1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin

ADC Cytotoxin

A cytotoxin is any substance which has a toxic effect on cells. Some common examples of cytotoxins include chemical agents and certain snake venoms. Cytotoxins typically attack only a specific type of cell or organ, rather than an entire body. Cells that have been affected by a cytotoxin can perish in several different ways. One is necrosis. In this form of cell death, the cells lose integrity in their membrane wall and collapse. Another type of possible cell death is apoptosis. This type of death is pre-programmed into the cell itself before the cytotoxin arrives. It is typically a beneficial property, as seen when cells in the fingers and toes of developing human babies undergo apoptosis, leading to the separation of digits. Chemotherapy as a treatment of cancer often relies on the ability of these agents to preferentially kill or damage cancer cells as opposed to healthy cells.

ADC Cytotoxin Related Products (34):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride Inhibitor
    Doxorubicin hydrochloride is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
  • HY-13316
    Mitomycin C Inhibitor
    Mitomycin C is a DNA-damaging agent and small-molecule inhibitor effectively sensitize cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL).
  • HY-B0015
    Paclitaxel Inhibitor
    Paclitaxel is a potent anticancer agent known to promote microtubule (MT) assembly, inhibit MT depolymerization, and change MT dynamics required for mitosis and cell proliferation.
  • HY-15162
    Monomethyl auristatin E Inhibitor
    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
  • HY-16261
    INNO-206 Inhibitor
    INNO-206 is a prodrug of the anticancer agent doxorubicin, which is released from albumin under acidic conditions.
  • HY-79256
    MMAF-OMe Inhibitor
    MMAF-Ome belongs to ADC, and inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.
  • HY-14519
    Methotrexate Antagonist
    Methotrexate is a traditional folate antagonist, with median IC50 of 78 nM for a 120 h drug exposure in a panel of six pediatric leukemia and lymphoma cell lines using the sulforhodamine B assay.
  • HY-32735
    Triptolide Inhibitor
    Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM.
  • HY-13062
    Daunorubicin Hydrochloride Inhibitor
    Daunorubicin hydrochloride is a topoisomerase II inhibitor.
  • HY-13061
    Daun02 Inhibitor
    Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor.
  • HY-16560
    Campathecin Inhibitor
    Campathecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor, with IC50 and IC70 of 50 nM and 0.225 μM in breast cancer cell line MDA-MB-231.
  • HY-16700
    PNU-159682 Inhibitor
    PNU-159682 is a major bioactive metabolite of Nemorubicin in human liver microsomes; > 3,000-fold cytotoxic than its parent compound(MMDX and doxorubicin).
  • HY-15739
    Ansamitocin P-3 Inhibitor
    Ansamitocin P-3 is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.
  • HY-15162A
    D8-MMAE Inhibitor
    D8-MMAE is a deuterated form of MMAE, which is a microtubule-disrupting agent.
  • HY-15581
    MMAD Inhibitor
    MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
  • HY-15579A
    MMAF Hydrochloride Inhibitor
    MMAF hydrochloride is an antitubulin agent that inhibit cell division; inhibits H3397 cell growth with an IC50 of 105 nM.
  • HY-15580
    Dolastatin 10 Inhibitor
    Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.
  • HY-15584
    Taltobulin Inhibitor
    Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
  • HY-15142A
    Doxorubicin Inhibitor
    Doxorubicin is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
  • HY-13062A
    Daunorubicin Inhibitor
    Daunorubicin(RP13057) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.