2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118411
    5-Ethynyl-2'-deoxyuridine 61135-33-9 99.77%
    5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-Ethynyl-2'-deoxyuridine
  • HY-W008574
    TGN-020 51987-99-6 99.52%
    TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.
    TGN-020
  • HY-40171
    NH2-C2-NH-Boc 57260-73-8 99.52%
    NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-C2-NH-Boc
  • HY-140272
    DBCO-PEG4-NHS ester 1427004-19-0
    DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DBCO-PEG4-NHS ester
  • HY-140346A
    L-Azidohomoalanine hydrochloride 942518-29-8 99.76%
    L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    L-Azidohomoalanine hydrochloride
  • HY-136158A
    6-Maleimidocaproic acid sulfo-NHS sodium 215312-86-0 98.91%
    6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    6-Maleimidocaproic acid sulfo-NHS sodium
  • HY-140307A
    Sulfo DBCO-PEG4-Maleimide TEA
    Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Sulfo DBCO-PEG4-Maleimide TEA
  • HY-W096162A
    NH2-PEG2-methyl acetate hydrochloride 208647-73-8
    NH2-PEG2-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG2-methyl acetate hydrochloride
  • HY-30105
    N-Boc-piperazine 57260-71-6 99.96%
    N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    N-Boc-piperazine
  • HY-136159
    3-Mercaptopropionic acid NHS ester 117235-10-6
    3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    3-Mercaptopropionic acid NHS ester
  • HY-W040304
    Alkynyl Palmitic Acid 99208-90-9
    Alkynyl Palmitic Acid (Alk-C16) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Alkynyl Palmitic Acid is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkynyl Palmitic Acid
  • HY-W017772
    Boc-NH-PEG3 139115-92-7 ≥98.0%
    Boc-NH-PEG3 (PROTAC Linker 10) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG3
  • HY-130143
    Biotin-PEG3-azide 875770-34-6
    Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG3-azide is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Biotin-PEG3-azide
  • HY-W096119
    NH2-PEG2-C6-Cl 744203-60-9 ≥98.0%
    NH2-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG2-C6-Cl
  • HY-W007713
    Fmoc-8-amino-3,6-dioxaoctanoic acid 166108-71-0 99.73%
    Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-8-amino-3,6-dioxaoctanoic acid
  • HY-W021401
    Amino-PEG3-C2-Azido 134179-38-7 98.52%
    Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645). Amino-PEG3-C2-Azido is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Amino-PEG3-C2-Azido
  • HY-W007545
    NH2-PEG3 6338-55-2 ≥98.0%
    NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 (PROTAC Linker 35) can be used in the synthesis of the PROTAC (β-NF-JQ1).
    NH2-PEG3
  • HY-130458
    EGNHS 70539-42-3
    EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    EGNHS
  • HY-W004945
    3,6-Dioxaoctanedioic acid 23243-68-7 ≥98.0%
    36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,6-Dioxaoctanedioic acid
  • HY-107608
    Leukotriene B4 71160-24-2 ≥98.0%
    Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Leukotriene B4
PROTAC Linkers Isoform Comparison

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