Atrial natriuretic peptide receptor 2/NPR2, Human (His)

Atrial natriuretic peptide receptor 2 (NPR2) serves as the receptor for C-type natriuretic peptide NPPC/CNP, activating guanylate cyclase upon ligand binding. NPR2 potentially regulates skeletal growth, indicating involvement in bone development. Its interaction with C-type natriuretic peptide highlights its significance in mediating cellular responses, especially in signaling pathways influencing skeletal growth dynamics. Atrial natriuretic peptide receptor 2/NPR2, Human (His) is the recombinant human-derived Atrial natriuretic peptide receptor 2/NPR2, expressed by P. pastoris , with N-His labeled tag. The total length of Atrial natriuretic peptide receptor 2/NPR2, Human (His) is 436 a.a., with molecular weight of ~51.0 kDa.

Atrial natriuretic peptide receptor 2 (NPR2) functions as a receptor for the C-type natriuretic peptide NPPC/CNP hormone, exhibiting guanylate cyclase activity upon ligand binding. This receptor plays a potential role in the regulation of skeletal growth, suggesting its involvement in processes that govern bone development and maintenance. The interaction between NPR2 and C-type natriuretic peptide highlights its significance in mediating cellular responses to this hormone, particularly in the context of signaling pathways that influence skeletal growth dynamics.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

P. pastoris

N-His

P20594 (R23-I458)

4882  [NCBI]

RNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAI

Approximately 51.0 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. or10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1.0 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.