1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin

ADC Cytotoxin

A cytotoxin is any substance which has a toxic effect on cells. Some common examples of cytotoxins include chemical agents and certain snake venoms. Cytotoxins typically attack only a specific type of cell or organ, rather than an entire body. Cells that have been affected by a cytotoxin can perish in several different ways. One is necrosis. In this form of cell death, the cells lose integrity in their membrane wall and collapse. Another type of possible cell death is apoptosis. This type of death is pre-programmed into the cell itself before the cytotoxin arrives. It is typically a beneficial property, as seen when cells in the fingers and toes of developing human babies undergo apoptosis, leading to the separation of digits. Chemotherapy as a treatment of cancer often relies on the ability of these agents to preferentially kill or damage cancer cells as opposed to healthy cells.

ADC Cytotoxin Related Products (38):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride 99.47%
    Doxorubicin hydrochloride is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
  • HY-13316
    Mitomycin C 98.51%
    Mitomycin C is a DNA-damaging agent and small-molecule inhibitor effectively sensitize cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL).
  • HY-B0015
    Paclitaxel 99.60%
    Paclitaxel is a potent anticancer agent known to promote microtubule (MT) assembly, inhibit MT depolymerization, and change MT dynamics required for mitosis and cell proliferation.
  • HY-15162
    Monomethyl auristatin E 99.94%
    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
  • HY-19610
    alpha-Amanitin
    alpha-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
  • HY-15579AS
    D8-MMAF hydrochloride 99.56%
    D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
  • HY-101127
    SGD-1882
    SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
  • HY-14519
    Methotrexate 99.69%
    Methotrexate is a traditional folate antagonist, with median IC50 of 78 nM for a 120 h drug exposure in a panel of six pediatric leukemia and lymphoma cell lines using the sulforhodamine B assay.
  • HY-16261
    INNO-206
    INNO-206 is a prodrug of the anticancer agent doxorubicin, which is released from albumin under acidic conditions.
  • HY-32735
    Triptolide 99.83%
    Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM.
  • HY-13062
    Daunorubicin Hydrochloride 99.64%
    Daunorubicin hydrochloride is a topoisomerase II inhibitor.
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin is a potent DNA-damaging cytotoxic agent.
  • HY-16560
    Campathecin 98.26%
    Campathecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor, with IC50 and IC70 of 50 nM and 0.225 μM in breast cancer cell line MDA-MB-231.
  • HY-13061
    Daun02 98.56%
    Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor.
  • HY-15162A
    D8-MMAE 98.31%
    D8-MMAE is a deuterated form of MMAE, which is a microtubule-disrupting agent.
  • HY-16700
    PNU-159682
    PNU-159682, a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a topoisomerase inhibitor and ADCs cytotoxin.
  • HY-15739
    Ansamitocin P-3 >98.0%
    Ansamitocin P-3 is a microtubule inhibitor.
  • HY-15581
    MMAD 99.92%
    MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
  • HY-15579A
    MMAF Hydrochloride 98.96%
    MMAF hydrochloride is an antitubulin agent that inhibit cell division; inhibits H3397 cell growth with an IC50 of 105 nM.
  • HY-15584
    Taltobulin 99.97%
    Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.