1. Signaling Pathways
  2. PROTAC
  3. PROTAC Linker

PROTAC Linker

The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein.

Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

PROTAC Linker Isoform Specific Products:

  • PEGs

  • Alkyl-Chain

  • Alkyl/ether

PROTAC Linker Related Products (36):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-42776
    PROTAC Linker 15 101187-40-0
    PROTAC Linker 15 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 15 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 15
  • HY-108370
    N33-TEG-COOH 201467-81-4
    N33-TEG-COOH is a PROTAC linker containing four polyethylene glycol (PEG) units.
    N33-TEG-COOH
  • HY-W008474
    PROTAC Linker 13 153086-78-3
    PROTAC Linker 13 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 13 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 13
  • HY-W017772
    PROTAC Linker 10 139115-92-7 >98.0%
    PROTAC Linker 10 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 10 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 10
  • HY-108371
    PROTAC Linker 1 1835705-53-7 >98.0%
    PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.
    PROTAC Linker 1
  • HY-112496
    PROTAC Linker 4 1799506-30-1 >98.0%
    PROTAC Linker 4 is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
    PROTAC Linker 4
  • HY-43869
    Vipivotide tetraxetan Linker 1703768-74-4
    Vipivotide tetraxetan Linker is a useful peptide linker for synthesis of Vipivotide tetraxetan (PSMA-617). Vipivotide tetraxetan (PSMA-617) is a ligand used to synthesize 177Lu-PSMA-617, which is a radioactive molecule for the treatment of prostate cancer.
    Vipivotide tetraxetan Linker
  • HY-40171
    PROTAC Linker 22 57260-73-8
    PROTAC Linker 22 is a PROTAC linker, which refers to the alkyl chain composition. PROTAC Linker 22 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 22
  • HY-108372
    PROTAC Linker 2 1835705-52-6
    PROTAC Linker 2 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.
    PROTAC Linker 2
  • HY-W004896
    PROTAC Linker 11 139115-91-6
    PROTAC Linker 11 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 11 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 11
  • HY-W006524
    H2N-PEG2-CH2COOH 134978-97-5
    H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB).
    H2N-PEG2-CH2COOH
  • HY-128804
    PROTAC Linker 8 51951-05-4
    PROTAC Linker 8 (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. SNIPER(ER)s contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. SNIPER(ER)s induce polyubiquitylation and proteasomal degradation of the target proteins in the cells.
    PROTAC Linker 8
  • HY-128801
    PROTAC Linker 5 189808-70-6
    PROTAC Linker 5 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 5 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 5
  • HY-128803
    PROTAC Linker 7 1246999-33-6
    PROTAC Linker 7 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 7 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 7
  • HY-W004816
    PROTAC Linker 16 37860-51-8
    PROTAC Linker 16 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 16 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 16
  • HY-W022240
    PROTAC Linker 17 189209-27-6
    PROTAC Linker 17 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 17 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 17
  • HY-128802
    PROTAC Linker 6 855120-17-1
    PROTAC Linker 6 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 6 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 6
  • HY-122702
    PEG6-(CH2CO2H)2 77855-76-6
    PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.
    PEG6-(CH2CO2H)2
  • HY-125844
    PROTAC Linker 28 88986-89-4
    PROTAC Linker 28 is a PROTAC linker, which refers to the alkyl chain composition. PROTAC Linker 28 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 28
  • HY-42637
    PROTAC Linker 14 172531-37-2
    PROTAC Linker 14 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 14 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
    PROTAC Linker 14
Isoform Specific Products

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