1. Recombinant Proteins
  2. Receptor Proteins
  3. Receptor Guanylyl Cyclase Family

Receptor Guanylyl Cyclase Family

Guanylyl cyclase, also termed guanylate cyclase or guanyl cyclase,are classified into two groups: receptor guanylyl cyclase (also called membrane or receptor-type GC) and soluble guanylyl cyclase. Receptor guanylyl cyclase are type-1 transmembrane receptors, comprising of cell-surface domains that function as neuropeptide receptors, a single transmembrane domain and intracellular domains that contain guanylyl cyclase catalytic activity. Ligands bind to their receptor and consequently activate the receptor domain, leading to activation of the catalytic domain. There are seven subtypes of transmembrane GC (GC-A through GC-G) have been identified. The presence of the extracellular domain suggests that all these guanylyl cyclase interaction with specific ligands, but such ligands have been found for only three of the membrane forms (GC-A through GC-C), with the remaining four forms presumed as orphan receptors. Receptor guanylyl cyclase play a crucial role in various important physiological and sensory processes, including blood pressure regulation, cell growth, intestinal electrolyte and water transport as well as vision and olfaction.

Cat. No. Product Name / Synonyms Species Source
  • HY-P72303
    Atrial natriuretic peptide receptor 2/NPR2, Human (His)

    AMDM; ANPB; GCB; GUC2B; NPRB

    Human P. pastoris
    Atrial natriuretic peptide receptor 2 (NPR2) serves as the receptor for C-type natriuretic peptide NPPC/CNP, activating guanylate cyclase upon ligand binding. NPR2 potentially regulates skeletal growth, indicating involvement in bone development. Its interaction with C-type natriuretic peptide highlights its significance in mediating cellular responses, especially in signaling pathways influencing skeletal growth dynamics. Atrial natriuretic peptide receptor 2/NPR2, Human (His) is the recombinant human-derived Atrial natriuretic peptide receptor 2/NPR2, expressed by P. pastoris , with N-His labeled tag. The total length of Atrial natriuretic peptide receptor 2/NPR2, Human (His) is 436 a.a., with molecular weight of ~51.0 kDa.
Cat. No. Product Name Effect Purity