Topoisomerase Inhibitors

Topoisomerase

Topo I

Topo II

DNA gyrase

Topoisomerase Inhibitors, Agonists, Modulators, Inducers & Degraders

Product Name	Topoisomerase	Topo I	Topo II	DNA gyrase	Purity
Etoposide			Topoisomerase II		99.93%
DXd		Topoisomerase I, IC₅₀: 0.31 μM			99.30%
SN-38		Topoisomerase I			99.94%
BWC0977 formic	TOPO IV				99.61%
Irinotecan		Topoisomerase I			99.97%
Camptothecin		Topoisomerase I, IC₅₀: 679 nM			99.77%
Datopotamab deruxtecan (solution)		Topoisomerase I			99.98%
Topotecan hydrochloride		Topoisomerase I			99.89%
Mitoxantrone			Topoisomerase II		99.58%
Daunorubicin hydrochloride			Topoisomerase II		99.67%
Irinotecan hydrochloride		Topoisomerase I			99.89%
Levofloxacin	TOPO IV				99.92%
Epirubicin hydrochloride	Topoisomerase				99.62%
Ifinatamab deruxtecan		Topoisomerase I			99.29%
Idarubicin hydrochloride			Topoisomerase II		99.94%
Betulinic acid		Topoisomerase I, IC₅₀: 5 μM			99.88%
β-Lapachone		Topoisomerase I			99.96%
DXd-d₅		Topoisomerase I, IC₅₀: 0.31 μM			99.02%
Mitoxantrone dihydrochloride			Topoisomerase II		98.98%
Etoposide phosphate			Topoisomerase II		99.44%
Teniposide			Topoisomerase II		99.00%
Telisotuzumab Adizutecan		Topoisomerase I			99.63%
PNU-159682		Topoisomerase I			98.50%
Irinotecan hydrochloride trihydrate		Topoisomerase I			99.89%
Nalidixic acid	Topoisomerase				99.97%
Aurintricarboxylic acid			Topoisomerase II
Daunorubicin			Topoisomerase II		99.94%
Aclacinomycin A		Topoisomerase I	Topoisomerase II		99.30%
Levofloxacin hydrate	TOPO IV				99.98%
Epirubicin	Topoisomerase				99.31%
Pirarubicin			Topoisomerase II		99.61%
ICRF-193			Topoisomerase II		99.64%
Belotecan hydrochloride		Top1			99.97%
Ellipticine			Topoisomerase II		99.59%
Pirarubicin Hydrochloride			Topoisomerase II		99.14%
Pixantrone			Topoisomerase II		98.75%
Banoxantrone dihydrochloride			Topoisomerase II		99.46%
Precemtabart tocentecan		Topoisomerase I			99.31%
Proscillaridin A		Topoisomerase I, IC₅₀: 30 nM	Topoisomerase II, IC₅₀: 100 nM		99.74%
Gatifloxacin			Topoisomerase II, IC₅₀: 36.7 μM		99.69%
Idarubicin			Topoisomerase II		99.89%
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride		Topoisomerase I			98.46%
(S)-10-Hydroxycamptothecin		Topoisomerase I			99.74%
DS-3939a		Topoisomerase I			99.15%
Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan		Topoisomerase I			98.62%
Amsacrine			Topoisomerase II		99.95%
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT		Topoisomerase I			98.71%
Bisantrene			Topoisomerase II		98.06%
Flumequine			Topoisomerase II, IC₅₀: 15 μM		99.65%
MC-GGFG-AM-(10Me-11F-Camptothecin)		Topoisomerase I			98.99%
PluriSIn #2			topoisomerase II alpha		98.0%
Amonafide			Topoisomerase II		99.92%
Puxitatug samrotecan		Topoisomerase I			98.51%
Tilatamig samrotecan		Topoisomerase I
Topotecan		Topoisomerase I			98.04%
Genz-644282		Topoisomerase I			99.13%
Levofloxacin hydrochloride	TOPO IV				99.99%
FZ-AD005		Topoisomerase I
Hycanthone		Topoisomerase I	Topoisomerase II		99.81%
Ellipticine hydrochloride			Topoisomerase II		99.01%
Topobexin			topoisomerase II beta, IC₅₀: 0.19 μM topoisomerase II alpha, IC₅₀: 4.8 μM		99.04%
Nalidixic acid sodium salt	Topoisomerase				99.83%
9-Aminocamptothecin		Topoisomerase I			98.89%
TAS-103 dihydrochloride		Topoisomerase I	Topoisomerase II		98.45%
Daun02	Topoisomerase				98.72%
Amsacrine hydrochloride			Topoisomerase II		99.92%
Coralyne chloride		Topoisomerase I			98.39%
P5(PEG24)-VC-PAB-Exatecan		Top1			99.74%
Voreloxin Hydrochloride			Topoisomerase II		99.58%
MC-DOXHZN hydrochloride			Topoisomerase II		98.0%
Indotecan		Topoisomerase I			98.0%
Amrubicin			Topoisomerase II		≥98.0%
DACA		Topoisomerase I	Topoisomerase II		98.89%
Isodiospyrin		Topoisomerase I			99.72%
VcMMAE-Deruxtecan		Topoisomerase I			98.10%
LMP744		Top1			98.33%
Gimatecan		Topoisomerase I			99.28%
LMP517		Topoisomerase I	Topoisomerase II		99.58%
Garenoxacin Mesylate hydrate	TOPO IV, IC₅₀: 1.5-2.5 μg/mL				99.95%
Voreloxin			Topoisomerase II		99.85%
ARN-21934			topoisomerase II alpha topoisomerase II beta		98.08%
LMP744 hydrochloride		Top1			99.08%
Indimitecan		Top1			98.30%
Chloroquinoxaline sulfonamide			topoisomerase II alpha topoisomerase II beta		99.06%
Pefloxacin		Topoisomerase I			99.37%
Podocarpusflavone A		Topoisomerase I, IC₅₀: 119.425 μM			99.62%
(±)-10-Hydroxycamptothecin		Topoisomerase I			99.57%
Intoplicine		Topoisomerase I	Topoisomerase II		98.36%
Namitecan		Topoisomerase I			98.03%
Gatifloxacin hydrochloride			Topoisomerase II, : 36.7 μM		99.94%
(±)-Evodiamine		Top1			99.74%
Topi MF-6		Top1			99.79%
BNS-22			topoisomerase II alpha, IC₅₀: 2.8 μM (in human) topoisomerase II beta, IC₅₀: 0.42 μM (in human)		99.50%
Seconeolitsine		Topoisomerase I, IC₅₀: 17 μM			98.65%
Topoisomerase I inhibitor 8		Topoisomerase I			99.87%
Karenitecin		Topoisomerase I			98.02%
Topoisomerase II inhibitor 13			Topoisomerase II		98.07%
Zabofloxacin hydrochloride		Topoisomerase I	Topoisomerase II		99.54%
Aclacinomycin A hydrochloride		Topoisomerase I	Topoisomerase II
PBX-7016		Topoisomerase I
Lurtotecan		Topoisomerase I
Elomotecan hydrochloride		Topoisomerase I	Topoisomerase II
9-Hydroxyellipticine hydrochloride			Topoisomerase II		99.0%
AMT-562		Topoisomerase I
PNU-142586			topoisomerase II alpha topoisomerase II beta
Razoxane			Topoisomerase II		99.78%
AQ4			Topoisomerase II
20-O-Acetylcamptothecin		Topoisomerase I			98.0%
DBCO-PEG3-GGFG-Exatecan		Topoisomerase I
Topoisomerase II inhibitor 20 TFA			Topoisomerase II, IC₅₀: 0.98 μM
TAS-103		Topoisomerase I	Topoisomerase II		99.69%
Doxorubicin hydrochloride		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM		99.90%
Doxorubicin		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM
Topoisomerase II inhibitor 20			Topoisomerase II, IC₅₀: 0.98 μM		98.44%
Groenlandicine		Topoisomerase I			99.87%
IID432			Topoisomerase II		98.20%
CH-0793076		Topoisomerase I, IC₅₀: 2.3 μM
Deruxtecan-Eribulin		Topoisomerase I
XK469			Topoisomerase II		98%
Edotecarin		Topoisomerase I, IC₅₀: 50 nM			98.39%
CH-0793076 TFA		Topoisomerase I, IC₅₀: 2.3 μM			98.71%
BWC0977	TOPO IV
Zabofloxacin		Topoisomerase I	Topoisomerase II		98.02%
SW044248		Topoisomerase I			99.60%
AZD5099			Topoisomerase II		98.40%
1,4-Di-tert-butylbenzene			Topoisomerase II		99.89%
Amrubicin hydrochloride			Topoisomerase II		98.78%
Pixantrone free base			Topoisomerase II
Garenoxacin	TOPO IV, IC₅₀: 1.5-2.5 μg/mL				98.62%
Topovale		Topoisomerase I			99.94%
Topotecan hydrochloride hydrate		Topoisomerase I
Silatecan		Topoisomerase I
Etoposide phosphate disodium			Topoisomerase II
Gatifloxacin sesquihydrate			Topoisomerase II, IC₅₀: 36.7 μM
Rebeccamycin		Topoisomerase I
Exatecan hydrochloride		Topoisomerase I, IC₅₀: 2.2 μM
Mitoxantrone diacetate			Topoisomerase II
Daunorubicin citrate			Topoisomerase II
Antitumor agent-63		Top1
TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT		Top1
Echinoside A			topoisomerase II alpha
Anticancer agent 276			Topoisomerase II
Topoisomerase II inhibitor 9			Topoisomerase II, IC₅₀: 0.97 μM
YCJ-02		Topoisomerase I
Topo I/COX-2-IN-1		Topoisomerase I, IC₅₀: 4.42 μM
Bimolane			Topoisomerase II
T-2513 hydrochloride		Topoisomerase I
TOPOI/PARP-1-IN-2		Top1, IC₅₀: 46.2 nM
Topo I/COX-2-IN-2		Topoisomerase I, IC₅₀: 0.90 μM
DK 507k				DNA Gyrase
Topoisomerase II inhibitor 11			Topoisomerase II, IC₅₀: 2.89 μM
CS1			topoisomerase II alpha
(1R,9S)-Exatecan		Topoisomerase I
NK-611			Topoisomerase II, IC₅₀: 56 μM
T-2513		Topoisomerase I
10-Nitrocamptothecin		Topoisomerase I, IC₅₀: 0.64 μM
Topoisomerase IIα-IN-3			topoisomerase II alpha
GI-149893		Topoisomerase I
Camsirubicin			topoisomerase II beta
XK469 sodium			Topoisomerase II
Topo I/DDX5-IN-1		Topoisomerase I
Topoisomerase II/EGFR-IN-1			Topoisomerase II
SN-28049			Topoisomerase II
Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6		Topoisomerase I
XSJ110		Topoisomerase I, IC₅₀: 0.133 μM
Premafloxacin	TOPO IV
Anticancer agent 75			Topoisomerase II
Nectandrin B		Topoisomerase I	Topoisomerase II
CP-67804			Topoisomerase II
ICRF-196			Topoisomerase II
DTS-108		Top1
Pixantrone hydrochloride			Topoisomerase II
Galarubicin hydrochloride			Topoisomerase II
Topoisomerase II inhibitor 4			Topoisomerase II
GENA-104A16		Topoisomerase I
Topoisomerase I/II-IN-9		Topoisomerase I, IC₅₀: <10 μM	Topoisomerase II, IC₅₀: <10 μM
Topoisomerase IIα-IN-6			topoisomerase II alpha, IC₅₀: 0.67 μM
Topoisomerase IIα-IN-2			topoisomerase II alpha topoisomerase II beta
Topoisomerase IIα-IN-4			topoisomerase II alpha, IC₅₀: 3.8 μM topoisomerase II beta, IC₅₀: 10.1 μM
Val-Cit-Exatecan		Topoisomerase I
GC-072	TOPO IV, IC₅₀: 4-30 μM (S. aureus) TOPO IV, IC₅₀: 4.22-8.45 μM (E.coli)			DNA Gyrase, IC₅₀: 2 μM (S. aureus) DNA Gyrase, IC₅₀: 0.18-1.5 μM (E.coli)
Topoisomerase II/EGFR-IN-2			topoisomerase II alpha, IC₅₀: 0.122 μM
ZLHQ-5f		Top1
SeSA-HCPT		Topoisomerase I
3-Fluoro-evodiamine glucose		Topoisomerase I	Topoisomerase II
LD2-3		Topoisomerase I
Topo I-IN-1		Topoisomerase I
Topoisomerase I/II inhibitor 6		Topoisomerase I, IC₅₀: 4.77 μM	Topoisomerase II, IC₅₀: 15 μM
MGB1Y		Topoisomerase I
Topo I/II-IN-3		Topoisomerase I, : 8.99	Topoisomerase II, : 26.92
Anti-SLC34A2 (Lifastuzumab)-MC-Vc-PAB-SN38		Topoisomerase I
EGFR-IN-116			Topoisomerase II, IC₅₀: 19.74 μM
β-Glu-PAB(CH2NH2)-Exatecan	Topoisomerase
Topoisomerase I-IN-19		Topoisomerase I
Top/HDAC-IN-2		Top1	Topoisomerase II
Anti-MRSA agent 7	TOPO IV, IC₅₀: 0.059 μM (E. coli ) TOPO IV, IC₅₀: 0.341 μM (S. aureus)
Topoisomerase II inhibitor 18			Topoisomerase II, IC₅₀: 7.5 μM
PNU-142586 sodium			topoisomerase II alpha topoisomerase II beta
Topoisomerase I inhibitor 17		Top1
MN33-63		Topoisomerase I
4"-Isovalerylspiramycin I		Top1
Topoisomerase I/II-IN-1		Topoisomerase I	Topoisomerase II
Topoisomerase IIα-IN-11			topoisomerase II alpha
Elomotecan		Topoisomerase I	Topoisomerase II
DNA/TOP2A-IN-1			topoisomerase II alpha
Cryptolepine			Topoisomerase II
Topoisomerase II inhibitor 5			Topoisomerase II
LE01		Topoisomerase I
HSP90-IN-13	Topoisomerase-2, IC₅₀: 25.85 nM
Topoisomerase I inhibitor 2		Topoisomerase I, IC₅₀: 0.58 μM
KW-2170 hydrochloride			Topoisomerase II
cis-THSG			Topoisomerase II
AT-9			Topoisomerase II
iNOS/TopoI-IN-1		Topoisomerase I, Ki: 2.72 μM
Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38		Topoisomerase I
Fmoc-Val-Cit-PAB-Exatecan		Topoisomerase I
Topoisomerase I-IN-21		Topoisomerase I, IC₅₀: 18.79 μM
TOP1/TDP1-IN-1		Top1
Topoisomerase II inhibitor 10			Topoisomerase II, IC₅₀: 7.45 μM
Salvicine			Topoisomerase II, IC₅₀: 3 μM
DBCO-PEG8-VKG-CPT2		Topoisomerase I
Topoisomerase IV inhibitor 1	TOPO IV, IC₅₀: 0.23 μM
Topoisomerase ll/ME-1-IN-1			Topoisomerase II, IC₅₀: 5.03 μM
A-74932 hydrochloride			Topoisomerase II
(±)-E-Homocamptothecin		Topoisomerase I
EGFR-IN-57			topoisomerase II beta, IC₅₀: 0.13 μM
Topoisomerase IIα-IN-1			topoisomerase II alpha topoisomerase II beta
Huanglongmycin N		Topoisomerase I, EC₅₀: 14 μM
Topoisomerase IIα-IN-8			topoisomerase II alpha
BCPT02		Topoisomerase I
CP-67015			Topoisomerase II
Tapcin		Topoisomerase I, IC₅₀: 203 nM	Topoisomerase II, IC₅₀: 71 nM
EGFR/VEGFR2-IN-13			Topoisomerase II
Topoisomerase I inhibitor 12		Topoisomerase I
Topoisomerase II inhibitor 17			Topoisomerase II, IC₅₀: 0.23 μM
Amonafide L-malate			Topoisomerase II
Topoisomerase I/IIα-IN-1		Topoisomerase I	Topoisomerase II
Topoisomerase I/II inhibitor 2		Topoisomerase I	Topoisomerase II
HU 331			Topoisomerase II
IKKβ-IN-6		Topoisomerase I
Topo I/II-IN-2		Topoisomerase I	Topoisomerase II
Diospyrin		Topoisomerase I
Saintopin		Topoisomerase I	Topoisomerase II
Intoplicine dimesylate		Topoisomerase I	Topoisomerase II		98.28%
Topoisomerase IV inhibitor 2	TOPO IV, IC₅₀: 0.35 μM
Topoisomerase II inhibitor 7			topoisomerase II alpha, IC₅₀: 3.19 μM
Orenasitecan		Top1
Topoisomerase I/II inhibitor 7		Topoisomerase I	Topoisomerase II
XSJ151		Topoisomerase I
Topoisomerase II-IN-24			topoisomerase II alpha, IC₅₀: 41.67 μM
Topoisomerase IIα-IN-7			topoisomerase II alpha, IC₅₀: 7.7 μM
MGB4		Topoisomerase I
Niranthin	Topoisomerase
Epolactaene			Topoisomerase II, IC₅₀: 10 μM
Topoisomerase I inhibitor 3		Topoisomerase I
Topoisomerase II inhibitor 19			Topoisomerase II, IC₅₀: 0.34 μM
RSK2/TOP2-IN-1			topoisomerase II alpha topoisomerase II beta
Corydamine		Topoisomerase I	Topoisomerase II
TP0480066			Topoisomerase II
MN33-47		Topoisomerase I
XSJ81		Topoisomerase I
Topoisomerase I inhibitor 16		Topoisomerase I
TP3011		Topoisomerase I
Topoisomerase II inhibitor 8			Topoisomerase II, IC₅₀: 0.52 μM
(Rac)-7-Ethyl-10-hydroxycamptothecin		Topoisomerase I
Topoisomerase I/II inhibitor 3		Topoisomerase I	Topoisomerase II
LD-38		Topoisomerase I
DNA gyrase/Topo IV-IN-3	TOPO IV, IC₅₀: 3.47 μM
IKE16			Topoisomerase II, IC₅₀: 13.68 μM
Gatifloxacin mesylate			Topoisomerase II, IC₅₀: 36.7 μM
Antibacterial agent 327	TOPO IV, IC₅₀: 2.31 (Deca μM TOPO IV, IC₅₀: 0.73 (ATPa μM
Heliquinomycin		Topoisomerase I	Topoisomerase II
Albicidin				DNA Gyrase
Eupolauridine		Topoisomerase I	Topoisomerase II
Topoisomerase IIα-IN-5			topoisomerase II alpha
Bakuchicin			Topoisomerase II, IC₅₀: 404 μM
NBTI 5463			Topoisomerase II
Thaspine acetate		Topoisomerase I	Topoisomerase II
Antibacterial agent 229	TOPO IV, IC₅₀: 10.88 μM
(-)-BO 2367			Topoisomerase II
8-Chloro-ATP tetrasodium			Topoisomerase II
Anti-Trypanosoma cruzi agent-9			Topoisomerase II
Topoisomerase IV-IN-3	TOPO IV, IC₅₀: 1.32 μM TOPO IV, IC₅₀: 0.48 μM			DNA Gyrase, IC₅₀: 0.88 μM DNA Gyrase, IC₅₀: 0.54 μM
Luotonin F			Topoisomerase II
NK 314			topoisomerase II alpha
8-Chloro-ATP			Topoisomerase II
Azithromycin-amide-C3-amide-quinoxaline		Topoisomerase I, IC₅₀: 120.7 μM

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