis. [Abstract]

2024 Feb 17;29(1):26. PMID: 38368371
Cell Death Dis

LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex. [Abstract]

2023 Nov 25;14(11):767. PMID: 38007473
Cell Death Dis

Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications. [Abstract]

2023 Nov 18;14(11):754. PMID: 37980334
Pharmacol Res

PIAS3 promotes ferroptosis by regulating TXNIP via TGF-β signaling pathway in hepatocellular carcinoma. [Abstract]

2023 Oct:196:106915. PMID: 37689128
Cell Death Dis

Downregulation of N6-methyladenosine-modified LINC00641 promotes EMT, but provides a ferroptotic vulnerability in lung cancer. [Abstract]

2023 Jun 13;14(6):359. PMID: 37311754
Cell Death Dis

Nodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance. [Abstract]

2023 Mar 31;14(3):229. PMID: 37002201
Cell Death Dis

Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis. [Abstract]

2022 Sep 26;13(9):825. PMID: 36163182

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Sep 26;13(9):825. [Abstract]

MSCs are treated with Erastin (100 nmol/L) or RSL3 (10 nmol/L) or treated with Fer-1 (10 μmol/L) or Lip-1 (20 μmol/L) during SPIO labeling. Cells are harvested at 24 h. Both of them reduce the cell viability of MSCs and induce the level of ROS and lipid peroxide in MSCs.

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Sep 26;13(9):825. [Abstract]

MSCs are treated with Erastin (100 nmol/L) or RSL3 (10 nmol/L) or treated with Fer-1 (10 μmol/L) or Lip-1 (20 μmol/L) during SPIO labeling. Cells are harvested at 24 h.
Cell Death Dis

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. [Abstract]

2022 Jul 28;13(7):653. PMID: 35902564
Cell Death Dis

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling. [Abstract]

2022 Jul 20;13(7):630. PMID: 35859150

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Jul 20;13(7):630. [Abstract]

ROS levels were detected in pancreatic cancer cells from different treatment groups with a ROS Assay Kit. The results showed that RSL3 (3 μM; 24 h) and TST significantly increased ROS production, and Fer-1 also reversed this change.
Cell Death Dis

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury. [Abstract]

2022 May 30;13(5):507. PMID: 35637215

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 May 30;13(5):507. [Abstract]

HE staining of retinal tissue in mice that underwent sham or IR injury at 3 and 7 d after intravitreal injection of vehicle (DMSO) or 50 μM Erastin and 500 nM RSL3. Scale bar = 50 μm.
Cell Death Dis

Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer. [Abstract]

2021 Nov 13;12(11):1079. PMID: 34775496

RSL3 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Nov 13;12(11):1079. [Abstract]

The protein levels of Keap1, Nrf2 and HO-1 in HCT116 and DLD-1 cells are measured by western blotting after treatment with RSL3 (1 μM), cetuximab (100 μg/ml) or their combination for 24 h.
Cell Death Dis

Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis. [Abstract]

2021 Sep 11;12(9):843. PMID: 34511597
Cell Death Dis

MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma. [Abstract]

2021 May 19;12(6):511. PMID: 34011924
Cell Death Dis

Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition. [Abstract]

2020 Sep 15;11(9):756. PMID: 32934217
Cell Death Dis

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. [Abstract]

2019 Oct 7;10(10):755. PMID: 31591388
Cell Death Dis

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells. [Abstract]

2019 Apr 15;10(5):331. PMID: 30988278
Cancer Lett

Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer. [Abstract]

2026 May 1:645:218392. PMID: 41780839
Cancer Lett

Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma. [Abstract]

2024 May 1:589:216811. PMID: 38490328
Small

A Ferrocene-Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis. [Abstract]

2021 Aug;17(32):e2101368. PMID: 34216420
Int J Biol Sci

METTL16 suppresses ferroptosis in cholangiocarcinoma by promoting ATF4 via m6A modification. [Abstract]

2025 Jan 1;21(1):189-203. PMID: 39744432
J Immunother Cancer

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma. [Abstract]

2024 Nov 24;12(11):e009805. PMID: 39581704
Int J Biol Sci

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer. [Abstract]

2022 Aug 29;18(14):5459-5474. PMID: 36147463
Int J Biol Sci

O-GlcNAcylation of ZEB1 facilitated mesenchymal pancreatic cancer cell ferroptosis. [Abstract]

2022 Jun 21;18(10):4135-4150. PMID: 35844792

RSL3 purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2022 Jun 21;18(10):4135-4150. [Abstract]

CCK-8 assay assessed the cell viability of PANC1 and PaTU8988 cells treated DMSO, Erastin (4, 15 µM) and RSL3 (0.5, 5 µM) with or without SC-26196 (10 µM).
Cell Commun Signal

Mitochondria-derived methylmalonic acid aggravates ischemia-reperfusion injury by activating reactive oxygen species-dependent ferroptosis. [Abstract]

2024 Jan 18;22(1):53. PMID: 38238728
Phytomedicine

Chlorella pyrenoidosa-derived extracellular vesicles ameliorate ulcerative colitis through microbiota-mediated AKT/mTOR/ferroptosis pathway. [Abstract]

2026 Jul:156:158199. PMID: 42030800
Phytomedicine

Nuciferine ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting BMSCs ferroptosis via HIF-1α. [Abstract]

2026 Jun:155:158070. PMID: 41861683
Phytomedicine

Indole-3-carbinol attenuates cisplatin-induced premature ovarian failure by activating Nrf2 through competitive binding of Keap1. [Abstract]

2026 May:154:158040. PMID: 41818942
Phytomedicine

2',4'-dihydroxychalcone induces ferroptosis through ERO1A/GPX4 regulatory axis in cholangiocarcinoma. [Abstract]

2025 Nov:147:157192. PMID: 40902362
Phytomedicine

Genkwanin reduces airway epithelial cell ferroptosis and alleviates asthma symptoms in mice. [Abstract]

2025 Sep 24:148:157306. PMID: 41046685
Phytomedicine

The cardiac glycoside periplocymarin sensitizes gastric cancer to ferroptosis via the ATP1A1-Src-YAP/TAZ-TFRC axis. [Abstract]

2025 Jul:142:156804. PMID: 40311597
Phytomedicine

Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis. [Abstract]

2024 Dec:135:156139. PMID: 39423479
Phytomedicine

Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression. [Abstract]

2024 Dec:135:156195. PMID: 39488871
Phytomedicine

Daphnetin induces ferroptosis in ovarian cancer by inhibiting NAD(P)H:Quinone oxidoreductase 1 (NQO1). [Abstract]

2024 Sep:132:155876. PMID: 39032284
Phytomedicine

TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway. [Abstract]

2024 Jul:129:155597. PMID: 38643713
Phytomedicine

Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice. [Abstract]

2023 Sep:118:154962. PMID: 37506403
Phytomedicine

Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib. [Abstract]

2023 Mar:111:154668. PMID: 36657316
Phytomedicine

Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells. [Abstract]

2021 May:85:153551. PMID: 33827043
EBioMedicine

2025 Dec 8;123:106058.
J Pharm Anal

Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6. [Abstract]

2025 May;15(5):101092. PMID: 40496065

RSL3 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

Cell viability of chondrocytes treated with ferroptosis inducers ((1S,3R)-RSL3 (RSL3; 0.5 μM), vitamin K1 (VK1,10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1, 1 μM) for 24 h was detected by Cell Counting Kit-8 (CCK-8).

RSL3 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

Bright-field and fluorescent images of live/dead staining of chondrocytes treated with ferroptosis inducers (1S,3R)-RSL3 (RSL3; 0.5 μM), vitamin K1 (VK1;10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h. Propidium iodide (PI) stained (Red) for dead cells, and Calcein-AM (Green) stained for live cells.
J Pharm Anal

Ursodeoxycholic acid inhibits the uptake of cystine through SLC7A11 and impairs de novo synthesis of glutathione. [Abstract]

2025 Jan;15(1):101068. PMID: 39902457
Adv Healthc Mater

Microenvironment-Adaptive Smart Hydrogel with 2D Vanadium Nitride MXenzyme Rescues Osteoarthritis via Coordinated ROS Scavenging and Hspa5/GPX4 Axis-Mediated Ferroptosis Suppression. [Abstract]

2026 Feb 21:e04967. PMID: 41721542
Mater Today Bio

IGF2BP3 is an essential N6-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells. [Abstract]

2022 Nov 24:17:100503. PMID: 36457846
J Hazard Mater

Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation. [Abstract]

2024 Dec 5:480:135952. PMID: 39341193
J Hazard Mater

Selenomethionine alleviates decabromodiphenyl ether-induced oxidative stress and ferroptosis via the NRF2/GPX4 pathway in the chicken brain. [Abstract]

2024 Mar 5:465:133307. PMID: 38154185
Cell Death Discov

Targeting USP10/SCD1 axis by RAF265 suppresses lipogenesis and induced ferroptosis in head and neck squamous cell carcinoma. [Abstract]

2026 Jun 2. PMID: 42230571
Cell Death Discov

SLC25A10 promotes cisplatin resistance by inhibiting ferroptosis in cervical cancer. [Abstract]

2025 Oct 7;11(1):447. PMID: 41057306
Cell Death Discov

Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer. [Abstract]

2025 Sep 25;11(1):423. PMID: 40998801
Cell Death Discov

ERBB3 influences the ferroptosis pathway via modulation of lipid peroxidation and GSH synthesis in gastric cancer. [Abstract]

2025 Aug 22;11(1):398. PMID: 40846695
Acta Pharmacol Sin

SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer. [Abstract]

2024 Apr;45(4):844-856. PMID: 38057506
Cell Death Discov

SCARB1 in extracellular vesicles promotes NPC metastasis by co-regulating M1 and M2 macrophage function. [Abstract]

2023 Aug 29;9(1):323. PMID: 37644041
Cell Death Discov

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation. [Abstract]

2023 Aug 25;9(1):311. PMID: 37626043
Acta Pharmacol Sin

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma. [Abstract]

2021 Jan;42(1):160-170. PMID: 32541921
Environ Int

Trimethyltin chloride triggers ferroptosis in myocardial injury: mitochondria-dependent protection by luteolin. [Abstract]

2026 May:211:110262. PMID: 42013553
NPJ Precis Oncol

M6A-ALKBH5-dependent RBMS3-AS3 down-regulation suppresses ferroptosis to promote lung adenocarcinoma progression through HNRNPDL/ZEB1/GPX4 axis. [Abstract]

2025 Nov 17;9(1):356. PMID: 41249383
J Transl Med

KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer. [Abstract]

2024 Oct 10;22(1):923. PMID: 39390559
Diabetes

Cooperative Action of Cathepsin K Inhibitor and hUMSC-EVs in Attenuating Ferroptosis Sensitivity for Superior Diabetic Wound Healing. [Abstract]

2026 Jun 1;75(6):1007-1023. PMID: 41979994
Basic Res Cardiol

Antimicrobial peptide CRAMP/LL-37 mediates ferroptosis resistance in cardiomyocytes by inhibiting cathepsin L. [Abstract]

2025 Jun 15. PMID: 40517353
Dev Cell

GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. [Abstract]

2024 Oct 7;59(19):2643-2658.e7. PMID: 38981469
Dev Cell

A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis. [Abstract]

2024 Feb 26;59(4):517-528.e3. PMID: 38272028
Oncogene

CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis. [Abstract]

2025 Jun;44(22):1678-1693. PMID: 40089640
Nano Lett

Polystyrene Nanoparticles Reduced ROS and Inhibited Ferroptosis by Triggering Lysosome Stress and TFEB Nucleus Translocation in a Size-Dependent Manner. [Abstract]

2019 Nov 13;19(11):7781-7792. PMID: 31558022
Int J Surg

RRFERV stabilizes TEAD1 expression to mediate nasopharyngeal cancer radiation resistance rendering tumor cells vulnerable to ferroptosis. [Abstract]

2025 Jan 1;111(1):450-466. PMID: 39352125
Apoptosis

Loss of AR-regulated AFF3 contributes to prostate cancer progression and reduces ferroptosis sensitivity by downregulating ACSL4 based on single-cell sequencing analysis. [Abstract]

2024 Oct;29(9-10):1679-1695. PMID: 38478171
Int J Biol Macromol

Structure-guided rational design of ferritin nanocages unlocks thermoresponsive channels for accelerated drug encapsulation. [Abstract]

2026 Feb:347:150643. PMID: 41638275
Int J Biol Macromol

The STING-OLA1-Keap1-Nrf2 axis regulates ferroptosis in premature ovarian failure. [Abstract]

2025 Dec 4;337(Pt 1):149424. PMID: 41352507
Int J Nanomedicine

GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress. [Abstract]

2025 Nov 24:20:14033-14055. PMID: 41321900
Int J Biol Macromol

TF and TFRC regulate ferroptosis in swine testicular cells through the JNK signaling pathway. [Abstract]

2025 Mar 20;307(Pt 4):142369. PMID: 40120870
Int J Biol Macromol

Poly-l-arginine promotes ferroptosis in asthmatic airway epithelial cells by modulating PBX1/GABARAPL1 axis. [Abstract]

2025 Jan:286:138478. PMID: 39645127
Int J Nanomedicine

Mitochondria-Rich Microvesicles Alleviate CNI ED by Transferring Mitochondria and Suppressing Local Ferroptosis. [Abstract]

2024 Nov 12:19:11745-11765. PMID: 39558916
Int J Biol Macromol

Chitosan oligosaccharides alleviate macrophage pyroptosis and protect sepsis mice via activating the Nrf2/GPX4 pathway. [Abstract]

2024 Oct;277(Pt 1):133899. PMID: 39019361
Int J Nanomedicine

RNA-Seq Explores the Mechanism of Oxygen-Boosted Sonodynamic Therapy Based on All-in-One Nanobubbles to Enhance Ferroptosis for the Treatment of HCC. [Abstract]

2022 Jan 7;17:105-123. PMID: 35027829
Mol Med

G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis. [Abstract]

2024 Feb 21;30(1):28. PMID: 38383297
Sens Actuators B Chem

2024 Jan 15, 399, 134872.
Antioxidants (Basel)

Hesperidin from Chenpi Ameliorates Skin Photoaging by Targeting HSPA1L to Stabilize GPX4 and Suppress Ferroptosis. [Abstract]

2026 Apr 14;15(4):484. PMID: 42072126
Antioxidants (Basel)

Aspirin Eugenol Ester Alleviates Gastric Injury by Inhibiting Ferroptosis and Oxidative Stress. [Abstract]

2026 Feb 9;15(2):225. PMID: 41750606
Antioxidants (Basel)

Aspirin Eugenol Ester Alleviates Vascular Endothelial Ferroptosis by Enhancing Antioxidant Ability and Inhibiting the JNK/c-Jun/NCOA4/FTH Signaling Pathway. [Abstract]

2025 Oct 10;14(10):1220. PMID: 41154529
Antioxidants (Basel)

Effect of Media Composition and Oxygen Tension on Cellular Stress Response and Nrf2 Activation in HepG2ARE Cells. [Abstract]

2025 Jan 24;14(2):137. PMID: 40002325
Antioxidants (Basel)

Analysis of High-Dose Ascorbate-Induced Cytotoxicity in Human Glioblastoma Cells and the Role of Dehydroascorbic Acid and Iron. [Abstract]

2024 Sep 10;13(9):1095. PMID: 39334754
Antioxidants (Basel)

Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway. [Abstract]

2024 Jan 23;13(2):140. PMID: 38397738
Antioxidants (Basel)

PTC596-Induced BMI-1 Inhibition Fights Neuroblastoma Multidrug Resistance by Inducing Ferroptosis. [Abstract]

2023 Dec 19;13(1):3. PMID: 38275623
Antioxidants (Basel)

Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition. [Abstract]

2023 Mar 13;12(3):705. PMID: 36978954
Antioxidants (Basel)

Identification of AP-1 as a Critical Regulator of Glutathione Peroxidase 4 (GPX4) Transcriptional Suppression and Acinar Cell Ferroptosis in Acute Pancreatitis. [Abstract]

2022 Dec 31;12(1):100. PMID: 36670963
Mater Design

15 November 2021, 110087.
Phytother Res

Oroxylin A alleviates myocardial ischemia-reperfusion injury by quelling ferroptosis via activating the DUSP10/MAPK-Nrf2 pathway. [Abstract]

2024 Nov;38(11):5290-5308. PMID: 39225191
Free Radic Biol Med

Repurposing the hERG activator NS-1643 as a ferroptosis-targeting therapeutic against doxorubicin cardiotoxicity. [Abstract]

2026 Jun:249:14-26. PMID: 41794151
Free Radic Biol Med

Radiotherapy disrupts ferroptosis tolerance by reducing DNMT1 levels and uncouples STING silencing in LKB1-deficient lung tumors. [Abstract]

2026 May:248:150-161. PMID: 41722660
Free Radic Biol Med

Protective effect of resveratrol against colistin-induced nephrotoxicity through regulating Nrf2 pathway and inhibiting ferroptosis. [Abstract]

2026 Apr:247:39-53. PMID: 41654146
Free Radic Biol Med

Eugenol attenuates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the Nrf2/GPX4 pathway. [Abstract]

2026 Jan:242:508-520. PMID: 41202942
Free Radic Biol Med

BMAL1-mediated circadian-ferroptosis crosstalk drives neuronal vulnerability after TBI. [Abstract]

2025 Nov 28:243:548-563. PMID: 41320098
Free Radic Biol Med

7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K/Akt/NRF2/GPX4 mediated ferroptosis suppression. [Abstract]

2025 Oct 30:242:275-287. PMID: 41173313
Free Radic Biol Med

Reticulon 3 deficiency induces ferroptosis via chaperone-mediated autophagy in ischemia-reperfusion induced acute kidney injury. [Abstract]

2025 Oct 10:242:9-20. PMID: 41077100
Free Radic Biol Med

Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway. [Abstract]

2025 Aug 11:240:238-252. PMID: 40803417
Free Radic Biol Med

Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]

2025 Aug 1:235:231-247. PMID: 40316059
Free Radic Biol Med

Lithium Enhances Ferroptosis sensitivity in melanoma cells and promotes CD8+ T Cell infiltration and differentiation. [Abstract]

2025 Feb 1:227:233-245. PMID: 39645207
Free Radic Biol Med

Ferroptosis and PANoptosis under hypoxia pivoting on the crosstalk between DHODH and GPX4 in corneal epithelium. [Abstract]

2025 Feb 16:228:173-182. PMID: 39761766
Free Radic Biol Med

Targeting ALDH2 to augment platinum-based chemosensitivity through ferroptosis in lung adenocarcinoma. [Abstract]

2024 Nov 1:224:310-324. PMID: 39216560
Free Radic Biol Med

Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression. [Abstract]

2024 Sep:222:229-243. PMID: 38906233

RSL3 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Sep:222:229-243. [Abstract]

HT1080 cells were pretreated with Verapamil (20 μM) or MK-571 sodium (40 μM) for 2 h and then treated with DMSO or RU486 (5 μM) together with concentration gradient of RSL3 (0–10 μM) for 24 h. Cell viability was measured by CCK-8 (n = 3).

RSL3 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Sep:222:229-243. [Abstract]

HUH7 cells were pretreated with Verapamil (20 μM) or MK-571 sodium (40 μM) for 2 h and then treated with DMSO or RU486 (5 μM) together with concentration gradient of RSL3 (0–10 μM) for 24 h. Cell viability was measured by CCK-8 (n = 3).
Free Radic Biol Med

Cannabidiol mitigates radiation-induced intestine ferroptosis via facilitating the heterodimerization of RUNX3 with CBFβ thereby promoting transactivation of GPX4. [Abstract]

2024 Sep:222:288-303. PMID: 38830513
Free Radic Biol Med

A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis. [Abstract]

2024 Sep:222:344-360. PMID: 38945457
Free Radic Biol Med

Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy. [Abstract]

2024 May 26:221:245-256. PMID: 38806104
Free Radic Biol Med

STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. [Abstract]

2023 Nov 1:208:348-360. PMID: 37634745
Drug Deliv

'Mito-Bomb': a novel mitochondria-targeting nanosystem for ferroptosis-boosted sonodynamic antitumor therapy. [Abstract]

2022 Dec;29(1):3111-3122. PMID: 36131565
Free Radic Biol Med

VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis. [Abstract]

2022 Nov 20;193(Pt 2):720-735. PMID: 36402439
Free Radic Biol Med

IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis. [Abstract]

2022 Nov 20;193(Pt 2):579-594. PMID: 36356714
Clin Transl Med

USP22 promotes the proliferation and Sorafenib resistance of hepatocellular carcinoma cells via its deubiquitinase activity. [Abstract]

2025 May;15(5):e70324. PMID: 40341781
EMBO Mol Med

FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer. [Abstract]

2024 Jul;16(7):1533-1559. PMID: 38926633
ACS Appl Mater Interfaces

Tannic Acid-Based Injectable Hydrogel Promotes the Recovery of Traumatic Brain Injury by Anti-Ferroptosis. [Abstract]

2025 Jun 4;17(22):31843-31858. PMID: 40402142
Stem Cell Res Ther

Reducing PDK4 level constitutes a pivotal mechanism for glucocorticoids to impede osteoblastic differentiation through the enhancement of ferroptosis in mesenchymal stem cells. [Abstract]

2025 Feb 25;16(1):91. PMID: 40001240
Am J Chin Med

Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol. [Abstract]

2022;50(8):2103-2123. PMID: 36309811
Stem Cell Res Ther

Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis. [Abstract]

2022 Sep 5;13(1):450. PMID: 36064453
Cell Rep

STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma. [Abstract]

2025 Oct 15;44(10):116429. PMID: 41105508
Cell Rep

Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis. [Abstract]

2025 Jul 12;44(7):116014. PMID: 40652510
World J Gastroenterol

Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells. [Abstract]

2024 Feb 7;30(5):485-498. PMID: 38414591
Cell Rep

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications. [Abstract]

2020 Dec 8;33(10):108487. PMID: 33296645
Cell Prolif

Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma. [Abstract]

2025 Jun;58(6):e13816. PMID: 40071723
Cell Prolif

CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway. [Abstract]

2021 Dec;54(12):e13142. PMID: 34632658
J Ginseng Res

2026 Jan 30.
Br J Pharmacol

Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway. [Abstract]

2022 Aug;179(15):3991-4009. PMID: 35303762
Chin Med

Ginsenoside Rb1 targets the NRF2-PPARγ-ACSL4 axis to inhibit PTECs ferroptosis. [Abstract]

2026 Jan 8;21(1):19. PMID: 41508002
Anal Chem

Reversible Quantum Dot-Driven Multiplex Technology for In Situ Subcellular Structure Imaging. [Abstract]

2026 Jul 7;98(26):19459-19470. PMID: 42340249
Anal Chem

Ferroptosis Pathway Discrimination and Anticancer Therapeutic Screening Enabled by Cascade-Activated Fluorescence Reporting of Cysteine-Viscosity Dynamics. [Abstract]

2025 Nov 18;97(45):25056-25066. PMID: 41191406
J Med Chem

Discovery of Novel Ortho-Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activities. [Abstract]

2024 Jun 13;67(11):9536-9551. PMID: 38822802
Int J Oncol

Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells. [Abstract]

2024 Jun;64(6):64. PMID: 38757341
Brief Bioinform

Ferroptosis-related lncRNA pairs to predict the clinical outcome and molecular characteristics of pancreatic ductal adenocarcinoma. [Abstract]

2022 Jan 17;23(1):bbab388. PMID: 34553745
Environ Pollut

Dibutyl phthalate exposure-induced AhR activation drives ferroptosis and HMGB1/TLR4-mediated inflammatory liver injury via NRF2-HO-1 signaling. [Abstract]

2026 Jun 1:398:128010. PMID: 41887355
Atherosclerosis

Alamandine suppresses vascular calcification through inhibition of ferroptosis. [Abstract]

2025 Dec:411:120548. PMID: 41110386
Emerg Microbes Infect

Streptococcus suis Stk1 sensitizes epithelial cells to ferroptosis and exacerbates disruption of the respiratory epithelial barrier. [Abstract]

2026 Dec;15(1):2627066. PMID: 41630441
J Invest Dermatol

Human T Helper 9 Cells Rely on Peroxisome Proliferator-Activated Receptor-γ-Mediated Cystine Uptake to Prevent Lipid Peroxidation and Bioenergetic Failure. [Abstract]

2025 Jul;145(7):1693-1705.e2. PMID: 39725162
J Invest Dermatol

CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway. [Abstract]

2022 Jan;142(1):189-200.e8. PMID: 34242660
Redox Rep

Prophylactic quercetin administration attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells. [Abstract]

2026 Dec;31(1):2632434. PMID: 41697789
Mol Cancer Ther

Targeting Monounsaturated Fatty Acid Metabolism for Radiosensitization of KRAS Mutant 3D Lung Cancer Models. [Abstract]

2025 Jun 4;24(6):920-930. PMID: 39834305
Pharmaceutics

Induction of Non-Canonical Ferroptosis by Targeting Clusters Suppresses Glioblastoma. [Abstract]

2024 Sep 13;16(9):1205. PMID: 39339241
JCI Insight

Hepatocyte hedgehog signaling controls ferroptosis to alleviate aging-related organ dysfunction. [Abstract]

2026 May 19:e207066. PMID: 42154541
J Ethnopharmacol

Duhuo mitigates intervertebral disc degeneration by activating PI3K/AKT to inhibit ferroptosis in nucleus pulposus cells. [Abstract]

2026 Mar 1:358:121027. PMID: 41380858
J Ethnopharmacol

Paris polyphylla Smith var. yunnanensis-derived saponins potentiate the antitumor activity of GPX4 inhibitors. [Abstract]

2026 Feb 28:357:120890. PMID: 41232632
J Ethnopharmacol

Hu Gan Tang ameliorates metabolic-associated fatty liver disease by inhibiting ferroptosis through the Nrf2/GPX4 pathway. [Abstract]

2025 Jul 31;353(Pt A):120342. PMID: 40752599
Antioxid Redox Signal

ALOX15 Modulates Ferroptosis via the Reactive Oxygen Species-Mediated MAPK Pathway in Doxorubicin-Induced Cardiotoxicity. [Abstract]

2025 Jun 2. PMID: 40455659
J Ethnopharmacol

Homocapsaicin II induce ferroptosis in colorectal cancer cells via cholesterol-centrosome amplification-multipolarity axis. [Abstract]

2025 May 28:348:119894. PMID: 40319933
J Ethnopharmacol

Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis. [Abstract]

2024 Nov 15:334:118582. PMID: 39009325
J Agric Food Chem

Discovery of Lignans and Stilbenes from the Seeds of Astragalus complanatus in Ferroptosis Regulation via Directly Acting on SLC7A11/GPX4 Pathway. [Abstract]

2026 May 20;74(19):15051-15072. PMID: 42096616
Eur J Med Chem

Chemical induction of ferroptosis through GPX4 inhibition: Rational design of triazole-benzoxazine hybrids for melanoma therapy. [Abstract]

2026 Feb 5:303:118434. PMID: 41370972
J Agric Food Chem

Nuciferine Alleviates High-Fat Diet- and ApoE-/--Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway. [Abstract]

2024 Nov 6;72(44):24417-24431. PMID: 39445611
J Agric Food Chem

Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis. [Abstract]

2024 May 29;72(21):12156-12170. PMID: 38755521
Eur J Med Chem

Design, synthesis, and biological evaluation of 2-amino-6-methyl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities. [Abstract]

2024 Jan 15:264:115997. PMID: 38056303
CNS Neurosci Ther

Vitamin D3 Attenuates Neuropathic Pain via Suppression of Mitochondria-Associated Ferroptosis by Inhibiting PKCα/NOX4 Signaling Pathway. [Abstract]

2024 Sep;30(9):e70067. PMID: 39328008
Biochem Pharmacol

5-Methoxyseselin inhibits neuronal ferroptosis and β-amyloid production in female APP/PS1 transgenic mice. [Abstract]

2026 Jun 25;251(Pt 2):118188. PMID: 42349617
Biochem Pharmacol

Loganin triggers ferroptosis in renal cell carcinoma by targeting the IGF2BP2/HMOX1 axis in an m6A-dependent manner. [Abstract]

2026 Jun 25:252:118202. PMID: 42349616
Biochem Pharmacol

TRAF6 promotes the ferroptosis defense through AKT/mitochondria damage in KRAS-driven lung cancer. [Abstract]

2026 Apr:246:117746. PMID: 41580038
Cell Mol Life Sci

Mechanism of LncRNA NORAD regulating ferroptosis in endometrial cancer cells by modifying GPX4 through FTO-mediated m6A methylation. [Abstract]

2025 Oct 25;82(1):364. PMID: 41137882
Biochem Pharmacol

Estradiol alleviated chemotherapy-induced premature ovarian failure by blocking the ferroptosis via activating ESR2/Sirt1/Nrf2 pathway. [Abstract]

2025 Oct 29;243(Pt 1):117481. PMID: 41173058
Biochem Pharmacol

HDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer. [Abstract]

2024 Jul:225:116257. PMID: 38705532
Biochem Pharmacol

Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. [Abstract]

2024 May:223:116194. PMID: 38583812
Biochem Pharmacol

G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis. [Abstract]

2024 Apr:222:116077. PMID: 38395264
Cell Insight

The NF-κB-SLC7A11 axis regulates ferroptosis sensitivity in inflammatory macrophages. [Abstract]

2025 Jun 11;4(4):100257. PMID: 40677785
Life Sci

Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway. [Abstract]

2025 Mar 15:365:123452. PMID: 39923835
Life Sci

Hypoxia impairs male reproductive functions via inducing rat Leydig cell ferroptosis under simulated environment at altitude of 5000 m. [Abstract]

2024 Nov 15:357:123076. PMID: 39332487
Life Sci

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury. [Abstract]

2023 May 15:321:121608. PMID: 36958437
Food Funct

Folic acid alleviates endothelial dysfunction caused by T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway. [Abstract]

2026 Apr 27;17(8):3587-3599. PMID: 41906715
Food Funct

Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis. [Abstract]

2024 Oct 28;15(21):10811-10822. PMID: 39403969
Food Funct

Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway. [Abstract]

2023 Nov 13;14(22):10052-10068. PMID: 37861458
Food Funct

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. [Abstract]

2021 May 11;12(9):3898-3918. PMID: 33977953
Inflamm Res

Methylmalonic acid as a ferroptosis-derived danger signal: activation of the PI3K-NF-κB pathway drives M1 macrophage polarization in renal ischemia-reperfusion injury. [Abstract]

2026 Jun 22;75(1):153. PMID: 42329408
Inflamm Res

Erianin protects chondrocytes against IL-1β-induced oxidative stress and ferroptosis by activating GPX4/STING signaling in osteoarthritis. [Abstract]

2026 Jan 14;75(1):19. PMID: 41533098
Drug Des Devel Ther

Exploratory Study on the Role of Emodin in Alleviating MPTP-Induced Neurotoxicity: A Focus on p53-Ferroptosis Signaling. [Abstract]

2025 Dec 1:19:10645-10660. PMID: 41356603
Gastric Cancer

The alkylglycerone phosphate synthase sustains the resistance of gastric cancer cells to ferroptosis induced by Apatinib. [Abstract]

2025 Apr 5. PMID: 40186794
Drug Des Devel Ther

Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury. [Abstract]

2024 Dec 21:18:6223-6241. PMID: 39722679
Biomater Sci

Assessment of zero-valent iron-based nanotherapeutics for ferroptosis induction and resensitization strategy in cancer cells. [Abstract]

2019 Mar 26;7(4):1311-1322. PMID: 30734774
Oncogenesis

ACSL6 modulates docosahexaenoic acid-induced cytotoxicity to potentiate chemotherapy response in colorectal and breast cancer. [Abstract]

2025 Nov 21;14(1):45. PMID: 41271644
Cells

Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF. [Abstract]

2022 Nov 12;11(22):3580. PMID: 36429010
Cancer Metab

2026 Apr 11;14(1):16.
Nutrients

Medium-Chain Fatty Acids Selectively Sensitize Cancer Cells to Ferroptosis by Inducing CD36 and ACSL4. [Abstract]

2025 Feb 25;17(5):794. PMID: 40077664
Eur J Pharmacol

Pharmacological inhibition of fatty acid-binding protein 4 alleviates sepsis-associated acute kidney injury in mice via suppressing ferroptosis. [Abstract]

2026 May 30:1030:179061. PMID: 42219054
Eur J Pharmacol

Obesity-associated metabolic dysregulation aggravates myocardial ischemia-reperfusion injury through Gls2-mediated ferroptosis. [Abstract]

2026 Mar 28:1019:178739. PMID: 41819522
Eur J Pharmacol

Corilagin alleviates cardiac ischemia-reperfusion injury by inhibiting ferroptosis via PI3K/AKT pathway. [Abstract]

2025 Nov 5:1006:178158. PMID: 40962010
Eur J Pharmacol

Targeting eEF2K induces oxidative stress and sensitizes cancer cells to ferroptosis induction. [Abstract]

2025 Aug 15:1001:177746. PMID: 40409701
Cell Biol Toxicol

The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1. [Abstract]

2025 Jul 17;41(1):118. PMID: 40670757
Eur J Pharmacol

Tiliroside induces ferroptosis and suppresses tumor growth by synergistically targeting AKR1B1 and modulating iron metabolism in ovarian cancer cells. [Abstract]

2025 Jun 15:997:177591. PMID: 40187595
Eur J Pharmacol

FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age related macular degeneration. [Abstract]

2025 Feb 15:989:177227. PMID: 39736411
Eur J Pharmacol

Exendin-4 promotes ischemia-reperfusion flap survival by upregulating Gpx4 to inhibit ferroptosis. [Abstract]

2024 Dec 5:984:177029. PMID: 39366501
Eur J Pharmacol

Tetramethylpyrazine alleviates ferroptosis and promotes functional recovery in spinal cord injury by regulating GPX4/ACSL4. [Abstract]

2024 Aug 15:977:176710. PMID: 38843947
Eur J Pharmacol

Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway. [Abstract]

2024 May 15:971:176524. PMID: 38561102
Eur J Pharmacol

Metformin improves nonalcoholic fatty liver disease in db/db mice by inhibiting ferroptosis. [Abstract]

2024 Mar 5:966:176341. PMID: 38244761
Eur J Pharmacol

Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis. [Abstract]

2023 Oct 5:956:175967. PMID: 37549729
Cell Biol Toxicol

The mtDNA-STING pathway plays an important role in both navitoclax- and S63845-induced autophagy and enhances cell death. [Abstract]

2023 Dec;39(6):2821-2839. PMID: 37002446
Eur J Pharmacol

Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction. [Abstract]

2023 Mar 15:943:175569. PMID: 36740037
Eur J Pharmacol

Ferroptosis involves in renal tubular cell death in diabetic nephropathy. [Abstract]

2020 Dec 5:888:173574. PMID: 32976829
Int Immunopharmacol

Se-methylselenocysteine alleviates sepsis-associated inflammation by upregulating GPX4 to inhibit macrophage ferroptosis. [Abstract]

2026 May 14:182:116851. PMID: 42134291
Int Immunopharmacol

Hydrogen alleviates cardiac ferroptosis damage under chronic intermittent hypoxia conditions by targeting Nrf2. [Abstract]

2026 Jan 15:169:115974. PMID: 41370977
Int J Mol Sci

MED12 Dictates Epithelial Ovarian Cancer Cell Ferroptosis Sensitivity via YAP-TEAD1 Signaling. [Abstract]

2026 Jan 20;27(2):1020. PMID: 41596664
Biomolecules

Methyl Protodioscin Promotes Ferroptosis of Prostate Cancer Cells by Facilitating Dissociation of RB1CC1 from the Detergent-Resistant Membranes and Its Nuclear Translocation. [Abstract]

2025 Dec 25;16(1):38. PMID: 41594579
Biomolecules

RSL3 Promotes STAT3 Ubiquitination to Induce Autophagy and Apoptosis in PARPi-Resistant Breast Cancer Cells. [Abstract]

2025 Dec 18;15(12):1749. PMID: 41463402
Int Immunopharmacol

Targeting GCS regulates the NRF2 axis to inhibit hepatocyte endoplasmic reticulum stress-ferroptosis improving immune-mediated liver injury. [Abstract]

2025 Sep 13:165:115532. PMID: 40946670
Int Immunopharmacol

Cucurbitacin B suppresses malignant progression of oral leukoplakia via ferroptosis-induced macrophage polarization. [Abstract]

2025 Sep 13:165:115485. PMID: 40946669
Int Immunopharmacol

Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis. [Abstract]

2025 Jun 17:158:114827. PMID: 40359890
Biomolecules

Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway. [Abstract]

2025 Apr 9;15(4):556. PMID: 40305351
Int J Mol Sci

Effects of Acrylamide on Mouse Implantation and Decidualization. [Abstract]

2025 Apr 26;26(9):4129. PMID: 40362368
Int J Mol Sci

MGST1 Protects Pancreatic Ductal Cells from Inflammatory Damage in Acute Pancreatitis by Inhibiting Ferroptosis: Bioinformatics Analysis with Experimental Validation. [Abstract]

2025 Feb 22;26(5):1899. PMID: 40076525
Int J Mol Sci

Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis. [Abstract]

2024 Feb 20;25(5):2458. PMID: 38473706
Int J Mol Sci

HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer. [Abstract]

2023 Mar 7;24(6):5144. PMID: 36982218
Int J Mol Sci

Increased Expression of the Δ133p53β Isoform Enhances Brain Metastasis. [Abstract]

2023 Jan 9;24(2):1267. PMID: 36674782
Int J Mol Sci

β-Caryophyllene Acts as a Ferroptosis Inhibitor to Ameliorate Experimental Colitis. [Abstract]

2022 Dec 16;23(24):16055. PMID: 36555694
Int J Mol Sci

Evaluation of the Combined Effect of Artemisinin and Ferroptosis Inducer RSL3 against Toxoplasma gondii. [Abstract]

2022 Dec 23;24(1):229. PMID: 36613672
Int Immunopharmacol

Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury. [Abstract]

2022 Nov:112:109162. PMID: 36067654
Int J Mol Sci

The Possible Connection of Two Dual Function Processes: The Relationship of Ferroptosis and the JNK Pathway. [Abstract]

2022 Sep 20;23(19):11004. PMID: 36232313
Int J Mol Sci

SHP-1/STAT3-Signaling-Axis-Regulated Coupling between BECN1 and SLC7A11 Contributes to Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma. [Abstract]

2022 Sep 21;23(19):11092. PMID: 36232407
Biol Direct

NSDHL as a regulator of lipid peroxidation and ER stress-mediated apoptosis in ovarian cancer. [Abstract]

2026 Apr 8;21(1):68. PMID: 41952197
Mol Neurobiol

3-n-Butylphthalide Protects SH-SY5Y Cells from Ferroptosis by Inhibiting ACSL4-Mediated Lipid Peroxidation. [Abstract]

2026 Jan 16;63(1):369. PMID: 41545774
Biol Direct

MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1. [Abstract]

2025 Oct 1;20(1):100. PMID: 41035046
Mol Neurobiol

Puerarin Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis Through SLC7A11/GPX4/ACSL4 Axis and Alleviate Pyroptosis Through Caspase-1/GSDMD Axis. [Abstract]

2025 Jul;62(7):8931-8948. PMID: 40056342
Mol Neurobiol

N-Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS-Mediated Pyroptosis and Ferroptosis. [Abstract]

2025 Jul;62(7):9416-9429. PMID: 40111652
Biol Direct

Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma. [Abstract]

2025 Feb 7;20(1):19. PMID: 39920793
Front Cell Infect Microbiol

Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to Bacillus Calmette-Guerin infection. [Abstract]

2022 Sep 23:12:1004148. PMID: 36211962
Front Cell Infect Microbiol

Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis. [Abstract]

2022 Feb 4;12:825824. PMID: 35186798
Am J Respir Cell Mol Biol

FSP1 Acts in Parallel with GPX4 to Inhibit Ferroptosis in COPD. [Abstract]

2025 May;72(5):551-562. PMID: 39453438
Biol Res

EZH1/2 plays critical roles in oocyte meiosis prophase I in mice. [Abstract]

2024 Nov 8;57(1):83. PMID: 39511641
Front Pharmacol

Hydrogen sulfide protects against toxicant acrolein-induced ferroptotic cell death in Sertoli cells. [Abstract]

2024 Aug 1:15:1440147. PMID: 39148534
COLLOID SURFACE A

2023 Apr 13, 131458.
Front Pharmacol

Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage. [Abstract]

2021 Mar 19:12:629379. PMID: 33815110
Front Cell Dev Biol

Exosomal MIF Derived From Nasopharyngeal Carcinoma Promotes Metastasis by Repressing Ferroptosis of Macrophages. [Abstract]

2021 Dec 31:9:791187. PMID: 35036405
Microchem J

2026 Apr 15.
Chem Biol Interact

Oridonin exposure induces testicular impairment through regulating ferroptosis via HIF-1α/HO-1 activation and STUB1-driven GPX4 ubiquitination-dependent degradation. [Abstract]

2026 Jan 5:423:111838. PMID: 41265811
J Nutr Biochem

1,25(OH)2D3 ameliorates DSS-induced intestinal ferroptosis through the SIRT3-SOD2-mtROS pathway. [Abstract]

2025 Oct:144:109999. PMID: 40513839
Chem Biol Interact

Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury. [Abstract]

2025 Sep 4:111724. PMID: 40914538
Microchem J

2025 Sep 9;218:115245.
Toxicology

NNMT is involved in deoxynivalenol-induced hepatocyte toxicity via promoting ferroptosis. [Abstract]

2025 May:513:154084. PMID: 39983889
Microchem J

2024 Dec.
Toxicology

Resveratrol protects against deoxynivalenol-induced ferroptosis in HepG2 cells. [Abstract]

2023 Aug 1:494:153589. PMID: 37419272
Bioorg Chem

DA-5: A novel azaindole-based GPX4 inhibitor inducing ferroptosis for targeted therapy of triple-negative breast cancer. [Abstract]

2026 Aug 5:177:109901. PMID: 42048687
Bioorg Chem

Pyrvinium pamoate inhibits the survival of intracellular Mycobacterium tuberculosis through suppression of macrophage ferroptosis. [Abstract]

2026 Jul 5:175:109753. PMID: 41875752
Bioorg Chem

A mitochondria-targeting glutathione fluorescent probe reveals distinct mitochondria-endoplasmic reticulum contact between disulfidptosis and ferroptosis. [Abstract]

2026 Feb:169:109437. PMID: 41453306
Bioorg Chem

Macelignan targets SLC7A11 to induce ferroptosis and modulate macrophage polarization via STAT6/PPAR-γ/KLF4 signaling. [Abstract]

2026 Feb:169:109422. PMID: 41456429
Molecules

Olive Pomace Extract Acts as a New Potent Ferroptosis Inhibitor in Human Cells. [Abstract]

2025 Jul 24;30(15):3095. PMID: 40807270
Bioorg Chem

Genome-guided discovery of coublibactins from Nocardia coubleae and their gallium complexes with potent antileukemic activity. [Abstract]

2025 Jun 15:160:108508. PMID: 40280014
Spine J

Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc. [Abstract]

2025 Mar;25(3):597-608. PMID: 39522771
Molecules

Research for a Common Thread: Insights into the Mechanisms of Six Potential Anticancer Agents. [Abstract]

2025 Feb 24;30(5):1031. PMID: 40076255
Brain Pathol

Amyloid-β aggregates induce vasculopathy via ferroptosis in brain endothelial cells. [Abstract]

2026 Mar 1:e70074. PMID: 41765417
Mol Med Rep

Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis. [Abstract]

2025 Jul;32(1):202. PMID: 40376993
J Mol Med (Berl)

Cerium oxide nanoparticles as potent inhibitors of ferroptosis: role of antioxidant activity and protein regulation. [Abstract]

2025 Jul;103(7):849-866. PMID: 40448735
Biochim Biophys Acta Mol Basis Dis

Nuclear receptor coactivator 4 linked to follicular dysplasia in polycystic ovary syndrome: A key regulator that aggravates ovarian granulosa cells ferritinophagy and ferroptosis. [Abstract]

2025 Jun 17;1871(7):167955. PMID: 40553994
Biochim Biophys Acta Mol Basis Dis

Lipocalin-2 inhibition alleviates neural injury by microglia ferroptosis suppression after experimental intracerebral hemorrhage in mice via enhancing ferritin light chain expression. [Abstract]

2024 Oct;1870(7):167435. PMID: 39067535
Sci Rep

VKORC1L1-mediated vitamin K recycling counters ferroptosis to promote endothelial repair. [Abstract]

2026 Jun 19;16(1):19171. PMID: 42321255
Sci Rep

Quercetin-4'-O-β-D-glucopyranoside inhibits ferroptosis though SIRT5-mediated desuccinylation of TFR1 in diabetic nephropathy. [Abstract]

2026 Mar 6;16(1):12384. PMID: 41792305
Sci Rep

IRX4204 sensitizes multiple myeloma to ferroptosis and improves lenalidomide efficacy through the HMOX1-GPX4 axis. [Abstract]

2026 Mar 17. PMID: 41844739
Cell Calcium

Basic calcium phosphate crystals aggravate senescence-related osteoarthritis through GPX4-NRF2-mediated ferroptosis. [Abstract]

2026 Mar:134:103123. PMID: 41581266
Sci Rep

Fine particulate matter exacerbates childhood asthma via DNMT3A-mediated modulation of GPX4 DNA methylation. [Abstract]

2026 Jan 16;16(1):5566. PMID: 41545575
Mediators Inflamm

LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation. [Abstract]

2025 Nov 12:2025:8862449. PMID: 41268533
Sci Rep

MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway. [Abstract]

2025 Jul 1;15(1):21199. PMID: 40595901
Sci Rep

RSL3 induces ferroptosis by activating the NF-κB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel. [Abstract]

2025 Jan 11;15(1):1654. PMID: 39794456
PLoS Pathog

Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia. [Abstract]

2024 Nov 5;20(11):e1012614. PMID: 39499730
Sci Rep

Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage. [Abstract]

2024 May 30;14(1):12427. PMID: 38816543
Mediators Inflamm

lnc-MRGPRF-6:1 Promotes ox-LDL-Induced Macrophage Ferroptosis via Suppressing GPX4. [Abstract]

2023 Aug 16:2023:5513245. PMID: 37621767
Mediators Inflamm

Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease. [Abstract]

2023 Jul 19:2023:6623329. PMID: 37501933
Spectrochim Acta A Mol Biomol Spectrosc

Cell biology and Raman spectroscopy jointly reveal the dual antioxidative mechanisms of ginsenosides under peroxide-induced stress. [Abstract]

2026 May 13:361:128064. PMID: 42143801
Eur J Med Res

Long non-coding RNA NORAD serves as a promoter of oncogenesis and inhibits ferroptosis via miR-144-3p-mTOR-ferritinophagy axis in cancer. [Abstract]

2025 Aug 4;30(1):704. PMID: 40760677
Exp Neurol

Inhibition of mitoNEET ameliorates traumatic brain injury-induced ferroptosis and cognitive dysfunction by stabilizing dihydroorotate dehydrogenase. [Abstract]

2025 Jul:389:115235. PMID: 40189124
Eur J Med Res

GDF-15 upregulates the SLC7A11/GPX4 signaling axis and promotes mitoxantrone resistance in AML cells. [Abstract]

2025 Jun 21;30(1):504. PMID: 40544302
Neoplasia

ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. [Abstract]

2021 Dec;23(12):1227-1239. PMID: 34768109
Cancers (Basel)

Mechanism of Differential Susceptibility of Two (Canine Lung Adenocarcinoma) Cell Lines to 5-Aminolevulinic Acid-Mediated Photodynamic Therapy. [Abstract]

2021 Aug 19;13(16):4174. PMID: 34439326
Cell Signal

NUPR1 alleviates renal ischemia reperfusion injury by inhibiting ferroptosis involving the ATF4-CHAC1 pathway. [Abstract]

2026 Aug:144:112547. PMID: 42019644
Oncol Rep

Role of iron and TfR1 in the application of high‑dose ascorbate against pancreatic cancer. [Abstract]

2026 Apr;55(4):78. PMID: 41789665
J Cell Mol Med

Kaempferol Mitigates CSE-Induced Lung Injury and Epithelial Cell Ferroptosis via Modulating Nrf2/NCOA4/GPx4 Axis. [Abstract]

2026 Jan;30(1):e71010. PMID: 41474210
Cell Signal

IL-6/KIAA1429 promotes ferroptosis resistance in endometrial cancer through m6A modification of DDIT3. [Abstract]

2025 Oct:134:111906. PMID: 40436288
Oncol Rep

HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma. [Abstract]

2025 Aug;54(2):94. PMID: 40539448
J Cell Mol Med

Pan-Cancer Analyses of Necroptosis, Pyroptosis and Ferroptosis Related Genes Reveal TLR4 as A Potential Therapeutic Target. [Abstract]

2025 Jul;29(14):e70742. PMID: 40696496
J Cell Mol Med

Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes. [Abstract]

2025 Jul;29(13):e70592. PMID: 40576283
Mol Cell Biochem

Cytoglobin augments ferroptosis through autophagic degradation of ferritin in colorectal cancer cells. [Abstract]

2025 May;480(5):2881-2892. PMID: 39503803
Cell Signal

HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism. [Abstract]

2025 Mar:127:111583. PMID: 39756501
Cell Signal

Pharmacological inhibition of SREBP1 suppresses pancreatic cancer growth via inducing GPX4-mediated ferroptosis. [Abstract]

2024 Dec:124:111381. PMID: 39243918
J Cell Mol Med

4-octyl itaconate alleviates cisplatin-induced ferroptosis possibly via activating the NRF2/HO-1 signalling pathway. [Abstract]

2024 Apr;28(7):e18207. PMID: 38506087
J Cell Mol Med

Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells. [Abstract]

2021 Apr;25(7):3300-3311. PMID: 33611811
J Inflamm Res

Gandouling Regulates Ferroptosis and Improves Neuroinflammation in Wilson's Disease Through the LCN2/NLRP3 Signaling Pathway. [Abstract]

2024 Aug 23:17:5599-5618. PMID: 39193124
iScience

2025 Dec 4.
iScience

NRF2 regulates lipid droplet dynamics to prevent lipotoxicity. [Abstract]

2025 Jun 18;28(7):112925. PMID: 40678507
Mol Nutr Food Res

Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin. [Abstract]

2024 Apr;68(7):e2300343. PMID: 38501770
Neurochem Res

Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury. [Abstract]

2023 Mar;48(3):956-966. PMID: 36402927
Mol Oncol

Loss of GABARAPL1 confers ferroptosis resistance to cancer stem-like cells in hepatocellular carcinoma. [Abstract]

2022 Oct;16(20):3703-3719. PMID: 36062307
Acta Biochim Biophys Sin (Shanghai)

Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer. [Abstract]

2021 Mar 2;53(3):333-341. PMID: 33522578
Brain Res Bull

Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway. [Abstract]

2020 Oct:163:40-48. PMID: 32679060

RSL3 purchased from MedChemExpress. Usage Cited in: Brain Res Bull. 2020 Oct:163:40-48. [Abstract]

Gpx4 and 4-HNE expression assessment by Western blotting after RSL3 treatment. Western blot analysis reveal that compared with the Mel group, the RSL3 group has significantly decreased and increased Gpx4 and 4-HNE expression, respectively.

RSL3 purchased from MedChemExpress. Usage Cited in: Brain Res Bull. 2020 Oct:163:40-48. [Abstract]

Representative images and NeuN + cell quantification in the hippocampus via immunohistochemistry after RSL3 treatment. Compared with the Mel group, the RSL3 group has a significantly decreased NueN + cell number.
Aquaculture

15 January 2023, 738876.
FASEB J

Transcriptional Control by FOXO4 Regulates Trophoblast Differentiation and Safeguards Placental Development Through MITD1- and PCBP2-Mediated Redox Homeostasis. [Abstract]

2026 Jun 15;40(11):e71971. PMID: 42201761
Water Biol Secur

2025 Nov 13.
FASEB J

Downregulation of Mg2+ Efflux Protein CNNM3 Predicts Poor Prognosis but Enhances Ferroptosis Sensitivity in Kidney Renal Clear Cell Carcinoma via NCOA4-Mediated Ferritinophagy. [Abstract]

2025 Aug 31;39(16):e70948. PMID: 40824137
FASEB J

The Ketone Body β-Hydroxybutyrate Mitigates the Ferroptosis of Alveolar Epithelial Cells Type II in Bleomycin-Induced Pulmonary Fibrosis. [Abstract]

2025 Aug 15;39(15):e70920. PMID: 40787805
FASEB J

Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway. [Abstract]

2025 Jan 15;39(1):e70298. PMID: 39760183
FASEB J

SREBP-1-mediated lipogenesis confers resistance to ferroptosis and improves endothelial injury. [Abstract]

2024 Jul 15;38(13):e23806. PMID: 38970404
FASEB J

Entacapone alleviates acute kidney injury by inhibiting ferroptosis. [Abstract]

2022 Jul;36(7):e22399. PMID: 35691001
Drug Dev Res

DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone Loss. [Abstract]

2026 May;87(3):e70295. PMID: 42041149
Antimicrob Agents Chemother

Synergistic activity of RSL3 and Pyrimethamine to inhibit the proliferation of Plasmodium falciparum. [Abstract]

2025 Aug 18:e0047125. PMID: 40823867
Cancer Res Treat

Elevated SLC3A2 Expression Promotes the Progression of Gliomas and Enhances Ferroptosis Resistance through the AKT/NRF2/GPX4 Axis. [Abstract]

2025 Mar 10. PMID: 40083086
Fish Shellfish Immunol

Vitamin D ameliorates Aeromonas hydrophila-induced iron-dependent oxidative damage of grass carp splenic macrophages by manipulating Nrf2-mediated antioxidant pathway. [Abstract]

2023 Nov:142:109145. PMID: 37805110
FEBS J

Interferon-γ induces retinal pigment epithelial cell Ferroptosis by a JAK1-2/STAT1/SLC7A11 signaling pathway in Age-related Macular Degeneration. [Abstract]

2022 Apr;289(7):1968-1983. PMID: 34741776
J Biol Chem

CEP55 promotes prostate cancer progression via TPX2-dependent activation of AURKA-PI3K-AKT signaling and inhibition of ferroptosis. [Abstract]

2026 Mar;302(3):111218. PMID: 41617029
Front Biosci (Landmark Ed)

Ferroptosis Induction is Insufficient to Ensure NK Cell Activation in High-Grade Ovarian Cancer. [Abstract]

2026 Feb 5;31(2):46641. PMID: 41761980
J Trace Elem Med Biol

Metallothionein 2A alleviates ulcerative colitis by inhibiting ferroptosis in intestinal epithelial cells with Tfrc downregulation. [Abstract]

2025 Sep 10:92:127746. PMID: 40945137
Front Biosci (Landmark Ed)

Aldo-keto Reductase 1B10 (AKR1B10) Suppresses Sensitivity of Ferroptosis in TNBC by Activating the AKT/GSK3β/Nrf2/GPX4 Axis. [Abstract]

2025 Jun 27;30(6):36615. PMID: 40613296
Front Biosci (Landmark Ed)

Protective Effects of Querectin against MPP+-Induced Dopaminergic Neurons Injury via the Nrf2 Signaling Pathway. [Abstract]

2023 Mar 2;28(3):42. PMID: 37005755
Cell Stress Chaperones

ALDH3B1 protects interfollicular epidermal cells against lipid peroxidation via the NRF2 pathway. [Abstract]

2022 Nov;27(6):703-715. PMID: 36327089
Mol Genet Metab

Expansion of genotype/phenotype correlation in an individual with compound heterozygous variants in CYP51A1 and congenital cataract. [Abstract]

2025 Sep 2;146(1-2):109230. PMID: 40912167
J Endocrinol Invest

CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma. [Abstract]

2023 Aug;46(8):1573-1587. PMID: 36853491
J Cell Physiol

Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis. [Abstract]

2021 Apr;236(4):2725-2739. PMID: 32892384
J Cell Physiol

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin. [Abstract]

2020 Apr;235(4):3425-3437. PMID: 31556117
J Funct Foods

2024 Oct.
J Hepatocell Carcinoma

miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway. [Abstract]

2023 Dec 6:10:2173-2185. PMID: 38084209
Ren Fail

Reserpine alleviates cisplatin-induced acute kidney injury via anti-ferroptosis and cGAS/STING pathway. [Abstract]

2024 Dec;46(2):2406395. PMID: 39377110
J Proteome Res

Taurine Alleviates Ferroptosis-Induced Metabolic Impairments in C2C12 Myoblasts by Stabilizing the Labile Iron Pool and Improving Redox Homeostasis. [Abstract]

2024 Aug 2;23(8):3444-3459. PMID: 39024330
Carcinogenesis

SOCS1 acts as a ferroptosis driver to inhibit the progression and chemotherapy resistance of triple-negative breast cancer. [Abstract]

2023 Dec 2;44(8-9):708-715. PMID: 37665951
Carcinogenesis

ACSL4: a Double-edged Sword Target in Multiple Myeloma, Promotes Cell Proliferation and Sensitizes Cell to Ferroptosis. [Abstract]

2023 May 27;44(3):242-251. PMID: 36999754
J Med Virol

Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis. [Abstract]

2024 Oct;96(10):e29945. PMID: 39370874
Mol Carcinog

Pregnane X Receptor Activation Induces Ferroptosis Resistance Through Upregulation of FSP1. [Abstract]

2025 Jul 17. PMID: 40674609
Arch Biochem Biophys

Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells. [Abstract]

2024 Nov:761:110188. PMID: 39490616
Mol Carcinog

PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. [Abstract]

2023 Aug;62(8):1119-1135. PMID: 37144835
Arch Biochem Biophys

PHKG2 regulates RSL3-induced ferroptosis in Helicobacter pylori related gastric cancer. [Abstract]

2023 May 15:740:109560. PMID: 36948350
Hum Exp Toxicol

Acetaminophen alleviates ferroptosis in mice with sepsis-associated encephalopathy via the GPX4 pathway. [Abstract]

2022 Jan-Dec;41:9603271221133547. PMID: 36214461
Nat Sci Sleep

The Role of Ferroptosis in Adenoid Hypertrophy in Children with Obstructive Sleep Apnea Syndrome. [Abstract]

2025 Dec 18:17:3167-3180. PMID: 41439202
J Cancer

SREBP1-SCD1 enhanced MUFAs Biosynthesis drives Nutrient Deprived Pancreatic cancer cell Ferroptosis Resistance. [Abstract]

2025 Sep 8;16(13):3960-3971. PMID: 41049011
J Cancer

PERK/ATF3-Reduced ER Stress on high potassium environment in the suppression of tumor ferroptosis. [Abstract]

2023 May 15;14(8):1336-1349. PMID: 37283787
Front Oncol

Solasonine Causes Redox Imbalance and Mitochondrial Oxidative Stress of Ferroptosis in Lung Adenocarcinoma. [Abstract]

2022 May 18:12:874900. PMID: 35664792
J Integr Neurosci

Activation of the p62/Keap1/Nrf2 Pathway Protects Against Ferroptosis in Cerebral Ischemia-Reperfusion Injury. [Abstract]

2026 May 26;25(5):48011. PMID: 42216635
J Cancer Res Clin Oncol

Targeting SLC6A8 suppresses tumor growth and enhances ferroptosis in hepatocellular carcinoma. [Abstract]

2026 Mar 5;152(3):59. PMID: 41787198
J Cancer Res Clin Oncol

Depletion of UBAP2L suppresses colorectal cancer cell proliferation and radiotherapy resistance by regulating GPX4. [Abstract]

2025 Jul 15;151(7):214. PMID: 40665007
Biochem Biophys Rep

Sorafenib induces ferroptosis in human renal cell carcinoma cells through CCAT/enhancer-binding protein homologous protein. [Abstract]

2025 Jul 7:43:102143. PMID: 40688501
Animals (Basel)

Forsythiaside A Alleviates LPS-Induced Mastitis by Inhibiting Ferroptosis and Oxidative Stress. [Abstract]

2026 Jun 5;16(11):1750. PMID: 42278181
Mol Biol Rep

miR-495-3p promotes chronic obstructive pulmonary disease by activating ferroptosis in lung epithelial cells through regulation of the ETS1/GPX4 axis. [Abstract]

2026 Apr 25;53(1):667. PMID: 42033558
J Therm Biol

Heat shock response-driven signature and DNAJB11 in HCC: A multifaceted role in prognosis, immune microenvironment, ferroptosis and therapeutic sensitivity. [Abstract]

2026 Feb:136:104415. PMID: 41713042
Food Chem Toxicol

Paeoniflorin attenuates cisplatin induced ototoxicity by inhibiting ferroptosis mediated by HMGB1/NRF2/GPX4 pathway. [Abstract]

2025 Aug:202:115550. PMID: 40374000
Brain Res

Nicotinamide mononucleotide mitigates neuroinflammation by enhancing GPX4-mediated ferroptosis defense in microglia. [Abstract]

2024 Dec 15:1845:149197. PMID: 39216693
Animals (Basel)

Transcriptome and Proteome Analyses Revealed Differences in JEV-Infected PK-15 Cells in Response to Ferroptosis Agonists and Antagonists. [Abstract]

2024 Dec 5;14(23):3516. PMID: 39682481
Food Chem Toxicol

Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo. [Abstract]

2022 Aug:166:113255. PMID: 35772596
Cell Tissue Res

Phenothiazine alleviates cisplatin-mediated acute kidney injury by inhibiting ferroptosis. [Abstract]

2026 Jan 23;403(1):12. PMID: 41575591
Free Radic Res

Melatonin inhibits liver ferroptosis in copper-laden rats: a potential therapy mechanism underlying Wilson's disease. [Abstract]

2025 Oct-Dec;59(10-12):797-814. PMID: 41273307
BMC Cardiovasc Disord

Empagliflozin ameliorates RSL3-induced ferroptosis in vascular endothelial cells via the NRF2/HO-1 pathway. [Abstract]

2025 Jun 7;25(1):437. PMID: 40483457
Free Radic Res

Dioscin induces ferroptosis to suppress the metastasis of gastric cancer through the SLC7A11/GPX4 axis. [Abstract]

2025 May;59(5):426-441. PMID: 40460255
Free Radic Res

Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress. [Abstract]

2024 Nov;58(11):686-701. PMID: 39422606
Am J Cancer Res

SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy. [Abstract]

2023 Feb 15;13(2):464-474. PMID: 36895980
Life Sci Alliance

Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis. [Abstract]

2022 Nov 1;6(1):e202201667. PMID: 36319062
Am J Cancer Res

Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells. [Abstract]

2020 Apr 1;10(4):1182-1193. PMID: 32368394
Hear Res

Screening a library of oxygen-containing potential natural molecular drugs for mitigating hearing loss with mechanistic envision. [Abstract]

2026 Mar:473:109570. PMID: 41719777
Theriogenology

Oleanolic acid prevents ferroptosis and enhances oocyte competence during in vitro maturation in a porcine model. [Abstract]

2026 Apr 15:255:117817. PMID: 41544544
PeerJ

Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase. [Abstract]

2023 May 8:11:e15377. PMID: 37180584
Microvasc Res

PRDX6-mediated pulmonary artery endothelial cell ferroptosis contributes to monocrotaline-induced pulmonary hypertension. [Abstract]

2023 Mar:146:104471. PMID: 36566948
Metallomics

Roles of glutathione peroxidase 4 on the mercury-triggered ferroptosis in renal cells: Implications for the antagonism between selenium and mercury. [Abstract]

2023 Mar 6;15(3):mfad014. PMID: 36869799
Int J Immunopathol Pharmacol

Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells. [Abstract]

2026 Jan-Dec:40:3946320261427239. PMID: 41747744
Hum Cell

Multi-omic analysis constructs ferroptosis subtypes and risk signature and reveals that PEBP1 is an important tumor suppressor in kidney cancer. [Abstract]

2025 Oct 6;38(6):173. PMID: 41053452
Hum Cell

CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia. [Abstract]

2025 Jul 3;38(5):123. PMID: 40608154
Genesis

Generation of Myeloid-Specific Bmal1 Knockout Mice and Identification of Bmal1-Regulated Ferroptosis in Macrophages. [Abstract]

2025 Apr;63(2):e70014. PMID: 40197722
Gene

Inhibit ALDH3A2 reduce ovarian cancer cells survival via elevating ferroptosis sensitivity. [Abstract]

2023 Aug 5:876:147515. PMID: 37247796
FEBS Open Bio

Mouse embryonic stem cell-derived motor neurons are susceptible to ferroptosis. [Abstract]

2023 Mar;13(3):419-433. PMID: 36595221
FEBS Open Bio

NSC-34 motor neuron-like cells are sensitized to ferroptosis upon differentiation. [Abstract]

2019 Feb 23;9(4):582-593. PMID: 30984534
DNA Cell Biol

Shen-Qi-Ling-Bi Decoction Inhibits Colorectal Cancer Cell Growth by Inducing Ferroptosis Through Inactivation of PI3K/AKT Signaling Pathway. [Abstract]

2024 Jul;43(7):315-324. PMID: 38884168
Clin Med Insights Oncol

MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells. [Abstract]

2024 Apr 15:18:11795549241244783. PMID: 38628842
J Chem Neuroanat

Ozone-Mediated Cerebral Protection: Unraveling the Mechanism through Ferroptosis and the NRF2/SLC7A11/GPX4 Signaling Pathway. [Abstract]

2024 Mar:136:102387. PMID: 38182039
DNA Cell Biol

ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma. [Abstract]

2023 Jun;42(6):336-347. PMID: 37126948
Biochem Biophys Res Commun

Targeting DHODH promoter G-quadruplex to induce ferroptosis in melanoma cells. [Abstract]

2026 Jan 8:795:153117. PMID: 41380445
Biochem Biophys Res Commun

Regorafenib promotes ferroptosis in acute myeloid leukemia by upregulating NOX4. [Abstract]

2025 Dec 15:792:152981. PMID: 41242297
Biochem Biophys Res Commun

CLDND1 as a prognostic ferroptosis-associated biomarker in oral squamous cell carcinoma. [Abstract]

2025 Nov 1:787:152788. PMID: 41086680
Arch Dermatol Res

Aug 2025 20.
Biochem Biophys Res Commun

Double-stranded RNA adenosine deaminases suppress ferroptosis through regulating SCD1. [Abstract]

2025 Aug 30:776:152218. PMID: 40544760
Biochem Biophys Res Commun

Ticlopidine protects hepatic ischemia-reperfusion injury via suppressing ferroptosis. [Abstract]

2024 Nov 12:733:150436. PMID: 39053102
Biochem Biophys Res Commun

Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis. [Abstract]

2024 May 28:710:149895. PMID: 38593620
Biochem Biophys Res Commun

2, 2-dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis. [Abstract]

2023 Oct 30:679:15-22. PMID: 37659274
Biochem Biophys Res Commun

Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress, inflammation and ferroptosis. [Abstract]

2021 Oct 1:572:7-14. PMID: 34332327
Biochem Biophys Res Commun

Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]

2018 Sep 3;503(1):297-303. PMID: 29890135
J Orthop Res

Dual Regulative Role of Alpha-Kinase 1 on Synovial Angiogenesis and Chondrocyte Ferroptosis in Inflammatory Osteoarthritis. [Abstract]

2026 Jan;44(1):e70116. PMID: 41388916
Radiat Res

Fludarabine Enhances Radiosensitivity by Promoting Ferroptosis in B-Cell Lymphoma. [Abstract]

2024 Mar 1;201(3):224-239. PMID: 38235545
Bioorg Med Chem Lett

Cyclic vinyl sulfones activate NRF2 to protect from oxidative stress-induced programmed necrosis. [Abstract]

2025 Mar 1:117:130058. PMID: 39644937
Head Neck

iPLA2β regulates the dual effects of arachidonic acid in thyroid cancer. [Abstract]

2025 Feb;47(2):504-516. PMID: 39290130
World J Surg

Ferroptosis Inducers in Thyroid Cancer. [Abstract]

2023 Feb;47(2):371-381. PMID: 36195678
Exp Ther Med

Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the Xc-/GPX4 axis. [Abstract]

2021 Jan;21(1):72. PMID: 33365072
BMC Ophthalmol

Lens epithelium cell ferroptosis mediated by m6A-lncRNA and GPX4 expression in lens tissue of age-related cataract. [Abstract]

2023 Dec 18;23(1):514. PMID: 38110879
In Vitro Cell Dev Biol Anim

ACOT7 protects epidermal stem cells against lipid peroxidation. [Abstract]

2022 Aug;58(7):549-557. PMID: 36036847
Biol Pharm Bull

Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. [Abstract]

2020;43(3):480-487. PMID: 32115506
Int Ophthalmol

Protective effects of luteolin on high glucose-induced ferroptosis in müller cells. [Abstract]

2025 Nov 19;45(1):494. PMID: 41258543
J Obstet Gynaecol Res

Estradiol regulates MBOAT1-mediated ferroptosis and participates in the progression of endometriosis. [Abstract]

2025 Sep;51(9):e70069. PMID: 40983106
Microbiol Immunol

Competitive Binding of Pseudomonas aeruginosa to Kelch-Like ECH-Associated Protein 1 Inhibits Nuclear Factor Erythroid 2-Related Factor 2 Ubiquitination and Suppresses Ferroptosis in Macrophages. [Abstract]

2025 Aug;69(8):418-428. PMID: 40468416
Acta Cir Bras

Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway. [Abstract]

2025 Apr 28:40:e403325. PMID: 40298655
Crit Rev Eukaryot Gene Expr

METTL3 Promotes Mitochondrial Dysfunction and Neuronal Ferroptosis in Cerebral Ischemia and Reperfusion Injury through YTHDC1/SLC7A11 Modification. [Abstract]

2025 Jun 24;35(6):59-70. PMID: 40972099
Nat Prod Commun

2023 Aug 16.
STAR Protoc

Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models. [Abstract]

2024 Feb 14;5(1):102892. PMID: 38363686
bioRxiv

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells. [Abstract]

2026 May 18:2026.05.16.725645. PMID: 42239248
SSRN

2026 Apr 13.
bioRxiv

2026 Mar 31.
bioRxiv

2026 Mar 16.
Res Sq

2026 Mar 10.
SSRN

2026 Mar 6.
bioRxiv

2026 Feb 2.
bioRxiv

2026 Feb 11.
Res Sq

2026 Jan 15.
Biomed Pharmacother

As a novel ferroptosis inhibitor, primaquine alleviates I/R-induced retinal neuron death via increasing GSTA1 activity. [Abstract]

2026 Feb:195:118973. PMID: 41529513
University of California San Diego

2025 Dec 20.
SSRN

2025 Dec 2.
Seoul National University

2026.
Res Sq

Acid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in senescent cells. [Abstract]

2025 Nov 28:rs.3.rs-8117957. PMID: 41356368
Res Sq

2025 Oct 6.
Biomed Pharmacother

MIT-001 ameliorates ferroptosis-induced mitochondrial dysfunction and enhances embryo quality in preimplantation embryos from aged female mice. [Abstract]

2025 Sep:190:118393. PMID: 40784125
University of Pennsylvania

2025.
Cornell University

2025.
SSRN

2025 Aug 6.
SSRN

2025 Jul 14.
Biomed Pharmacother

Lutein attenuates rhabdomyolysis-induced acute kidney injury by inhibiting ACSL4-mediated ferroptosis. [Abstract]

2025 Jul:188:118222. PMID: 40460552
Cell Investig

2025 May 31.
Res Sq

2025 Mar 03.
SSRN

2025 Jan 14.
SSRN

2025 Jan 23.
bioRxiv

2025 March 15.
DNA (Basel)

2025 Mar 12.
bioRxiv

2025 March 13.
SSRN

2025 Jan 8.
Heliyon

REV-ERBα inhibitor rescues MPTP/MPP+-induced ferroptosis of dopaminergic neuron through regulating FASN/SCD1 signaling pathway. [Abstract]

2024 Nov 15;10(23):e40388. PMID: 39654780
Heliyon

Targeting ferroptosis promotes diabetic wound healing via Nrf2 activation. [Abstract]

2024 Sep 5;10(19):e37477. PMID: 39421383
Biomed Pharmacother

Erastin promotes random-pattern skin flaps survival by inducing mTORC1-TFEB mediated autophagy. [Abstract]

2024 Aug:177:116918. PMID: 38878639
Biomed Pharmacother

Vitamin K2 ameliorates osteoarthritis by suppressing ferroptosis and extracellular matrix degradation through activation GPX4's dual functions. [Abstract]

2024 Jun:175:116697. PMID: 38759289
Research Square Preprint

2024 May 7.
Research Square Preprint

2024 Apr 9.
SSRN

2024 Mar 8.
Sci Total Environ

PM2.5 exposure exacerbates seizure symptoms and cognitive dysfunction by disrupting iron metabolism and the Nrf2-mediated ferroptosis pathway. [Abstract]

2024 Feb 1:910:168578. PMID: 37981141
Heliyon

YAP promotes the healing of ischemic wounds by reducing ferroptosis in skin fibroblasts through inhibition of ferritinophagy. [Abstract]

2024 Jan 16;10(2):e24602. PMID: 38298641
bioRxiv

Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer. [Abstract]

2023 Nov 5:2023.11.05.565697. PMID: 38496603
Chemosphere

Low-dose antimony exposure promotes prostate cancer proliferation by inhibiting ferroptosis via activation of the Nrf2-SLC7A11-GPX4 pathway. [Abstract]

2023 Oct:339:139716. PMID: 37562508
Research Square Preprint

2023 Aug 31.
Biomed Pharmacother

AP39 inhibits ferroptosis by inhibiting mitochondrial autophagy through the PINK1/parkin pathway to improve myocardial fibrosis with myocardial infarction. [Abstract]

2023 Sep:165:115195. PMID: 37516015
Research Square Preprint

2023 Aug 11.
bioRxiv

Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer. [Abstract]

2023 Aug 22:2023.08.21.554116. PMID: 37662291
bioRxiv

2023 Jul 3.
Ruperto Carola University Heidelberg

2023 Jun 20.
Research Square Preprint

2023 May 24.
bioRxiv

2023 Apr 17.
Research Square Print

2023 Mar 24.
bioRxiv

Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages. [Abstract]

2023 Feb 10:2023.02.09.527908. PMID: 36798271
bioRxiv

Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. [Abstract]

2023 Feb 18:2023.02.17.528937. PMID: 36824830
Research Square Print

November 8th, 2022
Research Square Print

posted 01 Nov, 2022
Research Square Print

September 1st, 2022.
Research Square Print

2022 Jul.
Research Square Print

2022 Jul.
Oxid Med Cell Longev

Pomelo Peel Essential Oil Ameliorates Cerebral Ischemia-Reperfusion Injury through Regulating Redox Homeostasis in Rats and SH-SY5Y Cells. [Abstract]

2022 May 5;2022:8279851. PMID: 35571242
Oxid Med Cell Longev

Ferroptosis Induction Improves the Sensitivity of Docetaxel in Prostate Cancer. [Abstract]

2022 May 24:2022:4930643. PMID: 39282153
Oxid Med Cell Longev

Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis. [Abstract]

2022 Feb 9;2022:4295208. PMID: 35186185
Research Square Preprint

2021 Jul.
Oxid Med Cell Longev

Stearoyl-CoA Desaturase 1 Potentiates Hypoxic plus Nutrient-Deprived Pancreatic Cancer Cell Ferroptosis Resistance. [Abstract]

2021 Apr 1:2021:6629804. PMID: 33868572
bioRxiv

2019 Oct 28.
bioRxiv

2019 Oct.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (226.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2682 mL

11.3410 mL

22.6819 mL

5 mM

0.4536 mL

2.2682 mL

4.5364 mL

10 mM

0.2268 mL

1.1341 mL

2.2682 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.72 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.72 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.72 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 4

Add each solvent one by one: 10% DMF 90% Corn Oil

Solubility: ≥ 0.56 mg/mL (1.27 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
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g
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μL
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (292 KB)
SDS (394 KB)
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- Deutsch - DE (394 KB)
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- Español - ES (394 KB)
- Swedish - SV (394 KB)
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- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462. [Content Brief]

[2]. Romani P, et al., Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol. 2022 Feb;24(2):168-180. [Content Brief]

[3]. Zhang Z, et al., CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes. Nat Chem Biol. 2024 Jan 11. [Content Brief]

[4]. Chen T, et al., Mitochondrial transplantation rescues neuronal cells from ferroptosis. Free Radic Biol Med. 2023 Nov 1;208:62-72. [Content Brief]

[5]. Zhu JF, et al., Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway. Cell Death Dis. 2023 Feb 23;14(2):151. [Content Brief]

[6]. Song H, et al., A potent GPX4 degrader to induce ferroptosis in HT1080 cells. Eur J Med Chem. 2024 Feb 5;265:116110. [Content Brief]

[7]. Zheng J, et al., Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines. Cell Death Dis. 2021 Jul 13;12(7):698. [Content Brief]

[8]. Cheff DM, et al., The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1. Redox Biol. 2023 Jun;62:102703. [Content Brief]

[9]. Li P, et al., Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death Dis. 2022 Sep 21;13(9):808. [Content Brief]

[10]. Brown CW, et al., Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export. Dev Cell. 2019 Dec 2;51(5):575-586.e4. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2682 mL	11.3410 mL	22.6819 mL	56.7048 mL
	5 mM	0.4536 mL	2.2682 mL	4.5364 mL	11.3410 mL
	10 mM	0.2268 mL	1.1341 mL	2.2682 mL	5.6705 mL
	15 mM	0.1512 mL	0.7561 mL	1.5121 mL	3.7803 mL
	20 mM	0.1134 mL	0.5670 mL	1.1341 mL	2.8352 mL
	25 mM	0.0907 mL	0.4536 mL	0.9073 mL	2.2682 mL
	30 mM	0.0756 mL	0.3780 mL	0.7561 mL	1.8902 mL
	40 mM	0.0567 mL	0.2835 mL	0.5670 mL	1.4176 mL
	50 mM	0.0454 mL	0.2268 mL	0.4536 mL	1.1341 mL
	60 mM	0.0378 mL	0.1890 mL	0.3780 mL	0.9451 mL
	80 mM	0.0284 mL	0.1418 mL	0.2835 mL	0.7088 mL
	100 mM	0.0227 mL	0.1134 mL	0.2268 mL	0.5670 mL

Bioz

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

RSL3

Erastin

Ferrostatin-1

ML-210

Liproxstatin-1

Z-VAD-FMK

iFSP1

ML162

Necrostatin-1

Imidazole ketone erastin

Deferoxamine mesylate

Staurosporine

MG-132

Publications Citing Use of MedChemExpress (MCE) RSL3

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Publications (551)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

RSL3

Erastin

Ferrostatin-1

ML-210

Liproxstatin-1

Z-VAD-FMK

iFSP1

ML162

Necrostatin-1

Imidazole ketone erastin

Deferoxamine mesylate

Staurosporine

MG-132

Publications Citing Use of MedChemExpress (MCE) RSL3

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Publications (551)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

RSL3 Related Classifications

HY-100218A Related Classifications

Bioz