1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin

ADC Cytotoxin

Antibody-drug conjugates (ADCs) represent a novel class of cancer therapeutics. Their design involves a tumor-specific antibody, a linker and a cytotoxic payload. The payload in ADCs are highly potent cytotoxins, exerting their effects on critical cellular processes required for survival. Typically, the cytotoxins used in ADCs are a 100-1000 times more potent than regular chemotherapeutics and preferably have sub-nanomolar potency. Most compounds in current clinical testing utilize either maytansine derivatives (DM1/DM4) or auristatins (MMAE/ MMAF), which are both microtubule inhibitors. These typically induce apoptosis in cells undergoing mitosis by causing cell cycle arrest at G2/M. More recent work shows that microtubule inhibitors may also disrupt non-dividing cells in interphase. Other classes of cytotoxins used in ADCs include enediynes (Calicheamicin ), duocarmycin derivatives, pyrrolobenzodiazepines (PBDs) and indolinobenzodiazepines, all of which target the minor groove of DNA, and quinoline alkaloids (SN-38), which inhibit topoisomerase. For example, the potent cytotoxic drug doxorubicin and daunorubicin may interact with DNA by intercalation.

ADC Cytotoxin Related Products (37):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride 99.47%
    Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic for the treatment of multiple cancers. The possible mechanisms by which doxorubicin acts in the cancer cell are intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair.
  • HY-13316
    Mitomycin C 98.89%
    Mitomycin C is an antitumor drug and antibiotic that shows extraordinary ability to inhibit DNA synthesis.
  • HY-B0015
    Paclitaxel 99.97%
    Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibit MT depolymerization, and change MT dynamics required for mitosis and cell proliferation.
  • HY-19610
    alpha-Amanitin 99.79%
    alpha-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
  • HY-15162
    Monomethyl auristatin E 99.94%
    Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
  • HY-13631D
    Dxd
    Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
  • HY-14519
    Methotrexate 99.75%
    Methotrexate is a folate antagonist, with median IC50 of 78 nM in in vitro assay.
  • HY-16261
    INNO-206
    INNO-206 is an albumin-binding prodrug of doxorubicin, which is released from albumin under acidic conditions. INNO-206 has potent antitumor activities in various cancer cell lines and in in murine tumor models.
  • HY-16560
    Campathecin 98.26%
    Campathecin is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM.
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin is a potent DNA-damaging cytotoxic agent.
  • HY-13062
    Daunorubicin Hydrochloride 99.64%
    Daunorubicin hydrochloride is a topoisomerase II inhibitor with potent antineoplastic activities.
  • HY-15162A
    D8-MMAE 98.31%
    D8-MMAE is a deuterated form of MMAE, which is a microtubule-disrupting agent.
  • HY-13061
    Daun02 98.56%
    Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor.
  • HY-15584
    Taltobulin 99.90%
    Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
  • HY-15579A
    MMAF Hydrochloride 98.96%
    MMAF hydrochloride is an antitubulin agent that inhibit cell division; inhibits H3397 cell growth with an IC50 of 105 nM.
  • HY-16700
    PNU-159682
    PNU-159682, a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a potent ADCs cytotoxin.
  • HY-15739
    Ansamitocin P-3 >98.0%
    Ansamitocin P-3 is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.
  • HY-15581
    MMAD 99.92%
    MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
  • HY-15580
    Dolastatin 10 99.83%
    Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.
  • HY-15583
    Auristatin F 98.35%
    Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.
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