1. Anti-infection
  2. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (97):

Cat. No. Product Name Effect Purity
  • HY-12320
    Cycloheximide Inhibitor 99.45%
    Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.
  • HY-B0490
    Hygromycin B Inhibitor >98.00%
    Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.
  • HY-B0221
    Amphotericin B Inhibitor >98.00%
    Amphotericin B is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
  • HY-17409
    Nystatin Inhibitor
    Nystatin is a polyene antifungal antibiotic effective against yeast and mycoplasma.
  • HY-17514
    Itraconazole Inhibitor 99.55%
    Itraconazole is a triazole antifungal agent.
  • HY-Y0051
    5-(Hydroxymethyl)furan-2-carbaldehyde Inhibitor
    5-(Hydroxymethyl)furan-2-carbaldehyde, derived from lignocellulosic biomass, inhibits yeast growth and fermentation as stressors.
  • HY-P1508
    Bactenecin Inhibitor
    Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.
  • HY-B0105
    Ketoconazole Inhibitor 99.67%
    Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-16321
    Micafungin sodium Inhibitor >98.0%
    Micafungin (sodium) is an inhibitor of 1, 3-beta-D-glucan synthesis, and used as an antifungal drug.
  • HY-17006
    Caspofungin Acetate Inhibitor 99.72%
    Caspofungin (Acetate) is an antifungal drug, and noncompetitively inhibits 1,3-β-d glucan synthase activity.
  • HY-B0139
    Flucytosine Inhibitor >99.0%
    Flucytosine (5-Fluorocytosine, 5-FC, Ancobon), a fluorinated pyrimidine analogue, is an antifungal drug.
  • HY-B0101
    Fluconazole Inhibitor 99.51%
    Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
  • HY-13553
    Anidulafungin Inhibitor 99.22%
    Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
  • HY-B0450
    Ciclopirox Inhibitor 98.76%
    Ciclopirox (Penlac) is a synthetic antifungal agent.
  • HY-17373
    Posaconazole Inhibitor 99.91%
    Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
  • HY-10882
    Clotrimazole Inhibitor 99.62%
    Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.
  • HY-76200
    Voriconazole Inhibitor 99.59%
    Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections.
  • HY-14273
    Isavuconazole Inhibitor 99.99%
    Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity.
  • HY-17395A
    Terbinafine Inhibitor 99.98%
    Terbinafine is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.
  • HY-13557
    Ascomycin Inhibitor >98.0%
    Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
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