1. Recombinant Proteins
  2. Ubiquitin Related Proteins
  3. Deubiquitinase

Deubiquitinating enzymes (DUBs) are a large group of proteases that specifically remove ubiquitin (Ub) or ubiquitin-like proteins (UBLs) from of interest undergoing proteasomal degradation. The DUBs are classified into distinct families based on their sequence similarities and likely mechanisms of action, the vast majority of which are cysteine proteases. These include ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), ovarian tumor proteases (OTUs), Machado-Joseph disease proteases (MJDs), Jab1/Mov34/Mpr1 (JAMM) metalloproteases, and the recently-discovered MIU-containing novel DUB family, (MINDY) proteases. They regulate several cellular functions, including proteasome-dependent and lysosome-dependent proteolysis, gene expression, cell cycle progression, chromosome segregation, kinase activation, apoptosis, localization, DNA repair, maintenance of stemness, spermatogenesis, and degradation of signaling intermediates.

Cat. No. Product Name / Synonyms Species Source
  • HY-P74479
    USP5 Protein, Human (sf9, His)

    Ubiquitin carboxyl-terminal hydrolase 5; Isopeptidase T; USP5; ISOT

    Human Sf9 insect cells
    USP5 protein selectively cleaves branched multiubiquitin polymers, favoring 'Lys-48'-linked polyubiquitin disassembly. It exhibits lower affinity for linear and 'Lys-63'-linked polyubiquitin. USP5 knockdown leads to p53/TP53 accumulation, enhancing p53/TP53 transcriptional activity, as unanchored polyubiquitin competes with ubiquitinated p53/TP53 for proteasomal recognition, unlike MDM2. USP5 Protein, Human (sf9, His) is the recombinant human-derived USP5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of USP5 Protein, Human (sf9, His) is 835 a.a., with molecular weight of ~100 kDa.
  • HY-P71096
    UCHL1 Protein, Human (His)

    Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1; UCH-L1; Neuron Cytoplasmic Protein 9.5; PGP 9.5; PGP9.5; Ubiquitin Thioesterase L1; UCHL1

    Human E. coli
    The UCHL1 protein is a multifunctional deubiquitinase that regulates a variety of cellular processes. It maintains synaptic and cardiac function, modulates inflammatory responses, and influences osteoclastogenesis. UCHL1 Protein, Human (His) is the recombinant human-derived UCHL1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of UCHL1 Protein, Human (His) is 223 a.a., with molecular weight of ~26.0 kDa.
  • HY-P71418
    USP14 Protein, Human (His)

    Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14; Ubiquitin Thioesterase 14; Ubiquitin-Specific-Processing Protease 14; USP14; TGT

    Human E. coli
    USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human (His) is the recombinant human-derived USP14 protein, expressed by E. coli , with N-6*His labeled tag. The total length of USP14 Protein, Human (His) is 404 a.a., with molecular weight of 47-52 kDa.
  • HY-P74483
    UCHL1 Protein, Rat (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1; Uchl1; PGP9.5

    Rat E. coli
    The UCHL1 protein is a ubiquitin proteolytic enzyme essential for processing ubiquitin precursors and hydrolyzing ubiquitinated proteins. As a thiol protease, it specifically cleaves the C-terminal glycine of ubiquitin. UCHL1 Protein, Rat (His) is the recombinant rat-derived UCHL1 protein, expressed by E. coli , with N-10*His labeled tag. The total length of UCHL1 Protein, Rat (His) is 222 a.a., with molecular weight of ~28 kDa.
  • HY-P700272
    USP14 Protein, Human (N-His)

    Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14; Ubiquitin Thioesterase 14; Ubiquitin-Specific-Processing Protease 14; USP14; TGT

    Human E. coli
    USP14, a proteasome-associated deubiquitinase, regulates ubiquitin dynamics by releasing it from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. Beyond proteasomal protein turnover, it degrades CXCR4 for cell chemotaxis and inhibits ERAD under non-stressed conditions. USP14 also aids synaptic development at NMJs and stabilizes CGAS for antiviral defense, revealing its multifaceted role in cellular processes. USP14 Protein, Human (N-His) is the recombinant human-derived USP14 protein, expressed by E. coli, with N-6*His labeled tag. The total length of USP14 Protein, Human (N-His) is 494 a.a., with molecular weight of ~60 kDa.
  • HY-P77277
    USP46 Protein, Human/Mouse (sf9)

    Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Usp46

    Human; Mouse Sf9 insect cells
    USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9) is the recombinant human, mouse-derived USP46 protein, expressed by Sf9 insect cells , with tag free. The total length of USP46 Protein, Human/Mouse (sf9) is 366 a.a., with molecular weight of ~43 kDa.
  • HY-P71115
    UCHL3 Protein, Human (His)

    Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3; UCH-L3; Ubiquitin Thioesterase L3; UCHL3

    Human E. coli
    UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is responsible for protein degradation and regulation of cellular processes. It is prominently expressed in the testes and plays a crucial role in spermatogenesis. UCHL3 Protein's involvement in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine. UCHL3 Protein, Human (His) is the recombinant human-derived UCHL3 protein, expressed by E. coli , with C-6*His labeled tag. The total length of UCHL3 Protein, Human (His) is 230 a.a., with molecular weight of ~25.0 kDa.
  • HY-P74478
    USP7 Protein, Human (sf9)

    Ubiquitin carboxyl-terminal hydrolase 7; USP7; HAUSP

    Human Sf9 insect cells
    The USP7 protein is a hydrolase that deubiquitinates multiple targets, including FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5, and DAXX. It cooperates with DAXX to enhance the E3 ligase activity of MDM2 and promote ubiquitination and degradation of p53/TP53. USP7 Protein, Human (sf9) is the recombinant human-derived USP7 protein, expressed by Sf9 insect cells , with tag free. The total length of USP7 Protein, Human (sf9) is 353 a.a., with molecular weight of ~41 kDa.
  • HY-P75952
    OTUB1 Protein, Human (His)

    Ubiquitin thioesterase OTUB1; Otubain-1; OTUB1; OTB1; OTU1

    Human E. coli
    OTUB1 protein directly interacts with RNF128, forming a ternary complex with USP8 through OTUB1's binding to the C-terminal UCH catalytic domain of USP8. OTUB1 Protein, Human (His) is the recombinant human-derived OTUB1 protein, expressed by E. coli , with N-His labeled tag. The total length of OTUB1 Protein, Human (His) is 271 a.a., with molecular weight of ~34-37 kDa.
  • HY-P76689
    UCHL3 Protein, Rat (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; Ubiquitin thioesterase L3

    Rat E. coli
    The UCHL3 protein is a deubiquitinating enzyme (DUB) that complexly controls cellular ubiquitin levels by processing ubiquitin precursors and ubiquitinated proteins. As a thiol protease, UCHL3 selectively recognizes and hydrolyzes the peptide bond of ubiquitin or the C-terminal glycine of NEDD8, showing a 10-fold preference for Arg and Lys at the P3 position, and has a special preference for "Lys-48" linked ubiquitin chains. affinity. UCHL3 Protein, Rat (His) is the recombinant rat-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag. The total length of UCHL3 Protein, Rat (His) is 229 a.a., with molecular weight of ~28 kDa.
  • HY-P77118
    OTUB2 Protein, Human (His)

    Ubiquitin thioesterase OTUB2; Otubain-2; C14orf137; OTB2; OTU2

    Human E. coli
    OTUB2 is a hydrolase that efficiently removes conjugated ubiquitin from proteins in vitro, implying a crucial role in preventing protein degradation and regulating turnover. Its deubiquitinating activity targets “Lys-11”, “Lys-48” and “Lys-63” linked polyubiquitin chains, with preference for the latter. OTUB2 Protein, Human (His) is the recombinant human-derived OTUB2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of OTUB2 Protein, Human (His) is 234 a.a., with molecular weight of ~28 kDa.
  • HY-P702603
    USP7 Protein, Human (His)

    Ubiquitin carboxyl-terminal hydrolase 7; USP7; HAUSP

    Human E. coli
  • HY-P76119A
    UCHL3 Protein, Mouse (His, solution)

    UCH-L3; Ubiquitin thioesterase L3; Uchl3

    Mouse E. coli
    UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is involved in the regulation of cellular processes and protein degradation. It is particularly expressed in the testes and plays a vital role in spermatogenesis. UCHL3 Protein's significance in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine. UCHL3 Protein, Mouse (His, solution) is the recombinant mouse-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag. The total length of UCHL3 Protein, Mouse (His, solution) is 229 a.a., with molecular weight of ~26 kDa.
  • HY-P73466
    UCHL1 Protein, Mouse (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1; Uchl1; PGP9.5

    Mouse E. coli
    UCHL1 Protein, a ubiquitin carboxyl-terminal hydrolase, plays a crucial role in protein degradation and regulation of cellular processes. It is involved in maintaining neuronal integrity and has been linked to neurodegenerative diseases. UCHL1 Protein's potential as a biomarker and therapeutic target in neurodegenerative disorders makes it a subject of intense research in the field of neuroscience. UCHL1 Protein, Mouse (His) is the recombinant mouse-derived UCHL1 protein, expressed by E. coli , with N-His labeled tag. The total length of UCHL1 Protein, Mouse (His) is 222 a.a., with molecular weight of ~29 kDa.
  • HY-P76119
    UCHL3 Protein, Mouse (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; Ubiquitin thioesterase L3

    Mouse E. coli
    UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is involved in the regulation of cellular processes and protein degradation. It is particularly expressed in the testes and plays a vital role in spermatogenesis. UCHL3 Protein's significance in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine. UCHL3 Protein, Mouse (His) is the recombinant mouse-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag. The total length of UCHL3 Protein, Mouse (His) is 229 a.a., with molecular weight of ~30 kDa.
  • HY-P71182
    OTUB2 Protein, Human (GST)

    Ubiquitin Thioesterase OTUB2; Deubiquitinating Enzyme OTUB2; OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein 2; Otubain-2; Ubiquitin-Specific-Processing Protease OTUB2; OTUB2; C14orf137; OTB2; OTU2

    Human E. coli
    OTUB2 is a hydrolase that efficiently removes conjugated ubiquitin from proteins in vitro, implying a crucial role in preventing protein degradation and regulating turnover. Its deubiquitinating activity targets “Lys-11”, “Lys-48” and “Lys-63” linked polyubiquitin chains, with preference for the latter. OTUB2 Protein, Human (GST) is the recombinant human-derived OTUB2 protein, expressed by E. coli , with N-GST labeled tag. The total length of OTUB2 Protein, Human (GST) is 234 a.a., with molecular weight of ~52.0 kDa.
  • HY-P77278
    USP46 Protein, Human/Mouse (sf9, SUMO)

    Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Usp46

    Mouse Sf9 insect cells
    USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9, SUMO) is the recombinant mouse-derived USP46 protein, expressed by Sf9 insect cells , with SUMO labeled tag. The total length of USP46 Protein, Human/Mouse (sf9, SUMO) is 366 a.a., with molecular weight of ~64 kDa.
  • HY-P701438
    EIF3S5 Protein, Human

    EIF3F; Eukaryotic translation initiation factor 3 subunit F; eIF3f; Deubiquitinating enzyme eIF3f; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

    Human E. coli
    The EIF3S5 protein is an important component of the eukaryotic translation initiation factor 3 (eIF-3) complex and plays a crucial role in various stages of protein synthesis initiation. It stimulates mRNA recruitment, scans for AUG recognition, and promotes disassembly and recycling of posttermination ribosomal complexes within the 43S preinitiation complex (43S PIC). EIF3S5 Protein, Human is the recombinant human-derived EIF3S5 protein, expressed by E. coli , with tag free. The total length of EIF3S5 Protein, Human is 356 a.a., .
  • HY-P702604
    USP7 Protein, Human

    Ubiquitin carboxyl-terminal hydrolase 7; USP7; HAUSP

    Human E. coli
  • HY-P701439
    EIF3S5 Protein, Human (GST)

    EIF3F; Eukaryotic translation initiation factor 3 subunit F; eIF3f; Deubiquitinating enzyme eIF3f; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

    Human E. coli
    The EIF3S5 protein is an important component of the eukaryotic translation initiation factor 3 (eIF-3) complex and plays a crucial role in various stages of protein synthesis initiation. It stimulates mRNA recruitment, scans for AUG recognition, and promotes disassembly and recycling of posttermination ribosomal complexes within the 43S preinitiation complex (43S PIC). EIF3S5 Protein, Human (GST) is the recombinant human-derived EIF3S5 protein, expressed by E. coli , with N-GST labeled tag. The total length of EIF3S5 Protein, Human (GST) is 356 a.a., .
Cat. No. Product Name Effect Purity