2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily

TGF-beta Superfamily

TGF-beta Superfamily

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The transforming growth factor β (TGF-beta) superfamily, a group of multifunctional polypeptide, is the largest family of secreted growth factors composed of several subfamilies, including TGF-βs, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), activins, inhibins, and the glial cell-derived neurotrophic factors (GDNFs). TGF-β signaling is initiated by the binding of the ligand to heteromeric complexes comprised of type I and II transmembrane serine/threonine kinase receptors. Upon ligand binding, type II receptors transphosphorylate the type I receptors. The type I receptor kinase subsequently phosphorylates receptor-regulated Smads (R-Smads), which can then associate with the co-Smad, Smad4, and translocate to the nucleus and activate transcription of target genes. This is considered as the “Smad signaling pathway.” Additionally, the receptor complex can activate “non-Smad signaling pathways” through type II receptor– and type I receptor–interacting proteins. TGF-β superfamily members regulate various biological processes including cell proliferation, differentiation, migration, adhesion, apoptosis and extracellular matrix (ECM) production. TGF-β superfamily members also have been implicated in the pathogenesis of many diseases.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7118
    TGF beta 1/TGFB1 Protein, Human (CHO)

    TGF-beta-1; TGFB1; TGFB; rHuTGF-β1

    		Human CHO
    TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. TGF beta 1/TGFB1 Protein, Human is a recombinant protein (A279-S390) produced by CHO cells.
  • HY-P70543
    TGF beta 1/TGFB1 Protein, Human (112a.a, HEK293)

    Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1

    		Human HEK293
    TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. TGF beta 1/TGFB1 Protein, Human (112a.a, HEK293) is a recombinant protein (A279-S390) produced by HEK293 cells.
  • HY-P7119
    TGF beta 2/TGFB2 Protein, Human

    TGF-beta-2; Cetermin; G-TSF; TGFB2; Polyergin; rHuTGF-β2

    		Human HEK293
    Transforming growth factor-beta 2 (TGF-β2), an extracellular glycosylated protein, is a member of the TGF-β superfamily. TGFβ2 controls key physiological processes including cell migration, proliferation and differentiation via signalling through type I and type II receptors (TGFβR1 and TGFβR2). TGF-β2 is an immune suppressor involved in the development of immune tolerance, and also regulates embryonic development. TGF beta 2/TGFB2 Protein, Human is produced in HEK293 cells, and consists of 112 amino acids (A303-S414).
  • HY-P77945
    GDF-15 Protein, Mouse (HEK293, Fc)

    GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta

    		Mouse HEK293
    Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Mouse (HEK293, Fc) has 115 amino acids expressed by HEK293 cells with N-terminal hFc tag.
  • HY-P70236
    TGF beta 1/TGFB1 Protein, Human (361a.a, HEK293, His)

    rHuLatent TGF Beta-1-C33S, His; Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB

    		Human HEK293
    Latent TGF beta 1/TGFB1 Protein is a large extracellular matrix protein and an associated ligand of fibrillinmicrofibrils. TGF beta 1/TGFB1 Protein, Human (361a.a, HEK293, His) is a recombinant Biotinylated protein (L30-S390) produced by HEK293 cells with His tag.
  • HY-P70433
    TGF beta 1/TGFB1 LAP Protein, Human (249a.a, HEK293)

    Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB

    		Human HEK293
  • HY-P70543G
    GMP TGF beta 1/TGFB1 Protein, Human (CHO)

    Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1

    		Human CHO
    TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. GMP TGF beta 1/TGFB1 Protein, Human (HEK293) is a GMP-grade recombinant protein (A279-S390) produced by HEK293 cells.
  • HY-P71056
    TGF beta 1/TGFB1 Protein, Human (HEK293, Avi)

    Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB

    		Human HEK293
    TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. TGF beta 1/TGFB1 Protein, Human (HEK293, Avi) is a recombinant protein (A279-S390) produced by HEK293 cells with Avi tag.
  • HY-P73075
    GDNF Protein, Rat (sf9, His)

    Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3

    		Rat Sf9 insect cells
    Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Rat (sf9, His) is produced in Sf9 insect cells with a N-Terminal His-tag. It consists of 134 amino acids (S78-I211).
  • HY-P73428
    TGFBR2/TGF-beta RII Protein, Human (sf9, His)

    TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II

    		Human Sf9 insect cells
  • HY-P73616
    TGF beta 1/TGFB1 Protein, Human (278a.a, HEK293, His)

    Transforming growth factor beta-1 proprotein; LAP; TGF-beta-1; TGFB1

    		Human HEK293
  • HY-P77946
    GDF-15 Protein, Mouse (Biotinylated, HEK293, Fc)

    GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta

    		Mouse HEK293
    Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Mouse (Biotinylated, HEK293, Fc) has 115 amino acids expressed by HEK293 cells with N-terminal hFc tag.
  • HY-P78134
    GDF-15 Protein, Human (Biotinylated, HEK293, Fc)

    GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β

    		Human HEK293
    Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Human (Biotinylated, HEK293, Fc) has 112 amino acids expressed by HEK293 cells with N-terminal hFc tag.
  • HY-P78168
    TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, His-Avi)

    CEDLAP; DPD1; TGF beta1; TGFB; TGFB1; TGFbeta; TGF-beta-1; TGF β1; TGFβ; TGF-β-1

    		Human HEK293
    TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein (A279-S390) produced by HEK293 cells with Avi tag.
  • HY-P78214
    Latent TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, His-Avi)

    CEDLAP; DPD1; TGF beta1; TGFB; TGFB1; TGFbeta; TGF-beta-1; TGF β1; TGFβ; TGF-β-1

    		Human HEK293
    Latent TGF beta 1/TGFB1 Protein is a large extracellular matrix protein and an associated ligand of fibrillinmicrofibrils. Latent TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant Biotinylated protein (L30-S390, C33S) produced by HEK293 cells with His-Avi tag.
  • HY-P78525
    TGFBR1/ALK-5 Protein, Human (HEK293, mFc-Avi)

    AAT5; ACVRLK4; ALK-5; LDS1A; LDS2A; SKR4; tbetaR-I; TGFB1R1; TGF-beta RI; TGFbetaRI; TGFBR1; TGF-bRI; TGFR-1; tβR-I; TGF-β RI; TGFβRI

    		Human HEK293
  • HY-P700033AF
    Animal-Free BMP-9/GDF-2 Protein, Human (His)

    GDF-2; BMP-9; GDF2; BMP9

    		Human E. coli
  • HY-P700084AF
    Animal-Free GDNF Protein, Human (His)

    Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3

    		Human E. coli
    Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. Animal-Free GDNF Protein, Human (His), a recombinant animal-free protein, is produced in E.coil with a C-Terminal His-tag. It consists of 134 amino acids (S78-I211).
  • HY-P700150AF
    Animal-Free TGF beta 1/TGFB1 Protein, Human (His)

    Transforming Growth Factor beta-1; TGF-beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1

    		Human E. coli
  • HY-P700151AF
    Animal-Free TGF beta 2/TGFB2 Protein, Human (His)

    G-TSF; LDS4; TGFB2

    		Human E. coli
Cat. No. Product Name Effect Purity