sFRP-1
Secreted frizzled related protein 1; SARP-2; FrzA
Secreted frizzled-related proteins (SFRPs) are soluble proteins that have highly restricted tissue distribution. SFRPs are capable of binding to Wnts and frizzled (Fz) receptors to interfere with Wnt signaling, which plays a major role in cell fate determination through the regulation of cell proliferation, differentiation, and apoptosis.
sFRP-1 contributes to the inhibition of apoptosis in fibroblast populations. sFRP-1 proteins are involved in apoptosis by negatively modulating wingless/int (WNT) signaling by interacting with either WNTs or Frizzled receptors. By sequestering WNTs, sFRP-1 removes the stimulus for β-catenin stabilization and mediates various biological processes.
SFRP proteins modulate Wnt signalling by interacting with either Wnt or frizzled receptors and are reported to affect epithelial/stromal interactions in prostate cancer.
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sFRP-1 Related Products (6)
Related Products (6)
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Antibodies (2)
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WAY-362692
0 ImagesWAY-362692 is a secreted frizzled-related protein (sFRP-1) inhibitor (IC50 of 0.02 μM), targeting the netrin domain of sFRP-1. WAY-362692 can competitively inhibit the interaction between sFRP-1 and Wnt proteins, and activate the Wnt/β-catenin signaling pathway (EC50 = 0.03 μM). WAY-362692 can activate osteoblasts and promote bone remodeling. WAY-362692 can be used for the research of metabolic disease, such as osteoporosis.
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BCN512
0 ImagesBCN512 is an inhibitor of SFRP1 that can inhibit tissue fibrosis. BCN512 can be used in the research about inflammatory diseases.
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SFRP1 modulator-1
0 ImagesCat. No.: HY-180876CAS No.: 405924-84-7SFRP1 modulator-1 (compound Way 316606 (positive control)) is a SFRP1 modulator.
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WAY 316606 (Standard)
0 ImagesCat. No.: HY-10858RCAS No.: 915759-45-4WAY 316606 (Standard) is the analytical standard of WAY 316606 (HY-10858). This product is intended for research and analytical applications. WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM.
