2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Neuregulins

Neuregulins

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Neuregulins, a family of EGF-like signaling molecules, are paracrine, autocrine, and juxtacrine signaling peptides which mediate a myriad of cellular functions including survival, proliferation, and differentiation in both neuronal and non-neural systems. Neuregulins are involved in cell-cell crosstalk and play an important role in development, maintenance and repair of the nervous system, heart, breast and other organs. The neuregulin family of ligands has four members: NRG1, NRG2, NRG3, and NRG4. Neuregulins transmit their signals to target cells by interacting with transmembrane tyrosine kinase receptors of the ErbB (HER) family. Receptor-ligand interaction induces the heterodimerization of receptor monomers, which in turn results in the activation of intracellular signaling cascades and the induction of cellular responses.

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