L-Azidohomoalanine hydrochloride
Based on 6 publication(s) in Google Scholar
L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 942518-29-8
- Formula: C4H9ClN4O2
- Molecular Weight:180.59
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Azidohomoalanine hydrochloride
MoreAll PROTAC Linkers Isoforms
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Biological Activity
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Alkyl-Chain |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 942518-29-8
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Appearance Solid
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Molecular Weight 180.59
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Formula C4H9ClN4O2
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Color White to off-white
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SMILES
O=C(O)[C@@H](N)CCN=[N+]=[N-].[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2026 Apr;652(8109):471-480. PMID: 41741642 -
Nat Commun
2024 Jun 28;15(1):5481. PMID: 38942792 -
Redox Biol
Suppression of ATG4B by copper inhibits autophagy and involves in Mallory body formation. [Abstract]2022 Jun:52:102284. PMID: 35349929 -
Cell Biosci
Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice. [Abstract]2022 Dec 21;12(1):206. PMID: 36539845 -
Microbiol Spectr
Intracellular Low Iron Exerts Anti-BK Polyomavirus Effect by Inhibiting the Protein Synthesis of Exogenous Genes. [Abstract]2021 Dec 22;9(3):e0109421. PMID: 34756078 -
Solvent & Solubility
H2O : 100 mg/mL (553.74 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (553.74 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (271 KB)
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SDS (466 KB)
- English - EN (466 KB)
- Français - FR (466 KB)
- Deutsch - DE (466 KB)
- Norwegian - NO (466 KB)
- Español - ES (466 KB)
- Swedish - SV (466 KB)
- Italian - IT (466 KB)
- Korean - KR (466 KB)
- Portuguese - PT (466 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.5374 mL | 27.6870 mL | 55.3741 mL | 138.4351 mL |
| 5 mM | 1.1075 mL | 5.5374 mL | 11.0748 mL | 27.6870 mL | |
| 10 mM | 0.5537 mL | 2.7687 mL | 5.5374 mL | 13.8435 mL | |
| 15 mM | 0.3692 mL | 1.8458 mL | 3.6916 mL | 9.2290 mL | |
| 20 mM | 0.2769 mL | 1.3844 mL | 2.7687 mL | 6.9218 mL | |
| 25 mM | 0.2215 mL | 1.1075 mL | 2.2150 mL | 5.5374 mL | |
| 30 mM | 0.1846 mL | 0.9229 mL | 1.8458 mL | 4.6145 mL | |
| 40 mM | 0.1384 mL | 0.6922 mL | 1.3844 mL | 3.4609 mL | |
| 50 mM | 0.1107 mL | 0.5537 mL | 1.1075 mL | 2.7687 mL | |
| 60 mM | 0.0923 mL | 0.4615 mL | 0.9229 mL | 2.3073 mL | |
| 80 mM | 0.0692 mL | 0.3461 mL | 0.6922 mL | 1.7304 mL | |
| 100 mM | 0.0554 mL | 0.2769 mL | 0.5537 mL | 1.3844 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Azidohomoalanine hydrochloride Related Classifications
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