1. Signaling Pathways
  2. PROTAC
  3. PROTAC Linker

PROTAC Linker

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linker Isoform Specific Products:

  • PEGs

  • Alkyl-Chain

  • Alkyl/ether

PROTAC Linker Related Products (2679):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118411
    5-Ethynyl-2'-deoxyuridine 61135-33-9 99.77%
    5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    5-Ethynyl-2'-deoxyuridine
  • HY-W008574
    TGN-020 51987-99-6 98.03%
    TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.
    TGN-020
  • HY-118297
    Ac4ManNAz 361154-30-5 99.09%
    Ac4ManNAz is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ac4ManNAz
  • HY-W008005
    Amino-PEG4-alcohol 86770-74-3
    Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Amino-PEG4-alcohol
  • HY-136159
    3-Mercaptopropionic acid NHS ester 117235-10-6
    3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    3-Mercaptopropionic acid NHS ester
  • HY-W013249
    Boc-piperazine-benzoic acid 162046-66-4
    Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229).
    Boc-piperazine-benzoic acid
  • HY-35261A
    Mal-PEG2-NH2 TFA 660843-23-2 98.09%
    Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-NH2 TFA
  • HY-140345A
    L-Homopropargylglycine hydrochloride 942518-19-6 ≥98.0%
    L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor.
    L-Homopropargylglycine hydrochloride
  • HY-W016735
    Azido-PEG3-alcohol 86520-52-7 ≥98.0%
    Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Azido-PEG3-alcohol
  • HY-113697
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD 1037589-69-7 98.97%
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
  • HY-22335
    Amino-PEG4-C2-amine 68960-97-4
    Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG4-C2-amine
  • HY-23408
    Tos-PEG3 77544-68-4
    Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports.
    Tos-PEG3
  • HY-112496
    Cl-C6-PEG4-O-CH2COOH 1799506-30-1
    Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
    Cl-C6-PEG4-O-CH2COOH
  • HY-130324
    Azido-PEG7-amine 1333154-77-0
    Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG7-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Azido-PEG7-amine
  • HY-30105
    N-Boc-piperazine 57260-71-6 ≥98.0%
    N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    N-Boc-piperazine
  • HY-W008474
    Boc-NH-PEG2-C2-NH2 153086-78-3
    Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-C2-NH2
  • HY-140346A
    L-Azidohomoalanine hydrochloride 942518-29-8 ≥98.0%
    L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    L-Azidohomoalanine hydrochloride
  • HY-42776
    NH2-PEG3-C2-NH-Boc 101187-40-0 ≥98.0%
    NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-PEG3-C2-NH-Boc
  • HY-23417
    PEG5-Tos 155130-15-7 99.05%
    PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG5-Tos
  • HY-W007713
    Fmoc-8-amino-3,6-dioxaoctanoic acid 166108-71-0 ≥98.0%
    Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-8-amino-3,6-dioxaoctanoic acid
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.