1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase Inhibitors

Topoisomerase Inhibitors

Topoisomerase

Topo I

Topo II

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Topoisomerase Inhibitors & Agonists
Product Name Topoisomerase Topo I Topo II Purity
Doxorubicin hydrochloride  
Topoisomerase I, IC50: 0.8 μM
Topoisomerase II, IC50: 2.67 μM
99.58%
Etoposide    
Topoisomerase II
99.94%
Exatecan mesylate  
Topoisomerase I, IC50: 0.975 μg/mL
  99.91%
SN-38  
Topoisomerase I
  99.80%
Irinotecan  
Topoisomerase I
  99.84%
Indimitecan  
Top1
  98.03%
Seconeolitsine  
Topoisomerase I, IC50: 17 μM
 
Camptothecin  
Topoisomerase I, IC50: 679 nM
  99.69%
Dxd  
Topoisomerase I, IC50: 0.31 μM
  98.02%
Topotecan Hydrochloride  
Topoisomerase I
  99.74%
Daunorubicin hydrochloride    
Topoisomerase II
99.23%
Irinotecan hydrochloride  
Topoisomerase I
  99.75%
Mitoxantrone    
Topoisomerase II
98.36%
Epirubicin hydrochloride
Topoisomerase
    99.16%
Betulinic acid  
Topoisomerase I, IC50: 5 μM
  ≥98.0%
Levofloxacin
TOPO IV
    99.84%
β-Lapachone  
Topoisomerase I
  99.85%
Idarubicin hydrochloride    
Topoisomerase II
99.83%
Pirarubicin    
Topoisomerase II
99.61%
Mitoxantrone dihydrochloride    
Topoisomerase II
99.55%
Banoxantrone dihydrochloride    
Topoisomerase II
99.17%
Aldoxorubicin    
Topoisomerase II
Bisantrene    
Topoisomerase II
Aclacinomycin A hydrochloride  
Topoisomerase I
Topoisomerase II
Irinotecan hydrochloride trihydrate  
Topoisomerase I
  99.89%
Teniposide    
Topoisomerase II
98.88%
Aurintricarboxylic acid    
Topoisomerase II
PNU-159682  
Topoisomerase I
 
Hycanthone  
Topoisomerase I
Topoisomerase II
99.73%
(S)-10-Hydroxycamptothecin  
Topoisomerase I
  99.38%
Pirarubicin Hydrochloride    
Topoisomerase II
98.51%
Belotecan hydrochloride  
Top1
  98.82%
Chloroquinoxaline sulfonamide    
topoisomerase II alpha
topoisomerase II beta
99.47%
Ellipticine hydrochloride    
Topoisomerase II
99.45%
Nalidixic acid
Topoisomerase
    99.99%
Amsacrine    
Topoisomerase II
99.95%
Pixantrone    
Topoisomerase II
98.38%
Genz-644282  
Topoisomerase I
  99.53%
Dxd-d5  
Topoisomerase I, IC50: 0.31 μM
  98.63%
Etoposide phosphate    
Topoisomerase II
98.40%
Coralyne chloride  
Topoisomerase I
  99.34%
Proscillaridin A  
Topoisomerase I, IC50: 30 nM
Topoisomerase II, IC50: 100 nM
99.74%
Amonafide    
Topoisomerase II
99.92%
Daun02
Topoisomerase
    98.85%
LMP744 hydrochloride  
Top1
  99.70%
Levofloxacin hydrate
TOPO IV
    99.28%
Amsacrine hydrochloride    
Topoisomerase II
98.98%
PluriSIn #2    
topoisomerase II alpha
≥98.0%
Garenoxacin Mesylate hydrate
TOPO IV, IC50: 1.5-2.5 μg/mL
    99.78%
Gatifloxacin    
Topoisomerase II, IC50: 36.7 μM
99.55%
9-amino-CPT  
Topoisomerase I
  99.05%
Flumequine    
Topoisomerase II, IC50: 15 μM
99.44%
Karenitecin  
Topoisomerase I
  98.27%
MC-DOXHZN hydrochloride    
Topoisomerase II
≥98.0%
Voreloxin Hydrochloride    
Topoisomerase II
99.96%
Gimatecan  
Topoisomerase I
  99.20%
Amrubicin    
Topoisomerase II
>98.0%
TAS-103 dihydrochloride  
Topoisomerase I
Topoisomerase II
98.87%
Gatifloxacin hydrochloride    
Topoisomerase II, : 36.7 μM
99.94%
(±)-Evodiamine  
Top1
  99.97%
(±)-10-Hydroxycamptothecin  
Topoisomerase I
  99.44%
Zabofloxacin hydrochloride  
Topoisomerase I
Topoisomerase II
98.06%
Namitecan  
Topoisomerase I
  98.11%
Topotecan  
Topoisomerase I
 
ARN-21934    
topoisomerase II alpha
topoisomerase II beta
98.02%
Groenlandicine  
Topoisomerase I
  99.69%
CH-0793076  
Topoisomerase I, IC50: 2.3 μM
 
Doxorubicin  
Topoisomerase I, IC50: 0.8 μM
Topoisomerase II, IC50: 2.67 μM
Ellipticine    
Topoisomerase II
Lurtotecan  
Topoisomerase I
 
Edotecarin  
Topoisomerase I, IC50: 50 nM
  98.39%
CH-0793076 TFA  
Topoisomerase I, IC50: 2.3 μM
  98.92%
Zabofloxacin  
Topoisomerase I
Topoisomerase II
SW044248  
Topoisomerase I
  99.60%
LMP744  
Top1
 
Pixantrone free base    
Topoisomerase II
Exatecan  
Topoisomerase I, IC50: 2.2 μM
 
Daunorubicin    
Topoisomerase II
TAS-103  
Topoisomerase I
Topoisomerase II
Intoplicine  
Topoisomerase I
Topoisomerase II
98.36%
MC-DOXHZN    
Topoisomerase II
Topotecan hydrochloride hydrate  
Topoisomerase I
 
Gatifloxacin sesquihydrate    
Topoisomerase II, IC50: 36.7 μM
Rebeccamycin  
Topoisomerase I
 
Mitoxantrone diacetate    
Topoisomerase II
Etoposide phosphate disodium    
Topoisomerase II
Idarubicin    
Topoisomerase II
Daunorubicin citrate    
Topoisomerase II
Antitumor agent-63  
Top1
 
Aclacinomycin A  
Topoisomerase I
Topoisomerase II
Levofloxacin hydrochloride
TOPO IV
   
Topoisomerase II inhibitor 9    
Topoisomerase II, IC50: 0.97 μM
Topo I/COX-2-IN-1  
Topoisomerase I, IC50: 4.42 μM
 
Bimolane    
Topoisomerase II
T-2513 hydrochloride  
Topoisomerase I
 
Topo I/COX-2-IN-2  
Topoisomerase I, IC50: 0.90 μM
 
Topoisomerase II inhibitor 11    
Topoisomerase II, IC50: 2.89 μM
CS1    
topoisomerase II alpha
Topoisomerase I inhibitor 8  
Topoisomerase I
 
T-2513  
Topoisomerase I
 
Razoxane    
Topoisomerase II
Topoisomerase IIα-IN-3    
topoisomerase II alpha
Nalidixic acid sodium salt
Topoisomerase
   
Podocarpusflavone A  
Topoisomerase I, IC50: 119.425 μM
 
Anticancer agent 75    
Topoisomerase II
CP-67804    
Topoisomerase II
AQ4    
Topoisomerase II
Pixantrone hydrochloride    
Topoisomerase II
Topoisomerase II inhibitor 4    
Topoisomerase II
Topoisomerase IIα-IN-2    
topoisomerase II alpha
topoisomerase II beta
Topoisomerase IIα-IN-4    
topoisomerase II alpha, IC50: 3.8 μM
topoisomerase II beta, IC50: 10.1 μM
ZLHQ-5f  
Top1
 
Topo I-IN-1  
Topoisomerase I
 
Top/HDAC-IN-2  
Top1
Topoisomerase II
Topoisomerase II inhibitor 5    
Topoisomerase II
HSP90-IN-13
Topoisomerase-2, IC50: 25.85 nM
   
Topoisomerase I inhibitor 2  
Topoisomerase I, IC50: 0.58 μM
 
Topoisomerase II inhibitor 10    
Topoisomerase II, IC50: 7.45 μM
Topoisomerase IV inhibitor 1
TOPO IV, IC50: 0.23 μM
   
EGFR-IN-57    
topoisomerase II beta, IC50: 0.13 μM
Topoisomerase IIα-IN-1    
topoisomerase II alpha
topoisomerase II beta
Huanglongmycin N  
Topoisomerase I, EC50: 14 μM
 
CP-67015    
Topoisomerase II
Elomotecan hydrochloride  
Topoisomerase I
Topoisomerase II
BNS-22    
topoisomerase II alpha, IC50: 2.8 μM (in human)
topoisomerase II beta, IC50: 0.42 μM (in human)
Topoisomerase I/II inhibitor 2  
Topoisomerase I
Topoisomerase II
Intoplicine dimesylate  
Topoisomerase I
Topoisomerase II
98.28%
Topoisomerase IV inhibitor 2
TOPO IV, IC50: 0.35 μM
   
Topoisomerase II inhibitor 7    
topoisomerase II alpha, IC50: 3.19 μM
Niranthin
Topoisomerase
   
Topoisomerase I inhibitor 3  
Topoisomerase I
 
Corydamine  
Topoisomerase I
Topoisomerase II
TP0480066    
Topoisomerase II
TP3011  
Topoisomerase I
 
Topoisomerase II inhibitor 8    
Topoisomerase II, IC50: 0.52 μM
Topoisomerase I/II inhibitor 3  
Topoisomerase I
Topoisomerase II
Gatifloxacin mesylate    
Topoisomerase II, IC50: 36.7 μM
Voreloxin    
Topoisomerase II
Garenoxacin
TOPO IV, IC50: 1.5-2.5 μg/mL
   
Epirubicin
Topoisomerase
   
9-Hydroxyellipticine hydrochloride    
Topoisomerase II
AZD5099    
Topoisomerase II