23288-49-5
23288-49-5
Chemical Structure
Probucol
Synonym(s): DH-581
- CAS No.: 23288-49-5
- Formula:C31H48O2S2
- Molecular Weight:516.84
IUPAC Name: 4,4'-(propane-2,2-diylbis(sulfanediyl))bis(2,6-di-tert-butylphenol)
InChIKey: FYPMFJGVHOHGLL-UHFFFAOYSA-N
SMILES: CC(SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)C
Biological Activity: Probucol (DH-581) is an anti-hyperlipidemic agent. Probucol activates glutathione peroxidase. Probucol promotes low density lipoprotein (LDL) catabolism, inhibits ABCA1-dependent cholesterol efflux, and decreases HDL-C levels. Probucol also has anti-inflammatory, antioxidant and neuroprotective properties. Probucol can be used for researches on bone, cardiovascular, cancer, neurological, and metabolism-related diseases[1][2][3][4][5][6][7][8][9][10][11][12][13].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Probucol | 99.85% | Probucol (DH-581) is an anti-hyperlipidemic agent. Probucol activates glutathione peroxidase. Probucol promotes low density lipoprotein (LDL) catabolism, inhibits ABCA1-dependent cholesterol efflux, and decreases HDL-C levels. Probucol also has anti-inflammatory, antioxidant and neuroprotective properties. Probucol can be used for researches on bone, cardiovascular, cancer, neurological, and metabolism-related diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Probucol (Standard) | 99.86% | Probucol (Standard) is the analytical standard of Probucol. This product is intended for research and analytical applications. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Probucol-d6 | Probucol-d6 is deuterium labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Probucol-13C3 | Probucol-13C3 is the 13C-labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. 1. A Unique Antilipidemic Drug - Probucol". Journal of Atherosclerosis and Thrombosis. 15 (6): 304–5. [Content Brief]
- [2]. 2. Steinberg D. Studies on the mechanism of action of probucol. Am J Cardiol. 1986 Jun 27;57(16):16H-21H. [Content Brief]
- [3]. 3. Favari E, et al. Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2345-50. [Content Brief]
- [4]. 4. Zhong JK, et al. Probucol alleviates atherosclerosis and improves high density lipoprotein function. Lipids Health Dis. 2011 Nov 12;10:210. [Content Brief]
- [5]. 5. Zhou X, et al. Probucol promotes high glucose-induced proliferation and inhibits apoptosis by reducing reactive oxygen species generation in Müller cells. Int Ophthalmol. 2019 Dec;39(12):2833-2842. [Content Brief]
- [6]. 6. Iqbal M, et al. Probucol as a potent inhibitor of oxygen radical-induced lipid peroxidation and DNA damage: in vitro studies. Redox Rep. 2004;9(3):167-72. [Content Brief]
- [7]. 7. Santos DB, et al. Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1. Mol Neurobiol. 2020 Aug;57(8):3245-3257. [Content Brief]
- [8]. 8. Siveski-Iliskovic, et al. Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation. 1994 Jun;89(6):2829-35. [Content Brief]
- [9]. 9. Siveski-Iliskovic, et al. Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect. Circulation. 1995 Jan 1;91(1):10-5. [Content Brief]
- [10]. 10. Wang H, et al. Probucol enhances the therapeutic efficiency of mesenchymal stem cells in the treatment of erectile dysfunction in diabetic rats by prolonging their survival time via Nrf2 pathway. Stem Cell Res Ther. 2020 Jul 21;11(1):302. [Content Brief]
- [11]. 11. Tao ZS, et al. Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress. Mol Med. 2022 Jun 28;28(1):75. [Content Brief]
- [12]. 12. Sia YT, et al. Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat. Circulation. 2002 May 28;105(21):2549-55. [Content Brief]
- [13]. 13. Zhang W, et al. Probucol recovers pathological damage in viral Myocarditis through improvement of myocardium-related proteins. Microb Pathog. 2020 Oct;147:104257. [Content Brief]
