1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin

ADC Cytotoxin

ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.

The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.

ADC Cytotoxin Related Products (39):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride 99.47%
    Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic for the treatment of multiple cancers. The possible mechanisms by which doxorubicin acts in the cancer cell are intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair.
  • HY-13316
    Mitomycin C 99.45%
    Mitomycin C is an antitumor drug and antibiotic that shows extraordinary ability to inhibit DNA synthesis. Mitomycin C is a DNA cross-linking agent, which induces DNA damaging.
  • HY-B0015
    Paclitaxel 99.97%
    Paclitaxel (Taxol), a naturally occurring antineoplastic agent, stabilizes tubulin polymerization, resulting in arrest at the G2/M phase of the cell cycle and apoptotic cell death.
  • HY-19610
    alpha-Amanitin 99.79%
    alpha-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
  • HY-15162
    Monomethyl auristatin E 99.94%
    Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
  • HY-16261B
    MC-DOXHZN hydrochloride
    MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin, with acid-sensitive properties.
  • HY-14519
    Methotrexate 99.75%
    Methotrexate is a folate antagonist, with median IC50 of 78 nM in in vitro assay.
  • HY-16560
    Campathecin 98.26%
    Campathecin is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM.
  • HY-16261
    Aldoxorubicin
    Aldoxorubicin (INNO-206) is an albumin-binding prodrug of doxorubicin, which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.
  • HY-19792
    Mertansine 98.74%
    Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).
  • HY-13062
    Daunorubicin Hydrochloride 99.27%
    Daunorubicin Hydrochloride is a topoisomerase II inhibitor with potent antineoplastic activities. Daunorubicin Hydrochloride inhibites DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks.
  • HY-15162A
    D8-MMAE 98.31%
    D8-MMAE is a deuterated labeled MMAE, a potent mitotic inhibitor.
  • HY-13061
    Daun02 98.56%
    Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin.
  • HY-15579A
    MMAF Hydrochloride 99.89%
    MMAF hydrochloride is an antitubulin agent that inhibit cell division; inhibits H3397 cell growth with an IC50 of 105 nM.
  • HY-15584
    Taltobulin 99.90%
    Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
  • HY-16700
    PNU-159682
    PNU-159682, a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a potent ADCs cytotoxin.
  • HY-15739
    Ansamitocin P-3 >98.0%
    Ansamitocin P-3 is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.
  • HY-15583
    Auristatin F
    Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.
  • HY-13631D
    Dxd 98.20%
    Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.