1. Anti-infection
  2. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (86):

Cat. No. Product Name Effect Purity
  • HY-12320
    Cycloheximide Inhibitor 99.17%
    Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.
  • HY-B0221
    Amphotericin B Inhibitor >98.00%
    Amphotericin B is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
  • HY-B0490
    Hygromycin B Inhibitor >98.00%
    Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.
  • HY-16321
    Micafungin sodium Inhibitor >98.0%
    Micafungin(FK463) is an echinocandin antifungal drug, Micafungin inhibits the production of beta-1,3-glucan, an essential component of fungal cell walls.
  • HY-17409
    Nystatin Inhibitor
    Nystatin (Fungicidin) is a polyene antifungal antibiotic effective against yeast and mycoplasma.
  • HY-102025
    Antifungal agent 1 Inhibitor >98.0%
    Antifungal agent 1 is a potent antifungal agent.
  • HY-14272
    Ravuconazole Inhibitor 99.81%
    Ravuconazole (BMS-207147;ER-30346) is an orally available triazoleantifungle agent that potently inhibits a wide range of fungi.
  • HY-P0269
    Magainin 1 Inhibitor
    Magainin 1 is an antimicrobial peptide discovered in the skin of Xenopus laevis.
  • HY-13553
    Anidulafungin Inhibitor 99.22%
    Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
  • HY-17006
    Caspofungin Acetate Inhibitor 99.72%
    Caspofungin (Acetate) is an antifungal drug, and noncompetitively inhibits 1,3-β-d glucan synthase activity.
  • HY-17514
    Itraconazole Inhibitor 99.91%
    Itraconazole is a triazole antifungal agent.
  • HY-17373
    Posaconazole Inhibitor 99.78%
    Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
  • HY-17395A
    Terbinafine Inhibitor 99.98%
    Terbinafine is an antifungal medication used to treat fungal infections.
  • HY-B0105
    Ketoconazole Inhibitor 99.67%
    Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-B0139
    Flucytosine Inhibitor 99.88%
    Flucytosine (5-Fluorocytosine, 5-FC, Ancobon), a fluorinated pyrimidine analogue, is an antifungal drug.
  • HY-14283
    Luliconazole Inhibitor 99.84%
    Luliconazole(NND 502) is an azole antifungal indicated for the topical treatment of interdigital tinea pedis.
  • HY-76200
    Voriconazole Inhibitor 99.59%
    Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections.
  • HY-12772
    Itraconazole metabolite Hydroxy Itraconazole Inhibitor >98.0%
    Itraconazole metabolite Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
  • HY-13557
    Ascomycin Inhibitor 98.04%
    Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
  • HY-B0454A
    Miconazole nitrate Inhibitor 99.71%
    Miconazole Nitrate is an imidazole antifungal agent.