1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. FGF Family

Fibroblast growth factors (FGFs) are a family of structurally related polypeptide growth factors that have diverse roles in regulating cell proliferation, migration, differentiation, and apoptosis. The FGFs exert multiple functions by binding to FGF receptors (FGFRs) with heparin/heparan sulphate as a cofactor. Activated FGFRs mediate signaling by recruiting specific molecules that bind to phosphorylated tyrosine at the cytosolic part of the receptor, triggering a number of signaling pathways, such as RAS-MAPK, PI3K-AKT, PLCγ, and STAT signaling pathways, and leading to specific cellular responses. The mammalian Fgf family contains 22 genes, 18 of which encode proteins (FGF1-FGF10 and FGF16-FGF23) known to signal through four highly conserved transmembrane tyrosine kinase receptors (FGFR1, FGFR2, FGFR3, and FGFR4). The FGF homologous factors (FGF11, FGF12, FGF13, and FGF14) have high sequence identity with the FGF family but do not activate FGFRs and are therefore not generally considered members of the FGF family. FGFs are highly conserved in both gene structure and amino-acid sequence between vertebrate species.

Cat. No. Product Name / Synonyms Species Source
  • HY-P7091
    FGF-2 Protein, Rat

    rRtbFGF; HBGF-2; FGF-2; FGF-b; FGF-basic

    Rat E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Rat, consists of 145 amino acids, produced by E.coli with tag free.
  • HY-P73052
    FGF-2 Protein, Mouse (His)

    Fibroblast growth factor 2; FGF-2; bFGF; HBGF-2; Fgf2

    Mouse E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Mouse (His), consists of 144 amino acids, produced by E.coli with tag free.
  • HY-P70694
    FGF-4 Protein, Human (153a.a)

    Fibroblast growth factor 4; FGF-4; Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3; FGF4; HST; HSTF1; KS3

    Human E. coli
    The FGF-4 protein coordinates embryonic development, cell proliferation and differentiation and is critical for normal limb and heart valve development. FGF-4 may promote embryonic molar tooth bud development by inducing key gene expression. FGF-4 Protein, Human (153a.a) is the recombinant human-derived FGF-4 protein, expressed by E. coli , with tag free. The total length of FGF-4 Protein, Human (153a.a) is 153 a.a., with molecular weight of ~16.0 kDa.
  • HY-P7345
    FGF-21 Protein, Human (CHO, His)

    rHuFGF-21, His; FGF21

    Human CHO
    FGF-21 Protein, Human (CHO, His) is a polypeptide chain containing the C-termimal His tag produced in CHO cells. FGF-21 Protein, Human (CHO, His) is a member of the fibroblast growth factor (FGF) subfamily, acts as a metabolic regulator with pleiotropic effects.
  • HY-P70673
    KGF/FGF-7 Protein, Human (HEK293, His)

    Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor; FGF7

    Human HEK293
    KGF/FGF-7 proteins coordinate embryonic development and regulate basic processes such as cell proliferation and differentiation. Its critical role extends to normal branching morphogenesis. KGF/FGF-7 Protein, Human (HEK293, His) is the recombinant human-derived KGF/FGF-7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of KGF/FGF-7 Protein, Human (HEK293, His) is 163 a.a., with molecular weight of 20-28 kDa.
  • HY-P73051
    FGF-18 Protein, Human (HEK293, His)

    Fibroblast growth factor 18; FGF-18; zFGF5; FGF18

    Human HEK293
    FGF-18 Protein intricately regulates cell proliferation, differentiation, and migration, crucial in normal ossification and bone development for skeletal maturation. It stimulates hepatic and intestinal proliferation, showcasing versatile functions. Interactions with FGFR3 and FGFR4 underscore FGF-18 Protein's significance in modulating intricate signaling pathways for fundamental tissue development and homeostasis. FGF-18 Protein, Human (HEK293, His) is the recombinant human-derived FGF-18 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGF-18 Protein, Human (HEK293, His) is 180 a.a., with molecular weight of ~32 kDa.
  • HY-P73057
    FGFR-4 Protein, Human (HEK293, Fc)

    Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

    Human HEK293
    The leptin R/LEPR protein is a receptor protein that binds to the hormone leptin. It plays a vital role in regulating energy balance and body weight. FGFR-4 Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-4 Protein, Human (HEK293, Fc) is 348 a.a., with molecular weight of 95-112 kDa.
  • HY-P73059
    FGFR-4 Protein, Human (HEK293, His)

    Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

    Human HEK293
    The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (HEK293, His) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Human (HEK293, His) is 369 a.a., with molecular weight of ~60 kDa.
  • HY-P76336
    FGFR-2 alpha IIIb Protein, Human (HEK293, His)

    Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK

    Human HEK293
    The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIb Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-2 alpha IIIb Protein, Human (HEK293, His) is 357 a.a., with molecular weight of 60-80 KDa.
  • HY-P76337
    FGFR-2 alpha IIIc Protein, Human (HEK293, His)

    Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK

    Human HEK293
    The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha IIIc Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-2 alpha IIIc Protein, Human (HEK293, His) is 356 a.a., with molecular weight of 60-80 KDa.
  • HY-P77659
    FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi)

    FGF R1a; FGFR1 alpha

    Human HEK293
    FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-85 kDa.
  • HY-P77660
    FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi)

    FGF R1a; FGFR1 alpha

    Human HEK293
    FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is 353 a.a., with molecular weight of 68-80 kDa.
  • HY-P78439
    FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi)

    ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4

    Human HEK293
    The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-75 kDa.
  • HY-P78442
    FGF-21 Protein, Human (HEK293, mFc-Avi)

    UNQ3115; PRO10196; FGF-21; FGF21

    Human HEK293
    FGF-21 Proteinas, pivotal in promoting glucose uptake in adipocytes, induces SLC2A1/GLUT1 expression, not affecting SLC2A4/GLUT4, contingent on KLB. It significantly regulates systemic glucose homeostasis and insulin sensitivity, with direct KLB interaction via its C-terminus. Engagement with FGFR4 adds complexity to its molecular mechanisms, highlighting its role in orchestrating cellular responses beyond localized effects. FGF-21 Protein, Human (HEK293, mFc-Avi) is the recombinant human-derived FGF-21 protein, expressed by HEK293 , with N-mFc, N-Avi labeled tag. The total length of FGF-21 Protein, Human (HEK293, mFc-Avi) is 181 a.a., with molecular weight of 52-60 kDa.
  • HY-P73052AF
    Animal-Free FGF-2 Protein, Mouse (His)

    rMubFGF; HBGF-2; FGF-2; FGF-b; FGF-basic

    Mouse E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.Animal-Free FGF-2 Protein, Mouse (His), consists of 144 amino acids, produced by E.coli with tag free.
  • HY-P78123
    KGF-2/FGF-10 Protein, Human (Biotinylated, Primary Amine Labeling)

    FGF-10; KGF2

    Human E. coli
    KGF-2/FGF-10 proteins coordinate embryonic development, regulate cell proliferation and differentiation, and are indispensable in branching morphogenesis. This multifunctional protein may aid in wound healing. KGF-2/FGF-10 Protein, Human (Biotinylated, Primary Amine Labeling) is the recombinant human-derived KGF-2/FGF-10 protein, expressed by E. coli , with tag free. The total length of KGF-2/FGF-10 Protein, Human (Biotinylated, Primary Amine Labeling) is 171 a.a., with molecular weight of ~19.3 kDa.
  • HY-P7014
    FGF-4 Protein, Human (166a.a)

    rHuFGF-4; HBGF-4; HST; HST-1; HSTF1

    Human E. coli
    FGF-4 Protein, Human (166a.a) is a member of the FGF family that transforms 3T3 cells with high efficiency, stimulates endothelial cell proliferation, migration, and protease production, and shows angiogenic activity.
  • HY-P7173
    FGF-21 Protein, Mouse

    rMuFGF-21; FGF21

    Mouse E. coli
    FGF-21 Protein, Mouse emerges as a metabolic hormone involved in the regulation of glucose, lipid, bile acid, and phosphate metabolism.
  • HY-P70533
    FGF-8b Protein, Human/Mouse

    Fibroblast growth factor 8; Androgen-induced growth factor; Heparin-binding growth factor 8; AIGF; HBGF-8; FGF-8B

    Mouse; Human E. coli
  • HY-P7066
    FGF-2 Protein, Mouse (145a.a)

    rMubFGF; HBGF-2; FGF-2; FGF-b; FGF-basic

    Mouse E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Mouse (145a.a), consists of 145 amino acids, produced by E.coli with tag free.
Cat. No. Product Name Effect Purity