1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. TGF-beta Superfamily

The transforming growth factor β (TGF-beta) superfamily, a group of multifunctional polypeptide, is the largest family of secreted growth factors composed of several subfamilies, including TGF-βs, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), activins, inhibins, and the glial cell-derived neurotrophic factors (GDNFs). TGF-β signaling is initiated by the binding of the ligand to heteromeric complexes comprised of type I and II transmembrane serine/threonine kinase receptors. Upon ligand binding, type II receptors transphosphorylate the type I receptors. The type I receptor kinase subsequently phosphorylates receptor-regulated Smads (R-Smads), which can then associate with the co-Smad, Smad4, and translocate to the nucleus and activate transcription of target genes. This is considered as the “Smad signaling pathway.” Additionally, the receptor complex can activate “non-Smad signaling pathways” through type II receptor– and type I receptor–interacting proteins. TGF-β superfamily members regulate various biological processes including cell proliferation, differentiation, migration, adhesion, apoptosis and extracellular matrix (ECM) production. TGF-β superfamily members also have been implicated in the pathogenesis of many diseases. (Targeting TGF-β Receptor )

Cat. No. Product Name / Synonyms Species Source
  • HY-P7006
    BMP-2 Protein, Human/Mouse/Rat

    rHuBMP-2; BMP2A; BMP-2A; BMP2

    Human; Rat; Mouse E. coli
    BMP-2 Protein, Human/Mouse/Rat is a bone morphogenetic protein, effective in bone fracture healing, and shortens the consolidation phase.
  • HY-P7007
    BMP-4 Protein, Human

    rHuBMP-4; BMP-2B

    Human E. coli
    BMP-4 Protein, Human is a member of the BMP-family, and a part of the transforming growth factor (TGF-β) superfamily, effectvie in mesenchyme formation and the development of multiple organs.
  • HY-P7118
    TGF beta 1 Protein, Human (CHO)

    TGF-beta-1; TGFB1; TGFB; rHuTGF-β1

    Human CHO
    TGF beta 1 Protein, Human (CHO) is a multifunctional cytokine which participates in foetal development, control of cell growth and differentiation, induces fibrosis, causes the suppression of immune response, is involved in angiogenesis, the development of tumours, and inflammatory processes.
  • HY-P7117
    TGF beta 1/TGFB1 Protein, Mouse (HEK293)

    rMuTGF-beta 1/TGFB1; Transforming growth factor beta-1; TGF-β1; LAP

    Mouse HEK 293
    TGF beta 1 Protein, Mouse (HEK293) is a multifunctional cytokine that controls numerous biological processes including immunity, differentiation, tumor suppression, tumor metastasis, senescence, migration, wound healing, apoptosis, cell division, adipogenesis, and osteogenesis.
  • HY-P70543
    TGF beta 1 Protein, Human (112a.a, HEK293)

    Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1

    Human HEK293
    TGF beta 1 Protein, Human (112a.a, HEK293) is a multifunctional cytokine which participates in foetal development, control of cell growth and differentiation, induces fibrosis, causes the suppression of immune response, is involved in angiogenesis, the development of tumours, and inflammatory processes.
  • HY-P70311
    Activin A Protein, Human/Mouse/Rat (HEK293)

    rHuActivin A; Inhibin beta A chain; INHBA; Activin A

    Human; Rat; Mouse HEK293
    Activin A Protein, Human/Mouse/Rat (HEK293) is a recombinant protein produced by HEK293 cells. Activin A, a multifunctional cytokine, is a member of transforming growth factor β (TGF β) superfamily. It is associated with a variety of pathophysiological processes, including inflammation, fibrosis, and tumorigenesis.
  • HY-P7008
    BMP-7 Protein, Human

    rHuBMP-7; OP-1

    Human E. coli
    BMP-7 Protein, Human is a member of the BMP-family, and a part of the transforming growth factor (TGF-β) superfamily, used for revision posterolateral lumbar spine fusion and for the treatment of long bone nonunion fractures after successful clinical trials.
  • HY-P70649
    TGFB2 Protein, Mouse/Rat (HEK 293)

    TGFB2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; MGC116892; Polyergin; TGF-beta2; TGF-beta-2; transforming growth factor beta-2

    Rat; Mouse HEK293
  • HY-P70648
    TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293)

    TGF-beta-1; CED; DPD1; TGFB; TGF-b1; TGFB1; CEDLAP; latency-associated peptide; TGFbeta; TGF-beta 1 protein; transforming growth factor beta-1; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta

    Mouse HEK 293
    TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293), is a recombinant cytokine produced in HEK293 cells, is implicated as a key regulator of the development and cyclic remodelling characteristic of reproductive tissues.
  • HY-P7182
    GDNF Protein, Human

    rHuGDNF; ATF

    Human E. coli
    GDNF Protein, Human is a small protein that potently promotes the survival of many types of neurons.
  • HY-P7456
    ACVR2B Protein, Human (HEK293, His)

    rHuActivin receptor type 2B, His; ACVR-2B; Activin receptor type 2B

    Human HEK293
    ACVR2B Protein, Human (HEK293, His) is a recombinant protein that in humans is encoded by the ACVR2B gene and produced in HEK293 cells, has a His tag.
  • HY-P7120
    TGF beta 3 Protein, Human/Mouse/Rat (HEK293)

    rHuTGF-β3; TGFB3; LAP

    Human; Rat; Mouse HEK293
    TGF beta 3 Protein, Human/Mouse/Rat (HEK293) is a multifunctional cytokine which participated in cell differentiation, embryogenesis and development.
  • HY-P70222
    GDF-11/BMP-11 Protein, Human (HEK293)

    rHuGrowth/differentiation factor 11; Growth/differentiation factor 11; GDF-11; Bone morphogenetic protein 11; BMP-11

    Human HEK 293
  • HY-P7119
    TGFB2 Protein, Human

    TGF-beta-2; Cetermin; G-TSF; TGFB2; Polyergin; rHuTGF-β2

    Human HEK293
    TGFB2 Protein, Human is a multifunctional cytokine which participates in control of cell growth and differentiation, induces fibrosis, causes the suppression of immune response and has a vital role during embryonic development.
  • HY-P7359
    GDNF Protein, Mouse (CHO)

    rMuGDNF; GDNF; ATF

    Mouse CHO
    GDNF Protein, Mouse (CHO) is a member of a group of closely related neurotrophic factors, functions in the nervous system.
  • HY-P74379
    BMP-4 Protein, Mouse (HEK293, Fc)

    BMP-2B; BMP-4; Bone morphogenetic protein 4; DVR4

    Mouse HEK293
  • HY-P7332
    BMP-3B/GDF10 Protein, Human

    rHuBMP-3B; BIP; BMP-3B; GDF-10

    Human E. coli
    BMP-3B/GDF10 Protein, Human belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). BMP-3B/GDF10 Protein plays a role in head formation and may have multiple roles in skeletal morphogenesis.
  • HY-P71323
    SMAD3 Protein, Human (Flag-His)

    Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3; SMAD3; MADH3

    Human E. coli
  • HY-P73241
    Activin A Protein, Mouse (HEK293, His)

    Activin beta-A chain; Activin A; Inhibin beta A chain; INHBA

    Mouse HEK293
  • HY-P72425
    GDF9 Protein, Human (GST)

    GDF9; Growth/differentiation factor 9; GDF-9

    Human E. coli
Cat. No. Product Name Effect Purity