1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. Neuregulins

Neuregulins, a family of EGF-like signaling molecules, are paracrine, autocrine, and juxtacrine signaling peptides which mediate a myriad of cellular functions including survival, proliferation, and differentiation in both neuronal and non-neural systems. Neuregulins are involved in cell-cell crosstalk and play an important role in development, maintenance and repair of the nervous system, heart, breast and other organs. The neuregulin family of ligands has four members: NRG1, NRG2, NRG3, and NRG4. Neuregulins transmit their signals to target cells by interacting with transmembrane tyrosine kinase receptors of the ErbB (HER) family. Receptor-ligand interaction induces the heterodimerization of receptor monomers, which in turn results in the activation of intracellular signaling cascades and the induction of cellular responses.

Cat. No. Product Name / Synonyms Species Source
  • HY-P73328
    NRG1-beta 1 Protein, Human (HEK293)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    Human HEK293
    NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 1 Protein, Human (HEK293) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with tag free. The total length of NRG1-beta 1 Protein, Human (HEK293) is 245 a.a., with molecular weight of ~26.8 kDa.
  • HY-P73326
    NRG1-alpha Protein, Human (HEK293, His)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    Human HEK293
    NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-alpha Protein, Human (HEK293, His) is the recombinant human-derived NRG1-alpha protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of NRG1-alpha Protein, Human (HEK293, His) is 222 a.a., with molecular weight of 40-50 kDa.
  • HY-P73329
    NRG1-beta 1 Protein, Human (245a.a, HEK293, Fc)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    Human HEK293
    NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 1 Protein, Human (245a.a, HEK293, Fc) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NRG1-beta 1 Protein, Human (245a.a, HEK293, Fc) is 245 a.a., with molecular weight of 58-83 kDa.
  • HY-P72007
    NRG1-beta 1 Protein, Human (65a.a, His)

    Acetylcholine receptor-inducing activity; Acetylcholine receptor-inducing activity, chick, homolog of; ARIA; Breast cancer cell differentiation factor p45; GGF; GGF2; glial growth factor 2; Glial growth factor; Heregulin; heregulin, alpha 45kD, ERBB2 p185-activator; ; heregulin, alpha; HGL; HRG; HRG1; HRGA; MST131; MSTP131;

    Human E. coli
    NRG1-α protein binds directly to ERBB3 and ERBB4 receptors, leading to the recruitment of ERBB1 and ERBB2 coreceptors. NRG1-beta 1 Protein, Human (65a.a, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of NRG1-beta 1 Protein, Human (65a.a, His) is 65 a.a., with molecular weight of ~ 7.5 kDa.
  • HY-P7365
    NRG1-beta 1 Protein, Human

    rHuHeregulin-1 β1; ARIA; HRG; NRG1; Neuregulin-1

    Human E. coli
    NRG-1 Protein, Human belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells.
  • HY-P73304
    NRG1-beta 2 Protein, Human

    NRG-1 EGF-like domain beta 2; Beta2; Neuregulin-1 beta 2

    Human E. coli
    NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 2 Protein, Human is the recombinant human-derived NRG1-beta 2 protein, expressed by E. coli , with tag free. The total length of NRG1-beta 2 Protein, Human is 61 a.a., with molecular weight of ~7.0 kDa.
  • HY-P71159
    RTN4RL1/NgR3 Protein, Human (395a.a, HEK293, His)

    Reticulon-4 Receptor-Like 1; Nogo Receptor-Like 2; Nogo-66 Receptor Homolog 2; Nogo-66 Receptor-Related Protein 3; NgR3; RTN4RL1; NGRH2; NGRL2

    Human HEK293
    The RTN4RL1/NgR3 protein is a cell surface receptor that functionally affects postnatal brain development and axonal regeneration in the adult central nervous system. It aids in axonal migration across the midline of the brain and formation of the corpus callosum. RTN4RL1/NgR3 Protein, Human (395a.a, HEK293, His) is the recombinant human-derived RTN4RL1/NgR3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of RTN4RL1/NgR3 Protein, Human (395a.a, HEK293, His) is 395 a.a., with molecular weight of ~63.0 kDa.
  • HY-P74709
    Neuregulin-1/NRG1 Protein, Canine (HEK293)

    Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1

    Canine HEK293
  • HY-P74682
    Neuregulin-2/NRG2 Protein, Human (HEK293, His)

    Pro-neuregulin-2; Pro-NRG2; Neuregulin-2; DON-1; NTAK; NRG-2

    Human HEK293
    Neuregulin-2/NRG2 protein serves as a direct ligand for the ERBB3 and ERBB4 tyrosine kinase receptors, initiating ligand-stimulated tyrosine phosphorylation and activation of these receptors. At the same time, NRG2 simultaneously recruits ERBB1 and ERBB2 coreceptors, possibly promoting heterodimerization with the EGF receptor. Neuregulin-2/NRG2 Protein, Human (HEK293, His) is the recombinant human-derived Neuregulin-2/NRG2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuregulin-2/NRG2 Protein, Human (HEK293, His) is 293 a.a., with molecular weight of ~34 kDa.
  • HY-P75944
    Neuregulin-3/NRG3 Protein, Human (61a.a, HEK293, His)

    Pro-NRG3; Neuregulin-3; NRG-3; NRG3

    Human HEK293
    Neuregulin-3/NRG3 Protein, a vital neuregulin family member, influences cellular signaling and development, contributing to diverse biological processes. Its unique structural characteristics, lacking conserved residues crucial for feature annotation propagation, hint at distinct regulatory mechanisms or interactions. This peculiarity within the neuregulin family underscores the need for further investigation into NRG3's precise role in cellular signaling and its potential implications in various physiological contexts. Neuregulin-3/NRG3 Protein, Human (61a.a, HEK293, His) is the recombinant human-derived Neuregulin-3/NRG3 protein, expressed by HEK293, with C-His labeled tag. The total length of Neuregulin-3/NRG3 Protein, Human (61a.a, HEK293, His) is 61 a.a., with molecular weight of ~8.5 kDa.
  • HY-P76524
    Neuregulin-4/NRG4 Protein, Human

    Pro-neuregulin-4, membrane-bound isoform; Pro-NRG4; NRG-4

    Human E. coli
    Neuregulin-4 (NRG4) Protein, a low-affinity ligand for the ERBB4 tyrosine kinase receptor, serves as a signaling molecule that recruits ERBB1 and ERBB2 coreceptors. This recruitment leads to ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 specifically interacts with the ERBB4 receptor, mediating cellular responses through its activation, without binding to ERBB1, ERBB2, and ERBB3 receptors. Neuregulin-4/NRG4 Protein, Human is the recombinant human-derived Neuregulin-4/NRG4 protein, expressed by E. coli , with tag free. The total length of Neuregulin-4/NRG4 Protein, Human is 61 a.a., with molecular weight of ~6.7 KDa.
  • HY-P70967
    NRG1-beta 1 Protein, Human (246a.a, His)

    Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1 ECD; NRG1; GGF; HGL; HRGA; NDF; SMDF;

    Human E. coli
    NRG1 is a direct ligand of the ERBB3 and ERBB4 tyrosine kinase receptors. NRG1 can induce the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1. NRG1 can induce cell growth, differentiation and proliferation. NRG1-beta 1 Protein, Human (246a.a, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of NRG1-beta 1 Protein, Human (246a.a, His) is 246 a.a., with molecular weight of ~35.0 kDa.
  • HY-P71171A
    NRG1-beta 1 Protein, Human (CHO)

    Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1; EGF; NRG1; GGF; HGL; HRGA; NDF; SMDF; Heregulin β-1; Heregulin; HRG

    Human CHO
    NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 1 Protein, Human (CHO) is the recombinant human-derived NRG1-beta 1 protein, expressed by CHO , with tag free. The total length of NRG1-beta 1 Protein, Human (CHO) is 71 a.a., with molecular weight of 7.5 kDa.
  • HY-P70524
    NRG1-beta 1 Protein, Human (245a.a)

    Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1; EGF; NRG1; GGF; HGL; HRGA; NDF; SMDF;

    Human E. coli
    NRG1-α protein binds directly to ERBB3 and ERBB4 receptors, leading to the recruitment of ERBB1 and ERBB2 coreceptors. NRG1-beta 1 Protein, Human (245a.a) is the recombinant human-derived NRG1-beta 1 protein, expressed by E. coli , with tag free. The total length of NRG1-beta 1 Protein, Human (245a.a) is 245 a.a., with molecular weight of ~32-34.0 kDa.
  • HY-P73327
    NRG1-alpha Protein, Human (65a.a, HEK293, Fc)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    Human HEK293
    NRG1-α protein binds directly to ERBB3 and ERBB4 receptors, leading to the recruitment of ERBB1 and ERBB2 coreceptors. NRG1-alpha Protein, Human (65a.a, HEK293, Fc) is the recombinant human-derived NRG1-alpha protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NRG1-alpha Protein, Human (65a.a, HEK293, Fc) is 65 a.a., with molecular weight of ~38 kDa.
  • HY-P700427
    NRG1-beta 1 Protein, Human (HEK293, His)

    Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512

    Human HEK293
    NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 1 Protein, Human (HEK293, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NRG1-beta 1 Protein, Human (HEK293, His) is 228 a.a., with molecular weight of 27.1 kDa.
  • HY-P73325
    NRG1-alpha Protein, Human (222a.a, HEK293, Fc)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    Human HEK293
    NRG1-α protein binds directly to ERBB3 and ERBB4 receptors, leading to the recruitment of ERBB1 and ERBB2 coreceptors. NRG1-alpha Protein, Human (222a.a, HEK293, Fc) is the recombinant human-derived NRG1-alpha protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NRG1-alpha Protein, Human (222a.a, HEK293, Fc) is 222 a.a., with molecular weight of ~60 kDa.
  • HY-P73330
    NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    Human HEK293
    NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is 71 a.a., with molecular weight of ~38 kDa.
  • HY-P74710
    Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc)

    Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1

    Canine HEK293
  • HY-P74712
    Neuregulin-1/NRG1 Protein, Canine (222a.a, HEK293, His)

    Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1

    Canine HEK293
Cat. No. Product Name Effect Purity