Virus Protease

Related Products

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Virus Protease Inhibitors (146)

Virus Protease Related Products (156)
Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-A0281

4-Phenylbutyric acid	Inhibitor	99.98%
4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-18234A

Leupeptin hemisulfate	Inhibitor	≥98.0%
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity.

HY-15304

Dynasore	Inhibitor	99.85%
Dynasore is a cell-permeable dynamin inhibitor with an IC₅₀ of 15 μM. Dynasore blocks cell migration.

HY-14654

Aspirin	Inhibitor	99.66%
Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.

HY-108325

Brequinar	Inhibitor	99.75%
Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC₅₀ of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.

HY-N0184

Glycyrrhizic acid	Inhibitor	99.65%
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

HY-144644A

NS2B/NS3-IN-3 hydrochloride	Inhibitor	98.00%
NS2B/NS3-IN-3 hydrochlorideis an inhibitor of Flavivirus NS2B-NS3 protease.

HY-155379

β-Herpesvirus protease-IN-1	Inhibitor
β-Herpesvirus protease-IN-1 (compound 19) is a β-herpesvirus protease inhibitor with IC₅₀s of 2.5 μM and 0.33 μM for HCMVPro and HHV6Pro, respectively.

HY-N0193

Artesunate	Inhibitor	98.09%
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

HY-13750

Ebselen	Inhibitor	99.58%
Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker. Ebselen potently inhibits M^pro (IC₅₀=0.67 μM) and COVID-19 virus (EC₅₀=4.67 μM).Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity.

HY-50912

Plerixafor octahydrochloride	Inhibitor	≥98.0%
Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM.

HY-117383

NGI-1	Inhibitor	99.90%
NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B. NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability.

HY-13428

Tubacin	Inhibitor
Tubacin is a potent and selective inhibitor of HDAC6, with an IC₅₀ value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).

HY-B2230

Hinokitiol	Inhibitor	98.97%
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-N0288

Lycorine	Inhibitor	99.71%
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a K_d value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription. Lycorine is also a melanoma vasculogenic inhibitor. Lycorine can be used for the study of prostate cancer and metabolic diseases.

HY-13447A

PF429242 dihydrochloride	Inhibitor	99.88%
PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC₅₀ of 175 nM.

HY-143216

Ensitrelvir	Inhibitor	99.48%
Ensitrelvir (S-217622) is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC₅₀=13 nM).

HY-N0328

alpha-Mangostin	Inhibitor	99.64%
alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a K_i of 2.85 μM.

HY-16704

ESI-09	Inhibitor	99.65%
ESI-09 is a novel noncyclic nucleotide EPAC antagonist with IC₅₀ values of 3.2 and 1.4 μM for EPAC1 and EPAC2, respectively.

HY-N0560

Oroxylin A	Inhibitor	99.87%
Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis.

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Virus Protease

Virus Protease

Virus Protease Related Products (156)

Antibodies (1)

Virus Protease Related Products (156):