2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. FGF Family

FGF Family

FGF Family

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Fibroblast growth factors (FGFs) are a family of structurally related polypeptide growth factors that have diverse roles in regulating cell proliferation, migration, differentiation, and apoptosis. The FGFs exert multiple functions by binding to FGF receptors (FGFRs) with heparin/heparan sulphate as a cofactor. Activated FGFRs mediate signaling by recruiting specific molecules that bind to phosphorylated tyrosine at the cytosolic part of the receptor, triggering a number of signaling pathways, such as RAS-MAPK, PI3K-AKT, PLCγ, and STAT signaling pathways, and leading to specific cellular responses. The mammalian Fgf family contains 22 genes, 18 of which encode proteins (FGF1-FGF10 and FGF16-FGF23) known to signal through four highly conserved transmembrane tyrosine kinase receptors (FGFR1, FGFR2, FGFR3, and FGFR4). The FGF homologous factors (FGF11, FGF12, FGF13, and FGF14) have high sequence identity with the FGF family but do not activate FGFRs and are therefore not generally considered members of the FGF family. FGFs are highly conserved in both gene structure and amino-acid sequence between vertebrate species.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7091
    FGF-2 Protein, Rat

    rRtbFGF; HBGF-2; FGF-2; FGF-b; FGF-basic

    		Rat E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Rat, consists of 145 amino acids, produced by E.coli with tag free.
  • HY-P73052
    FGF-2 Protein, Mouse (His)

    Fibroblast growth factor 2; FGF-2; bFGF; HBGF-2; Fgf2

    		Mouse E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Mouse (His), consists of 144 amino acids, produced by E.coli with tag free.
  • HY-P70694
    FGF-4 Protein, Human (153a.a)

    Fibroblast growth factor 4; FGF-4; Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3; FGF4; HST; HSTF1; KS3

    		Human E. coli
  • HY-P7345
    FGF-21 Protein, Human (CHO, His)

    rHuFGF-21, His; FGF21

    		Human CHO
    FGF-21 Protein, Human (CHO, His) is a polypeptide chain containing the C-termimal His tag produced in CHO cells. FGF-21 Protein, Human (CHO, His) is a member of the fibroblast growth factor (FGF) subfamily, acts as a metabolic regulator with pleiotropic effects.
  • HY-P70673
    KGF/FGF-7 Protein, Human (HEK293, His)

    Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor; FGF7

    		Human HEK293
  • HY-P71954
    FGFR-3 Protein, Human (HEK 293, hFc)

    ACH; CD 333; CD333; CD333 antigen; CEK 2; CEK2; FGFR 3; FGFR-3; FGFR3; FGFR3_HUMAN; Fibroblast growth factor receptor 3 achondroplasia thanatophoric dwarfism; ; Fibroblast growth factor receptor 3; Heparin binding growth factor receptor; HSFGFR3EX; Hydroxyaryl protein kinase; JTK 4; JTK4; MFR 3; SAM 3; Tyrosine kinase JTK 4; Tyrosine kinase JTK4; Z FGFR 3

    		Human HEK293
  • HY-P73051
    FGF-18 Protein, Human (HEK293, His)

    Fibroblast growth factor 18; FGF-18; zFGF5; FGF18

    		Human HEK293
  • HY-P73057
    FGFR-4 Protein, Human (HEK293, Fc)

    Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

    		Human HEK293
  • HY-P77660
    FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi)

    FGF R1a; FGFR1 alpha

    		Human HEK293
  • HY-P73052AF
    Animal-Free FGF-2 Protein, Mouse (His)

    rMubFGF; HBGF-2; FGF-2; FGF-b; FGF-basic

    		Mouse E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.Animal-Free FGF-2 Protein, Mouse (His), consists of 144 amino acids, produced by E.coli with tag free.
  • HY-P78123
    KGF-2/FGF-10 Protein, Human (Biotinylated, Primary Amine Labeling)

    FGF-10; KGF2

    		Human E. coli
  • HY-P7014
    FGF-4 Protein, Human (166a.a)

    rHuFGF-4; HBGF-4; HST; HST-1; HSTF1

    		Human E. coli
    FGF-4 Protein, Human (166a.a) is a member of the FGF family that transforms 3T3 cells with high efficiency, stimulates endothelial cell proliferation, migration, and protease production, and shows angiogenic activity.
  • HY-P7173
    FGF-21 Protein, Mouse

    rMuFGF-21; FGF21

    		Mouse E. coli
    FGF-21 Protein, Mouse emerges as a metabolic hormone involved in the regulation of glucose, lipid, bile acid, and phosphate metabolism.
  • HY-P70533
    FGF-8b Protein, Human/Mouse

    Fibroblast growth factor 8; Androgen-induced growth factor; Heparin-binding growth factor 8; AIGF; HBGF-8; FGF-8B

    		Human; Mouse E. coli
  • HY-P7066
    FGF-2 Protein, Mouse (145a.a)

    rMubFGF; HBGF-2; FGF-2; FGF-b; FGF-basic

    		Mouse E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Mouse (145a.a), consists of 145 amino acids, produced by E.coli with tag free.
  • HY-P7172
    FGF-19 Protein, Human

    rHuFGF-19; FGF19

    		Human E. coli
    FGF-19 Protein, Human could activate a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.
  • HY-P7012
    FGF-21 Protein, Human

    rHuFGF-21; Fibroblast Growth Factor-21(FGF-21)

    		Human E. coli
    FGF-21 Protein, Human is an atypical member of the fibroblast growth factor (FGF) subfamily, acts as a metabolic regulator with pleiotropic effects.
  • HY-P7047A
    KGF/FGF-7 Protein, Human (CHO)

    rHuKGF-1/FGF-7; Keratinocyte Growth Factor; Fibroblast Growth Factor-7; HBGF-7

    		Human CHO
    KGF/FGF-7 Protein, Human (CHO) is a polypeptide mitogen that belongs to the family of fibroblast growth factors, binds only to a splice variant of FGFR2 (FGFR2 IIIb) and is a highly specific paracrine growth factor for epithelial cells. KGF/FGF-7 Protein and its receptor are important for normal wound healing.
  • HY-P7013
    FGF-23 Protein, Human

    rHuFGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor

    		Human E. coli
    FGF-23 Protein, Human is a unique FGF subfamily member, acts as a hormone and requires α-Klotho to signal through canonical FGFR, and induces hypertrophy and mineralization during chondrogenesis.
  • HY-P70440G
    GMP FGF basic/bFGF Protein, Human

    Fibroblast growth factor 2; FGF-2; bFGF; HBGF-2

    		Human E. coli
    FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.GMP FGF basic/bFGF Protein, Human, consists of 157 amino acids, produced by E.coli with tag free.
Cat. No. Product Name Effect Purity