1. Signaling Pathways
  2. PROTAC
  3. PROTAC Linker

PROTAC Linker

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linker Isoform Specific Products:

  • PEGs

  • Alkyl-Chain

  • Alkyl/ether

PROTAC Linker Related Products (2041):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W008005
    Amino-PEG4-alcohol 86770-74-3
    Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Amino-PEG4-alcohol
  • HY-W008474
    Boc-NH-PEG2-C2-NH2 153086-78-3 99.01%
    Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-C2-NH2
  • HY-W015088
    Amino-PEG3-C2-Amine 929-75-9 98.80%
    Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-Amine
  • HY-42776
    NH2-PEG3-C2-NH-Boc 101187-40-0 >98.0%
    NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-PEG3-C2-NH-Boc
  • HY-40178
    NH2-C4-NH-Boc 68076-36-8
    NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    NH2-C4-NH-Boc
  • HY-30105
    N-Boc-piperazine 57260-71-6 >98.0%
    N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    N-Boc-piperazine
  • HY-W004701
    Br-C3-methyl ester 4897-84-1
    Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    Br-C3-methyl ester
  • HY-42619
    Amino-PEG4-C1-Boc 864680-64-8
    Amino-PEG4-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG4-C1-Boc
  • HY-W016735
    Azido-PEG3-alcohol 86520-52-7
    Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Azido-PEG3-alcohol
  • HY-23417
    PEG5-Tos 155130-15-7 99.05%
    PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG5-Tos
  • HY-112496
    Cl-C6-PEG4-O-CH2COOH 1799506-30-1 >98.0%
    Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
    Cl-C6-PEG4-O-CH2COOH
  • HY-22335
    Amino-PEG4-C2-amine 68960-97-4
    Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG4-C2-amine
  • HY-W008574
    TGN-020 51987-99-6 99.44%
    TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.
    TGN-020
  • HY-108370
    N33-TEG-COOH 201467-81-4
    N33-TEG-COOH (N3-TEG-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    N33-TEG-COOH
  • HY-W017772
    Boc-NH-PEG3 139115-92-7 >98.0%
    Boc-NH-PEG3 (PROTAC Linker 10) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG3
  • HY-23408
    Tos-PEG3 77544-68-4
    Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports.
    Tos-PEG3
  • HY-W067489
    NH2-PEG1-CH2CH2-Boc 1260092-46-3
    NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-PEG1-CH2CH2-Boc
  • HY-42637
    N3-PEG3-CH2COOH 172531-37-2
    N3-PEG3-CH2COOH (PROTAC Linker 14) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    N3-PEG3-CH2COOH
  • HY-W007545
    NH2-PEG3 6338-55-2
    NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 (PROTAC Linker 35) can be used in the synthesis of the PROTAC (β-NF-JQ1).
    NH2-PEG3
  • HY-W007322
    Boc-NH-PEG1-OH 26690-80-2
    Boc-NH-PEG1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG1-OH
Isoform Specific Products

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