1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase Inhibitors

Topoisomerase Inhibitors

Topoisomerase

Topo I

Topo II

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Topoisomerase Inhibitors & Agonists
Product Name Topoisomerase Topo I Topo II Purity
Doxorubicin hydrochloride  
Topoisomerase I, IC50: 0.8 μM
Topoisomerase II, IC50: 2.67 μM
99.60%
Etoposide    
Topoisomerase II
99.94%
Exatecan mesylate  
Topoisomerase I, IC50: 0.975 μg/mL
  99.92%
Dxd  
Topoisomerase I, IC50: 0.31 μM
  ≥99.0%
SN-38  
Topoisomerase I
  99.89%
Irinotecan  
Topoisomerase I
  99.84%
Camptothecin  
Topoisomerase I, IC50: 679 nM
  99.82%
Topotecan hydrochloride  
Topoisomerase I
  99.76%
Daunorubicin hydrochloride    
Topoisomerase II
99.62%
Mitoxantrone    
Topoisomerase II
98.36%
Irinotecan hydrochloride  
Topoisomerase I
  99.89%
Exatecan  
Topoisomerase I, IC50: 2.2 μM
  99.93%
Epirubicin hydrochloride
Topoisomerase
    99.16%
Levofloxacin
TOPO IV
    99.93%
Betulinic acid  
Topoisomerase I, IC50: 5 μM
  ≥98.0%
Idarubicin hydrochloride    
Topoisomerase II
99.94%
Mitoxantrone dihydrochloride    
Topoisomerase II
99.55%
Teniposide    
Topoisomerase II
98.88%
β-Lapachone  
Topoisomerase I
  99.99%
Pirarubicin    
Topoisomerase II
99.61%
Aldoxorubicin    
Topoisomerase II
Banoxantrone dihydrochloride    
Topoisomerase II
99.67%
Irinotecan hydrochloride trihydrate  
Topoisomerase I
  99.89%
Datopotamab deruxtecan  
Topoisomerase I
  99.54%
PNU-159682  
Topoisomerase I
  98.25%
Dxd-d5  
Topoisomerase I, IC50: 0.31 μM
  98.76%
Belotecan hydrochloride  
Top1
  99.88%
(S)-10-Hydroxycamptothecin  
Topoisomerase I
  99.38%
Aurintricarboxylic acid    
Topoisomerase II
Bisantrene    
Topoisomerase II
98.08%
Etoposide phosphate    
Topoisomerase II
Pirarubicin Hydrochloride    
Topoisomerase II
98.56%
Nalidixic acid
Topoisomerase
    99.97%
Amsacrine    
Topoisomerase II
99.95%
Pixantrone    
Topoisomerase II
98.38%
Chloroquinoxaline sulfonamide    
topoisomerase II alpha
topoisomerase II beta
99.06%
Levofloxacin hydrate
TOPO IV
    99.93%
Gatifloxacin    
Topoisomerase II, IC50: 36.7 μM
99.55%
Ellipticine hydrochloride    
Topoisomerase II
99.34%
Coralyne chloride  
Topoisomerase I
  99.34%
Hycanthone  
Topoisomerase I
Topoisomerase II
99.97%
Aclacinomycin A hydrochloride  
Topoisomerase I
Topoisomerase II
Indotecan  
Topoisomerase I
  ≥98.0%
PluriSIn #2    
topoisomerase II alpha
≥98.0%
Amonafide    
Topoisomerase II
99.92%
TAS-103 dihydrochloride  
Topoisomerase I
Topoisomerase II
98.87%
Genz-644282  
Topoisomerase I
  99.53%
Gatifloxacin hydrochloride    
Topoisomerase II, : 36.7 μM
99.94%
Amsacrine hydrochloride    
Topoisomerase II
99.98%
(±)-10-Hydroxycamptothecin  
Topoisomerase I
  99.44%
Daun02
Topoisomerase
    98.72%
Amrubicin    
Topoisomerase II
≥98.0%
9-Aminocamptothecin  
Topoisomerase I
  99.05%
Voreloxin Hydrochloride    
Topoisomerase II
99.96%
Ellipticine    
Topoisomerase II
98.17%
MC-DOXHZN hydrochloride    
Topoisomerase II
≥98.0%
Karenitecin  
Topoisomerase I
  98.27%
Garenoxacin Mesylate hydrate
TOPO IV, IC50: 1.5-2.5 μg/mL
    99.78%
Flumequine    
Topoisomerase II, IC50: 15 μM
99.89%
Intoplicine  
Topoisomerase I
Topoisomerase II
98.36%
MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan  
Topoisomerase I
 
(±)-Evodiamine  
Top1
  99.97%
Gimatecan  
Topoisomerase I
  99.28%
Groenlandicine  
Topoisomerase I
  99.87%
Lurtotecan  
Topoisomerase I
  98.01%
LMP744 hydrochloride  
Top1
  99.70%
MC-GGFG-AM-(10Me-11F-Camptothecin)  
Topoisomerase I
  98.06%
Indimitecan  
Top1
  98.03%
Isodiospyrin  
Topoisomerase I
  99.77%
Topotecan  
Topoisomerase I
 
Seconeolitsine  
Topoisomerase I, IC50: 17 μM
 
Zabofloxacin hydrochloride  
Topoisomerase I
Topoisomerase II
98.06%
Namitecan  
Topoisomerase I
  99.25%
ARN-21934    
topoisomerase II alpha
topoisomerase II beta
98.02%
CH-0793076  
Topoisomerase I, IC50: 2.3 μM
 
Doxorubicin  
Topoisomerase I, IC50: 0.8 μM
Topoisomerase II, IC50: 2.67 μM
Edotecarin  
Topoisomerase I, IC50: 50 nM
  98.39%
CH-0793076 TFA  
Topoisomerase I, IC50: 2.3 μM
  98.71%
Zabofloxacin  
Topoisomerase I
Topoisomerase II
98.02%
SW044248  
Topoisomerase I
  99.60%
LMP744  
Top1
 
Pixantrone free base    
Topoisomerase II
Daunorubicin    
Topoisomerase II
TAS-103  
Topoisomerase I
Topoisomerase II
MC-DOXHZN    
Topoisomerase II
Exatecan mesylate dihydrate  
Topoisomerase I, IC50: 2.2 μM
 
Topotecan hydrochloride hydrate  
Topoisomerase I
 
Etoposide phosphate disodium    
Topoisomerase II
Gatifloxacin sesquihydrate    
Topoisomerase II, IC50: 36.7 μM
Rebeccamycin  
Topoisomerase I
 
Mitoxantrone diacetate    
Topoisomerase II
Idarubicin    
Topoisomerase II
Daunorubicin citrate    
Topoisomerase II
Antitumor agent-63  
Top1
 
MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan  
Topoisomerase I
 
Topoisomerase II inhibitor 20    
Topoisomerase II, IC50: 0.98 μM
Topoisomerase II inhibitor 9    
Topoisomerase II, IC50: 0.97 μM
Topo I/COX-2-IN-1  
Topoisomerase I, IC50: 4.42 μM
 
Bimolane    
Topoisomerase II
T-2513 hydrochloride  
Topoisomerase I
 
Topo I/COX-2-IN-2  
Topoisomerase I, IC50: 0.90 μM
 
Topoisomerase II inhibitor 11    
Topoisomerase II, IC50: 2.89 μM
CS1    
topoisomerase II alpha
Topoisomerase I inhibitor 8  
Topoisomerase I
 
T-2513  
Topoisomerase I
 
Razoxane    
Topoisomerase II
Topoisomerase IIα-IN-3    
topoisomerase II alpha
Nalidixic acid sodium salt
Topoisomerase
    99.74%
Heliquinomycin  
Topoisomerase I
Topoisomerase II
Topoisomerase II/EGFR-IN-1    
Topoisomerase II
Gly-Cyclopropane-Exatecan  
Topoisomerase I
 
LMP517  
Topoisomerase I
Topoisomerase II
Anticancer agent 75    
Topoisomerase II
CP-67804    
Topoisomerase II
AQ4    
Topoisomerase II
Pixantrone hydrochloride    
Topoisomerase II
Topoisomerase II inhibitor 4    
Topoisomerase II
Topoisomerase IIα-IN-5    
topoisomerase II alpha
Topoisomerase IIα-IN-6    
topoisomerase II alpha, IC50: 0.67 μM
Topoisomerase IIα-IN-2    
topoisomerase II alpha
topoisomerase II beta
Topoisomerase IIα-IN-4    
topoisomerase II alpha, IC50: 3.8 μM
topoisomerase II beta, IC50: 10.1 μM
ZLHQ-5f  
Top1
 
Topo I-IN-1  
Topoisomerase I
 
Top/HDAC-IN-2  
Top1
Topoisomerase II
Anti-MRSA agent 7
TOPO IV, IC50: 0.059 μM (E. coli )
TOPO IV, IC50: 0.341 μM (S. aureus)
   
Topoisomerase II inhibitor 18    
Topoisomerase II, IC50: 7.5 μM
Elomotecan  
Topoisomerase I
Topoisomerase II
Topoisomerase II inhibitor 5    
Topoisomerase II
HSP90-IN-13
Topoisomerase-2, IC50: 25.85 nM
   
Topoisomerase I inhibitor 2  
Topoisomerase I, IC50: 0.58 μM
 
Topoisomerase II inhibitor 10    
Topoisomerase II, IC50: 7.45 μM
Topoisomerase IV inhibitor 1
TOPO IV, IC50: 0.23 μM
   
Topoisomerase II inhibitor 13    
Topoisomerase II
99.26%
EGFR-IN-57    
topoisomerase II beta, IC50: 0.13 μM
Topoisomerase IIα-IN-1    
topoisomerase II alpha
topoisomerase II beta
Huanglongmycin N  
Topoisomerase I, EC50: 14 μM
 
Topoisomerase IIα-IN-8    
topoisomerase II alpha
CP-67015    
Topoisomerase II
Elomotecan hydrochloride  
Topoisomerase I
Topoisomerase II
Topoisomerase I inhibitor 12  
Topoisomerase I
 
BNS-22    
topoisomerase II alpha, IC50: 2.8 μM (in human)
topoisomerase II beta, IC50: 0.42 μM (in human)
Topoisomerase II inhibitor 17    
Topoisomerase II, IC50: 0.23 μM
Topoisomerase I/II inhibitor 2  
Topoisomerase I
Topoisomerase II
Saintopin  
Topoisomerase I
Topoisomerase II
Intoplicine dimesylate  
Topoisomerase I
Topoisomerase II
98.28%
Topoisomerase IV inhibitor 2
TOPO IV, IC50: 0.35 μM
   
Topoisomerase II inhibitor 7    
topoisomerase II alpha, IC50: 3.19 μM
Topoisomerase IIα-IN-7    
topoisomerase II alpha, IC50: 7.7 μM
Niranthin
Topoisomerase
   
Topoisomerase I inhibitor 3  
Topoisomerase I
 
Topoisomerase II inhibitor 19    
Topoisomerase II, IC50: 0.34 μM
9-Hydroxyellipticine hydrochloride    
Topoisomerase II
Corydamine  
Topoisomerase I
Topoisomerase II
TP0480066    
Topoisomerase II
Topoisomerase I inhibitor 16  
Topoisomerase I
 
TP3011  
Topoisomerase I
 
Topoisomerase II inhibitor 8    
Topoisomerase II, IC50: 0.52 μM
Topoisomerase I/II inhibitor 3  
Topoisomerase I
Topoisomerase II
Gatifloxacin mesylate    
Topoisomerase II, IC50: 36.7 μM
Voreloxin    
Topoisomerase II
Garenoxacin
TOPO IV, IC50: 1.5-2.5 μg/mL
   
Luotonin F    
Topoisomerase II
Epirubicin
Topoisomerase