2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related Epigenetics Apoptosis Anti-infection
  3. Topoisomerase ADC Payload MicroRNA Influenza Virus Apoptosis Fungal Antibiotic
  4. Camptothecin

Camptothecin  (Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT)

Cat. No.: HY-16560 Purity: 99.77%
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Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.

For research use only. We do not sell to patients.

CAS No. : 7689-03-4

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ready for reconstitution
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Customer Review

Based on 68 publication(s) in Google Scholar

Other Forms of Camptothecin:

Camptothecin Related Antibodies

Top Publications Citing Use of Products

68 Publications Citing Use of MCE Camptothecin

WB
IF
IP
Cell Proliferation/Viability Assay

    Camptothecin purchased from MedChemExpress. Usage Cited in: Arch Cancer Res. 2023 Jan 30.

    Camptothecin (CPT; 10-5 -10-10 M; 72 h) demonstrates a strong antitumor activity and an inhibitory of proliferation (IC50 = 25.36 nM) in U937 cells.

    Camptothecin purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2020 Nov;27(11):3162-3176.  [Abstract]

    293T cells transfected with Flag-TopBP1 and GFP-tagged RBMX and its domain (RRM, RBM1CTR, and C-RBD) are treated with 100 nM CPT for 24 h and subjected to immunoprecipitation with Flag-beads. Immunoprecipitates are immunoblotted with Flag and GFP antibodies, respectively.

    Camptothecin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761.  [Abstract]

    Genotoxic stress-induced β-catenin signaling is activated via a TCF- or FOXO-independent mechanism. Representative images of the subcellular localization of β-catenin in the indicated cells treated with CPT (10 μM, 1 h), IR (10 Gy), and CDDP (10 μM, 1 h), as analyzed by immunofluorescence staining.

    Camptothecin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Oct 8;9(1):4139.  [Abstract]

    One hour after treated with UV or 2 h after treated with MMS, Camptothecin (CPT) (10 μM), or Doxorubicin (DOX; 0.5 μM), HEK293T cells expressing HA-SUMO2 and His-RhoB are subjected to sumoylation assay to detect the SUMO2 conjugation of RhoB.

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    Description

    Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].

    IC50 & Target[3]

    Topoisomerase I

    679 nM (IC50)

    Camptothecins

     

    Cellular Effect
    Cell Line Type Value Description References
    184B5 IC50
    4.96 μM
    Compound: Camptothecin
    Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay
    Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay
    		[PMID: 26602827]
    1A9 ED50
    3.2 nM
    Compound: 3a, CPT, Camptothecin
    Cytotoxicity against human 1A9 cells by sulforhodamine B assay
    Cytotoxicity against human 1A9 cells by sulforhodamine B assay
    		[PMID: 17350834]
    4T1 IC50
    0.17 μM
    Compound: 1; CPT
    Antiproliferative activity against mouse 4T1 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against mouse 4T1 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    4T1 IC50
    > 300 μM
    Compound: CPT
    Antiproliferative activity against mouse 4T1 cells incubated for 24 hrs by CCK-8 assay
    Antiproliferative activity against mouse 4T1 cells incubated for 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    786-0 IC50
    0.015 μM
    Compound: CPT
    Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay
    		10.1039/C4MD00133H
    833K IC50
    10 nM
    Compound: CPT
    Tested in vitro for growth inhibitory activity against 833K (human teratorcarcinoma) cells
    Tested in vitro for growth inhibitory activity against 833K (human teratorcarcinoma) cells
    		10.1016/S0960-894X(97)10181-0
    A 172 IC50
    0.14 μM
    Compound: 13 ((S)-CPT, Camptothecin)
    In vitro cytotoxicity against A172 human tumor cell lines.
    In vitro cytotoxicity against A172 human tumor cell lines.
    		10.1016/0960-894X(96)00132-1
    A 172 IC50
    0.14 μM
    Compound: CPT ((S)-Camptothecin)
    Cytotoxicity against A-172 human tumor cell lines
    Cytotoxicity against A-172 human tumor cell lines
    		10.1016/0960-894X(96)00131-X
    A-375 IC50
    0.013 μM
    Compound: Camptothecin
    Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay
    Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay
    		[PMID: 27096049]
    A-375 IC50
    0.187 μM
    Compound: CPT, Camptothecin
    Cytotoxicity against human A375 cells after 24 hrs by MTT assay
    Cytotoxicity against human A375 cells after 24 hrs by MTT assay
    		[PMID: 24980118]
    A-375 IC50
    0.66 μM
    Compound: CPT
    Cytotoxicity against human A-375 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    Cytotoxicity against human A-375 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    		[PMID: 35612499]
    A-427 IC50
    24 nM
    Compound: CPT
    Antiproliferative activity measured against A427 human lung carcinoma
    Antiproliferative activity measured against A427 human lung carcinoma
    		[PMID: 9876111]
    A-431 IC50
    0.011 μM
    Compound: 1, CPT
    Cytotoxicity against human A431 cells after 72 hrs by trypan blue assay
    Cytotoxicity against human A431 cells after 72 hrs by trypan blue assay
    		[PMID: 21071230]
    A20 IC50
    179.2 μM
    Compound: CPT
    Cytostatic activity against mouse A20 cells after 24 hrs by CCK-8 assay
    Cytostatic activity against mouse A20 cells after 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    A2780 GI50
    0.46 μM
    Compound: CPT
    Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 19664930]
    A2780 IC50
    0.004 μM
    Compound: camptothecin
    Cytotoxicity against human A2780 cells after 72 hrs by MTS method
    Cytotoxicity against human A2780 cells after 72 hrs by MTS method
    		[PMID: 11858737]
    A2780 IC50
    0.007 μM
    Compound: 1 (Camptothecin)
    In vitro cytotoxicity against A2780 (human ovarian cancer)
    In vitro cytotoxicity against A2780 (human ovarian cancer)
    		[PMID: 14552770]
    A2780 IC50
    0.029 μM
    Compound: 1; CPT
    Antiproliferative activity against human A2780 cells after 96 hrs by MTT assay
    Antiproliferative activity against human A2780 cells after 96 hrs by MTT assay
    		[PMID: 27871039]
    A2780 IC50
    0.07 μg/mL
    Compound: camptothecin
    Cytotoxicity against human A2780 cells by clonogenic assay
    Cytotoxicity against human A2780 cells by clonogenic assay
    		[PMID: 16499333]
    A2780 IC50
    0.2 μM
    Compound: 1, CPT
    Cytotoxicity against human A2780 cells after 4 days by MTT assay
    Cytotoxicity against human A2780 cells after 4 days by MTT assay
    		[PMID: 18554906]
    A2780 IC50
    0.2 μM
    Compound: camptothecin
    Cytotoxicity against human A2780 cells after 24 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 24 hrs by MTT assay
    		[PMID: 20961093]
    A2780 IC50
    0.26 μM
    Compound: Camptothecin
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    		[PMID: 22044245]
    A2780 IC50
    0.28 μM
    Compound: Camptothecin
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    		[PMID: 19453174]
    A2780 IC50
    0.28 μM
    Compound: camptothecin
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    		[PMID: 18095653]
    A2780 IC50
    0.28 μM
    Compound: camptothecin
    Cytotoxicity against human A2780 cells
    Cytotoxicity against human A2780 cells
    		[PMID: 19916529]
    A2780 IC50
    0.3 μM
    Compound: CPT
    Cytotoxicity against human A2780 cells after 4 days by MTT assay
    Cytotoxicity against human A2780 cells after 4 days by MTT assay
    		[PMID: 19702283]
    A2780 IC50
    0.3 μM
    Compound: camptothecin
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 96 hrs by MTT assay
    		[PMID: 19256478]
    A2780 IC50
    0.9 μM
    Compound: camptothecin
    Cytotoxicity against human A2780 cells by MTT assay
    Cytotoxicity against human A2780 cells by MTT assay
    		[PMID: 25237727]
    A2780 IC50
    13 nM
    Compound: CPT
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    		[PMID: 24900725]
    A2780 IC50
    7 nM
    Compound: Cpt
    Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 22749423]
    A549 EC50
    4.17 nM
    Compound: 1; CPT
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 38421819]
    A549 ED50
    6.9 nM
    Compound: 3a, CPT, Camptothecin
    Cytotoxicity against human A549 cells by sulforhodamine B assay
    Cytotoxicity against human A549 cells by sulforhodamine B assay
    		[PMID: 17350834]
    A549 GI50
    0.003 μM
    Compound: CPT
    Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 29705710]
    A549 GI50
    0.007 μM
    Compound: Camptothecin
    Growth inhibition of human A549 cells after 48 hrs by MTT assay
    Growth inhibition of human A549 cells after 48 hrs by MTT assay
    		[PMID: 23357037]
    A549 GI50
    0.01 μM
    Compound: 1, CPT
    Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay
    		[PMID: 19715319]
    A549 GI50
    0.099 μM
    Compound: CPT
    Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay
    		[PMID: 31176097]
    A549 GI50
    0.17 μM
    Compound: 1, CPT
    Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    A549 GI50
    0.2 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 21388138]
    A549 GI50
    0.21 μM
    Compound: 1
    Growth inhibition of human A549 cells after 72 hrs by MTT assay
    Growth inhibition of human A549 cells after 72 hrs by MTT assay
    		[PMID: 30336023]
    A549 GI50
    0.31 μM
    Compound: CPT
    Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 34008967]
    A549 GI50
    2.8 μM
    Compound: 1, camptothecin
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 18180162]
    A549 GI50
    2.8 μM
    Compound: CPT
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 20662543]
    A549 GI50
    5.69 ng/mL
    Compound: 1; CPT
    Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay
    		[PMID: 38421819]
    A549 IC50
    0.004 μM
    Compound: camptothecin
    Cytotoxicity against human A549 cells after 48 hrs
    Cytotoxicity against human A549 cells after 48 hrs
    		[PMID: 17673337]
    A549 IC50
    0.006 μM
    Compound: 1; CPT
    Antiproliferative activity against human A549 cells after 96 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 96 hrs by MTT assay
    		[PMID: 27871039]
    A549 IC50
    0.008 μM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells after 2 days by MTT assay
    Cytotoxicity against human A549 cells after 2 days by MTT assay
    		[PMID: 22325897]
    A549 IC50
    0.008 μM
    Compound: 1 (Camptothecin)
    In vitro cytotoxicity against A549 (human lung cancer)
    In vitro cytotoxicity against A549 (human lung cancer)
    		[PMID: 14552770]
    A549 IC50
    0.009 μM
    Compound: Camptothecin
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay
    		[PMID: 27096049]
    A549 IC50
    0.01 μM
    Compound: 1, CPT
    Cytotoxicity against human A549 cells after 4 days by MTT assay
    Cytotoxicity against human A549 cells after 4 days by MTT assay
    		[PMID: 18554906]
    A549 IC50
    0.0158 μM
    Compound: 1, CPT
    Cytotoxicity against human A549 cells by SRB assay
    Cytotoxicity against human A549 cells by SRB assay
    		[PMID: 23102893]
    A549 IC50
    0.016 μM
    Compound: 1
    Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B colorimetric assay
    Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B colorimetric assay
    		[PMID: 26994847]
    A549 IC50
    0.016 μM
    Compound: 1, CPT
    Cytotoxicity against human A549 cells after 72 hrs by SRB assay
    Cytotoxicity against human A549 cells after 72 hrs by SRB assay
    		[PMID: 25003995]
    A549 IC50
    0.021 μM
    Compound: CPT
    Cytotoxicity against human A549 cells measured after 72 hrs
    Cytotoxicity against human A549 cells measured after 72 hrs
    		[PMID: 38716896]
    A549 IC50
    0.03 μM
    Compound: Camptothecin
    Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay
    Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay
    		[PMID: 21074444]
    A549 IC50
    0.03 μM
    Compound: Camptothecin
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    		[PMID: 31546197]
    A549 IC50
    0.039 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK8 assay
    		[PMID: 32292547]
    A549 IC50
    0.04 μM
    Compound: 1, CPT
    Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay
    		[PMID: 19715319]
    A549 IC50
    0.04 μM
    Compound: CPT
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 30543429]
    A549 IC50
    0.047 μM
    Compound: 1, CPT
    Antitumor activity against human A549/ATCC cells by SRB method
    Antitumor activity against human A549/ATCC cells by SRB method
    		[PMID: 19541483]
    A549 IC50
    0.057 μM
    Compound: CPT
    Cytotoxicity against human A549 cells after 3 days by MTT assay
    Cytotoxicity against human A549 cells after 3 days by MTT assay
    		[PMID: 20942490]
    A549 IC50
    0.058 μM
    Compound: CPT
    Cytotoxicity against human A549 cells by sulforhodamine B assay
    Cytotoxicity against human A549 cells by sulforhodamine B assay
    		[PMID: 19345580]
    A549 IC50
    0.067 μM
    Compound: CPT, campothecin
    Cytotoxicity against human A549 cells by SRB assay
    Cytotoxicity against human A549 cells by SRB assay
    		[PMID: 17827007]
    A549 IC50
    0.069 μM
    Compound: 1, CPT
    Cytotoxicity against human A549 cells
    Cytotoxicity against human A549 cells
    		[PMID: 21095131]
    A549 IC50
    0.069 μM
    Compound: CPT
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 21353568]
    A549 IC50
    0.069 μM
    Compound: camptothecin
    Cytotoxicity against human A549 cells by SRB assay
    Cytotoxicity against human A549 cells by SRB assay
    		[PMID: 17498951]
    A549 IC50
    0.072 μg/mL
    Compound: CPT
    Cytotoxicity against human A549 cells by sulforhodamine B assay
    Cytotoxicity against human A549 cells by sulforhodamine B assay
    		[PMID: 21684168]
    A549 IC50
    0.074 μM
    Compound: CPT
    In-vitro antitumor activity against human A549 cells incubated for 72 hrs by CCK8 assay
    In-vitro antitumor activity against human A549 cells incubated for 72 hrs by CCK8 assay
    		[PMID: 35550978]
    A549 IC50
    0.09 μM
    Compound: CPT; 1
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 30509782]
    A549 IC50
    0.091 μM
    Compound: CPT
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 21873069]
    A549 IC50
    0.1 μM
    Compound: 1; CPT
    Antiproliferative activity against human A549 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    A549 IC50
    0.1 μM
    Compound: CPT
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 26226379]
    A549 IC50
    0.12 μM
    Compound: Camptothecin
    Growth inhibition of human A549 cells after 72 hrs by MTT assay
    Growth inhibition of human A549 cells after 72 hrs by MTT assay
    		[PMID: 27344492]
    A549 IC50
    0.17 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
    		[PMID: 34052678]
    A549 IC50
    0.24 μM
    Compound: CPT
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 28063351]
    A549 IC50
    0.26 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 28351590]
    A549 IC50
    0.26 μM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells after 96 hrs by MTT assay
    Cytotoxicity against human A549 cells after 96 hrs by MTT assay
    		[PMID: 22044245]
    A549 IC50
    0.32 nM
    Compound: 1; CPT
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 38421819]
    A549 IC50
    0.32 nM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells after 48 hrs by CCK8 assay
    Cytotoxicity against human A549 cells after 48 hrs by CCK8 assay
    		[PMID: 30702286]
    A549 IC50
    0.32 ng/mL
    Compound: 1; CPT
    Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 38421819]
    A549 IC50
    0.35 μM
    Compound: CPT
    Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by MTT assay
    		[PMID: 27156772]
    A549 IC50
    0.37 μM
    Compound: CPT
    Cytotoxicity against human A549 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    		[PMID: 35612499]
    A549 IC50
    0.39 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay
    		[PMID: 38169246]
    A549 IC50
    0.39 μM
    Compound: Camptothecin
    Antiproliferative activity against human A549 cells
    Antiproliferative activity against human A549 cells
    		[PMID: 38665827]
    A549 IC50
    0.46 μM
    Compound: 1; CPT
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 27416553]
    A549 IC50
    0.47 μM
    Compound: CPT
    Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    		[PMID: 35635947]
    A549 IC50
    0.65 μM
    Compound: 1, CPT
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 24069881]
    A549 IC50
    0.7 μM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 28506750]
    A549 IC50
    1 nM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis
    Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis
    		[PMID: 34952177]
    A549 IC50
    1 x 10-3 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay
    Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay
    		[PMID: 29501943]
    A549 IC50
    1 x 10-3 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
    		[PMID: 33962152]
    A549 IC50
    1 x 10-3 μM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by CCK8 assay
    Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by CCK8 assay
    		[PMID: 27017547]
    A549 IC50
    1 x 10-3 μM
    Compound: I; CPT
    Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay
    		[PMID: 31229877]
    A549 IC50
    1 x 10-3 μM
    Compound: camptothecin
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 25237727]
    A549 IC50
    1 μM
    Compound: I; CPT
    Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 32279049]
    A549 IC50
    1.3 μM
    Compound: 3
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    		[PMID: 25084144]
    A549 IC50
    1.31 μM
    Compound: CPT
    Cytotoxicity against against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 30340899]
    A549 IC50
    1.56 μM
    Compound: CPT
    Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    A549 IC50
    1.6 μM
    Compound: CPT
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 26188908]
    A549 IC50
    106.3 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells incubated for 24 hrs by CCK-8 assay
    Antiproliferative activity against human A549 cells incubated for 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    A549 IC50
    13.64 μM
    Compound: Camptothecin
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 28462840]
    A549 IC50
    14 nM
    Compound: CPT
    In Vitro cytotoxicity against human lung cancer cell line (A549)
    In Vitro cytotoxicity against human lung cancer cell line (A549)
    		[PMID: 11334569]
    A549 IC50
    2.21 μM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 30109008]
    A549 IC50
    2.53 μM
    Compound: Camptothecin
    In vitro antiproliferative activity of compound against AS-49 (human lung caner ) cell line was determined by SRB assay
    In vitro antiproliferative activity of compound against AS-49 (human lung caner ) cell line was determined by SRB assay
    		[PMID: 12639541]
    A549 IC50
    2.61 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells after 3 days by MTT assay
    Antiproliferative activity against human A549 cells after 3 days by MTT assay
    		[PMID: 23084702]
    A549 IC50
    2.8 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    A549 IC50
    26.45 μM
    Compound: CPT
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 25599951]
    A549 IC50
    3.1 μM
    Compound: camptothecin
    Cytotoxicity against human A549 cells after 96 hrs by MTT assay
    Cytotoxicity against human A549 cells after 96 hrs by MTT assay
    		[PMID: 19256478]
    A549 IC50
    3.12 μM
    Compound: camptothecin
    Cytotoxicity against human A549 cells after 96 hrs by MTT assay
    Cytotoxicity against human A549 cells after 96 hrs by MTT assay
    		[PMID: 18095653]
    A549 IC50
    3.32 μM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 30902399]
    A549 IC50
    3.6 μM
    Compound: camptothecin
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells after 24 hrs by MTT assay
    		[PMID: 20961093]
    A549 IC50
    32.1 μM
    Compound: Camptophecin
    Cytotoxicity against human A549 cells
    Cytotoxicity against human A549 cells
    		[PMID: 33421712]
    A549 IC50
    32.11 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation measured after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation measured after 48 hrs by MTT assay
    		[PMID: 30853330]
    A549 IC50
    33.8 nM
    Compound: 1, CPT
    Cytotoxicity against human A549 after 72 hrs by SRB assay
    Cytotoxicity against human A549 after 72 hrs by SRB assay
    		[PMID: 22647222]
    A549 IC50
    330 μM
    Compound: C (20)(S)-1
    In vitro cytotoxicity against human tumor cell line A549
    In vitro cytotoxicity against human tumor cell line A549
    		[PMID: 10576688]
    A549 IC50
    37.05 μM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells after 72 hrs ny MTT assay
    Cytotoxicity against human A549 cells after 72 hrs ny MTT assay
    		[PMID: 23974020]
    A549 IC50
    4 μM
    Compound: Camptothecin
    Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
    Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
    		[PMID: 11430001]
    A549 IC50
    4.43 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 30685528]
    A549 IC50
    5.379 nM
    Compound: CPT
    Cytotoxicity against human A549 cells after 48 hrs by MTT method
    Cytotoxicity against human A549 cells after 48 hrs by MTT method
    		[PMID: 20063889]
    A549 IC50
    5.5 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    A549 IC50
    5.5 μM
    Compound: Camptothecin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30025344]
    A549 IC50
    5.93 μM
    Compound: CPT
    Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay
    		[PMID: 27721148]
    A549 IC50
    5.93 μM
    Compound: CPT
    Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 28923388]
    A549 IC50
    50.88 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay
    		[PMID: 30853330]
    A549 IC50
    67 nM
    Compound: 1, CPT, NSC-100880
    Cytotoxicity against human A549 cells by WST assay
    Cytotoxicity against human A549 cells by WST assay
    		[PMID: 23578545]
    A549 IC50
    67 nM
    Compound: CPT
    Cytotoxicity against A549 tumor cell line determined by WST-1 assay
    Cytotoxicity against A549 tumor cell line determined by WST-1 assay
    		[PMID: 10841808]
    A549 IC50
    7.8 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 38154256]
    A549 IC50
    8.63 nM
    Compound: 1
    Cytotoxicity against human A549 cells after 72 hrs by SRB assay
    Cytotoxicity against human A549 cells after 72 hrs by SRB assay
    		[PMID: 28927790]
    A549 IC50
    8.63 nM
    Compound: 1; CPT
    Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28285912]
    A549 IC50
    8.87 μM
    Compound: Camptothecin
    Cytotoxicity in human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity in human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 28923382]
    A549 IC50
    8.9 μM
    Compound: CPT
    Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 34852457]
    A549 IC50
    99 nM
    Compound: CPT
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 24900725]
    A549 IC50
    < 0.01 μM
    Compound: Camptothecin
    Growth inhibition of human A549 cells after 72 hrs by MTT assay
    Growth inhibition of human A549 cells after 72 hrs by MTT assay
    		[PMID: 24180210]
    A549 IC50
    < 1 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 28511910]
    A549 IC50
    < 1.85 μM
    Compound: CPT
    Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    AGS GI50
    0.01 μM
    Compound: 1, CPT
    Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay
    Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay
    		[PMID: 19715319]
    AGS GI50
    23.76 μM
    Compound: 1, camptothecin
    Antiproliferative activity against human AGS cells after 48 hrs by MTT assay
    Antiproliferative activity against human AGS cells after 48 hrs by MTT assay
    		[PMID: 18180162]
    AGS IC50
    0.02 μM
    Compound: 1, CPT
    Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay
    Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay
    		[PMID: 19715319]
    AGS IC50
    23.76 μM
    Compound: CPT
    Antiproliferative activity against human AGS cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human AGS cells incubated for 72 hrs by MTT assay
    		10.1039/C4MD00133H
    B16-F10 IC50
    2.78 μM
    Compound: Camptothecin
    Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay
    Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay
    		[PMID: 24685545]
    BGC-823 IC50
    0.04 μM
    Compound: camptothecin
    Cytotoxicity against human BGC823 cells by MTT assay
    Cytotoxicity against human BGC823 cells by MTT assay
    		[PMID: 25237727]
    BGC-823 IC50
    0.057 μM
    Compound: 1; CPT
    Antiproliferative activity against human BGC823 cells after 96 hrs by MTT assay
    Antiproliferative activity against human BGC823 cells after 96 hrs by MTT assay
    		[PMID: 27871039]
    BGC-823 IC50
    0.21 μM
    Compound: camptothecin
    Cytotoxicity against human BGC823 cells
    Cytotoxicity against human BGC823 cells
    		[PMID: 19916529]
    BGC-823 IC50
    1.27 μM
    Compound: 1; CPT
    Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay
    Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay
    		[PMID: 27416553]
    BGC-823 IC50
    9.67 μM
    Compound: camptothecin
    Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay
    Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay
    		[PMID: 18095653]
    BGC-823 IC50
    9.7 μM
    Compound: camptothecin
    Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay
    Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay
    		[PMID: 19256478]
    BJ IC50
    > 40 μM
    Compound: Camp
    Cytotoxicity against human BJ cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    Cytotoxicity against human BJ cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    		[PMID: 29223099]
    BT-20 IC50
    0.07 μM
    Compound: CPT
    Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay
    Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay
    		[PMID: 22867707]
    BT-20 IC50
    0.07 μM
    Compound: Camptothecin
    Cytotoxicity against human BT20 cells assessed as growth inhibition after 48 hrs by CCK8 assay
    Cytotoxicity against human BT20 cells assessed as growth inhibition after 48 hrs by CCK8 assay
    		[PMID: 27017547]
    BT-20 IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human BT20 cells after 3 days by SRB assay
    Cytotoxicity against human BT20 cells after 3 days by SRB assay
    		[PMID: 23142674]
    BT-474 IC50
    12.75 μM
    Compound: CPT
    Cytotoxicity against human BT474 cells after 3 days by SRB assay
    Cytotoxicity against human BT474 cells after 3 days by SRB assay
    		[PMID: 23142674]
    BT-474 IC50
    7 μM
    Compound: Camptothecin
    Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay
    		[PMID: 26988802]
    BT-483 GI50
    1.03 μM
    Compound: CPT
    Cytotoxicity against human BT-483 cells after 48 hrs by MTT assay
    Cytotoxicity against human BT-483 cells after 48 hrs by MTT assay
    		[PMID: 20662543]
    BXPC-3 IC50
    0.24 μM
    Compound: 1, CPT
    Cytotoxicity against human BXPC3 cells after 4 days by MTT assay
    Cytotoxicity against human BXPC3 cells after 4 days by MTT assay
    		[PMID: 18554906]
    BXPC-3 IC50
    62.5 nM
    Compound: CPT
    Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth
    Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth
    		[PMID: 37806498]
    Bel-7402 IC50
    0.007 μM
    Compound: 1 (Camptothecin)
    In vitro cytotoxicity against Bel7402 (human liver cancer)
    In vitro cytotoxicity against Bel7402 (human liver cancer)
    		[PMID: 14552770]
    Bel-7402 IC50
    0.014 μM
    Compound: 1; CPT
    Antiproliferative activity against human Bel7402 cells after 96 hrs by MTT assay
    Antiproliferative activity against human Bel7402 cells after 96 hrs by MTT assay
    		[PMID: 27871039]
    Bel-7402 IC50
    0.17 μM
    Compound: 1, CPT
    Cytotoxicity against human BEL-7402 cells after 4 days by MTT assay
    Cytotoxicity against human BEL-7402 cells after 4 days by MTT assay
    		[PMID: 18554906]
    Bel-7402 IC50
    0.26 μM
    Compound: Camptothecin
    Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay
    Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay
    		[PMID: 22044245]
    Bel-7402 IC50
    12.5 μM
    Compound: camptothecin
    Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay
    Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay
    		[PMID: 18095653]
    Bel-7402 IC50
    12.5 μM
    Compound: camptothecin
    Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay
    Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay
    		[PMID: 19256478]
    Bel-7402 IC50
    2.72 μg/mL
    Compound: 1 Camptothecin
    In vitro cytotoxicity against Bel7402 cell line (human liver cancer) using MTT assay
    In vitro cytotoxicity against Bel7402 cell line (human liver cancer) using MTT assay
    		[PMID: 15225719]
    Bel-7402 IC50
    6.3 μM
    Compound: camptothecin
    Cytotoxicity against human Bel7402 cells by MTT assay
    Cytotoxicity against human Bel7402 cells by MTT assay
    		[PMID: 25237727]
    C6 IC50
    < 1.85 μM
    Compound: CPT
    Antiproliferative activity against human C6 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human C6 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    CA46 IC50
    0.52 μM
    Compound: CPT
    Cytotoxicity against human CA46 cells after 48 hrs by MTT assay
    Cytotoxicity against human CA46 cells after 48 hrs by MTT assay
    		[PMID: 26188908]
    CAKI-2 IC50
    3.96 μM
    Compound: Camptothecin
    In vitro antiproliferative activity of compound against Caki-2 (human renal caner ) cell line was determined by SRB assay
    In vitro antiproliferative activity of compound against Caki-2 (human renal caner ) cell line was determined by SRB assay
    		[PMID: 12639541]
    CAMA-1 IC50
    0.07 μM
    Compound: CPT
    Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay
    Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay
    		[PMID: 22867707]
    CAMA-1 IC50
    0.07 μM
    Compound: CPT
    Cytotoxicity against human CAMA1 cells after 3 days by SRB assay
    Cytotoxicity against human CAMA1 cells after 3 days by SRB assay
    		[PMID: 23142674]
    CAMA-1 IC50
    0.07 μM
    Compound: Camptothecin
    Antiproliferative activity against human CAMA-1 cells assessed as cell growth inhibition
    Antiproliferative activity against human CAMA-1 cells assessed as cell growth inhibition
    		[PMID: 38107170]
    CAPAN-1 IC50
    0.21 μM
    Compound: CPT
    Cytotoxicity against human Capan1 cells after 72 hrs by XTT assay
    Cytotoxicity against human Capan1 cells after 72 hrs by XTT assay
    		[PMID: 30017114]
    CCD 19Lu IC50
    2 μg/mL
    Compound: Camptothecin (CPT)
    Tested for the cytostatic activity as inhibitory concentration against CCD-19Lu (human normal pulmonary) cells
    Tested for the cytostatic activity as inhibitory concentration against CCD-19Lu (human normal pulmonary) cells
    		10.1016/S0960-894X(97)00071-1
    CCRF-CEM CC50
    0.003 μM
    Compound: Camptothecin
    Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay
    Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    CCRF-CEM CC50
    0.003 μM
    Compound: Camptothecin
    Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay
    Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    CCRF-CEM GI50
    0.002 μM
    Compound: CPT
    Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 29705710]
    CCRF-CEM GI50
    0.002 μM
    Compound: camptothecin
    Growth inhibition of human CEM cells by Alamar blue assay
    Growth inhibition of human CEM cells by Alamar blue assay
    		[PMID: 17418582]
    CCRF-CEM GI50
    0.007 μM
    Compound: 1
    Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay
    Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay
    		[PMID: 30336023]
    CCRF-CEM GI50
    0.023 nM
    Compound: camptothecin
    Cytotoxicity against human CCRF-CEM cells after 48 hrs by cell titer-blue assay
    Cytotoxicity against human CCRF-CEM cells after 48 hrs by cell titer-blue assay
    		[PMID: 19743858]
    CCRF-CEM GI50
    2 nM
    Compound: Camptothecin
    Growth inhibition of human CEM cells
    Growth inhibition of human CEM cells
    		[PMID: 23750455]
    CCRF-CEM GI50
    43.21 nM
    Compound: camptothecin
    Cytotoxicity against human CCRF-CEM/C2 cells after 48 hrs by cell titer-blue assay
    Cytotoxicity against human CCRF-CEM/C2 cells after 48 hrs by cell titer-blue assay
    		[PMID: 19743858]
    CCRF-CEM IC50
    0.002 μM
    Compound: CPT
    Cytotoxicity against human CCRF-CEM cells by MTT assay
    Cytotoxicity against human CCRF-CEM cells by MTT assay
    		[PMID: 30543429]
    CCRF-CEM IC50
    0.003 μM
    Compound: CPT
    Antiproliferative activity against human CCRF-CEM cells by MTT assay
    Antiproliferative activity against human CCRF-CEM cells by MTT assay
    		[PMID: 17254669]
    CCRF-CEM IC50
    0.003 μM
    Compound: Camptothecin
    Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay
    Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay
    		[PMID: 28233677]
    CCRF-CEM IC50
    0.005 μM
    Compound: CPT
    Cytotoxicity against human CEM cells
    Cytotoxicity against human CEM cells
    		[PMID: 22305342]
    CCRF-CEM IC50
    0.005 μg/mL
    Compound: Camptothecin (CPT)
    Tested for the cytostatic activity as inhibitory concentration against CCRF-CEM human leukemia cells
    Tested for the cytostatic activity as inhibitory concentration against CCRF-CEM human leukemia cells
    		10.1016/S0960-894X(97)00071-1
    CCRF-CEM IC50
    0.04 μM
    Compound: CPT
    Cytotoxicity against p38-proficient human CCRF-CEM cells after 3 days by MTT assay
    Cytotoxicity against p38-proficient human CCRF-CEM cells after 3 days by MTT assay
    		[PMID: 19203291]
    CCRF-CEM IC50
    0.08 μM
    Compound: CPT
    Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 24484281]
    CCRF-CEM IC50
    0.84 nM
    Compound: CPT
    Inhibitory concentration against CEM cell growth after incubation in liquid medium for 72 h
    Inhibitory concentration against CEM cell growth after incubation in liquid medium for 72 h
    		[PMID: 15916431]
    CCRF-CEM IC50
    5.3 μM
    Compound: Camptothecin
    Cytotoxicity in human leukemic CCRF-CEM cells.
    Cytotoxicity in human leukemic CCRF-CEM cells.
    		[PMID: 14667232]
    CCRF-SB CC50
    0.004 μM
    Compound: Camptothecin
    Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay
    Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    CCRF-SB CC50
    0.004 μM
    Compound: Camptothecin
    Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay
    Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    CCRF-SB IC50
    0.003 μM
    Compound: CPT
    Antiproliferative activity against human CCRF-SB cells by MTT assay
    Antiproliferative activity against human CCRF-SB cells by MTT assay
    		[PMID: 17254669]
    CEM/C2 GI50
    1000 nM
    Compound: Camptothecin
    Growth inhibition of multidrug-resistant human CEM/C2 cells
    Growth inhibition of multidrug-resistant human CEM/C2 cells
    		[PMID: 23750455]
    CEM/C2 GI50
    > 1 μM
    Compound: camptothecin
    Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay
    Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay
    		[PMID: 17418582]
    CEM/C2 IC50
    5385 nM
    Compound: CPT
    Inhibitory concentration against CEM/C2 cell growth after incubation in liquid medium for 72 h
    Inhibitory concentration against CEM/C2 cell growth after incubation in liquid medium for 72 h
    		[PMID: 15916431]
    CNE IC50
    0.34 μM
    Compound: CPT
    Antiproliferative activity against human CNE1 cells after 72 hrs by MTT assay
    Antiproliferative activity against human CNE1 cells after 72 hrs by MTT assay
    		[PMID: 30125725]
    CNE-2 IC50
    0.1 μM
    Compound: Camptothecin
    Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30025344]
    CNE-2 IC50
    0.98 μM
    Compound: CPT
    Antiproliferative activity against human CNE2 cells after 72 hrs by MTT assay
    Antiproliferative activity against human CNE2 cells after 72 hrs by MTT assay
    		[PMID: 30125725]
    COLO 201 IC50
    27 μM
    Compound: Camptothecin
    Cytotoxicity against human COLO201 cells assessed as inhibition of cell growth incubated for 24 hrs by WST-1 assay
    Cytotoxicity against human COLO201 cells assessed as inhibition of cell growth incubated for 24 hrs by WST-1 assay
    		[PMID: 39018435]
    COLO 205 IC50
    0.05 μM
    Compound: Camptothecin
    Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay
    Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay
    		[PMID: 24041234]
    COLO 205 IC50
    5.4 nM
    Compound: 1
    Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human colorectal cells (COLO 205)
    Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human colorectal cells (COLO 205)
    		[PMID: 10479293]
    CT26 IC50
    34 nM
    Compound: camptothecin
    Antiproliferative activity against mouse CT26 cell line
    Antiproliferative activity against mouse CT26 cell line
    		[PMID: 16686539]
    CT26.WT IC50
    0.43 μM
    Compound: CPT
    Antiproliferative activity against mouse CT26.WT cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    Antiproliferative activity against mouse CT26.WT cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    		[PMID: 35868003]
    Ca-Ski IC50
    1.8 μM
    Compound: Camptothecin
    Antiproliferative activity against human CaSki cells after 24 hrs by crystal violet staining-based assay
    Antiproliferative activity against human CaSki cells after 24 hrs by crystal violet staining-based assay
    		[PMID: 29407986]
    Ca-Ski IC50
    > 300 μM
    Compound: CPT
    Antiproliferative activity against human Ca-Ski cells incubated for 24 hrs by CCK-8 assay
    Antiproliferative activity against human Ca-Ski cells incubated for 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    Caco-2 IC50
    0.131 μM
    Compound: CPT, Camptothecin
    Cytotoxicity against human Caco2 cells after 24 hrs by MTT assay
    Cytotoxicity against human Caco2 cells after 24 hrs by MTT assay
    		[PMID: 24980118]
    Caco-2 IC50
    9.55 μM
    Compound: Camptothecin
    Cytotoxicity against human Caco2 cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human Caco2 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 21843907]
    Col2 ED50
    57 nM
    Compound: camptothecin
    Cytotoxicity against human Col2 cells
    Cytotoxicity against human Col2 cells
    		[PMID: 15043407]
    Col2 IC50
    0.045 μM
    Compound: 1, CPT
    Cytotoxicity against human Col2 cells
    Cytotoxicity against human Col2 cells
    		[PMID: 21095131]
    Col2 IC50
    0.045 μM
    Compound: CPT
    Cytotoxicity against human Col2 cells by MTT assay
    Cytotoxicity against human Col2 cells by MTT assay
    		[PMID: 21353568]
    Col2 IC50
    0.045 μM
    Compound: camptothecin
    Cytotoxicity against human Col2 cells by SRB assay
    Cytotoxicity against human Col2 cells by SRB assay
    		[PMID: 17498951]
    DC3F IC50
    6 nM
    Compound: CPT
    Tested in vitro for growth inhibitory activity against DC-3F (hamster lung) cells
    Tested in vitro for growth inhibitory activity against DC-3F (hamster lung) cells
    		10.1016/S0960-894X(97)10181-0
    DLD-1 IC50
    0.21 μM
    Compound: 13 ((S)-CPT, Camptothecin)
    In vitro cytotoxicity against DLD-1 human tumor cell lines.
    In vitro cytotoxicity against DLD-1 human tumor cell lines.
    		10.1016/0960-894X(96)00132-1
    DLD-1 IC50
    0.21 μM
    Compound: CPT ((S)-Camptothecin)
    Cytotoxicity against DLD-1 human tumor cell lines
    Cytotoxicity against DLD-1 human tumor cell lines
    		10.1016/0960-894X(96)00131-X
    DLD-1 IC50
    14000 μM
    Compound: C (20)(S)-1
    In vitro cytotoxicity against human tumor cell line DLD-1
    In vitro cytotoxicity against human tumor cell line DLD-1
    		[PMID: 10576688]
    DU-145 CC50
    0.015 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 96 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    DU-145 CC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 96 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    DU-145 ED50
    10.9 nM
    Compound: 3a, CPT, Camptothecin
    Cytotoxicity against human DU145 cells by sulforhodamine B assay
    Cytotoxicity against human DU145 cells by sulforhodamine B assay
    		[PMID: 17350834]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human DU145 cell line
    Antiproliferative activity against human DU145 cell line
    		[PMID: 16442283]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human DU145 cells
    Cytotoxicity against human DU145 cells
    		[PMID: 17402722]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human DU145 cells
    Antiproliferative activity against human DU145 cells
    		[PMID: 18630891]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human DU145 cells
    Cytotoxicity against human DU145 cells
    		[PMID: 19783447]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human DU145 cells
    Cytotoxicity against human DU145 cells
    		[PMID: 20630766]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human DU145 cells by SRB assay
    Antiproliferative activity against human DU145 cells by SRB assay
    		[PMID: 21710981]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
    Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
    		[PMID: 21823606]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human DU145 cells by SRB assay
    Cytotoxicity against human DU145 cells by SRB assay
    		[PMID: 24502276]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Growth inhibition of human DU145 cells after 48 hrs by SRB assay
    Growth inhibition of human DU145 cells after 48 hrs by SRB assay
    		[PMID: 24800942]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human DU145 cells after 48 hrs
    Antiproliferative activity against human DU145 cells after 48 hrs
    		[PMID: 27070999]
    DU-145 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human DU145 cells assessed as growth inhibition
    Antiproliferative activity against human DU145 cells assessed as growth inhibition
    		[PMID: 28657311]
    DU-145 GI50
    0.01 μM
    Compound: 1, CPT
    Antiproliferative activity against human DU145 cells
    Antiproliferative activity against human DU145 cells
    		[PMID: 20155916]
    DU-145 GI50
    0.01 μM
    Compound: 1, Camptothecin
    Cytotoxicity against human DU145 cells
    Cytotoxicity against human DU145 cells
    		[PMID: 17676830]
    DU-145 GI50
    0.01 μM
    Compound: 2
    Growth inhibitory activity against human prostate DU-145 cell line
    Growth inhibitory activity against human prostate DU-145 cell line
    		[PMID: 15509164]
    DU-145 GI50
    0.01 μM
    Compound: 2
    Antiproliferative activity against human DU145 cell line
    Antiproliferative activity against human DU145 cell line
    		[PMID: 16913702]
    DU-145 GI50
    0.01 μM
    Compound: 2
    Cytotoxicity against human DU145 cells
    Cytotoxicity against human DU145 cells
    		[PMID: 17696418]
    DU-145 GI50
    0.01 μM
    Compound: 2
    Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 22329436]
    DU-145 GI50
    0.01 μM
    Compound: 2 (Camptothecin)
    Antiproliferative activity was determined for 50% growth inhibition against human Prostate DU-145 cell line
    Antiproliferative activity was determined for 50% growth inhibition against human Prostate DU-145 cell line
    		[PMID: 11020283]
    DU-145 GI50
    0.01 μM
    Compound: Camptothecin
    Concentration required to inhibit the growth of human ProstateDU-145 cells
    Concentration required to inhibit the growth of human ProstateDU-145 cells
    		[PMID: 16033260]
    DU-145 GI50
    0.019 μM
    Compound: CPT
    Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 29705710]
    DU-145 GI50
    0.021 μM
    Compound: 1
    Growth inhibition of human DU145 cells after 72 hrs by MTT assay
    Growth inhibition of human DU145 cells after 72 hrs by MTT assay
    		[PMID: 30336023]
    DU-145 GI50
    0.21 μM
    Compound: CPT
    Growth inhibition of human DU145 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human DU145 cells incubated for 72 hrs by MTT assay
    		[PMID: 31176097]
    DU-145 GI50
    0.21 μM
    Compound: CPT
    Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 34008967]
    DU-145 GI50
    18.2 nM
    Compound: 1
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    		[PMID: 24502276]
    DU-145 IC50
    0.01 μM
    Compound: CPT
    Antiproliferative activity against human DU145 cells by MTT assay
    Antiproliferative activity against human DU145 cells by MTT assay
    		[PMID: 17254669]
    DU-145 IC50
    0.015 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 96 hrs
    Cytotoxicity against human DU145 cells after 96 hrs
    		[PMID: 22276775]
    DU-145 IC50
    0.016 μM
    Compound: CPT
    Cytotoxicity against human DU145 cells by MTT assay
    Cytotoxicity against human DU145 cells by MTT assay
    		[PMID: 30543429]
    DU-145 IC50
    0.02 μM
    Compound: Camptothecin
    Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay
    Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay
    		[PMID: 21074444]
    DU-145 IC50
    0.02 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay
    Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay
    		[PMID: 26945111]
    DU-145 IC50
    0.02 μM
    Compound: camptothecin
    Cytotoxicity against human DU145 cells measured on day 4 by CCK8 assay
    Cytotoxicity against human DU145 cells measured on day 4 by CCK8 assay
    		[PMID: 25936262]
    DU-145 IC50
    0.0287 μM
    Compound: 1, CPT
    Cytotoxicity against human DU145 cells by SRB assay
    Cytotoxicity against human DU145 cells by SRB assay
    		[PMID: 23102893]
    DU-145 IC50
    0.029 μM
    Compound: 1, CPT
    Cytotoxicity against human DU145 cells after 72 hrs by SRB assay
    Cytotoxicity against human DU145 cells after 72 hrs by SRB assay
    		[PMID: 25003995]
    DU-145 IC50
    0.042 μM
    Compound: CPT
    Cytotoxicity against human DU-145 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human DU-145 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    DU-145 IC50
    0.05 μM
    Compound: Camptothecin
    Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay
    Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay
    		[PMID: 31398033]
    DU-145 IC50
    0.07 μM
    Compound: 45
    Anti-proliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
    Anti-proliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
    		[PMID: 33143937]
    DU-145 IC50
    0.1 μM
    Compound: CPT
    Antiproliferative activity against human DU145 cells assessed as cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human DU145 cells assessed as cell viability incubated for 72 hrs by MTT assay
    		[PMID: 25799376]
    DU-145 IC50
    0.11 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay
    Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay
    		[PMID: 25481396]
    DU-145 IC50
    0.11 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 2 days by CCK8 assay
    Cytotoxicity against human DU145 cells after 2 days by CCK8 assay
    		[PMID: 26361737]
    DU-145 IC50
    0.11 μM
    Compound: Camptothecin
    Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
    		[PMID: 27643560]
    DU-145 IC50
    0.21 μM
    Compound: CPT
    Antiproliferative activity against human DU-145 cells after 72 hrs by EZ-Cytox colorimetric assay
    Antiproliferative activity against human DU-145 cells after 72 hrs by EZ-Cytox colorimetric assay
    		[PMID: 34678573]
    DU-145 IC50
    0.31 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 2 days
    Cytotoxicity against human DU145 cells after 2 days
    		[PMID: 21419530]
    DU-145 IC50
    0.38 μM
    Compound: Camptothecin
    Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay
    		[PMID: 27654394]
    DU-145 IC50
    0.39 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay
    Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay
    		[PMID: 24013413]
    DU-145 IC50
    0.4 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system
    Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system
    		[PMID: 20392646]
    DU-145 IC50
    0.4 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 2 days
    Cytotoxicity against human DU145 cells after 2 days
    		[PMID: 21601964]
    DU-145 IC50
    0.4 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay
    Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay
    		[PMID: 26022080]
    DU-145 IC50
    0.61 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells by MTT assay
    Cytotoxicity against human DU145 cells by MTT assay
    		[PMID: 21115246]
    DU-145 IC50
    0.61 μM
    Compound: Camptothecin
    Antiproliferative activity against human DU-145 cells incubated for 72 hrs by microplate reader analysis
    Antiproliferative activity against human DU-145 cells incubated for 72 hrs by microplate reader analysis
    		[PMID: 37418826]
    DU-145 IC50
    0.66 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay
    Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay
    		[PMID: 19939682]
    DU-145 IC50
    0.8 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay
    		[PMID: 24303808]
    DU-145 IC50
    0.94 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells in presence of 10% fetal bovine serum
    Cytotoxicity against human DU145 cells in presence of 10% fetal bovine serum
    		[PMID: 20188578]
    DU-145 IC50
    0.95 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay
    Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay
    		[PMID: 25062006]
    DU-145 IC50
    1 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells by MTT assay
    Cytotoxicity against human DU145 cells by MTT assay
    		[PMID: 19836231]
    DU-145 IC50
    1.06 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 2 days by cell counting kit-8 analysis
    Cytotoxicity against human DU145 cells after 2 days by cell counting kit-8 analysis
    		[PMID: 22503656]
    DU-145 IC50
    1.46 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 3 days
    Cytotoxicity against human DU145 cells after 3 days
    		[PMID: 19954977]
    DU-145 IC50
    1.99 μM
    Compound: Camptothecin
    Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    		[PMID: 32526552]
    DU-145 IC50
    2.37 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 2 days
    Cytotoxicity against human DU145 cells after 2 days
    		[PMID: 22318164]
    DU-145 IC50
    3.2 μM
    Compound: Camptothecin
    Cytotoxicity against human DU145 cells after 4 days by MTT assay
    Cytotoxicity against human DU145 cells after 4 days by MTT assay
    		[PMID: 20619511]
    DU-145 IC50
    3.2 μM
    Compound: camptothecin
    Cytotoxicity against human DU145 cells
    Cytotoxicity against human DU145 cells
    		[PMID: 18178085]
    DU-145 IC50
    3.57 μM
    Compound: camptothecin
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    		[PMID: 20093033]
    DU-145 IC50
    33.45 nM
    Compound: CPT
    Cytotoxicity against human DU-145 cells assessed as inhibition of cell growth
    Cytotoxicity against human DU-145 cells assessed as inhibition of cell growth
    		[PMID: 37806498]
    DU-145 IC50
    4.01 μM
    Compound: CPT
    Cytotoxicity against human DU145 cells after 2 days
    Cytotoxicity against human DU145 cells after 2 days
    		[PMID: 24904965]
    DU-145 IC50
    9.29 μM
    Compound: CPT
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
    		[PMID: 22819942]
    Daudi IC50
    118.9 μM
    Compound: CPT
    Antiproliferative activity against human Daudi cells incubated for 24 hrs by CCK-8 assay
    Antiproliferative activity against human Daudi cells incubated for 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    Detroit 551 GI50
    0.99 μM
    Compound: CPT
    Cytotoxicity against human Detroit 551 cells after 72 hrs by XTT assay
    Cytotoxicity against human Detroit 551 cells after 72 hrs by XTT assay
    		[PMID: 20591678]
    Detroit 551 GI50
    0.99 μM
    Compound: CPT
    Cytotoxicity against human Detroit 551 cells after 48 hrs by MTT assay
    Cytotoxicity against human Detroit 551 cells after 48 hrs by MTT assay
    		[PMID: 20662543]
    Detroit 551 IC50
    0.99 μM
    Compound: CPT
    Antiproliferative activity against human Detroit 551 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human Detroit 551 cells incubated for 72 hrs by MTT assay
    		10.1039/C4MD00133H
    Erythrocyte EC50
    429.9 μg/mL
    Compound: Camptothecin
    Hemolytic activity in Homo sapiens (human) Erythrocyte after 30 min
    Hemolytic activity in Homo sapiens (human) Erythrocyte after 30 min
    		10.1007/s00044-010-9381-7
    Fibroblast IC50
    459.3 nM
    Compound: camptothecin
    Cytotoxicity against human Fibroblasts by SRB assay
    Cytotoxicity against human Fibroblasts by SRB assay
    		[PMID: 21410162]
    H22 IC50
    0.54 μM
    Compound: 1; CPT
    Antiproliferative activity against mouse H22 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against mouse H22 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    H69AR IC50
    > 300 nM
    Compound: 1a
    Cytotoxicity against human H69AR cells overexpressing MDR1 after 72 hrs by alamar blue assay
    Cytotoxicity against human H69AR cells overexpressing MDR1 after 72 hrs by alamar blue assay
    		[PMID: 21341674]
    HBL-100 GI50
    0.2 μM
    Compound: Camptothecin
    Antiproliferative activity against human HBL-100 cells assessed as inhibition of culture growth incubated for 48 hrs by SRB assay
    Antiproliferative activity against human HBL-100 cells assessed as inhibition of culture growth incubated for 48 hrs by SRB assay
    		[PMID: 37531922]
    HBL-100 GI50
    0.23 μM
    Compound: CPT
    Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 19664930]
    HBL-100 GI50
    0.23 μM
    Compound: Camptothecin
    Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay
    Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay
    		[PMID: 23831507]
    HCC70 IC50
    0.044 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay
    Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay
    		[PMID: 31398033]
    HCCLM9 IC50
    > 150 μM
    Compound: CPT
    Antiproliferative activity against human HCCLM9 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human HCCLM9 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    HCT-116 EC50
    3.15 nM
    Compound: 1; CPT
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 38421819]
    HCT-116 GI50
    0.009 μM
    Compound: 1
    Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
    Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 30336023]
    HCT-116 GI50
    0.009 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 29705710]
    HCT-116 GI50
    0.009 μM
    Compound: CPT
    Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay
    		[PMID: 31176097]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cell line
    Antiproliferative activity against human HCT116 cell line
    		[PMID: 16442283]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Cytotoxicity against human HCT116 cells
    Cytotoxicity against human HCT116 cells
    		[PMID: 17402722]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cells
    Antiproliferative activity against human HCT116 cells
    		[PMID: 18630891]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Cytotoxicity against human HCT116 cells
    Cytotoxicity against human HCT116 cells
    		[PMID: 19783447]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Cytotoxicity against human HCT116 cells
    Cytotoxicity against human HCT116 cells
    		[PMID: 20630766]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cells by SRB assay
    Antiproliferative activity against human HCT116 cells by SRB assay
    		[PMID: 21710981]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
    Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
    		[PMID: 21823606]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Cytotoxicity against human HCT116 cells by SRB assay
    Cytotoxicity against human HCT116 cells by SRB assay
    		[PMID: 24502276]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
    Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
    		[PMID: 24800942]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cells after 48 hrs
    Antiproliferative activity against human HCT116 cells after 48 hrs
    		[PMID: 27070999]
    HCT-116 GI50
    0.03 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cells assessed as growth inhibition
    Antiproliferative activity against human HCT116 cells assessed as growth inhibition
    		[PMID: 28657311]
    HCT-116 GI50
    0.03 μM
    Compound: 1, CPT
    Antiproliferative activity against human HCT116 cells
    Antiproliferative activity against human HCT116 cells
    		[PMID: 20155916]
    HCT-116 GI50
    0.03 μM
    Compound: 1, Camptothecin
    Cytotoxicity against human HCT116 cells
    Cytotoxicity against human HCT116 cells
    		[PMID: 17676830]
    HCT-116 GI50
    0.03 μM
    Compound: 2
    Growth inhibitory activity against human colon HCT116 cell line
    Growth inhibitory activity against human colon HCT116 cell line
    		[PMID: 15509164]
    HCT-116 GI50
    0.03 μM
    Compound: 2
    Antiproliferative activity against human HCT116 cell line
    Antiproliferative activity against human HCT116 cell line
    		[PMID: 16913702]
    HCT-116 GI50
    0.03 μM
    Compound: 2
    Cytotoxicity against human HCT116 cells
    Cytotoxicity against human HCT116 cells
    		[PMID: 17696418]
    HCT-116 GI50
    0.03 μM
    Compound: 2
    Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 22329436]
    HCT-116 GI50
    0.03 μM
    Compound: 2 (Camptothecin)
    Antiproliferative activity was determined for 50% growth inhibition against human colon HCT116 cell line
    Antiproliferative activity was determined for 50% growth inhibition against human colon HCT116 cell line
    		[PMID: 11020283]
    HCT-116 GI50
    0.05 μM
    Compound: CPT
    Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 34008967]
    HCT-116 GI50
    0.05 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    HCT-116 GI50
    0.075 μM
    Compound: 1
    Growth inhibition of human HCT116 cells expressing TOP1 siRNA after 72 hrs by MTT assay
    Growth inhibition of human HCT116 cells expressing TOP1 siRNA after 72 hrs by MTT assay
    		[PMID: 30336023]
    HCT-116 GI50
    0.075 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells expressing TOP1 siRNA assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells expressing TOP1 siRNA assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 29705710]
    HCT-116 GI50
    0.075 μM
    Compound: CPT
    Growth inhibition of human HCT116 cells expressing siTOP1 incubated for 72 hrs by MTT assay
    Growth inhibition of human HCT116 cells expressing siTOP1 incubated for 72 hrs by MTT assay
    		[PMID: 31176097]
    HCT-116 GI50
    0.083 μM
    Compound: 1, CPT
    Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    HCT-116 GI50
    0.195 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT-116 p53-/- cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human HCT-116 p53-/- cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    HCT-116 GI50
    17.38 nM
    Compound: 1
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 24502276]
    HCT-116 GI50
    3.86 ng/mL
    Compound: 1; CPT
    Growth inhibition of human HCT-116 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human HCT-116 cells incubated for 72 hrs by MTT assay
    		[PMID: 38421819]
    HCT-116 GI50
    35.48 nM
    Compound: 1
    Cytotoxicity against human HCT116 cells transfected with Top1-siRNA after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells transfected with Top1-siRNA after 72 hrs by MTT assay
    		[PMID: 24502276]
    HCT-116 IC50
    0.00015 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
    Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
    		[PMID: 25247770]
    HCT-116 IC50
    0.003 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay
    		[PMID: 27096049]
    HCT-116 IC50
    0.009 μM
    Compound: CPT
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CCK8 assay
    		[PMID: 32292547]
    HCT-116 IC50
    0.009 μM
    Compound: camptothecin
    Cytotoxicity against human HCT116 cells after 72 hrs by MTS method
    Cytotoxicity against human HCT116 cells after 72 hrs by MTS method
    		[PMID: 11858737]
    HCT-116 IC50
    0.011 μM
    Compound: CPT
    Cytotoxicity against human HCT-116 cells measured after 72 hrs
    Cytotoxicity against human HCT-116 cells measured after 72 hrs
    		[PMID: 38716896]
    HCT-116 IC50
    0.0115 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
    		[PMID: 28454671]
    HCT-116 IC50
    0.013 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells by MTT assay
    Cytotoxicity against human HCT116 cells by MTT assay
    		[PMID: 30543429]
    HCT-116 IC50
    0.016 μM
    Compound: camptothecin
    Cytotoxicity against human HCT116 cells after 72 hrs by WST-8 assay
    Cytotoxicity against human HCT116 cells after 72 hrs by WST-8 assay
    		[PMID: 24033077]
    HCT-116 IC50
    0.017 μM
    Compound: CPT
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
    		[PMID: 34052678]
    HCT-116 IC50
    0.02 μM
    Compound: CPT
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    HCT-116 IC50
    0.03 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    		[PMID: 31546197]
    HCT-116 IC50
    0.04 μM
    Compound: CPT
    In-vitro antitumor activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay
    In-vitro antitumor activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay
    		[PMID: 35550978]
    HCT-116 IC50
    0.04 μM
    Compound: CPT
    Cytotoxicity against human HCT-116 cells
    Cytotoxicity against human HCT-116 cells
    		[PMID: 36924947]
    HCT-116 IC50
    0.05 μM
    Compound: CPT
    Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    HCT-116 IC50
    0.051 μM
    Compound: CPT
    Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    HCT-116 IC50
    0.07 μM
    Compound: 1, CPT
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 24069881]
    HCT-116 IC50
    0.09 μM
    Compound: 1; CPT
    Antiproliferative activity against human HCT-116 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    HCT-116 IC50
    0.09 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 26226379]
    HCT-116 IC50
    0.11 μM
    Compound: CPT
    Antiproliferative activity against human HCT116 cells after 3 days by MTT assay
    Antiproliferative activity against human HCT116 cells after 3 days by MTT assay
    		[PMID: 23084702]
    HCT-116 IC50
    0.12 μM
    Compound: CPT
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 28351590]
    HCT-116 IC50
    0.13 μM
    Compound: CPT
    Antiproliferative activity against human HCT116 cells after 3 days by XTT assay
    Antiproliferative activity against human HCT116 cells after 3 days by XTT assay
    		[PMID: 19691293]
    HCT-116 IC50
    0.159 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 27318980]
    HCT-116 IC50
    0.159 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT116 cells measured after 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells measured after 48 hrs by MTT assay
    		[PMID: 28477443]
    HCT-116 IC50
    0.21 μM
    Compound: CPT
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    HCT-116 IC50
    0.25 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 33158579]
    HCT-116 IC50
    0.4 μM
    Compound: CPT
    Antitumor activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    Antitumor activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    		[PMID: 32668379]
    HCT-116 IC50
    0.6 μM
    Compound: CPT
    Cytotoxicity against human HCT-116 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    		[PMID: 35612499]
    HCT-116 IC50
    1 μM
    Compound: camptothecin
    Cytotoxicity against human HCT116 cells
    Cytotoxicity against human HCT116 cells
    		[PMID: 18178085]
    HCT-116 IC50
    1.88 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 28923388]
    HCT-116 IC50
    1.88 μM
    Compound: CPT
    Cytotoxicity against against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 30340899]
    HCT-116 IC50
    2 nM
    Compound: camptothecin
    Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
    Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
    		[PMID: 19655762]
    HCT-116 IC50
    2.01 nM
    Compound: 1; CPT
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 38421819]
    HCT-116 IC50
    2.01 nM
    Compound: Camptothecin
    Cytotoxicity against human HCT-116 cells assessed as cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as cell viability incubated for 24 hrs by MTT assay
    		[PMID: 35567964]
    HCT-116 IC50
    2.01 ng/mL
    Compound: 1; CPT
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 38421819]
    HCT-116 IC50
    2.3 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT116 cells after 4 days by MTT assay
    Cytotoxicity against human HCT116 cells after 4 days by MTT assay
    		[PMID: 20619511]
    HCT-116 IC50
    2.77 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT116 cells after 3 days
    Cytotoxicity against human HCT116 cells after 3 days
    		[PMID: 19954977]
    HCT-116 IC50
    22.9 nM
    Compound: 1, CPT
    Cytotoxicity against human HCT116 after 72 hrs by SRB assay
    Cytotoxicity against human HCT116 after 72 hrs by SRB assay
    		[PMID: 22647222]
    HCT-116 IC50
    3.97 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT116 cells after 2 days
    Cytotoxicity against human HCT116 cells after 2 days
    		[PMID: 21419530]
    HCT-116 IC50
    4.75 μM
    Compound: Camptothecin
    Inhibition of DNA topoisomerase 1 in Homo sapiens (human) HCT116 cells
    Inhibition of DNA topoisomerase 1 in Homo sapiens (human) HCT116 cells
    		10.1007/s00044-009-9233-5
    HCT-116 IC50
    6.7 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells measured after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells measured after 72 hrs by MTT assay
    		[PMID: 27721148]
    HCT-116 IC50
    8.5 nM
    Compound: Camptothecin
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay
    		[PMID: 32952994]
    HCT-116 IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells after 3 days by SRB assay
    Cytotoxicity against human HCT116 cells after 3 days by SRB assay
    		[PMID: 23142674]
    HCT-116 IC50
    < 0.1 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
    Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
    		[PMID: 22409771]
    HCT-116 IC50
    < 1 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay
    Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay
    		[PMID: 22867707]
    HCT-116 IC50
    < 1.85 μM
    Compound: CPT
    Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    HCT-116 IC50
    <= 0.1 μM
    Compound: CPT
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 26810835]
    HCT-15 IC50
    0.0014 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay
    Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay
    		[PMID: 27484510]
    HCT-15 IC50
    0.02 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay
    		[PMID: 29510948]
    HCT-15 IC50
    0.049 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay
    Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay
    		[PMID: 31398033]
    HCT-15 IC50
    0.05 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT15 cells incubated for 72 hrs by CCK8 assay
    		[PMID: 29402741]
    HCT-15 IC50
    0.05 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay
    		[PMID: 30262132]
    HCT-15 IC50
    0.067 μM
    Compound: Camptothecin
    Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay
    Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay
    		[PMID: 21074444]
    HCT-15 IC50
    0.08 μM
    Compound: CPT
    Antiproliferative activity against human HCT-15 cells after 72 hrs by EZ-Cytox colorimetric assay
    Antiproliferative activity against human HCT-15 cells after 72 hrs by EZ-Cytox colorimetric assay
    		[PMID: 34678573]
    HCT-15 IC50
    0.08 μM
    Compound: CPT, campothecin
    Cytotoxicity against human HCT15 cells by SRB assay
    Cytotoxicity against human HCT15 cells by SRB assay
    		[PMID: 17827007]
    HCT-15 IC50
    0.083 μM
    Compound: camptothecin
    Cytotoxicity against human HCT15 cells after 48 hrs
    Cytotoxicity against human HCT15 cells after 48 hrs
    		[PMID: 17673337]
    HCT-15 IC50
    0.096 μg/mL
    Compound: CPT
    Cytotoxicity against human HCT15 cells by sulforhodamine B assay
    Cytotoxicity against human HCT15 cells by sulforhodamine B assay
    		[PMID: 21684168]
    HCT-15 IC50
    0.166 μM
    Compound: CPT
    Cytotoxicity against human HCT15 cells after 48 hrs by MTT assay
    Cytotoxicity against human HCT15 cells after 48 hrs by MTT assay
    		[PMID: 21873069]
    HCT-15 IC50
    0.26 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 2 days
    Cytotoxicity against human HCT15 cells after 2 days
    		[PMID: 22318164]
    HCT-15 IC50
    0.26 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay
    Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay
    		[PMID: 25481396]
    HCT-15 IC50
    0.26 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    		[PMID: 28384547]
    HCT-15 IC50
    0.3 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 2 days by CCK8 assay
    Cytotoxicity against human HCT15 cells after 2 days by CCK8 assay
    		[PMID: 26361737]
    HCT-15 IC50
    0.31 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    		[PMID: 27643560]
    HCT-15 IC50
    0.35 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay
    		[PMID: 27654394]
    HCT-15 IC50
    0.42 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay
    Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay
    		[PMID: 24013413]
    HCT-15 IC50
    0.5 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system
    Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system
    		[PMID: 20392646]
    HCT-15 IC50
    0.5 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 2 days
    Cytotoxicity against human HCT15 cells after 2 days
    		[PMID: 21601964]
    HCT-15 IC50
    0.52 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay
    Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay
    		[PMID: 26022080]
    HCT-15 IC50
    0.6 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    		[PMID: 28068603]
    HCT-15 IC50
    0.64 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells in presence of 10% fetal bovine serum
    Cytotoxicity against human HCT15 cells in presence of 10% fetal bovine serum
    		[PMID: 20188578]
    HCT-15 IC50
    0.76 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay
    Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay
    		[PMID: 19939682]
    HCT-15 IC50
    0.76 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    		[PMID: 28633898]
    HCT-15 IC50
    0.8 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells by MTT assay
    Cytotoxicity against human HCT15 cells by MTT assay
    		[PMID: 21115246]
    HCT-15 IC50
    1.29 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay
    Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay
    		[PMID: 26927425]
    HCT-15 IC50
    1.38 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 2 days by cell counting kit-8 analysis
    Cytotoxicity against human HCT15 cells after 2 days by cell counting kit-8 analysis
    		[PMID: 22503656]
    HCT-15 IC50
    1.59 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT-15 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    Antiproliferative activity against human HCT-15 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    		[PMID: 32526552]
    HCT-15 IC50
    1.98 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay
    Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay
    		[PMID: 25062006]
    HCT-15 IC50
    10.07 μM
    Compound: CPT
    Cytotoxicity against human HCT15 cells after 2 days
    Cytotoxicity against human HCT15 cells after 2 days
    		[PMID: 24904965]
    HCT-15 IC50
    18 nM
    Compound: camptothecin
    Antiproliferative activity against human HCT15 cell line
    Antiproliferative activity against human HCT15 cell line
    		[PMID: 16686539]
    HCT-15 IC50
    2.82 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay
    Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay
    		[PMID: 26945111]
    HCT-15 IC50
    2.82 μM
    Compound: camptothecin
    Cytotoxicity against human HCT15 cells measured on day 4 by CCK8 assay
    Cytotoxicity against human HCT15 cells measured on day 4 by CCK8 assay
    		[PMID: 25936262]
    HCT-15 IC50
    3 nM
    Compound: camptothecin
    Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay
    Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay
    		[PMID: 19655762]
    HCT-15 IC50
    6.08 μM
    Compound: CPT
    Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay
    Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay
    		[PMID: 26334499]
    HCT-15 IC50
    7.1 μM
    Compound: Camptothecin
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay
    		[PMID: 26988802]
    HCT-15 IC50
    9.92 μM
    Compound: CPT
    Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay
    Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay
    		[PMID: 22819942]
    HCT-8 IC50
    0.007 μM
    Compound: 1 (Camptothecin)
    In vitro cytotoxicity against HCT-8 (human colon cancer)
    In vitro cytotoxicity against HCT-8 (human colon cancer)
    		[PMID: 14552770]
    HCT-8 IC50
    0.024 μM
    Compound: 1; CPT
    Antiproliferative activity against human HCT8 cells after 96 hrs by MTT assay
    Antiproliferative activity against human HCT8 cells after 96 hrs by MTT assay
    		[PMID: 27871039]
    HCT-8 IC50
    0.26 μM
    Compound: Camptothecin
    Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
    Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
    		[PMID: 22044245]
    HCT-8 IC50
    3.15 μM
    Compound: camptothecin
    Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
    Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
    		[PMID: 18095653]
    HCT-8 IC50
    3.2 μM
    Compound: camptothecin
    Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
    Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
    		[PMID: 19256478]
    HCT-8 IC50
    3.6 μM
    Compound: camptothecin
    Cytotoxicity against human HCT8 cells by MTT assay
    Cytotoxicity against human HCT8 cells by MTT assay
    		[PMID: 25237727]
    HCT-8 IC50
    < 0.005 μg/mL
    Compound: 1 Camptothecin
    In vitro cytotoxicity against HCT-8 cell line (human colon cancer) using MTT assay
    In vitro cytotoxicity against HCT-8 cell line (human colon cancer) using MTT assay
    		[PMID: 15225719]
    HCT-8 IC50
    < 0.013 μM
    Compound: CPT
    Cytotoxicity against human HCT8 cells after 3 days by MTT assay
    Cytotoxicity against human HCT8 cells after 3 days by MTT assay
    		[PMID: 20392545]
    HEK-293T IC50
    0.03 μM
    Compound: CPT
    Cytotoxicity against HEK293T cells
    Cytotoxicity against HEK293T cells
    		[PMID: 36924947]
    HEK-293T IC50
    0.69 μM
    Compound: CPT
    Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay
    Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay
    		[PMID: 35612499]
    HEK-293T IC50
    5.65 μM
    Compound: CPT
    Cytotoxicity against human HEK293T cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HEK293T cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    HEK293 IC50
    0.01 μM
    Compound: Camptothecin
    Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay
    Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay
    		[PMID: 28027871]
    HEK293 IC50
    0.28 μM
    Compound: Camptothecin
    Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay
    Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay
    		[PMID: 25062006]
    HEK293 IC50
    0.6 μM
    Compound: CPT
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32668379]
    HEK293 IC50
    0.78 μM
    Compound: Camptothecin
    Cytotoxicity against HEK293 cells after 2 days by CCK-8 assay
    Cytotoxicity against HEK293 cells after 2 days by CCK-8 assay
    		[PMID: 24013413]
    HEK293 IC50
    0.81 μM
    Compound: CPT
    Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    HEK293 IC50
    0.83 μM
    Compound: Camptothecin
    Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay
    		[PMID: 27643560]
    HEK293 IC50
    0.89 μM
    Compound: CPT
    Cytotoxicity against human HEK293 cells measured after 72 hrs by MTT assay
    Cytotoxicity against human HEK293 cells measured after 72 hrs by MTT assay
    		[PMID: 27721148]
    HEK293 IC50
    1.01 μM
    Compound: Camptothecin
    Cytotoxicity against human HEK293 cells after 2 days by cell counting kit-8 analysis
    Cytotoxicity against human HEK293 cells after 2 days by cell counting kit-8 analysis
    		[PMID: 22503656]
    HEK293 IC50
    1.61 μM
    Compound: CPT
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 30340899]
    HEK293 IC50
    5.6 nM
    Compound: CPT
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis
    		[PMID: 34952177]
    HEK293 IC50
    5.6 x 10-4 μM
    Compound: CPT
    Antiproliferative activity against human HEK293 cells after 48 hrs by CCK-8 assay
    Antiproliferative activity against human HEK293 cells after 48 hrs by CCK-8 assay
    		[PMID: 29501943]
    HEK293 IC50
    54.69 μM
    Compound: Camptothecin
    Cytotoxicity in human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity in human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 28923382]
    HEK293 IC50
    7.94 μM
    Compound: CPT
    Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay
    		[PMID: 22819942]
    HEK293 IC50
    8.75 μM
    Compound: CPT
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
    		[PMID: 32682183]
    HEp-2 ED50
    0.02 μg/mL
    Compound: Camptothecin
    Cytotoxicity against human Hep2 cells by MTT assay
    Cytotoxicity against human Hep2 cells by MTT assay
    		[PMID: 18220355]
    HEp-2 IC50
    0.02 μg/mL
    Compound: camptothecin
    Cytotoxicity against human Hep2 cells by MTT assay
    Cytotoxicity against human Hep2 cells by MTT assay
    		[PMID: 18774864]
    HEp-2 IC50
    0.7 μM
    Compound: Camptothecin
    Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay
    Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay
    		[PMID: 21074444]
    HEp-2 IC50
    3.01 μM
    Compound: CPT
    Cytotoxicity against against human Hep2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against against human Hep2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 30340899]
    HEp-2 IC50
    3.04 μM
    Compound: CPT
    Cytotoxicity against human Hep2 cells measured after 72 hrs by MTT assay
    Cytotoxicity against human Hep2 cells measured after 72 hrs by MTT assay
    		[PMID: 27721148]
    HEp-2 IC50
    3.04 μM
    Compound: CPT
    Cytotoxicity against human Hep2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human Hep2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 28923388]
    HFL1 IC50
    1.06 μM
    Compound: Camptothecin
    Antiproliferative activity against HFL1 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against HFL1 cells after 72 hrs by CCK8 assay
    		[PMID: 27643560]
    HGC-27 IC50
    0.166 μM
    Compound: CPT
    Antiproliferative activity against human HGC-27 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HGC-27 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    		[PMID: 35868003]
    HGC-27 IC50
    > 150 μM
    Compound: CPT
    Antiproliferative activity against human HGC-27 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human HGC-27 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    HL-60 GI50
    0.03 μM
    Compound: camptothecin
    Growth inhibition of human HL60 cells by Almar blue assay
    Growth inhibition of human HL60 cells by Almar blue assay
    		[PMID: 17418582]
    HL-60 GI50
    1.7 nM
    Compound: CPT, camptothecin
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 17962028]
    HL-60 GI50
    < 0.003 μM
    Compound: 1, CPT
    Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    HL-60 IC50
    0.0067 μM
    Compound: Camptothecin
    Antiproliferative activity against human HL60 cells
    Antiproliferative activity against human HL60 cells
    		[PMID: 29429833]
    HL-60 IC50
    0.013 μM
    Compound: camptothecin
    Cytotoxicity against human HL60 cells
    Cytotoxicity against human HL60 cells
    		[PMID: 18178085]
    HL-60 IC50
    0.015 μM
    Compound: CPT
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 26188908]
    HL-60 IC50
    0.017 μM
    Compound: 1, CPT
    Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay
    Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay
    		[PMID: 21071230]
    HL-60 IC50
    0.018 μM
    Compound: 1, CPT
    Cytotoxicity against human HL60 cells
    Cytotoxicity against human HL60 cells
    		[PMID: 21095131]
    HL-60 IC50
    0.018 μM
    Compound: CPT
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 21353568]
    HL-60 IC50
    0.018 μM
    Compound: Camptothecin
    Antiproliferation activity against human HL60 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Antiproliferation activity against human HL60 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32201190]
    HL-60 IC50
    0.018 μM
    Compound: camptothecin
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 17498951]
    HL-60 IC50
    0.019 μM
    Compound: Camptothecin
    Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 assay
    Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 assay
    		[PMID: 27318980]
    HL-60 IC50
    0.019 μM
    Compound: Camptothecin
    Antiproliferative activity against human HL60 cells measured after 48 hrs by WST1 assay
    Antiproliferative activity against human HL60 cells measured after 48 hrs by WST1 assay
    		[PMID: 28477443]
    HL-60 IC50
    0.02 μM
    Compound: Camp
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    		[PMID: 29223099]
    HL-60 IC50
    0.035 μM
    Compound: Camptothecin
    Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay
    Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay
    		[PMID: 27096049]
    HL-60 IC50
    0.06 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 24041234]
    HL-60 IC50
    0.065 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells after 2 days
    Cytotoxicity against human HL60 cells after 2 days
    		[PMID: 21419530]
    HL-60 IC50
    0.065 μM
    Compound: camptothecin
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 20093033]
    HL-60 IC50
    0.066 μM
    Compound: Camptothecin
    In vitro antiproliferative activity of compound against HL-60 (human assay
    In vitro antiproliferative activity of compound against HL-60 (human assay
    		[PMID: 12639541]
    HL-60 IC50
    0.067 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 19836231]
    HL-60 IC50
    0.07 μM
    Compound: CPT
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 25599951]
    HL-60 IC50
    0.07 μM
    Compound: Camp
    Induction of apoptosis in human HL60 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    Induction of apoptosis in human HL60 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    		[PMID: 29223099]
    HL-60 IC50
    0.089 μM
    Compound: CPT
    Cytotoxicity against human HL60 cells by sulforhodamine B assay
    Cytotoxicity against human HL60 cells by sulforhodamine B assay
    		[PMID: 19345580]
    HL-60 IC50
    0.1 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system
    Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system
    		[PMID: 20392646]
    HL-60 IC50
    0.1 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells after 2 days
    Cytotoxicity against human HL60 cells after 2 days
    		[PMID: 21601964]
    HL-60 IC50
    0.42 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 30109008]
    HL-60 IC50
    0.59 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 20356735]
    HL-60 IC50
    0.6 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells after 2 days by MTT assay
    Cytotoxicity against human HL60 cells after 2 days by MTT assay
    		[PMID: 22325897]
    HL-60 IC50
    0.68 μM
    Compound: 1
    Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells
    Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells
    		[PMID: 8410981]
    HL-60 IC50
    0.8 μM
    Compound: camptothecin
    Cytotoxicity against human HL60 cells by rapid colorimetric assay
    Cytotoxicity against human HL60 cells by rapid colorimetric assay
    		[PMID: 19585998]
    HL-60 IC50
    0.91 μM
    Compound: Camptothecin
    Antitumor activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    HL-60 IC50
    0.92 μM
    Compound: Camptothecin
    Antiproliferative activity against human HL60 cells after 72 hrs by tryphan blue staining based hematocytometric method
    Antiproliferative activity against human HL60 cells after 72 hrs by tryphan blue staining based hematocytometric method
    		[PMID: 29131616]
    HL-60 IC50
    1.7 μM
    Compound: Camptothecin
    Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
    Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
    		[PMID: 33161122]
    HL-60 IC50
    130 μM
    Compound: Camptothecin
    Cytotoxicity against human HL60 cells by MTT assay
    Cytotoxicity against human HL60 cells by MTT assay
    		[PMID: 15974606]
    HL-60 IC50
    5 nM
    Compound: CPT
    Tested in vitro for growth inhibitory activity against HL60 (human promyelocytic leukemic) cells
    Tested in vitro for growth inhibitory activity against HL60 (human promyelocytic leukemic) cells
    		10.1016/S0960-894X(97)10181-0
    HL-60 IC50
    6 nM
    Compound: camptothecin
    Cytotoxicity against human HL60 cells after 72 hrs by MTS assay
    Cytotoxicity against human HL60 cells after 72 hrs by MTS assay
    		[PMID: 19655762]
    HL-60 IC50
    < 0.064 μM
    Compound: CPT; 1
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
    		[PMID: 30509782]
    HL60/MX2 GI50
    1.5 nM
    Compound: CPT, camptothecin
    Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
    Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
    		[PMID: 17962028]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human HOP62 cell line
    Antiproliferative activity against human HOP62 cell line
    		[PMID: 16442283]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human HOP62 cells
    Cytotoxicity against human HOP62 cells
    		[PMID: 17402722]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human HOP62 cells
    Antiproliferative activity against human HOP62 cells
    		[PMID: 18630891]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human HOP62 cells
    Cytotoxicity against human HOP62 cells
    		[PMID: 19783447]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human HOP62 cells
    Cytotoxicity against human HOP62 cells
    		[PMID: 20630766]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human HOP62 cells by SRB assay
    Antiproliferative activity against human HOP62 cells by SRB assay
    		[PMID: 21710981]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay
    Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay
    		[PMID: 21823606]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human HOP62 cells by SRB assay
    Cytotoxicity against human HOP62 cells by SRB assay
    		[PMID: 24502276]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Growth inhibition of human HOP62 cells after 48 hrs by SRB assay
    Growth inhibition of human HOP62 cells after 48 hrs by SRB assay
    		[PMID: 24800942]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human HOP62 cells after 48 hrs
    Antiproliferative activity against human HOP62 cells after 48 hrs
    		[PMID: 27070999]
    HOP-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human HOP62 cells assessed as growth inhibition
    Antiproliferative activity against human HOP62 cells assessed as growth inhibition
    		[PMID: 28657311]
    HOP-62 GI50
    0.01 μM
    Compound: 1, CPT
    Antiproliferative activity against human HOP62 cells
    Antiproliferative activity against human HOP62 cells
    		[PMID: 20155916]
    HOP-62 GI50
    0.01 μM
    Compound: 1, Camptothecin
    Cytotoxicity against human HOP62 cells
    Cytotoxicity against human HOP62 cells
    		[PMID: 17676830]
    HOP-62 GI50
    0.01 μM
    Compound: 2
    Growth inhibitory activity against human lung HOP-62 cell line
    Growth inhibitory activity against human lung HOP-62 cell line
    		[PMID: 15509164]
    HOP-62 GI50
    0.01 μM
    Compound: 2
    Antiproliferative activity against human HOP62 cell line
    Antiproliferative activity against human HOP62 cell line
    		[PMID: 16913702]
    HOP-62 GI50
    0.01 μM
    Compound: 2
    Cytotoxicity against human HOP62 cells
    Cytotoxicity against human HOP62 cells
    		[PMID: 17696418]
    HOP-62 GI50
    0.01 μM
    Compound: 2
    Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 22329436]
    HOP-62 GI50
    0.01 μM
    Compound: 2 (Camptothecin)
    Antiproliferative activity was determined for 50% growth inhibition against human lung HOP-62 cell line
    Antiproliferative activity was determined for 50% growth inhibition against human lung HOP-62 cell line
    		[PMID: 11020283]
    HOP-62 GI50
    < 0.01 μM
    Compound: 18
    Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay
    Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay
    		[PMID: 28418653]
    HOS IC50
    0.049 μM
    Compound: CPT
    Cytotoxicity against human HOS cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human HOS cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    HT-1080 IC50
    0.08 μM
    Compound: 1, CPT
    Cytotoxicity against human HT1080 cells
    Cytotoxicity against human HT1080 cells
    		[PMID: 21095131]
    HT-1080 IC50
    0.08 μM
    Compound: CPT
    Cytotoxicity against human HT1080 cells by MTT assay
    Cytotoxicity against human HT1080 cells by MTT assay
    		[PMID: 21353568]
    HT-1080 IC50
    0.08 μM
    Compound: camptothecin
    Cytotoxicity against human HT1080 cells by SRB assay
    Cytotoxicity against human HT1080 cells by SRB assay
    		[PMID: 17498951]
    HT-29 EC50
    60 nM
    Compound: Camptothecin
    Cytotoxicity against human HT-29 cells
    Cytotoxicity against human HT-29 cells
    		[PMID: 20825206]
    HT-29 ED50
    0.06 μM
    Compound: Camptothecin
    Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
    		[PMID: 20939540]
    HT-29 ED50
    0.06 μM
    Compound: camptothecin
    Cytotoxicity against human HT-29 cells
    Cytotoxicity against human HT-29 cells
    		[PMID: 19839614]
    HT-29 GI50
    0.03 μM
    Compound: 1, CPT
    Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay
    Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay
    		[PMID: 19715319]
    HT-29 GI50
    0.05 μM
    Compound: Camptothecin
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 21115210]
    HT-29 GI50
    0.05 μM
    Compound: Camptothecin
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 23831811]
    HT-29 IC50
    0.014 μM
    Compound: camptothecin
    Growth inhibition of human HT29 cells by neutral red assay
    Growth inhibition of human HT29 cells by neutral red assay
    		[PMID: 17204425]
    HT-29 IC50
    0.03 μM
    Compound: Camptothecin
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    		[PMID: 31546197]
    HT-29 IC50
    0.06 μM
    Compound: CPT
    Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 24360564]
    HT-29 IC50
    0.07 μM
    Compound: CPT
    Cytotoxicity against human HT-29 cells by MTT assay
    Cytotoxicity against human HT-29 cells by MTT assay
    		[PMID: 36924947]
    HT-29 IC50
    0.0878 μM
    Compound: Camptothecin
    Inhibitory concentration that reduced the viability of HT 29 cell population by 50%.
    Inhibitory concentration that reduced the viability of HT 29 cell population by 50%.
    		[PMID: 9003520]
    HT-29 IC50
    0.09 μM
    Compound: 1, CPT
    Cytotoxicity against human HT29 cells after 4 days by MTT assay
    Cytotoxicity against human HT29 cells after 4 days by MTT assay
    		[PMID: 18554906]
    HT-29 IC50
    0.12 μM
    Compound: 1, CPT
    Antitumor activity against human HT-29 cells by SRB method
    Antitumor activity against human HT-29 cells by SRB method
    		[PMID: 19541483]
    HT-29 IC50
    0.19 μM
    Compound: CPT
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    HT-29 IC50
    0.4 μM
    Compound: 1, CPT
    Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay
    Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay
    		[PMID: 19715319]
    HT-29 IC50
    0.7 nM
    Compound: Camptothecin
    Antiproliferative activity against human HT-29 cells by SRB assay
    Antiproliferative activity against human HT-29 cells by SRB assay
    		[PMID: 24200393]
    HT-29 IC50
    0.85 μM
    Compound: camptothecin
    Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 20093033]
    HT-29 IC50
    1.07 μM
    Compound: Camptothecin
    Cytotoxicity against human HT-29 cells by MTT assay
    Cytotoxicity against human HT-29 cells by MTT assay
    		[PMID: 19836231]
    HT-29 IC50
    1.22 μM
    Compound: camptothecin
    Cytotoxicity against human HT-29 cells by SRB staining-based fluorescence cytometry
    Cytotoxicity against human HT-29 cells by SRB staining-based fluorescence cytometry
    		[PMID: 19653666]
    HT-29 IC50
    1.37 μM
    Compound: CPT
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    		[PMID: 35868003]
    HT-29 IC50
    1.4 μM
    Compound: Camptothecin
    In vitro antiproliferative activity of compound against HT-29 (human colon caner ) cell line aws determined by SRB assay
    In vitro antiproliferative activity of compound against HT-29 (human colon caner ) cell line aws determined by SRB assay
    		[PMID: 12639541]
    HT-29 IC50
    1.87 μM
    Compound: CPT
    Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 38154256]
    HT-29 IC50
    10 μM
    Compound: Camptothecin
    Cytotoxicity against human HT-29 cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 21843907]
    HT-29 IC50
    2 μM
    Compound: camptothecin
    Cytotoxicity against human HT29 cells by MTT assay
    Cytotoxicity against human HT29 cells by MTT assay
    		[PMID: 18841903]
    HT-29 IC50
    2.35 μM
    Compound: CPT
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 38128233]
    HT-29 IC50
    260 nM
    Compound: 1a
    Cytotoxicity against human HT-29 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human HT-29 cells after 72 hrs by alamar blue assay
    		[PMID: 21341674]
    HT-29 IC50
    3.16 μM
    Compound: 1, CPT
    Cytotoxicity against human HT29 cells after 1 hr
    Cytotoxicity against human HT29 cells after 1 hr
    		[PMID: 18419110]
    HT-29 IC50
    3.16 μM
    Compound: 1, camptothecin, CPT
    Antiproliferative activity against human HT29 cells after 1 hr of drug exposure measured after 72 hrs
    Antiproliferative activity against human HT29 cells after 1 hr of drug exposure measured after 72 hrs
    		[PMID: 18424133]
    HT-29 IC50
    30 nM
    Compound: camptothecin
    Antiproliferative activity against human HT29 cell line
    Antiproliferative activity against human HT29 cell line
    		[PMID: 16686539]
    HT-29 IC50
    46 nM
    Compound: 1
    Cytotoxicity was determined in vitro in HT-29 cells(colon) of human tumor cell lines by using MTT assay
    Cytotoxicity was determined in vitro in HT-29 cells(colon) of human tumor cell lines by using MTT assay
    		[PMID: 7853331]
    HT-29 IC50
    8.81 μM
    Compound: 1, CPT
    Cytotoxicity against human mitoxantrone-resistant HT29 cells after 1 hr
    Cytotoxicity against human mitoxantrone-resistant HT29 cells after 1 hr
    		[PMID: 18419110]
    HT-29 IC50
    8.81 μM
    Compound: 1, camptothecin, CPT
    Antiproliferative activity against BCRP overexpressing mitoxantrone-resistant human HT29 cells after 1 hr of drug exposure measured after 72 hrs
    Antiproliferative activity against BCRP overexpressing mitoxantrone-resistant human HT29 cells after 1 hr of drug exposure measured after 72 hrs
    		[PMID: 18424133]
    HT-29 IC50
    80 nM
    Compound: CPT
    Cytotoxicity against HT-29 tumor cell line determined by WST-1 assay
    Cytotoxicity against HT-29 tumor cell line determined by WST-1 assay
    		[PMID: 10841808]
    HT-29 IC50
    > 100 μM
    Compound: CPT
    Cytotoxicity against human HT-29 cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    HT-29 IC50
    > 150 μM
    Compound: CPT
    Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    HUVEC ED50
    258 nM
    Compound: camptothecin
    Cytotoxicity against HUVEC
    Cytotoxicity against HUVEC
    		[PMID: 15043407]
    HUVEC IC50
    0.01 μM
    Compound: CPT
    Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    HUVEC IC50
    0.012 μM
    Compound: CPT
    In-vitro cytotoxic activity against human HUVEC cells incubated for 72 hrs by CCK8 assay
    In-vitro cytotoxic activity against human HUVEC cells incubated for 72 hrs by CCK8 assay
    		[PMID: 35550978]
    HUVEC IC50
    0.04 μM
    Compound: CPT
    Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human HUVEC cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    HUVEC IC50
    0.06 μM
    Compound: CPT
    Cytotoxicity against HUVEC cells
    Cytotoxicity against HUVEC cells
    		[PMID: 36924947]
    HUVEC IC50
    0.2 μM
    Compound: Camptothecin
    Toxicity against HUVEC incubated for 48 hrs by MTT assay
    Toxicity against HUVEC incubated for 48 hrs by MTT assay
    		[PMID: 25590864]
    HeLa ED50
    0.19 μg/mL
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 18220355]
    HeLa GI50
    0.0054 μM
    Compound: CPT
    Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay
    Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay
    		[PMID: 27597409]
    HeLa GI50
    0.01 μM
    Compound: camptothecin
    Growth inhibition of HeLa cells after 4 days
    Growth inhibition of HeLa cells after 4 days
    		[PMID: 17418582]
    HeLa GI50
    0.04 μM
    Compound: 1, CPT
    Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay
    Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay
    		[PMID: 19715319]
    HeLa GI50
    0.05 μM
    Compound: Camptothecin
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay
    Growth inhibition of human HeLa cells after 48 hrs by MTT assay
    		[PMID: 23357037]
    HeLa GI50
    0.08 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 20662543]
    HeLa GI50
    0.18 μM
    Compound: 1, camptothecin
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 18180162]
    HeLa GI50
    0.19 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    HeLa GI50
    0.6 μM
    Compound: Camptothecin
    Growth inhibitory concentration of compound was determined against HeLa cells by alamar blue assay
    Growth inhibitory concentration of compound was determined against HeLa cells by alamar blue assay
    		[PMID: 15026047]
    HeLa GI50
    0.6 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
    Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
    		[PMID: 23831507]
    HeLa GI50
    0.6 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells assessed as inhibition of culture growth incubated for 48 hrs by SRB assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of culture growth incubated for 48 hrs by SRB assay
    		[PMID: 37531922]
    HeLa GI50
    1.3 μM
    Compound: 1
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 21388138]
    HeLa GI50
    1.3 μM
    Compound: CPT
    Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay
    		[PMID: 19664930]
    HeLa IC50
    0.0089 μM
    Compound: 1, CPT
    Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay
    Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay
    		[PMID: 21071230]
    HeLa IC50
    0.06 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    		[PMID: 28384547]
    HeLa IC50
    0.072 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells by sulforhodamine B assay
    Cytotoxicity against human HeLa cells by sulforhodamine B assay
    		[PMID: 19345580]
    HeLa IC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 48 hrs by WST-1 assay
    Cytotoxicity against human HeLa cells after 48 hrs by WST-1 assay
    		[PMID: 28557449]
    HeLa IC50
    0.09 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    		[PMID: 28068603]
    HeLa IC50
    0.108 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells measured after 72 hrs
    Cytotoxicity against human HeLa cells measured after 72 hrs
    		[PMID: 38716896]
    HeLa IC50
    0.12 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay
    		[PMID: 28425292]
    HeLa IC50
    0.13 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells by SRB assay
    Antiproliferative activity against human HeLa cells by SRB assay
    		[PMID: 24200393]
    HeLa IC50
    0.13 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay
    		[PMID: 27484510]
    HeLa IC50
    0.13 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay
    		[PMID: 29510948]
    HeLa IC50
    0.18 μM
    Compound: CPT
    Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay
    		10.1039/C4MD00133H
    HeLa IC50
    0.18 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay
    Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay
    		[PMID: 26945111]
    HeLa IC50
    0.18 μM
    Compound: camptothecin
    Cytotoxicity against human HeLa cells measured on day 4 by CCK8 assay
    Cytotoxicity against human HeLa cells measured on day 4 by CCK8 assay
    		[PMID: 25936262]
    HeLa IC50
    0.19 μg/mL
    Compound: camptothecin
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 18774864]
    HeLa IC50
    0.2 μM
    Compound: 1, CPT
    Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay
    Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay
    		[PMID: 19715319]
    HeLa IC50
    0.23 μM
    Compound: CPT
    Antiproliferative activity against human HeLa cells after 72 hrs by EZ-Cytox colorimetric assay
    Antiproliferative activity against human HeLa cells after 72 hrs by EZ-Cytox colorimetric assay
    		[PMID: 34678573]
    HeLa IC50
    0.28 μg/mL
    Compound: Camptothecin
    Cytotoxicity against Homo sapiens (human) HeLa cells by MTT assay
    Cytotoxicity against Homo sapiens (human) HeLa cells by MTT assay
    		10.1007/s00044-010-9381-7
    HeLa IC50
    0.4 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
    		[PMID: 22542106]
    HeLa IC50
    0.4 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
    		[PMID: 23153813]
    HeLa IC50
    0.4 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system
    Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system
    		[PMID: 20392646]
    HeLa IC50
    0.4 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 2 days
    Cytotoxicity against human HeLa cells after 2 days
    		[PMID: 21601964]
    HeLa IC50
    0.4 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 2 days by CCK-8 assay
    Cytotoxicity against human HeLa cells after 2 days by CCK-8 assay
    		[PMID: 25481396]
    HeLa IC50
    0.4 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    		[PMID: 27643560]
    HeLa IC50
    0.41 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay
    Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay
    		[PMID: 26022080]
    HeLa IC50
    0.42 μM
    Compound: CPT, Camptothecin
    Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
    		[PMID: 24980118]
    HeLa IC50
    0.5 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay
    		[PMID: 24303808]
    HeLa IC50
    0.5 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay
    Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay
    		[PMID: 31398033]
    HeLa IC50
    0.5 μM
    Compound: camptothecine
    Cytotoxicity against human HeLa cells by MTT method
    Cytotoxicity against human HeLa cells by MTT method
    		[PMID: 17547457]
    HeLa IC50
    0.58 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 19836231]
    HeLa IC50
    0.59 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 3 days by CCK8 assay
    Cytotoxicity against human HeLa cells after 3 days by CCK8 assay
    		[PMID: 26927425]
    HeLa IC50
    0.63 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay
    Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay
    		[PMID: 19939682]
    HeLa IC50
    0.63 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells in presence of 10% fetal bovine serum
    Cytotoxicity against human HeLa cells in presence of 10% fetal bovine serum
    		[PMID: 20188578]
    HeLa IC50
    0.66 μM
    Compound: CPT
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 30125725]
    HeLa IC50
    0.86 μM
    Compound: camptothecin
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 20093033]
    HeLa IC50
    0.94 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 20356735]
    HeLa IC50
    0.94 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 24 hrs by crystal violet staining-based assay
    Antiproliferative activity against human HeLa cells after 24 hrs by crystal violet staining-based assay
    		[PMID: 29407986]
    HeLa IC50
    1.01 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 2 days
    Cytotoxicity against human HeLa cells after 2 days
    		[PMID: 22318164]
    HeLa IC50
    1.08 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 2 days
    Cytotoxicity against human HeLa cells after 2 days
    		[PMID: 21419530]
    HeLa IC50
    1.08 μM
    Compound: camptothecin
    Cytotoxicity against human HeLa cells
    Cytotoxicity against human HeLa cells
    		[PMID: 18178085]
    HeLa IC50
    1.1 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 4 days by MTT assay
    Cytotoxicity against human HeLa cells after 4 days by MTT assay
    		[PMID: 20619511]
    HeLa IC50
    1.22 μM
    Compound: camptothecin
    Cytotoxicity against human HeLa cells by SRB staining-based fluorescence cytometry
    Cytotoxicity against human HeLa cells by SRB staining-based fluorescence cytometry
    		[PMID: 19653666]
    HeLa IC50
    1.3 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells by MTT assay
    Antiproliferative activity against human HeLa cells by MTT assay
    		[PMID: 30007563]
    HeLa IC50
    1.37 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay
    		[PMID: 29402741]
    HeLa IC50
    1.37 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay
    Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay
    		[PMID: 30262132]
    HeLa IC50
    1.41 μM
    Compound: 1; CPT
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 27416553]
    HeLa IC50
    1.5 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 21186067]
    HeLa IC50
    1.57 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells after 24 hrs by MTS assay
    Cytotoxicity against human HeLa cells after 24 hrs by MTS assay
    		[PMID: 22542106]
    HeLa IC50
    1.57 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells after 24 hrs by MTS assay
    Cytotoxicity against human HeLa cells after 24 hrs by MTS assay
    		[PMID: 23153813]
    HeLa IC50
    1.59 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells measured after 2 days by MTT assay
    Cytotoxicity against human HeLa cells measured after 2 days by MTT assay
    		[PMID: 26334499]
    HeLa IC50
    1.66 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells
    Cytotoxicity against human HeLa cells
    		[PMID: 32932211]
    HeLa IC50
    1.85 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 3 days
    Cytotoxicity against human HeLa cells after 3 days
    		[PMID: 19954977]
    HeLa IC50
    10.1 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 28462840]
    HeLa IC50
    11.36 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells assessed as decrease in cell proliferation after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as decrease in cell proliferation after 48 hrs by MTT assay
    		[PMID: 27667553]
    HeLa IC50
    11.62 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 25599951]
    HeLa IC50
    117.2 nM
    Compound: Camptothecin (table 1)
    Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
    Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
    		[PMID: 15454230]
    HeLa IC50
    127 μM
    Compound: Camptothecin
    Inhibitory activity against DNA topoisomerase-1 obtained from Hela cells
    Inhibitory activity against DNA topoisomerase-1 obtained from Hela cells
    		[PMID: 7699697]
    HeLa IC50
    14 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 26188908]
    HeLa IC50
    19.8 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 24 hrs by XTT assay
    Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 24 hrs by XTT assay
    		[PMID: 26649907]
    HeLa IC50
    2.62 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    		[PMID: 28633898]
    HeLa IC50
    24 nM
    Compound: CPT
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 24900725]
    HeLa IC50
    3.8 μM
    Compound: CPT
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 28511910]
    HeLa IC50
    59.13 μM
    Compound: Camptothecin
    Growth inhibition of human HeLa cells after 72 hrs by MTT assay
    Growth inhibition of human HeLa cells after 72 hrs by MTT assay
    		[PMID: 27344492]
    HeLa IC50
    6 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    		[PMID: 32526552]
    HeLa IC50
    6.13 μM
    Compound: Camptothecin
    Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
    Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
    		[PMID: 26602827]
    HeLa IC50
    6.51 μM
    Compound: CPT
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 30685528]
    HeLa IC50
    60.01 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 28063351]
    HeLa IC50
    8.28 μM
    Compound: CPT
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 34852457]
    HeLa IC50
    8.9 nM
    Compound: 1; CPT
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 38421819]
    HeLa IC50
    8.93 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 24 hrs by MTT assay
    		[PMID: 21983445]
    HeLa IC50
    8.9 ng/mL
    Compound: 1; CPT
    Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 38421819]
    HeLa IC50
    9 μM
    Compound: Camptothecin
    Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
    Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
    		[PMID: 11430001]
    HeLa IC50
    > 300 μM
    Compound: CPT
    Cytostatic activity against human HeLa cells after 24 hrs by CCK-8 assay
    Cytostatic activity against human HeLa cells after 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    HeLa IC50
    > 50 μM
    Compound: Camptothecin
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 30109008]
    Hep 3B2 GI50
    0.01 μM
    Compound: 1, CPT
    Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay
    Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay
    		[PMID: 19715319]
    Hep 3B2 IC50
    0.06 μM
    Compound: 1, CPT
    Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay
    Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay
    		[PMID: 19715319]
    Hep 3B2 IC50
    102.9 μM
    Compound: CPT
    Antiproliferative activity against human Hep3B cells at 2:1 compound:(2R)-2,6-diamino-N-[(1R)-5-amino-1-[[(1R)-2-[[(1R)-2-[[(1R)-5-amino-1-[[(1R)-5-amino-1-[[(1R)-2-[[(1R)-1-[[(1R)-5-amino-1-carbamoyl-pentyl]carbamoyl]-2,2-diphenyl-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]pentyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]hexanamide molar ratio incubated for 24 hrs by CCK-8 assay
    Antiproliferative activity against human Hep3B cells at 2:1 compound:(2R)-2,6-diamino-N-[(1R)-5-amino-1-[[(1R)-2-[[(1R)-2-[[(1R)-5-amino-1-[[(1R)-5-amino-1-[[(1R)-2-[[(1R)-1-[[(1R)-5-amino-1-carbamoyl-pentyl]carbamoyl]-2,2-diphenyl-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]pentyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]hexanamide molar ratio incubated for 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    Hep 3B2 IC50
    434.29 nM
    Compound: CPT
    Cytotoxicity against human Hep3B cells assessed as inhibition of cell growth
    Cytotoxicity against human Hep3B cells assessed as inhibition of cell growth
    		[PMID: 37806498]
    Hep 3B2 IC50
    < 1 μM
    Compound: CPT
    Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 26810835]
    Hep 3B2 IC50
    > 300 μM
    Compound: CPT
    Antiproliferative activity against human Hep3B cells incubated for 24 hrs by CCK-8 assay
    Antiproliferative activity against human Hep3B cells incubated for 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    Hep 3B2 IC50
    > 300 μM
    Compound: CPT
    Antiproliferative activity against human Hep3B cells incubated for 24 hrs in presence of 12.5 uM (2R)-2,6-diamino-N-[(1R)-5-amino-1-[[(1R)-2-[[(1R)-2-[[(1R)-5-amino-1-[[(1R)-5-amino-1-[[(1R)-2-[[(1R)-1-[[(1R)-5-amino-1-carbamoyl-pentyl]carbamoyl]-2,2-diphenyl-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]pentyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]hexanamide by CCK-8 assay
    Antiproliferative activity against human Hep3B cells incubated for 24 hrs in presence of 12.5 uM (2R)-2,6-diamino-N-[(1R)-5-amino-1-[[(1R)-2-[[(1R)-2-[[(1R)-5-amino-1-[[(1R)-5-amino-1-[[(1R)-2-[[(1R)-1-[[(1R)-5-amino-1-carbamoyl-pentyl]carbamoyl]-2,2-diphenyl-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]pentyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]hexanamide by CCK-8 assay
    		[PMID: 38278140]
    Hep 3B2 IC50
    > 300 μM
    Compound: CPT
    Antiproliferative activity against human Hep3B cells incubated for 24 hrs in presence of 25 uM (2R)-2,6-diamino-N-[(1R)-5-amino-1-[[(1R)-2-[[(1R)-2-[[(1R)-5-amino-1-[[(1R)-5-amino-1-[[(1R)-2-[[(1R)-1-[[(1R)-5-amino-1-carbamoyl-pentyl]carbamoyl]-2,2-diphenyl-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]pentyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]hexanamide by CCK-8 assay
    Antiproliferative activity against human Hep3B cells incubated for 24 hrs in presence of 25 uM (2R)-2,6-diamino-N-[(1R)-5-amino-1-[[(1R)-2-[[(1R)-2-[[(1R)-5-amino-1-[[(1R)-5-amino-1-[[(1R)-2-[[(1R)-1-[[(1R)-5-amino-1-carbamoyl-pentyl]carbamoyl]-2,2-diphenyl-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]pentyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]pentyl]hexanamide by CCK-8 assay
    		[PMID: 38278140]
    HepG2 CC50
    0.02 μM
    Compound: Camptothecin
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    HepG2 CC50
    0.04 μM
    Compound: Camptothecin
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    HepG2 GI50
    0.1 μM
    Compound: 1, CPT
    Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay
    Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay
    		[PMID: 19715319]
    HepG2 GI50
    0.22 μM
    Compound: 1, CPT
    Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    HepG2 IC50
    0.01 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay
    Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay
    		[PMID: 22867707]
    HepG2 IC50
    0.02 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    		[PMID: 36924947]
    HepG2 IC50
    0.02 μM
    Compound: Camptothecin
    Cytotoxicity against human HepG2 cells after 96 hrs
    Cytotoxicity against human HepG2 cells after 96 hrs
    		[PMID: 22276775]
    HepG2 IC50
    0.03 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells by MTT assay
    Antiproliferative activity against human HepG2 cells by MTT assay
    		[PMID: 17254669]
    HepG2 IC50
    0.04 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    HepG2 IC50
    0.04 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    HepG2 IC50
    0.05 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 24360564]
    HepG2 IC50
    0.06 μM
    Compound: camptothecin
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    		[PMID: 19863101]
    HepG2 IC50
    0.09 μg/mL
    Compound: 1
    Cytotoxicity in HepG2-T14 cancer cell line
    Cytotoxicity in HepG2-T14 cancer cell line
    		10.1016/S0960-894X(01)80158-X
    HepG2 IC50
    0.11 μM
    Compound: 1; CPT
    Antiproliferative activity against human HepG2 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    HepG2 IC50
    0.13 μM
    Compound: 1, CPT
    Cytotoxicity against human HepG2 cells after 4 days by MTT assay
    Cytotoxicity against human HepG2 cells after 4 days by MTT assay
    		[PMID: 18554906]
    HepG2 IC50
    0.2 μM
    Compound: 1, CPT
    Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay
    Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay
    		[PMID: 19715319]
    HepG2 IC50
    0.2 μM
    Compound: Camptothecin
    Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
    		10.1039/C4MD00344F
    HepG2 IC50
    0.2 μM
    Compound: Camptothecin
    Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 24041234]
    HepG2 IC50
    0.3 μM
    Compound: camptothecin
    Cytotoxicity against human HEPG2 cells by MTT assay
    Cytotoxicity against human HEPG2 cells by MTT assay
    		[PMID: 18841903]
    HepG2 IC50
    0.37 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 30055465]
    HepG2 IC50
    0.4 μM
    Compound: CPT
    Antitumor activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    Antitumor activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    		[PMID: 32668379]
    HepG2 IC50
    0.43 μM
    Compound: Camp
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    		[PMID: 29223099]
    HepG2 IC50
    0.5 μM
    Compound: Camptothecin
    Antiproliferative activity against human HepG2 cells by MTT assay
    Antiproliferative activity against human HepG2 cells by MTT assay
    		[PMID: 30007563]
    HepG2 IC50
    0.6 μM
    Compound: Camptothecin
    Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay
    		[PMID: 24303808]
    HepG2 IC50
    0.66 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 30600208]
    HepG2 IC50
    1.36 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 30125725]
    HepG2 IC50
    1.36 μM
    Compound: Camptothecin
    Antiproliferative activity against human HepG2 cells assessed reduction in cell proliferation incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed reduction in cell proliferation incubated for 48 hrs by MTT assay
    		[PMID: 38107170]
    HepG2 IC50
    1.52 μM
    Compound: 1; CPT
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 27416553]
    HepG2 IC50
    1.8 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 38154256]
    HepG2 IC50
    13.2 μM
    Compound: Camptothecin
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 30025344]
    HepG2 IC50
    13.2 μM
    Compound: Camptothecin
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by alamarBlue assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by alamarBlue assay
    		[PMID: 38107170]
    HepG2 IC50
    29.81 μM
    Compound: Camptothecin
    Growth inhibition of human HepG2 cells after 72 hrs by MTT assay
    Growth inhibition of human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 27344492]
    HepG2 IC50
    3.5 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 34852457]
    HepG2 IC50
    32.3 μM
    Compound: Camptothecin
    Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
    Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
    		[PMID: 23562244]
    HepG2 IC50
    33.16 nM
    Compound: CPT
    Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth
    Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth
    		[PMID: 37806498]
    HepG2 IC50
    4.37 μM
    Compound: Camp
    Induction of apoptosis in human HepG2 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    Induction of apoptosis in human HepG2 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    		[PMID: 29223099]
    HepG2 IC50
    4.79 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 30685528]
    HepG2 IC50
    4.92 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 28511910]
    HepG2 IC50
    455 nM
    Compound: camptothecin
    Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay
    		[PMID: 19655762]
    HepG2 IC50
    5.69 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 30875505]
    HepG2 IC50
    6.08 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 30125725]
    HepG2 IC50
    6.3 nM
    Compound: 1
    Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human hepatocellular cells (HepG2)
    Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human hepatocellular cells (HepG2)
    		[PMID: 10479293]
    HepG2 IC50
    6.4 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 22326393]
    HepG2 IC50
    7.25 nM
    Compound: 1; CPT
    Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 38421819]
    HepG2 IC50
    7.25 ng/mL
    Compound: 1; CPT
    Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
    		[PMID: 38421819]
    HepG2 IC50
    < 0.1 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
    Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
    		[PMID: 22409771]
    HepG2 IC50
    < 1 μM
    Compound: CPT
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 26810835]
    HepG2 IC50
    < 1.85 μM
    Compound: CPT
    Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    Hs 683 IC50
    < 0.01 μM
    Compound: Camptothecin
    Growth inhibition of human Hs683 cells after 72 hrs by MTT assay
    Growth inhibition of human Hs683 cells after 72 hrs by MTT assay
    		[PMID: 24180210]
    Huh-7 GI50
    0.006 μM
    Compound: CPT
    Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 29705710]
    Huh-7 GI50
    0.099 μM
    Compound: 1
    Growth inhibition of human HuH7 cells after 72 hrs by MTT assay
    Growth inhibition of human HuH7 cells after 72 hrs by MTT assay
    		[PMID: 30336023]
    Huh-7 IC50
    0.0023 μM
    Compound: CPT
    Cytotoxicity against human HuH7 cells by MTT assay
    Cytotoxicity against human HuH7 cells by MTT assay
    		[PMID: 30543429]
    Huh-7 IC50
    0.004 μM
    Compound: CPT
    Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay
    Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay
    		[PMID: 25247770]
    Huh-7 IC50
    0.06 μM
    Compound: CPT
    Cytotoxicity against human HuH7 cells after 3 days by SRB assay
    Cytotoxicity against human HuH7 cells after 3 days by SRB assay
    		[PMID: 23142674]
    Huh-7 IC50
    0.1 μM
    Compound: CPT
    Cytotoxicity against human HuH7 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
    Cytotoxicity against human HuH7 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
    		10.1039/C4MD00306C
    Huh-7 IC50
    0.15 μM
    Compound: CPT
    Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay
    Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay
    		[PMID: 22867707]
    Huh-7 IC50
    0.32 nM
    Compound: Camptothecin
    Cytotoxicity against human HuH7 cells after 48 hrs by CCK8 assay
    Cytotoxicity against human HuH7 cells after 48 hrs by CCK8 assay
    		[PMID: 30702286]
    Huh-7 IC50
    113.1 μM
    Compound: CPT
    Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by CCK-8 assay
    Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    Huh-7 IC50
    < 0.1 μM
    Compound: CPT
    Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay
    Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay
    		[PMID: 22409771]
    Huh-7 IC50
    < 1.85 μM
    Compound: CPT
    Antiproliferative activity against human Huh-7 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human Huh-7 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    Huh-7 IC50
    <= 0.1 μM
    Compound: CPT
    Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 26810835]
    IGROV-1 IC50
    0.012 μM
    Compound: 1, CPT
    Cytotoxicity against human IGROV1 cells after 72 hrs
    Cytotoxicity against human IGROV1 cells after 72 hrs
    		[PMID: 18419110]
    IGROV-1 IC50
    1.65 μM
    Compound: 1, CPT
    Cytotoxicity against human IGROV1 cells after 1 hr
    Cytotoxicity against human IGROV1 cells after 1 hr
    		[PMID: 18419110]
    IMR-32 IC50
    0.08 μM
    Compound: Camptothecin
    Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay
    Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay
    		[PMID: 21074444]
    IMR-32 IC50
    2.21 nM
    Compound: Camptothecin
    Cytotoxic activity against human neuroblastoma IMR32 cells which over-express somatostatin receptors
    Cytotoxic activity against human neuroblastoma IMR32 cells which over-express somatostatin receptors
    		[PMID: 12617894]
    IMR-90 IC50
    0.43 μM
    Compound: Camptothecin
    Cytotoxicity against human IMR90 cells incubated for 3 days by SRB assay
    Cytotoxicity against human IMR90 cells incubated for 3 days by SRB assay
    		[PMID: 22863526]
    Jurkat GI50
    0.06 μM
    Compound: Camptothecin
    Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    Jurkat GI50
    0.09 μM
    Compound: 1
    Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
    Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
    		[PMID: 21388138]
    Jurkat IC50
    0.026 μM
    Compound: Camptothecin
    Cytotoxicity against human Jurkat cells after 2 days by MTT assay
    Cytotoxicity against human Jurkat cells after 2 days by MTT assay
    		[PMID: 22325897]
    Jurkat IC50
    0.085 μM
    Compound: CPT
    Anticancer activity against human Jurkat cells after 48 hrs by MTT assay
    Anticancer activity against human Jurkat cells after 48 hrs by MTT assay
    		[PMID: 26890120]
    Jurkat IC50
    0.1 μM
    Compound: 1; CPT
    Anticancer activity against human Jurkat cells incubated for 48 hrs by MTT assay
    Anticancer activity against human Jurkat cells incubated for 48 hrs by MTT assay
    		[PMID: 34175539]
    Jurkat IC50
    0.11 μM
    Compound: CPT, Camptothecin
    Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay
    Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay
    		[PMID: 24980118]
    Jurkat IC50
    1.4 nM
    Compound: camptothecin
    Growth inhibition of human Jurkat cells after 96 hrs
    Growth inhibition of human Jurkat cells after 96 hrs
    		[PMID: 18061452]
    Jurkat IC50
    22 μM
    Compound: CPT
    Antiproliferative activity against human Jurkat cells assessed as reduction in cell proliferation measured after 48 hrs by MTT assay
    Antiproliferative activity against human Jurkat cells assessed as reduction in cell proliferation measured after 48 hrs by MTT assay
    		[PMID: 30853330]
    Jurkat IC50
    22 μM
    Compound: Camptophecin
    Cytotoxicity against human Jurkat cells
    Cytotoxicity against human Jurkat cells
    		[PMID: 33421712]
    Jurkat IC50
    5.6 nM
    Compound: Camptothecin
    Inhibitory activity against Jurkat human leukemia cells
    Inhibitory activity against Jurkat human leukemia cells
    		[PMID: 11384245]
    Jurkat IC50
    5.6 nM
    Compound: Camptothecin
    Growth inhibitory activity against human Jurkat leukemia cell line (JLC)
    Growth inhibitory activity against human Jurkat leukemia cell line (JLC)
    		[PMID: 12620081]
    Jurkat IC50
    51.5 μM
    Compound: CPT
    Antiproliferative activity against human Jurkat cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay
    Antiproliferative activity against human Jurkat cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay
    		[PMID: 30853330]
    K562 GI50
    0.06 μM
    Compound: CPT
    Cytotoxicity against human K562 cells after 72 hrs by XTT assay
    Cytotoxicity against human K562 cells after 72 hrs by XTT assay
    		[PMID: 20591678]
    K562 GI50
    0.06 μM
    Compound: Camptothecin
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    		[PMID: 21115210]
    K562 GI50
    54.3 ng/mL
    Compound: 1; CPT
    Growth inhibition of human K562 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human K562 cells incubated for 72 hrs by MTT assay
    		[PMID: 38421819]
    K562 IC50
    0.04 μM
    Compound: CPT
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 24360564]
    K562 IC50
    0.04 μM
    Compound: CPT
    Cytotoxicity against human K562 cells by MTT assay
    Cytotoxicity against human K562 cells by MTT assay
    		[PMID: 36924947]
    K562 IC50
    0.04 μM
    Compound: camptothecin
    Growth inhibition of K562 cells by XTT assay after 5 days
    Growth inhibition of K562 cells by XTT assay after 5 days
    		[PMID: 17411092]
    K562 IC50
    0.04 μM
    Compound: camptothecin
    Cytotoxicity against human K562 cells after 5 days by XTT assay
    Cytotoxicity against human K562 cells after 5 days by XTT assay
    		[PMID: 18076140]
    K562 IC50
    0.07 μM
    Compound: CPT
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 30055465]
    K562 IC50
    0.08 μM
    Compound: CPT
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    K562 IC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human K562 cells after 4 days by ELISA reader assay
    Cytotoxicity against human K562 cells after 4 days by ELISA reader assay
    		[PMID: 19939682]
    K562 IC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human K562 cells in presence of 10% fetal bovine serum
    Cytotoxicity against human K562 cells in presence of 10% fetal bovine serum
    		[PMID: 20188578]
    K562 IC50
    0.09 μM
    Compound: Camp
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    		[PMID: 29223099]
    K562 IC50
    0.13 μM
    Compound: Camptothecin
    Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
    Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
    		[PMID: 25590864]
    K562 IC50
    0.32 μM
    Compound: CPT
    Cytotoxicity against human K562 cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    K562 IC50
    0.4 μM
    Compound: Camptothecin
    Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay
    Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay
    		[PMID: 24303808]
    K562 IC50
    0.58 μM
    Compound: Camptothecin
    Antitumor activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    K562 IC50
    0.59 μM
    Compound: Camptothecin
    Cytotoxicity against human K562 cells by MTT assay
    Cytotoxicity against human K562 cells by MTT assay
    		[PMID: 21115246]
    K562 IC50
    0.711 μM
    Compound: Camp
    Induction of apoptosis in human K562 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    Induction of apoptosis in human K562 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    		[PMID: 29223099]
    K562 IC50
    1.18 μM
    Compound: Camptothecin
    Cytotoxicity against human K562 cells after 2 days
    Cytotoxicity against human K562 cells after 2 days
    		[PMID: 22318164]
    K562 IC50
    1.4 μM
    Compound: 1, CPT
    Cytotoxicity against p53-deficient human K562 cells after 48 hrs by SRB assay
    Cytotoxicity against p53-deficient human K562 cells after 48 hrs by SRB assay
    		[PMID: 19715319]
    K562 IC50
    2 nM
    Compound: 1; CPT
    Cytotoxicity against human K562 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity against human K562 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
    		[PMID: 38421819]
    K562 IC50
    2 nM
    Compound: camptothecin
    Cytotoxicity against human imitinib-resistant K562 cells by MTT assay
    Cytotoxicity against human imitinib-resistant K562 cells by MTT assay
    		[PMID: 20329739]
    K562 IC50
    2 nM
    Compound: camptothecin
    Cytotoxicity against imatinib-resistant human K562 cells after 72 hrs by MTT assay
    Cytotoxicity against imatinib-resistant human K562 cells after 72 hrs by MTT assay
    		[PMID: 20590148]
    K562 IC50
    2.69 μM
    Compound: Camptothecin
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    		[PMID: 32526552]
    K562 IC50
    31 nM
    Compound: CPT
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    		[PMID: 24900725]
    K562 IC50
    5.37 μM
    Compound: CPT
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 25599951]
    K562 IC50
    57 nM
    Compound: CPT
    Antiproliferative activity measured against K562adr leukemia cells.
    Antiproliferative activity measured against K562adr leukemia cells.
    		[PMID: 9876111]
    K562 IC50
    < 0.003 μM
    Compound: CPT
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    Cytotoxicity against human K562 cells after 72 hrs by MTT assay
    		[PMID: 26226379]
    K562 IC50
    < 0.003 μM
    Compound: CPT
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    KB CC50
    0.006 μM
    Compound: Camptothecin
    Compound concentration required to reduce the exponential growth of KB cells by 50%
    Compound concentration required to reduce the exponential growth of KB cells by 50%
    		[PMID: 9767632]
    KB EC50
    0.0036 μM
    Compound: camptothecin
    Cytotoxicity against human KB cells
    Cytotoxicity against human KB cells
    		[PMID: 17552563]
    KB EC50
    0.01 μg/mL
    Compound: camptothecin
    Cytotoxicity against human KB cells after 72 hrs by MTS method
    Cytotoxicity against human KB cells after 72 hrs by MTS method
    		[PMID: 11858737]
    KB EC50
    0.01 μg/mL
    Compound: camptothecin
    Cytotoxicity against human KB cells
    Cytotoxicity against human KB cells
    		[PMID: 15270571]
    KB ED50
    2.3 μg/mL
    Compound: Camptothecin
    Cytotoxicity against human KB cells
    Cytotoxicity against human KB cells
    		[PMID: 7130986]
    KB ED50
    20.9 nM
    Compound: 3a, CPT, Camptothecin
    Cytotoxicity against human KB cells by sulforhodamine B assay
    Cytotoxicity against human KB cells by sulforhodamine B assay
    		[PMID: 17350834]
    KB ED50
    22 nM
    Compound: camptothecin
    Cytotoxicity against human KB cells
    Cytotoxicity against human KB cells
    		[PMID: 15043407]
    KB IC50
    0.003 μM
    Compound: 1, CPT
    Cytotoxicity against human KB cells after 4 days by MTT assay
    Cytotoxicity against human KB cells after 4 days by MTT assay
    		[PMID: 18554906]
    KB IC50
    0.008 μM
    Compound: Camptothecin
    Inhibitory concentration that reduced the viability of KB cell population by 50%.
    Inhibitory concentration that reduced the viability of KB cell population by 50%.
    		[PMID: 9003520]
    KB IC50
    0.009 μM
    Compound: 1 (Camptothecin)
    In vitro cytotoxicity against KB (human epidermoid carcinoma of the nasopharynx)
    In vitro cytotoxicity against KB (human epidermoid carcinoma of the nasopharynx)
    		[PMID: 14552770]
    KB IC50
    0.01 μg/mL
    Compound: 1
    Cytotoxicity in KB cancer cell line
    Cytotoxicity in KB cancer cell line
    		10.1016/S0960-894X(01)80158-X
    KB IC50
    0.01 μg/mL
    Compound: Camptothecin
    Cytotoxicity against human KB cells
    Cytotoxicity against human KB cells
    		[PMID: 8759170]
    KB IC50
    0.02 μM
    Compound: CPT
    Concentration required to inhibit cell proliferation in KBV-1 tumor cell line; overexpress MDR1
    Concentration required to inhibit cell proliferation in KBV-1 tumor cell line; overexpress MDR1
    		[PMID: 15482929]
    KB IC50
    0.02 μM
    Compound: Camptothecin
    Antiproliferative activity against human KB cells by SRB assay
    Antiproliferative activity against human KB cells by SRB assay
    		[PMID: 24200393]
    KB IC50
    0.03 μM
    Compound: Camptothecin
    Antiproliferative activity against drug-resistant tumor cell line KBV20C.
    Antiproliferative activity against drug-resistant tumor cell line KBV20C.
    		[PMID: 10411476]
    KB IC50
    0.035 μM
    Compound: Camptothecin
    Antiproliferative activity against drug-resistant tumor cell line KB7D.
    Antiproliferative activity against drug-resistant tumor cell line KB7D.
    		[PMID: 10411476]
    KB IC50
    0.037 μM
    Compound: 1
    Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B colorimetric assay
    Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B colorimetric assay
    		[PMID: 26994847]
    KB IC50
    0.037 μM
    Compound: 1, CPT
    Cytotoxicity against human KB cells after 72 hrs by SRB assay
    Cytotoxicity against human KB cells after 72 hrs by SRB assay
    		[PMID: 25003995]
    KB IC50
    0.04 μM
    Compound: Camptothecin
    Antiproliferative activity against drug-resistant tumor cell line KBwt.
    Antiproliferative activity against drug-resistant tumor cell line KBwt.
    		[PMID: 10411476]
    KB IC50
    0.04 μg/mL
    Compound: 1
    Cytotoxicity in KB VP-16 R cancer cell line
    Cytotoxicity in KB VP-16 R cancer cell line
    		10.1016/S0960-894X(01)80158-X
    KB IC50
    0.07 μM
    Compound: Camptothecin
    Antiproliferative activity against drug-resistant tumor cell line KBMDR.
    Antiproliferative activity against drug-resistant tumor cell line KBMDR.
    		[PMID: 10411476]
    KB IC50
    0.121 μM
    Compound: 1, CPT
    Cytotoxicity against human KB cells by SRB assay
    Cytotoxicity against human KB cells by SRB assay
    		[PMID: 23102893]
    KB IC50
    1.04 μM
    Compound: Camptothecin
    Antiproliferative activity against drug-resistant tumor cell line KBCamp.
    Antiproliferative activity against drug-resistant tumor cell line KBCamp.
    		[PMID: 10411476]
    KB IC50
    1.22 μM
    Compound: camptothecin
    Cytotoxicity against human KB cells by SRB staining-based fluorescence cytometry
    Cytotoxicity against human KB cells by SRB staining-based fluorescence cytometry
    		[PMID: 19653666]
    KB IC50
    28.7 nM
    Compound: Camptothecin
    Cytotoxicity against human KB cells by MTT assay
    Cytotoxicity against human KB cells by MTT assay
    		[PMID: 11858760]
    KB IC50
    38 nM
    Compound: camptothecin
    Cytotoxicity against human KB cells after 72 hrs by MTS assay
    Cytotoxicity against human KB cells after 72 hrs by MTS assay
    		[PMID: 19655762]
    KB IC50
    50 nM
    Compound: 1
    Cytotoxicity against human KB cells after 72 hrs by SRB assay
    Cytotoxicity against human KB cells after 72 hrs by SRB assay
    		[PMID: 28927790]
    KB IC50
    50 nM
    Compound: 1; CPT
    Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28285912]
    KB IC50
    8.8 nM
    Compound: CPT
    Antiproliferative activity against human KB cells after 72 hrs by ethylene blue dye assay
    Antiproliferative activity against human KB cells after 72 hrs by ethylene blue dye assay
    		[PMID: 22698783]
    KB IC50
    < 0.005 μg/mL
    Compound: 1 Camptothecin
    In vitro cytotoxicity against KB cell line (human epidermoid carcinoma of the nasopharynx) using MTT assay
    In vitro cytotoxicity against KB cell line (human epidermoid carcinoma of the nasopharynx) using MTT assay
    		[PMID: 15225719]
    KB IC50
    < 0.013 μM
    Compound: CPT
    Cytotoxicity against human KB cells after 3 days by MTT assay
    Cytotoxicity against human KB cells after 3 days by MTT assay
    		[PMID: 20392545]
    KB 3-1 IC50
    0.01 μM
    Compound: CPT
    Concentration required to inhibit cell proliferation in KB3-1 tumor cell line
    Concentration required to inhibit cell proliferation in KB3-1 tumor cell line
    		[PMID: 15482929]
    KB 3-1 IC50
    0.015 μM
    Compound: CPT
    Cytotoxicity against human KB3-1 cells after 4 days by MTT assay
    Cytotoxicity against human KB3-1 cells after 4 days by MTT assay
    		[PMID: 18676151]
    KB 3-1 IC50
    0.015 μM
    Compound: CPT
    Cytotoxicity against human KB3-1 cells by MTT method
    Cytotoxicity against human KB3-1 cells by MTT method
    		[PMID: 18771930]
    KB 3-1 IC50
    0.02 μM
    Compound: CPT
    Concentration required to inhibit cell proliferation in KBH5.0 tumor cell line; overexpress BCRP
    Concentration required to inhibit cell proliferation in KBH5.0 tumor cell line; overexpress BCRP
    		[PMID: 15482929]
    KB VCR R IC50
    0.009 μM
    Compound: 1 (Camptothecin)
    In vitro cytotoxicity against KB/VCR (Vincristine-resistant cancer cell line)
    In vitro cytotoxicity against KB/VCR (Vincristine-resistant cancer cell line)
    		[PMID: 14552770]
    KB VCR R IC50
    0.03 μg/mL
    Compound: 1
    Cytotoxicity in KB VCR R cancer cell line
    Cytotoxicity in KB VCR R cancer cell line
    		10.1016/S0960-894X(01)80158-X
    KB-V1 IC50
    0.025 μM
    Compound: CPT
    Cytotoxicity against human multidrug resistant MDR1 overexpressing human KBV1 cells after 4 days by MTT assay
    Cytotoxicity against human multidrug resistant MDR1 overexpressing human KBV1 cells after 4 days by MTT assay
    		[PMID: 18676151]
    KB-V1 IC50
    0.025 μM
    Compound: CPT
    Cytotoxicity against human KBV1 cells by MTT method
    Cytotoxicity against human KBV1 cells by MTT method
    		[PMID: 18771930]
    KG-1 IC50
    1.6 μM
    Compound: Camptothecin
    Cytotoxicity against human KG-1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
    Cytotoxicity against human KG-1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
    		[PMID: 33161122]
    KG-1 IC50
    2.31 μM
    Compound: Camptothecin
    Antitumor activity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    L02 IC50
    0.14 μM
    Compound: CPT
    Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay
    Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay
    		[PMID: 35612499]
    L02 IC50
    0.59 μM
    Compound: CPT
    Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 38154256]
    L02 IC50
    2.15 μM
    Compound: CPT
    Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 30875505]
    L02 IC50
    > 150 μM
    Compound: CPT
    Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay
    Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    L1210 ED50
    2.8 x 10-6 mM
    Compound: 1, Camptothecin
    Cytotoxicity against mouse L1210 cells
    Cytotoxicity against mouse L1210 cells
    		[PMID: 423214]
    L1210 IC50
    0.014 μM
    Compound: 1
    Concentration that inhibits the proliferation of L1210 cells by 50%
    Concentration that inhibits the proliferation of L1210 cells by 50%
    		[PMID: 2537428]
    L1210 IC50
    0.015 μM
    Compound: Camptothecin
    Cytotoxicity was measured on cultured murine lymphoblastic leukemia cells (L1210)
    Cytotoxicity was measured on cultured murine lymphoblastic leukemia cells (L1210)
    		[PMID: 8246238]
    L1210 IC50
    0.03 μM
    Compound: 1, CPT, NSC-100880
    Cytotoxicity against mouse L1210 cells
    Cytotoxicity against mouse L1210 cells
    		[PMID: 23578545]
    L1210 IC50
    0.03 μM
    Compound: Camptothecin
    Inhibitory concentration required against L1210 leukemia cells
    Inhibitory concentration required against L1210 leukemia cells
    		[PMID: 12182872]
    L1210 IC50
    0.06 μM
    Compound: CPT
    In vitro cytotoxic activity of compound against mouse leukemia L1210 cell line
    In vitro cytotoxic activity of compound against mouse leukemia L1210 cell line
    		[PMID: 15081041]
    L1210 IC50
    0.18 μM
    Compound: 13 ((S)-CPT, Camptothecin)
    In vitro cytotoxicity against L1210 mouse leukemia tumor cell line.
    In vitro cytotoxicity against L1210 mouse leukemia tumor cell line.
    		10.1016/0960-894X(96)00132-1
    L1210 IC50
    0.18 μM
    Compound: CPT ((S)-Camptothecin)
    Cytotoxicity against L1210 tumor cell lines in mice
    Cytotoxicity against L1210 tumor cell lines in mice
    		10.1016/0960-894X(96)00131-X
    L1210 IC50
    0.33 μM
    Compound: CPT
    Inhibitory concentration against L1210 leukemia cell proliferation
    Inhibitory concentration against L1210 leukemia cell proliferation
    		[PMID: 12873503]
    L1210 IC50
    126 nM
    Compound: CPT
    Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells
    Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells
    		10.1016/S0960-894X(97)00398-3
    L1210 IC50
    14 nM
    Compound: 1; CPT
    Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay
    Cytotoxicity against mouse L1210 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay
    		[PMID: 38421819]
    L1210 IC50
    23 nM
    Compound: 1 (Camptothecin)
    Inhibitory activity in mice bearing L1210 leukemia
    Inhibitory activity in mice bearing L1210 leukemia
    		[PMID: 1846923]
    L1210 IC50
    510 nM
    Compound: CPT
    Cytotoxicity against mouse L1210 cells overexpressing folate receptor assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against mouse L1210 cells overexpressing folate receptor assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 24901491]
    L2987 IC50
    0.4 μM
    Compound: 1 (CPT)
    Compound was evaluated for antigen specific activity in vitro L2987 cell line
    Compound was evaluated for antigen specific activity in vitro L2987 cell line
    		[PMID: 11755358]
    L929 IC50
    1.132 μM
    Compound: CPT
    Cytotoxicity against mouse L929 cells measured after 72 hrs
    Cytotoxicity against mouse L929 cells measured after 72 hrs
    		[PMID: 38716896]
    LN-229 IC50
    0.32 nM
    Compound: Camptothecin
    Cytotoxicity against human LN229 cells after 48 hrs by CCK8 assay
    Cytotoxicity against human LN229 cells after 48 hrs by CCK8 assay
    		[PMID: 30702286]
    LNCaP ED50
    2 nM
    Compound: 3a, CPT, Camptothecin
    Cytotoxicity against human LNCAP cells by sulforhodamine B assay
    Cytotoxicity against human LNCAP cells by sulforhodamine B assay
    		[PMID: 17350834]
    LNCaP ED50
    28 nM
    Compound: camptothecin
    Cytotoxicity against human LNCAP cells
    Cytotoxicity against human LNCAP cells
    		[PMID: 15043407]
    LNCaP ED50
    > 10 μM
    Compound: Camptothecin
    Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodamine B assay
    Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodamine B assay
    		[PMID: 19026551]
    LNCaP IC50
    86.1 nM
    Compound: Camptothecin
    Cytotoxicity against human LNCAP cells by MTT assay
    Cytotoxicity against human LNCAP cells by MTT assay
    		[PMID: 11858760]
    LOX IMVI IC50
    48 nM
    Compound: 1
    Cytotoxicity was determined in vitro in LOX cells (melanoma) of human tumor cell lines by using MTT assay
    Cytotoxicity was determined in vitro in LOX cells (melanoma) of human tumor cell lines by using MTT assay
    		[PMID: 7853331]
    LX-1 IC50
    0.12 μM
    Compound: camptothecin
    Cytotoxicity against human LX1 cells after 72 hrs by MTS method
    Cytotoxicity against human LX1 cells after 72 hrs by MTS method
    		[PMID: 11858737]
    LoVo GI50
    0.008 μM
    Compound: 1
    Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
    Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
    		[PMID: 21388138]
    LoVo IC50
    0.32 nM
    Compound: Camptothecin
    Cytotoxicity against human LoVo cells after 48 hrs by CCK8 assay
    Cytotoxicity against human LoVo cells after 48 hrs by CCK8 assay
    		[PMID: 30702286]
    LoVo IC50
    1.54 μM
    Compound: 1; CPT
    Antiproliferative activity against human LoVo cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against human LoVo cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    LoVo IC50
    3.1 μM
    Compound: CPT
    Cytotoxicity against human LoVo cells after 3 days by MTT assay
    Cytotoxicity against human LoVo cells after 3 days by MTT assay
    		[PMID: 20942490]
    Lu1 ED50
    29 nM
    Compound: camptothecin
    Cytotoxicity against human Lu1 cells
    Cytotoxicity against human Lu1 cells
    		[PMID: 15043407]
    Lu1 ED50
    > 10 μM
    Compound: Camptothecin
    Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay
    Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay
    		[PMID: 19026551]
    Lu1 IC50
    28.7 nM
    Compound: Camptothecin
    Cytotoxicity against human Lu1 cells by MTT assay
    Cytotoxicity against human Lu1 cells by MTT assay
    		[PMID: 11858760]
    M059J IC50
    5.5 μM
    Compound: CPT
    Cytotoxicity against human M059J cells assessed as cell growth inhibition after 24 hrs by XTT assay
    Cytotoxicity against human M059J cells assessed as cell growth inhibition after 24 hrs by XTT assay
    		[PMID: 26649907]
    MCF-10A IC50
    0.27 μM
    Compound: CPT
    Cytotoxicity against human MCF10A cells after 2 days
    Cytotoxicity against human MCF10A cells after 2 days
    		[PMID: 24904965]
    MCF-10A IC50
    0.97 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF10A cells after 2 days by CCK8 assay
    Cytotoxicity against human MCF10A cells after 2 days by CCK8 assay
    		[PMID: 26361737]
    MCF-10A IC50
    2.19 μM
    Compound: 1; CPT
    Antiproliferative activity against human MCF-10A cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MCF-10A cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    MCF-10A IC50
    2.58 μM
    Compound: CPT
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36351049]
    MCF-10A IC50
    3.02 μM
    Compound: CPT
    Cytotoxicity against HER-negative human MCF-10A cells incubated for 48 hrs by CCK-8 assay
    Cytotoxicity against HER-negative human MCF-10A cells incubated for 48 hrs by CCK-8 assay
    		[PMID: 38104378]
    MCF-12A IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human MCF12A cells after 3 days by SRB assay
    Cytotoxicity against human MCF12A cells after 3 days by SRB assay
    		[PMID: 23142674]
    MCF10 IC50
    24.77 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF10 cells assessed as reduction in cell viability after 3 hrs by MTT assay
    Cytotoxicity against human MCF10 cells assessed as reduction in cell viability after 3 hrs by MTT assay
    		[PMID: 33962153]
    MCF7 CC50
    0.02 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    MCF7 CC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    MCF7 EC50
    0.072 μM
    Compound: camptothecin
    Cytotoxicity against human MCF7 after 3 days by SRB assay
    Cytotoxicity against human MCF7 after 3 days by SRB assay
    		[PMID: 15730238]
    MCF7 ED50
    3.2 nM
    Compound: 3a, CPT, Camptothecin
    Cytotoxicity against human MCF7 cells by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells by sulforhodamine B assay
    		[PMID: 17350834]
    MCF7 ED50
    > 10 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay
    		[PMID: 19026551]
    MCF7 GI50
    0.002 μM
    Compound: Camptothecin
    Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
    Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23357037]
    MCF7 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells
    Cytotoxicity against human MCF7 cells
    		[PMID: 20630766]
    MCF7 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human MCF7 cells by SRB assay
    Antiproliferative activity against human MCF7 cells by SRB assay
    		[PMID: 21710981]
    MCF7 GI50
    0.01 μM
    Compound: 1
    Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
    Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 24800942]
    MCF7 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human MCF7 cells after 48 hrs
    Antiproliferative activity against human MCF7 cells after 48 hrs
    		[PMID: 27070999]
    MCF7 GI50
    0.01 μM
    Compound: 1, CPT
    Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay
    Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay
    		[PMID: 19715319]
    MCF7 GI50
    0.01 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 21115210]
    MCF7 GI50
    0.01 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 23831811]
    MCF7 GI50
    0.01 μM
    Compound: camptothecin
    Growth inhibition of MCF7 cells after 4 days
    Growth inhibition of MCF7 cells after 4 days
    		[PMID: 17418582]
    MCF7 GI50
    0.01 μM
    Compound: camptothecin
    Growth inhibition of adriamycin-resistant MCF7 cells after 4 days
    Growth inhibition of adriamycin-resistant MCF7 cells after 4 days
    		[PMID: 17418582]
    MCF7 GI50
    0.012 μM
    Compound: CPT
    Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
    		[PMID: 31176097]
    MCF7 GI50
    0.013 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 21823606]
    MCF7 GI50
    0.013 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 24502276]
    MCF7 GI50
    0.013 μM
    Compound: 1
    Antiproliferative activity against human MCF7 cells assessed as growth inhibition
    Antiproliferative activity against human MCF7 cells assessed as growth inhibition
    		[PMID: 28657311]
    MCF7 GI50
    0.013 μM
    Compound: 18
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 28418653]
    MCF7 GI50
    0.013 μM
    Compound: 2
    Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 22329436]
    MCF7 GI50
    0.06 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    MCF7 GI50
    0.28 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay
    		[PMID: 20438092]
    MCF7 GI50
    0.35 μM
    Compound: CPT
    Cytotoxicity against human MCF-7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF-7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 34008967]
    MCF7 GI50
    0.57 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells after 72 hrs by XTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by XTT assay
    		[PMID: 20591678]
    MCF7 GI50
    1.98 ng/mL
    Compound: 1; CPT
    Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
    Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
    		[PMID: 38421819]
    MCF7 GI50
    3.21 μM
    Compound: CPT
    Cytotoxicity against human MCF-7/TDP1 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF-7/TDP1 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 34008967]
    MCF7 GI50
    6 μM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 21388138]
    MCF7 IC50
    0.0005 μM
    Compound: 3
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 25084144]
    MCF7 IC50
    0.0006 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
    		[PMID: 25247770]
    MCF7 IC50
    0.003 μM
    Compound: 3
    Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay
    		[PMID: 25084144]
    MCF7 IC50
    0.021 μM
    Compound: CPT
    In-vitro antitumor activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
    In-vitro antitumor activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
    		[PMID: 35550978]
    MCF7 IC50
    0.02 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells after 3 days by MTT assay
    Cytotoxicity against human MCF7 cells after 3 days by MTT assay
    		[PMID: 20392545]
    MCF7 IC50
    0.02 μg/mL
    Compound: 1
    Cytotoxicity in MCF-7 cancer cell line
    Cytotoxicity in MCF-7 cancer cell line
    		10.1016/S0960-894X(01)80158-X
    MCF7 IC50
    0.03 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells by SRB assay
    Antiproliferative activity against human MCF7 cells by SRB assay
    		[PMID: 28274626]
    MCF7 IC50
    0.03 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    		[PMID: 31546197]
    MCF7 IC50
    0.04 μM
    Compound: CPT
    Antiproliferative activity against human MCF7 cells by MTT assay
    Antiproliferative activity against human MCF7 cells by MTT assay
    		[PMID: 17254669]
    MCF7 IC50
    0.04 μM
    Compound: CPT
    Cytotoxicity against against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 30340899]
    MCF7 IC50
    0.056 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay
    		[PMID: 21978950]
    MCF7 IC50
    0.06 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay
    Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay
    		[PMID: 19939682]
    MCF7 IC50
    0.07 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
    		[PMID: 21513293]
    MCF7 IC50
    0.073 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay
    		[PMID: 28409637]
    MCF7 IC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells incubated for 3 days by SRB assay
    Cytotoxicity against human MCF7 cells incubated for 3 days by SRB assay
    		[PMID: 22863526]
    MCF7 IC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 2 days by CCK-8 assay
    Cytotoxicity against human MCF7 cells after 2 days by CCK-8 assay
    		[PMID: 25481396]
    MCF7 IC50
    0.084 μM
    Compound: CPT
    Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
    		[PMID: 32292547]
    MCF7 IC50
    0.2 μM
    Compound: 1, CPT
    Cytotoxicity against human MCF7 cells after 4 days by MTT assay
    Cytotoxicity against human MCF7 cells after 4 days by MTT assay
    		[PMID: 18554906]
    MCF7 IC50
    0.32 μM
    Compound: CPT
    In vitro cytotoxic activity of compound against human MCF-7 cell line
    In vitro cytotoxic activity of compound against human MCF-7 cell line
    		[PMID: 15081041]
    MCF7 IC50
    0.324 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    MCF7 IC50
    0.34 μM
    Compound: Camp
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    		[PMID: 29223099]
    MCF7 IC50
    0.35 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    		[PMID: 35612499]
    MCF7 IC50
    0.42 μM
    Compound: CPT
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 30125725]
    MCF7 IC50
    0.56 μM
    Compound: 1; CPT
    Antiproliferative activity against human MCF7 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    MCF7 IC50
    0.65 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 21186067]
    MCF7 IC50
    0.68 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 30600208]
    MCF7 IC50
    0.68 μM
    Compound: CPT; 1
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 30509782]
    MCF7 IC50
    1.1 μM
    Compound: 1, CPT
    Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay
    Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay
    		[PMID: 19715319]
    MCF7 IC50
    1.22 μM
    Compound: camptothecin
    Cytotoxicity against human MCF7 cells by SRB staining-based fluorescence cytometry
    Cytotoxicity against human MCF7 cells by SRB staining-based fluorescence cytometry
    		[PMID: 19653666]
    MCF7 IC50
    1.6 nM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 22376176]
    MCF7 IC50
    1.6 nM
    Compound: camptothecin
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 21410162]
    MCF7 IC50
    1.67 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    MCF7 IC50
    1.8 μM
    Compound: camptothecin
    Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
    Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
    		[PMID: 22197145]
    MCF7 IC50
    10 nM
    Compound: camptothecin
    Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
    		[PMID: 19655762]
    MCF7 IC50
    10 μM
    Compound: camptothecin
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 18841903]
    MCF7 IC50
    11.12 μM
    Compound: 4
    Anticancer activity against human MCF7 cells
    Anticancer activity against human MCF7 cells
    		[PMID: 21599000]
    MCF7 IC50
    13.62 μM
    Compound: Camptothecin
    Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 28923382]
    MCF7 IC50
    14.2 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 4 days by MTT assay
    Cytotoxicity against human MCF7 cells after 4 days by MTT assay
    		[PMID: 20619511]
    MCF7 IC50
    160 nM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 29541373]
    MCF7 IC50
    18.6 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 36996717]
    MCF7 IC50
    2.43 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 21115246]
    MCF7 IC50
    2.5 μM
    Compound: CPT
    Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis
    Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis
    		[PMID: 30897325]
    MCF7 IC50
    2.5 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
    		[PMID: 32682183]
    MCF7 IC50
    2.6 μM
    Compound: camptothecin
    Cytotoxicity against human MCF7 cells by WST-1 assay
    Cytotoxicity against human MCF7 cells by WST-1 assay
    		[PMID: 22197145]
    MCF7 IC50
    2.8 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay
    		[PMID: 32526552]
    MCF7 IC50
    26 nM
    Compound: CPT
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 24900725]
    MCF7 IC50
    28.66 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 28462840]
    MCF7 IC50
    3 nM
    Compound: camptothecin
    Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay
    Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay
    		[PMID: 19655762]
    MCF7 IC50
    3.1 nM
    Compound: 1; CPT
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 38421819]
    MCF7 IC50
    3.1 nM
    Compound: CPT
    Antiproliferative activity measured against MCF-7-mdr cells.
    Antiproliferative activity measured against MCF-7-mdr cells.
    		[PMID: 9876111]
    MCF7 IC50
    3.3 nM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells by SRB assay
    Antiproliferative activity against human MCF7 cells by SRB assay
    		[PMID: 24200393]
    MCF7 IC50
    3.91 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 2 days
    Cytotoxicity against human MCF7 cells after 2 days
    		[PMID: 22318164]
    MCF7 IC50
    4.54 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay
    		[PMID: 27654394]
    MCF7 IC50
    6 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 24 hrs by XTT assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 24 hrs by XTT assay
    		[PMID: 26649907]
    MCF7 IC50
    6.39 μM
    Compound: CPT
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    MCF7 IC50
    6.85 μM
    Compound: CPT
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 38154256]
    MCF7 IC50
    65.1 nM
    Compound: CPT
    Cytotoxicity against human MCF7 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 24901491]
    MCF7 IC50
    7.42 μM
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 3 days
    Cytotoxicity against human MCF7 cells after 3 days
    		[PMID: 19954977]
    MCF7 IC50
    71.3 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 28063351]
    MCF7 IC50
    87.5 nM
    Compound: 1
    Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
    		[PMID: 28927790]
    MCF7 IC50
    87.5 nM
    Compound: 1; CPT
    Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28285912]
    MCF7 IC50
    < 0.0018 μM
    Compound: Camptothecin
    Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay
    Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay
    		[PMID: 28006904]
    MCF7 IC50
    < 0.0018 μM
    Compound: Camptothecin
    Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay
    Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay
    		[PMID: 28006904]
    MCF7 IC50
    < 0.0018 μM
    Compound: Camptothecin
    Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay
    Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay
    		[PMID: 28006904]
    MCF7 IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells after 3 days by SRB assay
    Cytotoxicity against human MCF7 cells after 3 days by SRB assay
    		[PMID: 23142674]
    MCF7 IC50
    < 0.01 μM
    Compound: Camptothecin
    Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
    Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 24180210]
    MCF7 IC50
    < 0.01 μM
    Compound: Camptothecin
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 6 days by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 6 days by SRB assay
    		[PMID: 38107170]
    MCF7 IC50
    < 0.024 μg/mL
    Compound: Camptothecin
    Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 24940955]
    MCF7 IC50
    < 0.1 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
    		[PMID: 22409771]
    MCF7 IC50
    < 1 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay
    Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay
    		[PMID: 22867707]
    MCF7 IC50
    <= 0.1 μM
    Compound: CPT
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 26810835]
    MDA-MB-157 IC50
    0.02 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-157 cells after 3 days by SRB assay
    Cytotoxicity against human MDA-MB-157 cells after 3 days by SRB assay
    		[PMID: 23142674]
    MDA-MB-231 GI50
    0.4 μM
    Compound: Camptothecin
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    MDA-MB-231 GI50
    1.3 μM
    Compound: Camptothecin
    Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay
    Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay
    		[PMID: 20438092]
    MDA-MB-231 IC50
    0.108 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    MDA-MB-231 IC50
    0.17 μM
    Compound: CPT
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
    		[PMID: 34171512]
    MDA-MB-231 IC50
    0.241 μM
    Compound: CPT
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
    		[PMID: 34052678]
    MDA-MB-231 IC50
    0.291 μM
    Compound: camptothecin
    Growth inhibition of human MDA-MB-231 cells by neutral red assay
    Growth inhibition of human MDA-MB-231 cells by neutral red assay
    		[PMID: 17204425]
    MDA-MB-231 IC50
    0.3 μM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system
    Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system
    		[PMID: 20392646]
    MDA-MB-231 IC50
    0.32 nM
    Compound: Camptothecin
    Cytotoxicity against human MDA231 cells after 48 hrs by CCK8 assay
    Cytotoxicity against human MDA231 cells after 48 hrs by CCK8 assay
    		[PMID: 30702286]
    MDA-MB-231 IC50
    0.33 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-231 after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-231 after 48 hrs by SRB assay
    		[PMID: 21044847]
    MDA-MB-231 IC50
    0.342 μM
    Compound: CPT, Camptothecin
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 24980118]
    MDA-MB-231 IC50
    0.42 μM
    Compound: 1; CPT
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    MDA-MB-231 IC50
    0.49 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-231 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
    		[PMID: 35612499]
    MDA-MB-231 IC50
    0.53 μM
    Compound: CPT
    Cytotoxicity against HER-negative human MDA-MB-231 cells incubated for 48 hrs by CCK-8 assay
    Cytotoxicity against HER-negative human MDA-MB-231 cells incubated for 48 hrs by CCK-8 assay
    		[PMID: 38104378]
    MDA-MB-231 IC50
    0.62 μM
    Compound: CPT
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 38154256]
    MDA-MB-231 IC50
    0.68 μM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-231 cells by MTT assay
    Cytotoxicity against human MDA-MB-231 cells by MTT assay
    		[PMID: 19836231]
    MDA-MB-231 IC50
    0.92 μM
    Compound: camptothecin
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 20093033]
    MDA-MB-231 IC50
    0.97 μM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-231 cells after 2 days
    Cytotoxicity against human MDA-MB-231 cells after 2 days
    		[PMID: 21419530]
    MDA-MB-231 IC50
    1.06 μM
    Compound: CPT
    Cytotoxicity against HER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity against HER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36351049]
    MDA-MB-231 IC50
    1.1 μM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-231 cells after 3 days
    Cytotoxicity against human MDA-MB-231 cells after 3 days
    		[PMID: 19954977]
    MDA-MB-231 IC50
    16.44 μM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 30109008]
    MDA-MB-231 IC50
    162 nM
    Compound: CPT
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
    		[PMID: 24900725]
    MDA-MB-231 IC50
    2.11 μM
    Compound: CPT
    Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
    		10.1039/C4MD00133H
    MDA-MB-231 IC50
    2.7 μM
    Compound: camptothecin
    Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
    Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
    		[PMID: 22197145]
    MDA-MB-231 IC50
    23.98 μM
    Compound: Camptothecin
    Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay
    Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay
    		[PMID: 31398033]
    MDA-MB-231 IC50
    264 nM
    Compound: 1; CPT
    Antiproliferative activity against human MDA-MB-231 cells transfected with siRNA-Ctrl assessed as cell viability by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells transfected with siRNA-Ctrl assessed as cell viability by MTT assay
    		[PMID: 34844412]
    MDA-MB-231 IC50
    28.4 nM
    Compound: Camptothecin
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay
    		[PMID: 32952994]
    MDA-MB-231 IC50
    307 nM
    Compound: 1
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
    		[PMID: 28927790]
    MDA-MB-231 IC50
    307 nM
    Compound: 1; CPT
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 28285912]
    MDA-MB-231 IC50
    4.16 μM
    Compound: camptothecin
    Cytotoxicity against human MDA-MB-231 cells
    Cytotoxicity against human MDA-MB-231 cells
    		[PMID: 18178085]
    MDA-MB-231 IC50
    4.2 μM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay
    		[PMID: 20619511]
    MDA-MB-231 IC50
    5.77 μM
    Compound: Camptothecin
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
    		[PMID: 26602827]
    MDA-MB-231 IC50
    540 nM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 29541373]
    MDA-MB-231 IC50
    8.83 μM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay
    		[PMID: 27707625]
    MDA-MB-231 IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay
    Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay
    		[PMID: 23142674]
    MDA-MB-231 IC50
    < 0.01 μM
    Compound: Camptothecin
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition
    		[PMID: 38107170]
    MDA-MB-231 IC50
    > 100 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-231 cells
    Cytotoxicity against human MDA-MB-231 cells
    		[PMID: 36924947]
    MDA-MB-231 IC50
    > 100 μM
    Compound: CPT
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    MDA-MB-231 IC50
    > 6.4 μM
    Compound: 1; CPT
    Antiproliferative activity against human MDA-MB-231 cells transfected with siRNA-Top1 assessed as cell viability by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells transfected with siRNA-Top1 assessed as cell viability by MTT assay
    		[PMID: 34844412]
    MDA-MB-361 IC50
    0.17 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-361 cells after 3 days by SRB assay
    Cytotoxicity against human MDA-MB-361 cells after 3 days by SRB assay
    		[PMID: 23142674]
    MDA-MB-361 IC50
    0.17 μM
    Compound: Camptothecin
    Antitumor activity against human MDA-MB-361 cells assessed as tumor growth inhibition
    Antitumor activity against human MDA-MB-361 cells assessed as tumor growth inhibition
    		[PMID: 38107170]
    MDA-MB-435 GI50
    0.033 μM
    Compound: 1, CPT
    Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 1
    Antiproliferative activity against human MDA-MB-435 cell line
    Antiproliferative activity against human MDA-MB-435 cell line
    		[PMID: 16442283]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 1
    Antiproliferative activity against human MDA-MB-435 cells
    Antiproliferative activity against human MDA-MB-435 cells
    		[PMID: 18630891]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 1
    Cytotoxicity against human MDA-MB-435 cells
    Cytotoxicity against human MDA-MB-435 cells
    		[PMID: 19783447]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 1, CPT
    Antiproliferative activity against human MDA-MB-435 cells
    Antiproliferative activity against human MDA-MB-435 cells
    		[PMID: 20155916]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 1, Camptothecin
    Cytotoxicity against human MDA-MB-435 cells
    Cytotoxicity against human MDA-MB-435 cells
    		[PMID: 17676830]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 2
    Growth inhibitory activity against human breast MDA-MB-435 cell line
    Growth inhibitory activity against human breast MDA-MB-435 cell line
    		[PMID: 15509164]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 2
    Antiproliferative activity against human MDA-MB-435 cell line
    Antiproliferative activity against human MDA-MB-435 cell line
    		[PMID: 16913702]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 2
    Cytotoxicity against human MDA-MB-435 cells
    Cytotoxicity against human MDA-MB-435 cells
    		[PMID: 17696418]
    MDA-MB-435 GI50
    0.04 μM
    Compound: 2 (Camptothecin)
    Antiproliferative activity was determined for 50% growth inhibition against human breast MDA-MB-435 cell line
    Antiproliferative activity was determined for 50% growth inhibition against human breast MDA-MB-435 cell line
    		[PMID: 11020283]
    MDA-MB-435 GI50
    0.04 μM
    Compound: Camptothecin
    Concentration required to inhibit the growth of human Breast MDA-MB-435 cells
    Concentration required to inhibit the growth of human Breast MDA-MB-435 cells
    		[PMID: 16033260]
    MDA-MB-435 IC50
    0.0436 μM
    Compound: CPT
    Antiproliferative activity against human MDA-MB-435 cells after 3 days by MTT assay
    Antiproliferative activity against human MDA-MB-435 cells after 3 days by MTT assay
    		[PMID: 23084702]
    MDA-MB-435 IC50
    0.31 μM
    Compound: 1; CPT
    Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition rate incubated for 72 hrs by MTT assay
    		[PMID: 34844412]
    MDA-MB-435 IC50
    0.71 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay
    Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay
    		[PMID: 20942490]
    MDA-MB-435 IC50
    1 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
    		[PMID: 26226379]
    MDA-MB-435 IC50
    15 nM
    Compound: camptothecin
    Inhibition against MDA-MB-435 human breast cancer cells in the absence of HSA
    Inhibition against MDA-MB-435 human breast cancer cells in the absence of HSA
    		[PMID: 11052802]
    MDA-MB-435 IC50
    2.7 μM
    Compound: CPT
    Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    MDA-MB-435 IC50
    375 nM
    Compound: camptothecin
    Inhibition against MDA-MB-435 human breast cancer cells in the presence of 11 mg/mL HSA
    Inhibition against MDA-MB-435 human breast cancer cells in the presence of 11 mg/mL HSA
    		[PMID: 11052802]
    MDA-MB-435 IC50
    < 0.001 μM
    Compound: 1, CPT
    Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay
    		[PMID: 24069881]
    MDA-MB-436 IC50
    31.86 μM
    Compound: Camptothecin
    Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay
    Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay
    		[PMID: 31398033]
    MDA-MB-453 IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human MDA-MB-453 cells after 3 days by SRB assay
    Cytotoxicity against human MDA-MB-453 cells after 3 days by SRB assay
    		[PMID: 23142674]
    MDA-MB-453 IC50
    < 0.01 μM
    Compound: Camptothecin
    Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell growth after 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell growth after 72 hrs by MTT assay
    		[PMID: 38107170]
    MDA-MB-468 IC50
    1.71 μM
    Compound: Camptothecin
    Cytotoxicity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay
    Cytotoxicity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay
    		[PMID: 27707625]
    MDA-MB-468 IC50
    14.76 μM
    Compound: Camptothecin
    Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay
    		[PMID: 26602827]
    MDA-MB-468 IC50
    > 100 μM
    Compound: CPT
    Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    MEF IC50
    5.87 μg/mL
    Compound: Camptothecin
    Cytotoxicity against mouse MEF cells after 72 hrs by MTT assay
    Cytotoxicity against mouse MEF cells after 72 hrs by MTT assay
    		[PMID: 25867737]
    MES-SA IC50
    57 nM
    Compound: 1a
    Cytotoxicity against human MESSA cells after 72 hrs by alamar blue assay
    Cytotoxicity against human MESSA cells after 72 hrs by alamar blue assay
    		[PMID: 21341674]
    MES-SA/Dx5 IC50
    52 nM
    Compound: 1a
    Cytotoxicity against human MES-SA/Dx5 cells overexpressing MDR1 after 72 hrs by alamar blue assay
    Cytotoxicity against human MES-SA/Dx5 cells overexpressing MDR1 after 72 hrs by alamar blue assay
    		[PMID: 21341674]
    MFE-296 IC50
    < 1 μM
    Compound: CPT
    Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay
    Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay
    		[PMID: 22867707]
    MG-63 IC50
    0.046 μM
    Compound: CPT
    Cytotoxicity against human MG-63 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human MG-63 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    MGC-803 IC50
    17.76 μM
    Compound: Camptothecin
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 36996717]
    MGC-803 IC50
    2.96 μM
    Compound: CPT
    Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
    		[PMID: 30685528]
    MGC-803 IC50
    4.27 μM
    Compound: CPT
    Antiproliferative activity against human MGC803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MGC803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 30875505]
    MGC-803 IC50
    9.45 μM
    Compound: Camptothecin
    Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
    		[PMID: 28462840]
    MGC-803 IC50
    > 100 μM
    Compound: CPT
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    MGC-803 IC50
    > 150 μM
    Compound: CPT
    Antiproliferative activity against human MGC-803 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human MGC-803 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    MHCC97H IC50
    0.32 nM
    Compound: Camptothecin
    Cytotoxicity against human MHCC97H cells after 48 hrs by CCK8 assay
    Cytotoxicity against human MHCC97H cells after 48 hrs by CCK8 assay
    		[PMID: 30702286]
    MIA PaCa-2 IC50
    0.18 μM
    Compound: CPT
    Antiproliferative activity against human MIAPaCa2 cells after 48 hrs in presence of type 1 collagen coated surface by MTT assay
    Antiproliferative activity against human MIAPaCa2 cells after 48 hrs in presence of type 1 collagen coated surface by MTT assay
    		[PMID: 28689976]
    MIA PaCa-2 IC50
    0.19 μM
    Compound: Camptothecin
    Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by MTT assay
    		10.1039/C4MD00344F
    MIA PaCa-2 IC50
    0.19 μM
    Compound: Camptothecin
    Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay
    Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay
    		[PMID: 24041234]
    MIA PaCa-2 IC50
    0.4 μM
    Compound: Camptothecin
    Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
    Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
    		[PMID: 21775156]
    MIA PaCa-2 IC50
    > 10 μM
    Compound: CPT
    Cytotoxicity against human MIAPaCa2 cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human MIAPaCa2 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 24484281]
    MKN-45 IC50
    17 nM
    Compound: CPT
    In Vitro cytotoxicity against human stomach cancer cell line (MKN45)
    In Vitro cytotoxicity against human stomach cancer cell line (MKN45)
    		[PMID: 11334569]
    MOLT-4 IC50
    0.04 nM
    Compound: CPT
    Cytotoxicity against human MOLT4 cells after 72 hrs by MTT assay
    Cytotoxicity against human MOLT4 cells after 72 hrs by MTT assay
    		[PMID: 24900725]
    MRC5 CC50
    0.2 μM
    Compound: Camptothecin
    Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay
    Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    MRC5 CC50
    0.2 μM
    Compound: Camptothecin
    Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay
    Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    MRC5 IC50
    0.8 μM
    Compound: CPT
    Cytotoxicity against human MRC5 cells assessed as cell growth inhibition measured after 3 days by resazurin staining based analysis
    Cytotoxicity against human MRC5 cells assessed as cell growth inhibition measured after 3 days by resazurin staining based analysis
    		[PMID: 34952177]
    MRC5 IC50
    0.89 μM
    Compound: 4
    Antiproliferative activity against human MRC5 cells
    Antiproliferative activity against human MRC5 cells
    		[PMID: 21599000]
    MRC5 IC50
    1.7 x 10-5 μM
    Compound: CPT
    Antiproliferative activity against human MRC5 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human MRC5 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
    		[PMID: 33962152]
    MRC5 IC50
    1.7 μM
    Compound: I; CPT
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
    		[PMID: 32279049]
    MRC5 IC50
    9.02 μM
    Compound: Camptothecin
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 36758308]
    MRC5 IC50
    > 300 μM
    Compound: CPT
    Cytostatic activity against human MRC5 cells after 24 hrs by CCK-8 assay
    Cytostatic activity against human MRC5 cells after 24 hrs by CCK-8 assay
    		[PMID: 38278140]
    MSTO-211H GI50
    0.0021 μM
    Compound: CPT
    Growth inhibition of human MSTO-211H cells after 72 hrs by trypan blue assay
    Growth inhibition of human MSTO-211H cells after 72 hrs by trypan blue assay
    		[PMID: 27597409]
    MT4 CC50
    0.004 μM
    Compound: Camptothecin
    Cytotoxicity against human MT4 cells after 96 hrs by MTT assay
    Cytotoxicity against human MT4 cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    MT4 CC50
    0.01 μM
    Compound: Camptothecin
    Compound concentration required to reduce the exponential growth of MT-4 cells by 50%
    Compound concentration required to reduce the exponential growth of MT-4 cells by 50%
    		[PMID: 9767632]
    MT4 IC50
    0.004 μM
    Compound: CPT
    Antiproliferative activity against human MT4 cells by MTT assay
    Antiproliferative activity against human MT4 cells by MTT assay
    		[PMID: 17254669]
    MT4 IC50
    0.004 μM
    Compound: Camptothecin
    Cytotoxicity against human MT4 cells after 96 hrs
    Cytotoxicity against human MT4 cells after 96 hrs
    		[PMID: 22276775]
    MX1 IC50
    1700 nM
    Compound: CPT
    Cytotoxicity against human MX1 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MX1 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 24901491]
    Macrophage EC50
    18.32 μM
    Compound: CPT
    Cytotoxicity against BALB/c mouse macrophage assessed as cell viability measured after 48 hrs infection by propidium iodide staining analysis relative to control
    Cytotoxicity against BALB/c mouse macrophage assessed as cell viability measured after 48 hrs infection by propidium iodide staining analysis relative to control
    		[PMID: 36823782]
    Macrophage IC50
    0.62 μM
    Compound: CPT
    Cytotoxicity against BALB/C mouse macrophages
    Cytotoxicity against BALB/C mouse macrophages
    		[PMID: 22932312]
    Mahlavu IC50
    < 0.1 μM
    Compound: CPT
    Cytotoxicity against human Mahlavu cells after 72 hrs by SRB assay
    Cytotoxicity against human Mahlavu cells after 72 hrs by SRB assay
    		[PMID: 22409771]
    Mahlavu IC50
    < 1 μM
    Compound: CPT
    Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 26810835]
    NB-4 IC50
    2.01 μM
    Compound: Camptothecin
    Antitumor activity against human NB4 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against human NB4 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    NCI-H128 IC50
    18 nM
    Compound: CPT
    In Vitro cytotoxicity against human lung cancer cell line (H128)
    In Vitro cytotoxicity against human lung cancer cell line (H128)
    		[PMID: 11334569]
    NCI-H1299 IC50
    0.8 μM
    Compound: Camptothecin
    Cytotoxicity against human NCI-H1299 cells by MTT assay
    Cytotoxicity against human NCI-H1299 cells by MTT assay
    		[PMID: 28506750]
    NCI-H1299 IC50
    3.14 μM
    Compound: CPT
    Antiproliferative activity against human H1299 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human H1299 cells incubated for 72 hrs by MTT assay
    		10.1039/C4MD00133H
    NCI-H1299 IC50
    > 100 μM
    Compound: CPT
    Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    NCI-H1975 IC50
    1.2 μM
    Compound: Camptothecin
    Cytotoxicity against human NCI-H1975 cells by MTT assay
    Cytotoxicity against human NCI-H1975 cells by MTT assay
    		[PMID: 28506750]
    NCI-H23 IC50
    0.07 μM
    Compound: CPT
    Cytotoxicity against human NCI-H23 cells assessed as cell viability after 96 hrs by MTT assay
    Cytotoxicity against human NCI-H23 cells assessed as cell viability after 96 hrs by MTT assay
    		[PMID: 27156772]
    NCI-H446 IC50
    > 200 μM
    Compound: CPT
    Cytotoxicity against human NCI-H446 cells after 72 hrs by MTT assay
    Cytotoxicity against human NCI-H446 cells after 72 hrs by MTT assay
    		[PMID: 26226379]
    NCI-H446 IC50
    > 200 μM
    Compound: CPT
    Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    NCI-H460 EC50
    0.0069 μM
    Compound: camptothecin
    Cytotoxicity against human H460 after 3 days by SRB assay
    Cytotoxicity against human H460 after 3 days by SRB assay
    		[PMID: 15730238]
    NCI-H460 GI50
    0.002 μM
    Compound: CPT
    Growth inhibition of human H460 cells after 72 hrs by trypan blue assay
    Growth inhibition of human H460 cells after 72 hrs by trypan blue assay
    		[PMID: 27597409]
    NCI-H460 GI50
    0.0057 μM
    Compound: Camptothecin
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    NCI-H460 GI50
    0.03 μM
    Compound: CPT
    Cytotoxicity against human NCI-H460 cells after 72 hrs by XTT assay
    Cytotoxicity against human NCI-H460 cells after 72 hrs by XTT assay
    		[PMID: 20591678]
    NCI-H460 IC50
    0.002 μM
    Compound: Camptothecin
    Cytotoxicity against human NCI-H460 cells incubated for 3 days by SRB assay
    Cytotoxicity against human NCI-H460 cells incubated for 3 days by SRB assay
    		[PMID: 22863526]
    NCI-H460 IC50
    0.003 μM
    Compound: Camptothecin
    Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay
    		[PMID: 22758788]
    NCI-H460 IC50
    0.0062 μM
    Compound: 1, CPT
    Cytotoxicity against human H460 cells after 72 hrs
    Cytotoxicity against human H460 cells after 72 hrs
    		[PMID: 18419110]
    NCI-H460 IC50
    0.03 μM
    Compound: 4
    Anticancer activity against human NCI-H460 cells
    Anticancer activity against human NCI-H460 cells
    		[PMID: 21599000]
    NCI-H460 IC50
    0.12 μM
    Compound: CPT
    Cytotoxicity against human NCI-H460 cells assessed as cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as cell viability measured after 48 hrs by MTT assay
    		[PMID: 32711231]
    NCI-H460 IC50
    0.18 μM
    Compound: 1, camptothecin, CPT
    Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs
    Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs
    		[PMID: 18424133]
    NCI-H460 IC50
    0.19 μM
    Compound: CPT
    Cytotoxicity against human NCI-H460 cells assessed as cell viability after 96 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as cell viability after 96 hrs by MTT assay
    		[PMID: 27156772]
    NCI-H460 IC50
    0.33 μM
    Compound: 1, CPT
    Cytotoxicity against human H460 cells after 1 hr
    Cytotoxicity against human H460 cells after 1 hr
    		[PMID: 18419110]
    NCI-H460 IC50
    0.33 μM
    Compound: 1, CPT
    Antiproliferative activity against human NCI-H460 cells after short term exposure for 1 hr measured after 72 hrs in drug-free medium
    Antiproliferative activity against human NCI-H460 cells after short term exposure for 1 hr measured after 72 hrs in drug-free medium
    		[PMID: 19530720]
    NCI-H460 IC50
    0.33 μM
    Compound: 1a (Camptothecin)
    In vitro cytotoxic activity against human non small cell lung carcinoma H460 cell line
    In vitro cytotoxic activity against human non small cell lung carcinoma H460 cell line
    		[PMID: 11052801]
    NCI-H460 IC50
    0.79 μM
    Compound: Camptothecin
    Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 36758308]
    NCI-H460 IC50
    110 nM
    Compound: Camptothecin
    Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 29541373]
    NCI-H460 IC50
    13 nM
    Compound: 1a
    Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay
    		[PMID: 21341674]
    NCI-H460 IC50
    5 nM
    Compound: Cpt
    Cytotoxicity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 22749423]
    NCI-H460 IC50
    5.37 μM
    Compound: CPT
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 30875505]
    NCI-H460 IC50
    < 0.04 μM
    Compound: Camptothecin
    Cytotoxicity against human H460 cells after 72 hrs by MTS assay
    Cytotoxicity against human H460 cells after 72 hrs by MTS assay
    		[PMID: 21513293]
    NCI-H460 IC50
    > 1000 nM
    Compound: 1a
    Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay in presence of 40 mg/ml HSA
    Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay in presence of 40 mg/ml HSA
    		[PMID: 21341674]
    NCI-H460 IC50
    > 25 μM
    Compound: CPT
    Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
    		[PMID: 20638158]
    NCI-H520 IC50
    25.01 nM
    Compound: CPT
    Cytotoxicity against human NCI-H520 cells assessed as inhibition of cell growth
    Cytotoxicity against human NCI-H520 cells assessed as inhibition of cell growth
    		[PMID: 37806498]
    NCI-H69 IC50
    1 nM
    Compound: 1a
    Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay
    		[PMID: 21341674]
    NCI-H928 IC50
    7.8 nM
    Compound: 1
    Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]-thymidine into cellular DNA of human lung carcinoma cells (H928)
    Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]-thymidine into cellular DNA of human lung carcinoma cells (H928)
    		[PMID: 10479293]
    NCI-N87 IC50
    0.6 μM
    Compound: Camptothecin
    Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay
    Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay
    		[PMID: 27484510]
    NCI-N87 IC50
    2.07 μM
    Compound: CPT
    Cytotoxicity against HER-positive human NCI-N87 cells incubated for 48 hrs by CCK-8 assay
    Cytotoxicity against HER-positive human NCI-N87 cells incubated for 48 hrs by CCK-8 assay
    		[PMID: 38104378]
    NCI-N87 IC50
    2.32 μM
    Compound: CPT
    Cytotoxicity against HER-positive human NCI-N87 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity against HER-positive human NCI-N87 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36351049]
    NCI/ADR-RES IC50
    0.8 μM
    Compound: camptothecin
    Cytotoxicity against human MCF7/ADR cells by WST-1 assay
    Cytotoxicity against human MCF7/ADR cells by WST-1 assay
    		[PMID: 22197145]
    NHDF IC50
    5.38 μM
    Compound: Camptothecin
    Cytotoxicity against HDF cells
    Cytotoxicity against HDF cells
    		[PMID: 32932211]
    NIH3T3 IC50
    0.086 μM
    Compound: CPT
    Cytotoxicity against mouse NIH3T3 cells measured after 72 hrs
    Cytotoxicity against mouse NIH3T3 cells measured after 72 hrs
    		[PMID: 38716896]
    NIH3T3 IC50
    12 μM
    Compound: Camptothecin
    Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
    Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
    		[PMID: 11430001]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Antiproliferative activity against human OVCAR-3 cell line
    Antiproliferative activity against human OVCAR-3 cell line
    		[PMID: 16442283]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Cytotoxicity against human OVCAR-3 cells
    Cytotoxicity against human OVCAR-3 cells
    		[PMID: 17402722]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Antiproliferative activity against human OVCAR-3 cells
    Antiproliferative activity against human OVCAR-3 cells
    		[PMID: 18630891]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Cytotoxicity against human OVCAR-3 cells
    Cytotoxicity against human OVCAR-3 cells
    		[PMID: 19783447]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Cytotoxicity against human OVCAR-3 cells
    Cytotoxicity against human OVCAR-3 cells
    		[PMID: 20630766]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Antiproliferative activity against human OVCAR3 cells by SRB assay
    Antiproliferative activity against human OVCAR3 cells by SRB assay
    		[PMID: 21710981]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay
    Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay
    		[PMID: 21823606]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Cytotoxicity against human OVCAR3 cells by SRB assay
    Cytotoxicity against human OVCAR3 cells by SRB assay
    		[PMID: 24502276]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay
    Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay
    		[PMID: 24800942]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Antiproliferative activity against human OVCAR3 cells after 48 hrs
    Antiproliferative activity against human OVCAR3 cells after 48 hrs
    		[PMID: 27070999]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1
    Antiproliferative activity against human OVCAR3 cells assessed as growth inhibition
    Antiproliferative activity against human OVCAR3 cells assessed as growth inhibition
    		[PMID: 28657311]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1, CPT
    Antiproliferative activity against human OVCAR-3 cells
    Antiproliferative activity against human OVCAR-3 cells
    		[PMID: 20155916]
    OVCAR-3 GI50
    0.22 μM
    Compound: 1, Camptothecin
    Cytotoxicity against human OVCAR-3 cells
    Cytotoxicity against human OVCAR-3 cells
    		[PMID: 17676830]
    OVCAR-3 GI50
    0.22 μM
    Compound: 18
    Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay
    Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay
    		[PMID: 28418653]
    OVCAR-3 GI50
    0.22 μM
    Compound: 2
    Growth inhibitory activity against human ovarian OVCAR-3 cell line
    Growth inhibitory activity against human ovarian OVCAR-3 cell line
    		[PMID: 15509164]
    OVCAR-3 GI50
    0.22 μM
    Compound: 2
    Antiproliferative activity against human OVCAR-3 cell line
    Antiproliferative activity against human OVCAR-3 cell line
    		[PMID: 16913702]
    OVCAR-3 GI50
    0.22 μM
    Compound: 2
    Cytotoxicity against human OVCAR-3 cells
    Cytotoxicity against human OVCAR-3 cells
    		[PMID: 17696418]
    OVCAR-3 GI50
    0.22 μM
    Compound: 2
    Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 22329436]
    OVCAR-3 GI50
    0.22 μM
    Compound: 2 (Camptothecin)
    Antiproliferative activity was determined for 50% growth inhibition against human ovarian OVCAR-3 cell line
    Antiproliferative activity was determined for 50% growth inhibition against human ovarian OVCAR-3 cell line
    		[PMID: 11020283]
    P388 ED50
    8.6 x 10-6 mM
    Compound: 1, Camptothecin
    Cytotoxicity against mouse P388 cells
    Cytotoxicity against mouse P388 cells
    		[PMID: 423214]
    P388 IC50
    0.004 nM
    Compound: CPT, campothecin
    Cytotoxicity against human P388 cells
    Cytotoxicity against human P388 cells
    		[PMID: 18511275]
    P388 IC50
    0.004 μM
    Compound: CPT
    Cytotoxicity against mouse P388 cells by MTT method
    Cytotoxicity against mouse P388 cells by MTT method
    		[PMID: 18771930]
    P388 IC50
    0.004 μM
    Compound: CPT
    Cytotoxicity against mouse P388 cells after 4 days by MTT assay
    Cytotoxicity against mouse P388 cells after 4 days by MTT assay
    		[PMID: 19299037]
    P388 IC50
    0.004 μM
    Compound: CPT
    Cytotoxicity against mouse P388 cells after 4 days by MTT method
    Cytotoxicity against mouse P388 cells after 4 days by MTT method
    		[PMID: 19303306]
    P388 IC50
    0.005 μg/mL
    Compound: Camptothecin (CPT)
    Tested for the cytostatic activity as inhibitory concentration against P-388 mouse leukemia cells
    Tested for the cytostatic activity as inhibitory concentration against P-388 mouse leukemia cells
    		10.1016/S0960-894X(97)00071-1
    P388 IC50
    0.009 μM
    Compound: CPT
    Cytotoxicity against mouse P388 cells after 4 days by MTT assay
    Cytotoxicity against mouse P388 cells after 4 days by MTT assay
    		[PMID: 18676151]
    P388 IC50
    0.01 μM
    Compound: CPT
    Concentration required to inhibit cell proliferation in P388 tumor cell line
    Concentration required to inhibit cell proliferation in P388 tumor cell line
    		[PMID: 15482929]
    P388 IC50
    0.014 μM
    Compound: CPT
    Cytotoxicity against mouse P388 cells after MTT assay
    Cytotoxicity against mouse P388 cells after MTT assay
    		[PMID: 18829334]
    P388 IC50
    0.014 μM
    Compound: CPT
    Cytotoxicity against mouse P388 cells by MTT method
    Cytotoxicity against mouse P388 cells by MTT method
    		[PMID: 19012996]
    P388 IC50
    0.032 μM
    Compound: CPT
    In vitro inhibitory concentration against murine P388 leukemia cell proliferation
    In vitro inhibitory concentration against murine P388 leukemia cell proliferation
    		[PMID: 10346933]
    P388 IC50
    13 nM
    Compound: Camptothecin
    Inhibitory activity against P388 murine leukemia cells
    Inhibitory activity against P388 murine leukemia cells
    		[PMID: 11384245]
    P388 IC50
    13 nM
    Compound: Camptothecin
    Growth inhibitory activity against murine P388 leukemia cells
    Growth inhibitory activity against murine P388 leukemia cells
    		[PMID: 12620081]
    P388 IC50
    32.1 nM
    Compound: camptothecin
    Cytotoxicity against mouse P388 cells after 72 hrs
    Cytotoxicity against mouse P388 cells after 72 hrs
    		[PMID: 17624792]
    P388 IC50
    4.74 ng/mL
    Compound: 1
    In vitro antitumor activity against P388 (murine leukemia) cells.
    In vitro antitumor activity against P388 (murine leukemia) cells.
    		[PMID: 9632364]
    P388 IC50
    4.74 ng/mL
    Compound: 1a
    Tested in vitro for the inhibition of P388 (mouse leukemia) cell line by MTT assay
    Tested in vitro for the inhibition of P388 (mouse leukemia) cell line by MTT assay
    		[PMID: 7932525]
    P388 IC50
    7 nM
    Compound: Camptothecin
    Inhibitory activity against P388 Leukemia cells
    Inhibitory activity against P388 Leukemia cells
    		[PMID: 12565975]
    P388 IC50
    > 10 μM
    Compound: CPT
    Cytotoxicity against mouse CPT45-resistant topoisomerase 1-deficient P388 cells after 4 days by MTT assay
    Cytotoxicity against mouse CPT45-resistant topoisomerase 1-deficient P388 cells after 4 days by MTT assay
    		[PMID: 18676151]
    P388 IC50
    > 10 μM
    Compound: CPT
    Cytotoxicity against camptothecin-resistant mouse P388 cells by MTT method
    Cytotoxicity against camptothecin-resistant mouse P388 cells by MTT method
    		[PMID: 18771930]
    P388 IC50
    > 10 μM
    Compound: CPT
    Cytotoxicity against camptothecin-resistant mouse P388 cells after 4 days by MTT method
    Cytotoxicity against camptothecin-resistant mouse P388 cells after 4 days by MTT method
    		[PMID: 19303306]
    P388CPT45 IC50
    > 10 μM
    Compound: CPT
    Cytotoxicity against camptothecin-resistant and TOP1 deficient mouse P388/CPT45 cells after MTT assay
    Cytotoxicity against camptothecin-resistant and TOP1 deficient mouse P388/CPT45 cells after MTT assay
    		[PMID: 18829334]
    P388CPT45 IC50
    > 10 μM
    Compound: CPT
    Cytotoxicity against mouse P388/CPT45 cells after 4 days by MTT assay
    Cytotoxicity against mouse P388/CPT45 cells after 4 days by MTT assay
    		[PMID: 19299037]
    P388CPT5 IC50
    2.8 μM
    Compound: CPT
    In vitro inhibitory concentration against murine P388CPT5 leukemia cell proliferation
    In vitro inhibitory concentration against murine P388CPT5 leukemia cell proliferation
    		[PMID: 10346933]
    PANC-1 GI50
    6.29 μM
    Compound: 1, CPT
    Cytotoxicity against human PANC1 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human PANC1 cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    PANC-1 IC50
    0.09 μM
    Compound: CPT
    Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay
    Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay
    		[PMID: 30017114]
    PANC-1 IC50
    0.18 μM
    Compound: CPT
    Cytotoxicity against human PANC1 cells after 48 hrs by XTT assay
    Cytotoxicity against human PANC1 cells after 48 hrs by XTT assay
    		[PMID: 30017114]
    PANC-1 IC50
    0.233 μM
    Compound: CPT
    Cytotoxicity against human PANC-1 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human PANC-1 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    PBMC IC50
    > 10 μM
    Compound: CPT
    Cytotoxicity against human PBMC assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human PBMC assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 24484281]
    PC-3 ED50
    16.7 nM
    Compound: 3a, CPT, Camptothecin
    Cytotoxicity against human PC3 cells by sulforhodamine B assay
    Cytotoxicity against human PC3 cells by sulforhodamine B assay
    		[PMID: 17350834]
    PC-3 GI50
    0.06 μM
    Compound: Camptothecin
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    		[PMID: 21115210]
    PC-3 GI50
    0.09 μM
    Compound: 1, camptothecin
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 18180162]
    PC-3 GI50
    0.09 μM
    Compound: CPT
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 20662543]
    PC-3 GI50
    0.48 μM
    Compound: 1
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    		[PMID: 21388138]
    PC-3 GI50
    0.7 μM
    Compound: 1, CPT
    Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay
    		[PMID: 19715319]
    PC-3 GI50
    > 287 μM
    Compound: 1, CPT
    Cytotoxicity against human PC3 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    PC-3 IC50
    0.01 μM
    Compound: Camptothecin
    Growth inhibition of human PC3 cells after 72 hrs by MTT assay
    Growth inhibition of human PC3 cells after 72 hrs by MTT assay
    		[PMID: 24180210]
    PC-3 IC50
    0.03 μM
    Compound: Camptothecin
    Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay
    Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay
    		[PMID: 21074444]
    PC-3 IC50
    0.1 μM
    Compound: CPT
    Antiproliferative activity against human PC3 cells assessed as cell viability incubated for 72 hrs by MTT assay
    Antiproliferative activity against human PC3 cells assessed as cell viability incubated for 72 hrs by MTT assay
    		[PMID: 25799376]
    PC-3 IC50
    0.234 μM
    Compound: CPT
    Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    PC-3 IC50
    0.31 μM
    Compound: CPT
    In vitro cytotoxic activity of compound against human PC3 cell line
    In vitro cytotoxic activity of compound against human PC3 cell line
    		[PMID: 15081041]
    PC-3 IC50
    0.4 μM
    Compound: Camp
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    		[PMID: 29223099]
    PC-3 IC50
    1.2 μM
    Compound: Camptothecin
    Antiproliferative activity against human PC3 cells assessed as cell viability after 48 hrs by MTT assay
    Antiproliferative activity against human PC3 cells assessed as cell viability after 48 hrs by MTT assay
    		10.1039/C4MD00344F
    PC-3 IC50
    1.2 μM
    Compound: Camptothecin
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 24041234]
    PC-3 IC50
    1.4 μM
    Compound: 1, CPT
    Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay
    Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay
    		[PMID: 19715319]
    PC-3 IC50
    12 nM
    Compound: 1a
    Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay
    		[PMID: 21341674]
    PC-3 IC50
    1414.4 nM
    Compound: Camptothecin (table 1)
    Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
    Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
    		[PMID: 15454230]
    PC-3 IC50
    16.24 μM
    Compound: CPT
    Cytotoxicity against human PC3 after 48 hrs by SRB assay
    Cytotoxicity against human PC3 after 48 hrs by SRB assay
    		[PMID: 21044847]
    PC-3 IC50
    18.24 μM
    Compound: Camptothecin
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 30109008]
    PC-3 IC50
    2.4 μM
    Compound: CPT
    Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    PC-3 IC50
    2.5 μM
    Compound: CPT
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    		[PMID: 26226379]
    PC-3 IC50
    52 nM
    Compound: camptothecin
    Antiproliferative activity against human PC3 cell line
    Antiproliferative activity against human PC3 cell line
    		[PMID: 16686539]
    PC-3 IC50
    57 nM
    Compound: CPT
    Antiproliferative activity measured against PC-3 human prostate adenocarcinoma
    Antiproliferative activity measured against PC-3 human prostate adenocarcinoma
    		[PMID: 9876111]
    PC-3 IC50
    6.6 μM
    Compound: CPT
    Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 38154256]
    PC-3 IC50
    6.96 μM
    Compound: Camptothecin
    Antiproliferative activity against human PC3 cells by MTT assay
    Antiproliferative activity against human PC3 cells by MTT assay
    		[PMID: 29131616]
    PC-3 IC50
    78 nM
    Compound: CPT
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
    		[PMID: 24900725]
    PC-3 IC50
    > 100 μM
    Compound: CPT
    Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    PC-3 IC50
    > 40 μM
    Compound: Camp
    Induction of apoptosis in human PC3 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    Induction of apoptosis in human PC3 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    		[PMID: 29223099]
    PC-3M IC50
    0.19 μM
    Compound: Camptothecin
    Anticancer activity in human PC-3M cells expressing PTB/GFP fusion protein assessed as perinucleolar compartment disassembly and measured after 24 hrs by Hoechst 33342 staining based microscopic method
    Anticancer activity in human PC-3M cells expressing PTB/GFP fusion protein assessed as perinucleolar compartment disassembly and measured after 24 hrs by Hoechst 33342 staining based microscopic method
    		[PMID: 35696646]
    PC-3M IC50
    0.48 μM
    Compound: Camptothecin
    Cytotoxicity against human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction in ATP level and measured after 24 to 48 hrs by ATPlite luminescence assay
    Cytotoxicity against human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction in ATP level and measured after 24 to 48 hrs by ATPlite luminescence assay
    		[PMID: 35696646]
    Panel (56 tumour cell lines) IC50
    0.04 μM
    Compound: 20(S)-Camptothecin
    Tested in vitro for cytotoxicity against 56 human tumor cell lines
    Tested in vitro for cytotoxicity against 56 human tumor cell lines
    		[PMID: 10714502]
    Panel NCI-60 (60 carcinoma cell lines) GI50
    10 nM
    Compound: Camptothecin E
    Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program
    Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program
    		[PMID: 15743190]
    QG-56 IC50
    4.63 ng/mL
    Compound: 1
    In vitro antitumor activity against QG-56 (human lung cancer) cells.
    In vitro antitumor activity against QG-56 (human lung cancer) cells.
    		[PMID: 9632364]
    QG-56 IC50
    4.63 ng/mL
    Compound: 1a
    Tested in vitro for the inhibition of QG-56 (human lung squamous cell carcinoma) cell line by MTT assay
    Tested in vitro for the inhibition of QG-56 (human lung squamous cell carcinoma) cell line by MTT assay
    		[PMID: 7932525]
    RD IC50
    1.24 μM
    Compound: CPT
    Cytotoxicity against human TE32 cells measured after 72 hrs by MTT assay
    Cytotoxicity against human TE32 cells measured after 72 hrs by MTT assay
    		[PMID: 27721148]
    RD IC50
    1.24 μM
    Compound: CPT
    Cytotoxicity against human TE32 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human TE32 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 28923388]
    RD IC50
    1.72 μM
    Compound: CPT
    Cytotoxicity against against human RD cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against against human RD cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 30340899]
    RD IC50
    4.47 μM
    Compound: Camptothecin
    Cytotoxicity against human TE-32 cells after 72 hrs ny MTT assay
    Cytotoxicity against human TE-32 cells after 72 hrs ny MTT assay
    		[PMID: 23974020]
    RD IC50
    4.49 μM
    Compound: Camptothecin
    Cytotoxicity in human RD cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Cytotoxicity in human RD cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 28923382]
    RKO IC50
    0.0617 μM
    Compound: CPT
    Antiproliferative activity against human RKO cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    Antiproliferative activity against human RKO cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    		[PMID: 35868003]
    RKO IC50
    < 1.85 μM
    Compound: CPT
    Antiproliferative activity against human RKO cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human RKO cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    RPMI 8402 IC50
    0.004 μM
    Compound: CPT
    Cytotoxicity against human RPMI8402 cells by MTT method
    Cytotoxicity against human RPMI8402 cells by MTT method
    		[PMID: 18771930]
    RPMI 8402 IC50
    0.004 μM
    Compound: CPT
    Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay
    Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay
    		[PMID: 19299037]
    RPMI 8402 IC50
    0.004 μM
    Compound: CPT
    Cytotoxicity against human RPMI8402 cells after 4 days by MTT method
    Cytotoxicity against human RPMI8402 cells after 4 days by MTT method
    		[PMID: 19303306]
    RPMI 8402 IC50
    0.005 μM
    Compound: CPT
    Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay
    Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay
    		[PMID: 18676151]
    RPMI 8402 IC50
    0.005 μM
    Compound: Camptothecin
    Cytotoxic activity against human lymphoblast tumor cell line RPMI8402 after 4 days of treatment
    Cytotoxic activity against human lymphoblast tumor cell line RPMI8402 after 4 days of treatment
    		[PMID: 12747798]
    RPMI 8402 IC50
    0.006 μM
    Compound: CPT
    Concentration required to inhibit cell proliferation in RPM18402 tumor cell line
    Concentration required to inhibit cell proliferation in RPM18402 tumor cell line
    		[PMID: 15482929]
    RPMI 8402 IC50
    0.006 μM
    Compound: CPT
    Cytotoxicity against human RPMI8402 cells after MTT assay
    Cytotoxicity against human RPMI8402 cells after MTT assay
    		[PMID: 18829334]
    RPMI 8402 IC50
    > 10 μM
    Compound: CPT
    Concentration required to inhibit cell proliferation in CPT-K5 tumor cell line; camptothecin resistant
    Concentration required to inhibit cell proliferation in CPT-K5 tumor cell line; camptothecin resistant
    		[PMID: 15482929]
    RPMI-7951 IC50
    0.22 μM
    Compound: CPT
    Cytotoxicity against human RPMI7951 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human RPMI7951 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32435422]
    RPMI-8226 IC50
    0.006 μM
    Compound: CPT
    Cytotoxicity against human RPMI8226 cells by MTT method
    Cytotoxicity against human RPMI8226 cells by MTT method
    		[PMID: 19012996]
    RPMI-8226 IC50
    2.05 μg/mL
    Compound: Camptothecin
    Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay
    Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay
    		[PMID: 25867737]
    Raji IC50
    1 μM
    Compound: camptothecin
    Cytotoxicity against human Raji cells by MTT assay
    Cytotoxicity against human Raji cells by MTT assay
    		[PMID: 20329739]
    Raji IC50
    3.27 μM
    Compound: Camptothecin
    Cytotoxicity against human Raji cells after 48 hrs by MTT assay
    Cytotoxicity against human Raji cells after 48 hrs by MTT assay
    		[PMID: 30109008]
    Renca IC50
    304 nM
    Compound: camptothecin
    Antiproliferative activity against mouse Renca cell line
    Antiproliferative activity against mouse Renca cell line
    		[PMID: 16686539]
    SAOS-2 GI50
    > 287 μM
    Compound: 1, CPT
    Cytotoxicity against human Saos2 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human Saos2 cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    SAOS-2 IC50
    0.055 μM
    Compound: CPT
    Cytotoxicity against human SAOS-2 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human SAOS-2 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    SAS GI50
    6 μM
    Compound: 1, camptothecin
    Antiproliferative activity against human SAS cells after 48 hrs by MTT assay
    Antiproliferative activity against human SAS cells after 48 hrs by MTT assay
    		[PMID: 18180162]
    SAS GI50
    6 μM
    Compound: CPT
    Cytotoxicity against human SAS cells after 48 hrs by MTT assay
    Cytotoxicity against human SAS cells after 48 hrs by MTT assay
    		[PMID: 20662543]
    SAS IC50
    6 μM
    Compound: CPT
    Antiproliferative activity against human SAS cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human SAS cells incubated for 72 hrs by MTT assay
    		10.1039/C4MD00133H
    SF-268 EC50
    0.059 μM
    Compound: camptothecin
    Cytotoxicity against human SF-268 after 3 days by SRB assay
    Cytotoxicity against human SF-268 after 3 days by SRB assay
    		[PMID: 15730238]
    SF-268 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human SF268 cell line
    Antiproliferative activity against human SF268 cell line
    		[PMID: 16442283]
    SF-268 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human SF268 cells
    Cytotoxicity against human SF268 cells
    		[PMID: 17402722]
    SF-268 GI50
    0.19 μM
    Compound: CPT
    Cytotoxicity against human SF268 cells after 72 hrs by XTT assay
    Cytotoxicity against human SF268 cells after 72 hrs by XTT assay
    		[PMID: 20591678]
    SF-268 IC50
    0.04 μM
    Compound: Camptothecin
    Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
    Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
    		[PMID: 21513293]
    SF-268 IC50
    0.07 μM
    Compound: Camptothecin
    Cytotoxicity against human SF268 cells incubated for 3 days by SRB assay
    Cytotoxicity against human SF268 cells incubated for 3 days by SRB assay
    		[PMID: 22863526]
    SF-268 IC50
    0.19 μM
    Compound: 4
    Anticancer activity against human SF268 cells
    Anticancer activity against human SF268 cells
    		[PMID: 21599000]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human SF539 cells
    Antiproliferative activity against human SF539 cells
    		[PMID: 18630891]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human SF539 cells
    Cytotoxicity against human SF539 cells
    		[PMID: 19783447]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human SF539 cells
    Cytotoxicity against human SF539 cells
    		[PMID: 20630766]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human SF539 cells by SRB assay
    Antiproliferative activity against human SF539 cells by SRB assay
    		[PMID: 21710981]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human SF539 cells after 48 hrs by SRB assay
    Cytotoxicity against human SF539 cells after 48 hrs by SRB assay
    		[PMID: 21823606]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human SF539 cells by SRB assay
    Cytotoxicity against human SF539 cells by SRB assay
    		[PMID: 24502276]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Growth inhibition of human SF539 cells after 48 hrs by SRB assay
    Growth inhibition of human SF539 cells after 48 hrs by SRB assay
    		[PMID: 24800942]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human SF539 cells after 48 hrs
    Antiproliferative activity against human SF539 cells after 48 hrs
    		[PMID: 27070999]
    SF-539 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human SF539 cells assessed as growth inhibition
    Antiproliferative activity against human SF539 cells assessed as growth inhibition
    		[PMID: 28657311]
    SF-539 GI50
    0.01 μM
    Compound: 1, CPT
    Antiproliferative activity against human SF539 cells
    Antiproliferative activity against human SF539 cells
    		[PMID: 20155916]
    SF-539 GI50
    0.01 μM
    Compound: 1, Camptothecin
    Cytotoxicity against human SF539 cells
    Cytotoxicity against human SF539 cells
    		[PMID: 17676830]
    SF-539 GI50
    0.01 μM
    Compound: 2
    Antiproliferative activity against human SF539 cell line
    Antiproliferative activity against human SF539 cell line
    		[PMID: 16913702]
    SF-539 GI50
    0.01 μM
    Compound: 2
    Cytotoxicity against human SF539 cells
    Cytotoxicity against human SF539 cells
    		[PMID: 17696418]
    SF-539 GI50
    0.01 μM
    Compound: 2
    Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 22329436]
    SF-539 GI50
    0.01 μM
    Compound: 2 (Camptothecin)
    Antiproliferative activity was determined for 50% growth inhibition against human CNS SF-539 cell line
    Antiproliferative activity was determined for 50% growth inhibition against human CNS SF-539 cell line
    		[PMID: 11020283]
    SF-539 GI50
    < 0.01 μM
    Compound: 18
    Cytotoxicity against human SF539 cells after 48 hrs by SRB assay
    Cytotoxicity against human SF539 cells after 48 hrs by SRB assay
    		[PMID: 28418653]
    SGC-7901 IC50
    5.8 μM
    Compound: CPT
    Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay
    		[PMID: 35868003]
    SGC-7901 IC50
    < 1.85 μM
    Compound: CPT
    Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    SH-SY5Y IC50
    0.61 μM
    Compound: CPT
    Cytotoxicity against human SH-SY5Y cells expressing low level of topoisomerase I/II measured after 72 hrs by MTT assay
    Cytotoxicity against human SH-SY5Y cells expressing low level of topoisomerase I/II measured after 72 hrs by MTT assay
    		[PMID: 35612499]
    SH-SY5Y IC50
    > 100 μM
    Compound: Camptothecin
    Growth inhibition of human SH-SY5Y cells after 72 hrs by MTT assay
    Growth inhibition of human SH-SY5Y cells after 72 hrs by MTT assay
    		[PMID: 27344492]
    SK-BR-3 GI50
    0.15 μM
    Compound: Camptothecin
    Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay
    Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay
    		[PMID: 20438092]
    SK-BR-3 IC50
    0.21 μM
    Compound: CPT
    Cytotoxicity against HER-positive human SK-BR-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity against HER-positive human SK-BR-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36351049]
    SK-BR-3 IC50
    0.38 μM
    Compound: CPT
    Cytotoxicity against HER-positive human SK-BR-3 cells incubated for 48 hrs by CCK-8 assay
    Cytotoxicity against HER-positive human SK-BR-3 cells incubated for 48 hrs by CCK-8 assay
    		[PMID: 38104378]
    SK-BR-3 IC50
    20 nM
    Compound: CPT
    In Vitro cytotoxicity against human breast cancer cell line (SK-BR-3)
    In Vitro cytotoxicity against human breast cancer cell line (SK-BR-3)
    		[PMID: 11334569]
    SK-BR-3 IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human SKBR3 cells after 3 days by SRB assay
    Cytotoxicity against human SKBR3 cells after 3 days by SRB assay
    		[PMID: 23142674]
    SK-BR-3 IC50
    < 0.01 μM
    Compound: Camptothecin
    Antiproliferative activity against human SK-BR-3 cells incubated for 72 hrs by MTT assay
    Antiproliferative activity against human SK-BR-3 cells incubated for 72 hrs by MTT assay
    		[PMID: 38107170]
    SK-HEP1 IC50
    0.9 μM
    Compound: CPT
    Antiproliferative activity against human SKHEP1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human SKHEP1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    SK-HEP1 IC50
    0.96 μM
    Compound: CPT
    Cytotoxicity against human SKHEP1 cells after 72 hrs by MTT assay
    Cytotoxicity against human SKHEP1 cells after 72 hrs by MTT assay
    		[PMID: 26226379]
    SK-MEL GI50
    0.047 μM
    Compound: 1
    Cytotoxicity against human SK-MEL cells after 72 hrs by MTT assay
    Cytotoxicity against human SK-MEL cells after 72 hrs by MTT assay
    		[PMID: 21388138]
    SK-MEL-2 IC50
    0.075 μM
    Compound: CPT, campothecin
    Cytotoxicity against human SK-MEL-2 cells by SRB assay
    Cytotoxicity against human SK-MEL-2 cells by SRB assay
    		[PMID: 17827007]
    SK-MEL-2 IC50
    0.165 μM
    Compound: camptothecin
    Cytotoxicity against human SK-MEL-2 cells after 48 hrs
    Cytotoxicity against human SK-MEL-2 cells after 48 hrs
    		[PMID: 17673337]
    SK-MEL-2 IC50
    6.88 μg/mL
    Compound: CPT
    Cytotoxicity against human SK-MEL-2 cells by sulforhodamine B assay
    Cytotoxicity against human SK-MEL-2 cells by sulforhodamine B assay
    		[PMID: 21684168]
    SK-MEL-2 IC50
    7.86 μM
    Compound: CPT
    Cytotoxicity against human SK-MEL-2 cells after 48 hrs by MTT assay
    Cytotoxicity against human SK-MEL-2 cells after 48 hrs by MTT assay
    		[PMID: 21873069]
    SK-MEL-24 IC50
    0.46 μM
    Compound: CPT
    Cytotoxicity against human SK-MEL-24 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human SK-MEL-24 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32435422]
    SK-MEL-28 CC50
    0.07 μM
    Compound: Camptothecin
    Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay
    Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    SK-MEL-28 CC50
    0.07 μM
    Compound: Camptothecin
    Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay
    Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    SK-MEL-28 IC50
    0.04 μM
    Compound: CPT
    Antiproliferative activity against human SK-MEL-28 cells by MTT assay
    Antiproliferative activity against human SK-MEL-28 cells by MTT assay
    		[PMID: 17254669]
    SK-MEL-28 IC50
    2.26 μM
    Compound: CPT
    Cytotoxicity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    Cytotoxicity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
    		[PMID: 35635947]
    SK-MEL-28 IC50
    < 0.01 μM
    Compound: Camptothecin
    Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay
    Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay
    		[PMID: 24180210]
    SK-MES-1 CC50
    0.03 μM
    Compound: Camptothecin
    Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay
    Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    SK-MES-1 CC50
    0.05 μM
    Compound: Camptothecin
    Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay
    Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    SK-MES-1 IC50
    0.01 μM
    Compound: CPT
    Antiproliferative activity against human SKMES1 cells by MTT assay
    Antiproliferative activity against human SKMES1 cells by MTT assay
    		[PMID: 17254669]
    SK-OV-3 IC50
    0.014 μM
    Compound: camptothecin
    Cytotoxicity against human SK-OV3 cells after 48 hrs
    Cytotoxicity against human SK-OV3 cells after 48 hrs
    		[PMID: 17673337]
    SK-OV-3 IC50
    0.051 μM
    Compound: Camptothecin
    Inhibitory concentration the viability of SKOV 3 cell population by 50%.
    Inhibitory concentration the viability of SKOV 3 cell population by 50%.
    		[PMID: 9003520]
    SK-OV-3 IC50
    0.241 μM
    Compound: CPT
    Cytotoxicity against human SK-OV-3 cells incubated for 48 hrs by MTT assay
    Cytotoxicity against human SK-OV-3 cells incubated for 48 hrs by MTT assay
    		[PMID: 38185054]
    SK-OV-3 IC50
    1.54 μg/mL
    Compound: CPT
    Cytotoxicity against human SKOV3 cells by sulforhodamine B assay
    Cytotoxicity against human SKOV3 cells by sulforhodamine B assay
    		[PMID: 21684168]
    SK-OV-3 IC50
    2.544 μM
    Compound: CPT
    Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay
    Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay
    		[PMID: 21873069]
    SK-OV-3 IC50
    2.56 μM
    Compound: Camptothecin
    Antitumor activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    SK-OV-3 IC50
    20 nM
    Compound: CPT
    In Vitro cytotoxicity against human ovarian cancer cell line (SK-OV-3)
    In Vitro cytotoxicity against human ovarian cancer cell line (SK-OV-3)
    		[PMID: 11334569]
    SK-OV-3 IC50
    3.82 μM
    Compound: CPT
    Cytotoxicity against HER-positive human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity against HER-positive human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 36351049]
    SK-OV-3 IC50
    37 nM
    Compound: 1
    Cytotoxicity was determined in vitro in SK-OV-3 cells (ovarian) of human tumor cell lines by using MTT assay
    Cytotoxicity was determined in vitro in SK-OV-3 cells (ovarian) of human tumor cell lines by using MTT assay
    		[PMID: 7853331]
    SK-OV-3 IC50
    4.07 μM
    Compound: CPT
    Cytotoxicity against HER-positive human SK-OV-3 cells incubated for 48 hrs by CCK-8 assay
    Cytotoxicity against HER-positive human SK-OV-3 cells incubated for 48 hrs by CCK-8 assay
    		[PMID: 38104378]
    SK-OV-3 IC50
    4.86 μM
    Compound: Camptothecin
    Antitumor activity against taxol-resistant human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against taxol-resistant human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    SK-OV-3 IC50
    5.5 nM
    Compound: CPT
    Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis
    Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis
    		[PMID: 34952177]
    SK-OV-3 IC50
    5.5 x 10-3 μM
    Compound: CPT
    Antiproliferative activity against human SKOV3 cells after 48 hrs by CCK-8 assay
    Antiproliferative activity against human SKOV3 cells after 48 hrs by CCK-8 assay
    		[PMID: 29501943]
    SK-OV-3 IC50
    5.5 x 10-3 μM
    Compound: CPT
    Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
    		[PMID: 33962152]
    SK-OV-3 IC50
    5.5 x 10-3 μM
    Compound: Camptothecin
    Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by CCK8 assay
    Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by CCK8 assay
    		[PMID: 27017547]
    SK-OV-3 IC50
    5.5 x 10-3 μM
    Compound: I; CPT
    Antiproliferative activity against human SKOV3 cells incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human SKOV3 cells incubated for 48 hrs by CCK8 assay
    		[PMID: 31229877]
    SK-OV-3 IC50
    5.5 μM
    Compound: I; CPT
    Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 32279049]
    SK-VLB IC50
    0.053 μM
    Compound: Camptothecin
    Inhibitory concentration that reduced the viability of SKVLB cell population by 50%.
    Inhibitory concentration that reduced the viability of SKVLB cell population by 50%.
    		[PMID: 9003520]
    SK-VLB IC50
    41 nM
    Compound: 1
    Cytotoxicity was determined in vitro in SKVLB cells(ovarian with upregulated MDRp-glycoprotein) of human tumor cell lines by using MTT assay
    Cytotoxicity was determined in vitro in SKVLB cells(ovarian with upregulated MDRp-glycoprotein) of human tumor cell lines by using MTT assay
    		[PMID: 7853331]
    SMMC-7721 IC50
    0.003 μM
    Compound: camptothecin
    Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay
    Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay
    		[PMID: 21973054]
    SMMC-7721 IC50
    0.02 μM
    Compound: CPT
    Cytotoxicity against human SMMC7721 after 48 hrs by SRB assay
    Cytotoxicity against human SMMC7721 after 48 hrs by SRB assay
    		[PMID: 21044847]
    SMMC-7721 IC50
    0.45 μM
    Compound: CPT; 1
    Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
    Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
    		[PMID: 30509782]
    SMMC-7721 IC50
    1.08 μM
    Compound: CPT
    Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
    Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
    		[PMID: 30125725]
    SMMC-7721 IC50
    3.95 μM
    Compound: Camptothecin
    Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell growth by SRB assay
    Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell growth by SRB assay
    		[PMID: 38107170]
    SMMC-7721 IC50
    > 10 μM
    Compound: CPT
    Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 34852457]
    SN12C GI50
    0.02 μM
    Compound: 1
    Antiproliferative activity against human SN12C cell line
    Antiproliferative activity against human SN12C cell line
    		[PMID: 16442283]
    SN12C GI50
    0.02 μM
    Compound: 1
    Cytotoxicity against human SN12C cells
    Cytotoxicity against human SN12C cells
    		[PMID: 17402722]
    SN12C GI50
    0.02 μM
    Compound: 1
    Antiproliferative activity against human SN12C cells
    Antiproliferative activity against human SN12C cells
    		[PMID: 18630891]
    SN12C GI50
    0.02 μM
    Compound: 1
    Cytotoxicity against human SN12C cells
    Cytotoxicity against human SN12C cells
    		[PMID: 19783447]
    SN12C GI50
    0.02 μM
    Compound: 1
    Cytotoxicity against human SN12C cells
    Cytotoxicity against human SN12C cells
    		[PMID: 20630766]
    SN12C GI50
    0.02 μM
    Compound: 1
    Antiproliferative activity against human SN12C cells by SRB assay
    Antiproliferative activity against human SN12C cells by SRB assay
    		[PMID: 21710981]
    SN12C GI50
    0.02 μM
    Compound: 1
    Cytotoxicity against human SN12C cells after 48 hrs by SRB assay
    Cytotoxicity against human SN12C cells after 48 hrs by SRB assay
    		[PMID: 21823606]
    SN12C GI50
    0.02 μM
    Compound: 1
    Cytotoxicity against human SN12C cells by SRB assay
    Cytotoxicity against human SN12C cells by SRB assay
    		[PMID: 24502276]
    SN12C GI50
    0.02 μM
    Compound: 1
    Growth inhibition of human SN12C cells after 48 hrs by SRB assay
    Growth inhibition of human SN12C cells after 48 hrs by SRB assay
    		[PMID: 24800942]
    SN12C GI50
    0.02 μM
    Compound: 1
    Antiproliferative activity against human SN12C cells after 48 hrs
    Antiproliferative activity against human SN12C cells after 48 hrs
    		[PMID: 27070999]
    SN12C GI50
    0.02 μM
    Compound: 1
    Antiproliferative activity against human SN12C cells assessed as growth inhibition
    Antiproliferative activity against human SN12C cells assessed as growth inhibition
    		[PMID: 28657311]
    SN12C GI50
    0.02 μM
    Compound: 1, CPT
    Antiproliferative activity against human SN12C cells
    Antiproliferative activity against human SN12C cells
    		[PMID: 20155916]
    SN12C GI50
    0.02 μM
    Compound: 1, Camptothecin
    Cytotoxicity against human SN12C cells
    Cytotoxicity against human SN12C cells
    		[PMID: 17676830]
    SN12C GI50
    0.02 μM
    Compound: 18
    Cytotoxicity against human SN12C cells after 48 hrs by SRB assay
    Cytotoxicity against human SN12C cells after 48 hrs by SRB assay
    		[PMID: 28418653]
    SN12C GI50
    0.02 μM
    Compound: 2
    Growth inhibitory activity against human renal SN12C cell line
    Growth inhibitory activity against human renal SN12C cell line
    		[PMID: 15509164]
    SN12C GI50
    0.02 μM
    Compound: 2
    Antiproliferative activity against human SN12C cell line
    Antiproliferative activity against human SN12C cell line
    		[PMID: 16913702]
    SN12C GI50
    0.02 μM
    Compound: 2
    Cytotoxicity against human SN12C cells
    Cytotoxicity against human SN12C cells
    		[PMID: 17696418]
    SN12C GI50
    0.02 μM
    Compound: 2
    Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay
    		[PMID: 22329436]
    SN12C GI50
    0.02 μM
    Compound: 2 (Camptothecin)
    Antiproliferative activity was determined for 50% growth inhibition against human renal SN12C cell line
    Antiproliferative activity was determined for 50% growth inhibition against human renal SN12C cell line
    		[PMID: 11020283]
    SN12C GI50
    0.02 μM
    Compound: Camptothecin
    Concentration required to inhibit the growth of human Renal SN12C cells
    Concentration required to inhibit the growth of human Renal SN12C cells
    		[PMID: 16033260]
    SNU-475 IC50
    < 1 μM
    Compound: CPT
    Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay
    		[PMID: 26810835]
    SNU-638 IC50
    0.098 μM
    Compound: 1, CPT
    Cytotoxicity against human SNU638 cells
    Cytotoxicity against human SNU638 cells
    		[PMID: 21095131]
    SNU-638 IC50
    0.098 μM
    Compound: CPT
    Cytotoxicity against human SNU638 cells by MTT assay
    Cytotoxicity against human SNU638 cells by MTT assay
    		[PMID: 21353568]
    SNU-638 IC50
    0.098 μM
    Compound: camptothecin
    Cytotoxicity against human SNU638 cells by SRB assay
    Cytotoxicity against human SNU638 cells by SRB assay
    		[PMID: 17498951]
    SNU-638 IC50
    0.28 μM
    Compound: Camptothecin
    Cytotoxicity against human SNU638 cells by MTT assay
    Cytotoxicity against human SNU638 cells by MTT assay
    		[PMID: 23608763]
    SU-DHL-2 IC50
    0.94 μM
    Compound: Camptothecin
    Antitumor activity against human SUDHL2 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against human SUDHL2 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    SW-620 EC50
    0.0021 μM
    Compound: Cpt, camptothecin
    Antiproliferative activity against human SW620 cells by soft agar assay
    Antiproliferative activity against human SW620 cells by soft agar assay
    		[PMID: 17287122]
    SW-620 EC50
    0.15 nM
    Compound: Camptothecin
    Concentration required to inhibit growth of SW620 (human colon cancer) cells in the presence of 10 uM of Compound 2e
    Concentration required to inhibit growth of SW620 (human colon cancer) cells in the presence of 10 uM of Compound 2e
    		[PMID: 15857116]
    SW-620 EC50
    1.2 nM
    Compound: Camptothecin
    Concentration required to inhibit growth of SW620 (human colon cancer) cells
    Concentration required to inhibit growth of SW620 (human colon cancer) cells
    		[PMID: 15857116]
    SW1573 GI50
    0.21 μM
    Compound: CPT
    Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 19664930]
    SW1573 GI50
    0.25 μM
    Compound: Camptothecin
    Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay
    Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay
    		[PMID: 23831507]
    SW1573 GI50
    0.3 μM
    Compound: Camptothecin
    Antiproliferative activity against human SW1573 cells assessed as inhibition of culture growth incubated for 48 hrs by SRB assay
    Antiproliferative activity against human SW1573 cells assessed as inhibition of culture growth incubated for 48 hrs by SRB assay
    		[PMID: 37531922]
    SW1990 IC50
    0.2 μM
    Compound: CPT
    Antitumor activity against human SW1990 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    Antitumor activity against human SW1990 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
    		[PMID: 32668379]
    SW480 IC50
    0.01 μg/mL
    Compound: 1
    Cytotoxicity in SW480 cancer cell line
    Cytotoxicity in SW480 cancer cell line
    		10.1016/S0960-894X(01)80158-X
    SW480 IC50
    0.21 μM
    Compound: Camptothecin
    Antiproliferation activity against human SW480 cells assessed as reduction in cell viability measured after 72 hours by MTT assay
    Antiproliferation activity against human SW480 cells assessed as reduction in cell viability measured after 72 hours by MTT assay
    		[PMID: 32201190]
    SW480 IC50
    0.29 μM
    Compound: CPT; 1
    Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
    Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
    		[PMID: 30509782]
    SW480 IC50
    3.75 μM
    Compound: Camptothecin
    Inhibition of DNA topoisomerase 1 in Homo sapiens (human) SW480 cells
    Inhibition of DNA topoisomerase 1 in Homo sapiens (human) SW480 cells
    		10.1007/s00044-009-9233-5
    SW480 IC50
    8.56 μM
    Compound: CPT
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 38128233]
    SW626 IC50
    28.7 nM
    Compound: Camptothecin
    Cytotoxicity against human SW626 cells by MTT assay
    Cytotoxicity against human SW626 cells by MTT assay
    		[PMID: 11858760]
    SW948 IC50
    0.16 μM
    Compound: CPT
    Antiproliferative activity against human SW948 cells after 3 days by XTT assay
    Antiproliferative activity against human SW948 cells after 3 days by XTT assay
    		[PMID: 19691293]
    Sf9 IC50
    0.025 μM
    Compound: CPT
    Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis
    Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis
    		[PMID: 30897325]
    SiHa GI50
    0.55 μM
    Compound: Camptothecin
    Antiproliferative activity against human SiHa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human SiHa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    Splenocyte CC50
    0.62 μM
    Compound: CPT
    Cytotoxicity against BALB/c mouse splenocytes assessed as cell viability after 48 hrs by alamar blue assay
    Cytotoxicity against BALB/c mouse splenocytes assessed as cell viability after 48 hrs by alamar blue assay
    		[PMID: 27639365]
    T-24 IC50
    0.006 μM
    Compound: camptothecin
    Growth inhibition of human T24 cells by neutral red assay
    Growth inhibition of human T24 cells by neutral red assay
    		[PMID: 17204425]
    T-24 IC50
    3.09 μM
    Compound: CPT
    Antiproliferative activity against human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 30875505]
    T-24 IC50
    6.8 μM
    Compound: CPT
    Antiproliferative activity against human T24 cells after 48 hrs by MTT assay
    Antiproliferative activity against human T24 cells after 48 hrs by MTT assay
    		[PMID: 30685528]
    T-24 IC50
    88 nM
    Compound: 1, CPT, NSC-100880
    Cytotoxicity against human chemo-resistant T24 cells by WST assay
    Cytotoxicity against human chemo-resistant T24 cells by WST assay
    		[PMID: 23578545]
    T-24 IC50
    88 nM
    Compound: CPT
    Cytotoxicity against T24 tumor cell line determined by WST-1 assay
    Cytotoxicity against T24 tumor cell line determined by WST-1 assay
    		[PMID: 10841808]
    T47D GI50
    1.9 μM
    Compound: CPT
    Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay
    		[PMID: 19664930]
    T47D GI50
    2 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay
    Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay
    		[PMID: 20438092]
    T47D GI50
    2 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells after 48 hrs by SRB assay
    Antiproliferative activity against human T47D cells after 48 hrs by SRB assay
    		[PMID: 23831507]
    T47D GI50
    2 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells assessed as inhibition of culture growth incubated for 48 hrs by SRB assay
    Antiproliferative activity against human T47D cells assessed as inhibition of culture growth incubated for 48 hrs by SRB assay
    		[PMID: 37531922]
    T47D IC50
    0.07 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells by MTT assay
    Cytotoxicity against human T47D cells by MTT assay
    		[PMID: 23608763]
    T47D IC50
    0.07 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay
    		[PMID: 29402741]
    T47D IC50
    0.07 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay
    Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay
    		[PMID: 30262132]
    T47D IC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells after 2 days by CCK8 assay
    Cytotoxicity against human T47D cells after 2 days by CCK8 assay
    		[PMID: 26361737]
    T47D IC50
    0.08 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells assessed as reduction in cell growth after 72 hrs by CCK8 assay
    Cytotoxicity against human T47D cells assessed as reduction in cell growth after 72 hrs by CCK8 assay
    		[PMID: 27484510]
    T47D IC50
    0.09 μM
    Compound: CPT
    Antiproliferative activity against human T47D cells after 72 hrs by EZ-Cytox colorimetric assay
    Antiproliferative activity against human T47D cells after 72 hrs by EZ-Cytox colorimetric assay
    		[PMID: 34678573]
    T47D IC50
    0.25 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay
    Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay
    		[PMID: 31398033]
    T47D IC50
    0.28 μM
    Compound: CPT
    Cytotoxicity against human T47D cells after 2 days
    Cytotoxicity against human T47D cells after 2 days
    		[PMID: 24904965]
    T47D IC50
    0.3 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells after 2 days by CCK-8 assay
    Cytotoxicity against human T47D cells after 2 days by CCK-8 assay
    		[PMID: 24013413]
    T47D IC50
    0.31 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay
    Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay
    		[PMID: 26022080]
    T47D IC50
    0.49 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human T47D cells after 72 hrs by CCK-8 assay
    		[PMID: 29510948]
    T47D IC50
    0.59 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay
    		[PMID: 27654394]
    T47D IC50
    0.75 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells after 4 days by CCK-8 assay
    Cytotoxicity against human T47D cells after 4 days by CCK-8 assay
    		[PMID: 25062006]
    T47D IC50
    1.53 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells after 2 days by cell counting kit-8 analysis
    Cytotoxicity against human T47D cells after 2 days by cell counting kit-8 analysis
    		[PMID: 22503656]
    T47D IC50
    1.62 μM
    Compound: CPT
    Cytotoxicity against human T47D cells measured after 2 days by MTT assay
    Cytotoxicity against human T47D cells measured after 2 days by MTT assay
    		[PMID: 26334499]
    T47D IC50
    1.84 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay
    Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay
    		[PMID: 26945111]
    T47D IC50
    1.84 μM
    Compound: camptothecin
    Cytotoxicity against human T47D cells measured on day 4 by CCK8 assay
    Cytotoxicity against human T47D cells measured on day 4 by CCK8 assay
    		[PMID: 25936262]
    T47D IC50
    11.17 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells after 3 days by CCK8 assay
    Cytotoxicity against human T47D cells after 3 days by CCK8 assay
    		[PMID: 26927425]
    T47D IC50
    13.7 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    		[PMID: 27643560]
    T47D IC50
    2.1 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    		[PMID: 28068603]
    T47D IC50
    2.1 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    		[PMID: 28384547]
    T47D IC50
    2.31 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    		[PMID: 28633898]
    T47D IC50
    207 nM
    Compound: 1
    Cytotoxicity was determined in vitro in T47D cells(breast) of human tumor cell lines by using MTT assay
    Cytotoxicity was determined in vitro in T47D cells(breast) of human tumor cell lines by using MTT assay
    		[PMID: 7853331]
    T47D IC50
    3.67 μM
    Compound: Camptothecin
    Cytotoxicity against human T47D cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay
    Cytotoxicity against human T47D cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay
    		[PMID: 27707625]
    T47D IC50
    4.1 μM
    Compound: Camptothecin
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay
    		[PMID: 26988802]
    T47D IC50
    9.17 μM
    Compound: CPT
    Cytotoxicity against human T47D cells after 72 hrs by MTT assay
    Cytotoxicity against human T47D cells after 72 hrs by MTT assay
    		[PMID: 22819942]
    T47D IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human T47D cells after 3 days by SRB assay
    Cytotoxicity against human T47D cells after 3 days by SRB assay
    		[PMID: 23142674]
    T47D IC50
    < 1 μM
    Compound: CPT
    Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay
    Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay
    		[PMID: 22867707]
    TERT-RPE1 ED50
    230 nM
    Compound: camptothecin
    Cytotoxicity against human telomerase reverse transcriptase expressing human RPE1 cells
    Cytotoxicity against human telomerase reverse transcriptase expressing human RPE1 cells
    		[PMID: 15043407]
    TERT-RPE1 IC50
    27.2 μM
    Compound: Camp
    Induction of apoptosis in human RPE1 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    Induction of apoptosis in human RPE1 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
    		[PMID: 29223099]
    TERT-RPE1 IC50
    > 40 μM
    Compound: Camp
    Cytotoxicity against human RPE1 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    Cytotoxicity against human RPE1 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay
    		[PMID: 29223099]
    THP-1 EC50
    0.16 μM
    Compound: camptothecin
    Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
    Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
    		[PMID: 20192247]
    THP-1 IC50
    0.071 μM
    Compound: Camptothecin
    Cytotoxicity against human THP1 cells after 2 days by MTT assay
    Cytotoxicity against human THP1 cells after 2 days by MTT assay
    		[PMID: 22325897]
    THP-1 IC50
    0.6 μM
    Compound: 1, CPT
    Cytotoxicity against human THP1 cells expressing p53 mutant after 48 hrs by SRB assay
    Cytotoxicity against human THP1 cells expressing p53 mutant after 48 hrs by SRB assay
    		[PMID: 19715319]
    THP-1 IC50
    1.89 μM
    Compound: Camptothecin
    Antitumor activity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    Tumor Cell line GI50
    44 nM
    Compound: camptothecin
    Mean GI50 against variety of human tumor cell lines
    Mean GI50 against variety of human tumor cell lines
    		[PMID: 11052802]
    U-251 GI50
    0.01 μM
    Compound: Camptothecin
    Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay
    		[PMID: 29313676]
    U-373MG ATCC GI50
    0.033 μM
    Compound: 1
    Cytotoxicity against human U373 cells after 72 hrs by MTT assay
    Cytotoxicity against human U373 cells after 72 hrs by MTT assay
    		[PMID: 21388138]
    U-373MG ATCC IC50
    0.015 μM
    Compound: Camptothecin
    Growth inhibition of human U373 cells after 72 hrs by MTT assay
    Growth inhibition of human U373 cells after 72 hrs by MTT assay
    		[PMID: 24180210]
    U-87MG ATCC IC50
    0.25 μM
    Compound: 21
    Antiproliferative activity against human U-87 MG cells assessed as reduction in cell viability
    Antiproliferative activity against human U-87 MG cells assessed as reduction in cell viability
    		[PMID: 32858470]
    U-87MG ATCC IC50
    0.5 μM
    Compound: Camptothecin
    Cytotoxicity against human U87 cells after 72 hrs by MTT assay
    Cytotoxicity against human U87 cells after 72 hrs by MTT assay
    		[PMID: 21186067]
    U-87MG ATCC IC50
    < 1.85 μM
    Compound: CPT
    Antiproliferative activity against human U87 cells measured after 72 hrs by MTT assay
    Antiproliferative activity against human U87 cells measured after 72 hrs by MTT assay
    		[PMID: 35462164]
    U-937 IC50
    0.015 μM
    Compound: camptothecin
    Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
    Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
    		[PMID: 17158054]
    U-937 IC50
    0.032 μM
    Compound: camptothecin
    Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
    Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
    		[PMID: 17158054]
    U-937 IC50
    0.3 μM
    Compound: 1, CPT
    Cytotoxicity against human U937 cells expressing p53 mutant after 48 hrs by SRB assay
    Cytotoxicity against human U937 cells expressing p53 mutant after 48 hrs by SRB assay
    		[PMID: 19715319]
    U-937 IC50
    0.68 μM
    Compound: camptothecin
    Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
    Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
    		[PMID: 17158054]
    U-937 IC50
    1.81 μM
    Compound: Camptothecin
    Antitumor activity against human U-937 cells assessed as reduction in cell viability incubated for 72 hrs
    Antitumor activity against human U-937 cells assessed as reduction in cell viability incubated for 72 hrs
    		[PMID: 36906964]
    U-937 IC50
    1.98 μM
    Compound: Camptothecin
    Cytotoxicity against human U937 cells after 2 days by MTT assay
    Cytotoxicity against human U937 cells after 2 days by MTT assay
    		[PMID: 22325897]
    U-937 IC50
    18.24 μM
    Compound: Camptothecin
    Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 36996717]
    U2OS GI50
    > 287 μM
    Compound: 1, CPT
    Cytotoxicity against human U2OS cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human U2OS cells incubated for 72 hrs by MTT assay
    		[PMID: 22867019]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human UACC62 cell line
    Antiproliferative activity against human UACC62 cell line
    		[PMID: 16442283]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human UACC62 cells
    Cytotoxicity against human UACC62 cells
    		[PMID: 17402722]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human UACC62 cells
    Antiproliferative activity against human UACC62 cells
    		[PMID: 18630891]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human UACC62 cells
    Cytotoxicity against human UACC62 cells
    		[PMID: 19783447]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human UACC62 cells
    Cytotoxicity against human UACC62 cells
    		[PMID: 20630766]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human UACC62 cells by SRB assay
    Antiproliferative activity against human UACC62 cells by SRB assay
    		[PMID: 21710981]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay
    Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay
    		[PMID: 21823606]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Cytotoxicity against human UACC62 cells by SRB assay
    Cytotoxicity against human UACC62 cells by SRB assay
    		[PMID: 24502276]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Growth inhibition of human UACC62 cells after 48 hrs by SRB assay
    Growth inhibition of human UACC62 cells after 48 hrs by SRB assay
    		[PMID: 24800942]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human UACC62 cells after 48 hrs
    Antiproliferative activity against human UACC62 cells after 48 hrs
    		[PMID: 27070999]
    UACC-62 GI50
    0.01 μM
    Compound: 1
    Antiproliferative activity against human UACC62 cells assessed as growth inhibition
    Antiproliferative activity against human UACC62 cells assessed as growth inhibition
    		[PMID: 28657311]
    UACC-62 GI50
    0.01 μM
    Compound: 1, CPT
    Antiproliferative activity against human UACC62 cells
    Antiproliferative activity against human UACC62 cells
    		[PMID: 20155916]
    UACC-62 GI50
    0.01 μM
    Compound: 1, Camptothecin
    Cytotoxicity against human UACC62 cells
    Cytotoxicity against human UACC62 cells
    		[PMID: 17676830]
    UACC-62 GI50
    0.01 μM
    Compound: 2
    Growth inhibitory activity against human melanoma UACC-62 cell line
    Growth inhibitory activity against human melanoma UACC-62 cell line
    		[PMID: 15509164]
    UACC-62 GI50
    0.01 μM
    Compound: 2
    Antiproliferative activity against human UACC62 cell line
    Antiproliferative activity against human UACC62 cell line
    		[PMID: 16913702]
    UACC-62 GI50
    0.01 μM
    Compound: 2
    Cytotoxicity against human UACC62 cells
    Cytotoxicity against human UACC62 cells
    		[PMID: 17696418]
    UACC-62 GI50
    0.01 μM
    Compound: 2
    Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 22329436]
    UACC-62 GI50
    0.01 μM
    Compound: 2 (Camptothecin)
    Antiproliferative activity was determined for 50% growth inhibition against human melanoma UACC-62 cell line
    Antiproliferative activity was determined for 50% growth inhibition against human melanoma UACC-62 cell line
    		[PMID: 11020283]
    UACC-62 GI50
    0.01 μM
    Compound: Camptothecin
    Concentration required to inhibit the growth of human Melanoma UACC-62 cells
    Concentration required to inhibit the growth of human Melanoma UACC-62 cells
    		[PMID: 16033260]
    UACC-62 GI50
    < 0.01 μM
    Compound: 18
    Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay
    Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay
    		[PMID: 28418653]
    Vero IC50
    0.02 μg/mL
    Compound: camptothecin
    Cytotoxicity against african green monkey Vero cells after 7 days by XTT assay
    Cytotoxicity against african green monkey Vero cells after 7 days by XTT assay
    		[PMID: 8021652]
    Vero IC50
    0.054 μg/mL
    Compound: camptothecin
    Cytotoxicity against african green monkey Vero cells
    Cytotoxicity against african green monkey Vero cells
    		[PMID: 8254347]
    Vero IC50
    0.054 μg/mL
    Compound: camptothecin
    Cytotoxicity against african green monkey Vero cells
    Cytotoxicity against african green monkey Vero cells
    		[PMID: 9514005]
    Vero IC50
    0.6 μg/mL
    Compound: Camptothecin
    Cytotoxicity against african green monkey Vero cells
    Cytotoxicity against african green monkey Vero cells
    		[PMID: 21985060]
    Vero IC50
    27 μM
    Compound: Camptothecin
    Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
    Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
    		[PMID: 11430001]
    Vero IC50
    58 μg/mL
    Compound: Camptothecin
    Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells by MTT assay
    Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells by MTT assay
    		10.1007/s00044-010-9381-7
    WI-38 IC50
    0.03 μM
    Compound: Camptothecin
    Cytotoxicity against human WI38 cells after 48 hrs by WST-1 assay
    Cytotoxicity against human WI38 cells after 48 hrs by WST-1 assay
    		[PMID: 28557449]
    WI-38 IC50
    0.03 μg/mL
    Compound: camptothecin
    Cytotoxicity against human WI38 cells assessed as cell viability by WST-1 assay
    Cytotoxicity against human WI38 cells assessed as cell viability by WST-1 assay
    		[PMID: 24593048]
    WI-38 IC50
    0.23 μM
    Compound: Campthotecin
    Cytotoxicity against human WI38 cells by MTT assay
    Cytotoxicity against human WI38 cells by MTT assay
    		[PMID: 26063305]
    WI-38 IC50
    0.4 μg/mL
    Compound: Camptothecin
    Cytotoxicity against human WI38 cells by MTT assay
    Cytotoxicity against human WI38 cells by MTT assay
    		[PMID: 23816880]
    WI-38 IC50
    786 nM
    Compound: CPT
    Cytotoxicity against human WI38 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human WI38 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 24901491]
    WI-38 IC50
    8.37 μM
    Compound: CPT
    Antiproliferative activity against human WI38 cells after 48 hrs by MTT assay
    Antiproliferative activity against human WI38 cells after 48 hrs by MTT assay
    		[PMID: 30685528]
    WIL2-NS CC50
    0.005 μM
    Compound: Camptothecin
    Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay
    Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay
    		[PMID: 22047799]
    WIL2-NS CC50
    0.005 μM
    Compound: Camptothecin
    Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay
    Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay
    		[PMID: 22884523]
    WIL2-NS IC50
    0.005 μM
    Compound: CPT
    Antiproliferative activity against human WIL-2NS cells by MTT assay
    Antiproliferative activity against human WIL-2NS cells by MTT assay
    		[PMID: 17254669]
    WiDr ED50
    0.07 μg/mL
    Compound: Camptothecin
    Cytotoxicity against human WiDr cells by MTT assay
    Cytotoxicity against human WiDr cells by MTT assay
    		[PMID: 18220355]
    WiDr GI50
    1.7 μM
    Compound: CPT
    Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay
    Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay
    		[PMID: 19664930]
    WiDr GI50
    1.8 μM
    Compound: Camptothecin
    Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay
    Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay
    		[PMID: 23831507]
    WiDr IC50
    0.07 μg/mL
    Compound: camptothecin
    Cytotoxicity against human WiDr cells by MTT assay
    Cytotoxicity against human WiDr cells by MTT assay
    		[PMID: 18774864]
    WiDr IC50
    17 nM
    Compound: CPT
    In Vitro cytotoxicity against human colon cancer cell line (WiDr)
    In Vitro cytotoxicity against human colon cancer cell line (WiDr)
    		[PMID: 11334569]
    ZR-75-1 IC50
    < 0.01 μM
    Compound: CPT
    Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
    Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
    		[PMID: 23142674]
    ZR-75-30 IC50
    0.24 μM
    Compound: CPT
    Antiproliferative activity against human ZR-7530 cells after 72 hrs by MTT assay
    Antiproliferative activity against human ZR-7530 cells after 72 hrs by MTT assay
    		[PMID: 28351590]
    carcinoma cell line IC50
    0.33 μM
    Compound: CPT (Camptothecin)
    Cytotoxicity against human non-small-cell lung carcinoma cell line H460 (NSCLC-H460)
    Cytotoxicity against human non-small-cell lung carcinoma cell line H460 (NSCLC-H460)
    		[PMID: 11563925]
    In Vitro

    High TOP1 enzymatic activity MCF7 (Luminal subtype) and HCC1419 (HER2 subtype) show high sensitivity toward Camptothecin (0.1 μM to 5 μM; 72 hours) treatment, exhibiting the IC50 values of 0.089 μM and 0.067 μM, respectively[4].
    Camptothecin (0.5 μM; 6 and 24 hours) reduces desferrioxamine-activated VEGF expression.
    Camptothecin (0.5 μM; 8 to 24 hours) strongly prevents the desferrioxamine-dependent HIF-1a accumulation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Camptothecin Related Antibodies

    Cell Viability Assay[4]

    Cell Line: MCF7 (Luminal subtype) and HCC1419 (HER2 subtype)
    Concentration: 0.1 μM to 5 μM
    Incubation Time: 72 hours
    Result: High TOP1 enzymatic activity MCF7 (Luminal subtype) and HCC1419 (HER2 subtype) show high sensitivity toward CPT (0.1 μM to 5 μM; 72 hours) treatment, exhibiting the IC50 values of 0.089 μM and 0.067 μM, respectively.

    RT-PCR[2]

    Cell Line: HeLa and HEK293 cell lines
    Concentration: 0.5 μmol/L
    Incubation Time: 6 and 24 hours
    Result: Reduces desferrioxamine-activated VEGF expression in both cell lines after 6 and 24 hours of treatment, whereas in normoxic condition camptothecin does not affect the VEGF mRNA level.

    Western Blot Analysis[2]

    Cell Line: HeLa and HEK293 cell lines
    Concentration: 0.5 μmol/L
    Incubation Time: 8 to 24 hours
    Result: Strongly prevents the desferrioxamine-dependent HIF-1a accumulation after 8 to 24 hours, whereas it does not affect HIF-1b levels.
    In Vivo

    Camptothecin (2 mg/kg every other day) treats mice, has developed numerous pulmonary metastases.
    Treatment with both kinase inhibitor of nuclear factor-kappaB-1 (KINK-1) and Camptothecin led to a statistically significant reduction in the number of pulmonary metastases[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL6 mice (injected with B16F10 melanoma cells)[5]
    Dosage: 2 mg/kg
    Administration: every other day, after 19 days
    Result: Has developed numerous pulmonary metastases.
    Clinical Trial
    Molecular Weight

    348.35

    Formula

    C20H16N2O4
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C1C2=C([C@@](O)(CC)C(OC2)=O)C=C(N1C3)C(C3=C4)=NC5=C4C=CC=C5
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

    Solvent & Solubility
    In Vitro: 

    1M NaOH : 10 mg/mL (28.71 mM; ultrasonic and adjust pH to 11 with NaOH)

    DMSO : 6.25 mg/mL (17.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8707 mL 14.3534 mL 28.7068 mL
    5 mM 0.5741 mL 2.8707 mL 5.7414 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 10 mg/mL (28.71 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.77%

    SDS (644 KB)

    COA (259 KB) RP-HPLC (243 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / 1M NaOH 1 mM 2.8707 mL 14.3534 mL 28.7068 mL 71.7669 mL
    5 mM 0.5741 mL 2.8707 mL 5.7414 mL 14.3534 mL
    10 mM 0.2871 mL 1.4353 mL 2.8707 mL 7.1767 mL
    15 mM 0.1914 mL 0.9569 mL 1.9138 mL 4.7845 mL
    1M NaOH 20 mM 0.1435 mL 0.7177 mL 1.4353 mL 3.5883 mL
    25 mM 0.1148 mL 0.5741 mL 1.1483 mL 2.8707 mL
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    Camptothecin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Camptothecin7689-03-4Campathecin (S)-(+)-Camptothecin CPTTopoisomeraseADC PayloadMicroRNAInfluenza VirusApoptosisFungalAntibioticADC CytotoxinmiRNAalkaloidDNA topoisomerase ITop1hypoxia-inducible factor-1αHIF-1αmicroRNAsmiRNInhibitorinhibitorinhibit

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