1. Signaling Pathways
  2. Anti-infection
  3. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal Related Products (119):

Cat. No. Product Name Effect Purity
  • HY-12320
    Cycloheximide Inhibitor 99.45%
    Cycloheximide (Naramycin A) is an eukaryote protein synthesis inhibitor, with IC50s of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.
  • HY-B0490
    Hygromycin B Inhibitor >98.00%
    Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.
  • HY-B0221
    Amphotericin B Inhibitor >98.00%
    Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
  • HY-17409
    Nystatin Inhibitor 98.29%
    Nystatin is a polyene antifungal antibiotic effective against yeast and mycoplasma.
  • HY-17514
    Itraconazole Inhibitor 99.55%
    Itraconazole is a triazole antifungal agent.
  • HY-16909
    Leptomycin B Inhibitor >98.0%
    Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
  • HY-114495
    Caerulomycin A Inhibitor >98.0%
    Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases.
  • HY-123230
    Trifloxystrobin Inhibitor 99.14%
    Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h.
  • HY-17006
    Caspofungin Acetate Inhibitor 99.72%
    Caspofungin (Acetate) is an antifungal drug, and noncompetitively inhibits 1,3-β-d glucan synthase activity.
  • HY-B0105
    Ketoconazole Inhibitor 99.67%
    Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-B0101
    Fluconazole Inhibitor 99.51%
    Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
  • HY-16321
    Micafungin sodium Inhibitor >98.0%
    Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.
  • HY-17373
    Posaconazole Inhibitor 99.91%
    Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
  • HY-14273
    Isavuconazole Inhibitor 99.99%
    Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity.
  • HY-76200
    Voriconazole Inhibitor 99.97%
    Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections.
  • HY-B0450
    Ciclopirox Inhibitor 98.76%
    Ciclopirox (Penlac) is a synthetic antifungal agent.
  • HY-13553
    Anidulafungin Inhibitor 98.98%
    Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
  • HY-17395A
    Terbinafine Inhibitor 99.98%
    Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.
  • HY-14603
    Clioquinol Inhibitor >98.0%
    Clioquinol(Iodochlorhydroxyquin) is an antifungal drug and antiprotozoal compound that shows effectivity for Alzheimer's disease treatment and induce cancer cell death.
  • HY-B0139
    Flucytosine Inhibitor >99.0%
    Flucytosine (5-Fluorocytosine, 5-FC, Ancobon), a fluorinated pyrimidine analogue, is an antifungal drug.
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