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Cat. No.: HY-140346

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L-Azidohomoalanine

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

CAS No.: 120042-14-0
Formula: C₄H₈N₄O₂
Molecular Weight:144.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

L-Azidohomoalanine Chemical Structure

CAS No.: 120042-14-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (6)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. L-Azidohomoalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

Alkyl-Chain

All PROTAC Linkers Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 120042-14-0
Molecular Weight 144.13
Formula C₄H₈N₄O₂
SMILES

O=C(O)[C@@H](N)CCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

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Nature

CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis. [Abstract]

2026 Apr;652(8109):471-480. PMID: 41741642
Nat Commun

Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. [Abstract]

2024 Jun 28;15(1):5481. PMID: 38942792
Redox Biol

Suppression of ATG4B by copper inhibits autophagy and involves in Mallory body formation. [Abstract]

2022 Jun:52:102284. PMID: 35349929
Cell Biosci

Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice. [Abstract]

2022 Dec 21;12(1):206. PMID: 36539845
Microbiol Spectr

Intracellular Low Iron Exerts Anti-BK Polyomavirus Effect by Inhibiting the Protein Synthesis of Exogenous Genes. [Abstract]

2021 Dec 22;9(3):e0109421. PMID: 34756078
bioRxiv

2026 Feb 20.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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L-Azidohomoalanine

6 Cited Publications

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Biological Activity
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- In Vitro
Chemical Information
Publications (6)
Purity & Documentation
References

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L-Azidohomoalanine

Publications Citing Use of MedChemExpress (MCE) L-Azidohomoalanine

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Publications (6)

Purity & Documentation

References

Calculators

Help & FAQs

L-Azidohomoalanine Related Classifications

Cat. No.: HY-140346