1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin

ADC Cytotoxin

Antibody-drug conjugates (ADCs) represent a novel class of cancer therapeutics. Their design involves a tumor-specific antibody, a linker and a cytotoxic payload. The payload in ADCs are highly potent cytotoxins, exerting their effects on critical cellular processes required for survival. Typically, the cytotoxins used in ADCs are a 100-1000 times more potent than regular chemotherapeutics and preferably have sub-nanomolar potency. Most compounds in current clinical testing utilize either maytansine derivatives (DM1/DM4) or auristatins (MMAE/ MMAF), which are both microtubule inhibitors. These typically induce apoptosis in cells undergoing mitosis by causing cell cycle arrest at G2/M. More recent work shows that microtubule inhibitors may also disrupt non-dividing cells in interphase. Other classes of cytotoxins used in ADCs include enediynes (Calicheamicin ), duocarmycin derivatives, pyrrolobenzodiazepines (PBDs) and indolinobenzodiazepines, all of which target the minor groove of DNA, and quinoline alkaloids (SN-38), which inhibit topoisomerase. For example, the potent cytotoxic drug doxorubicin and daunorubicin may interact with DNA by intercalation.

ADC Cytotoxin Related Products (38):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride 99.47%
    Doxorubicin hydrochloride is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
  • HY-13316
    Mitomycin C 98.89%
    Mitomycin C is a DNA-damaging agent and small-molecule inhibitor effectively sensitize cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL).
  • HY-B0015
    Paclitaxel 99.64%
    Paclitaxel is a potent anticancer agent known to promote microtubule (MT) assembly, inhibit MT depolymerization, and change MT dynamics required for mitosis and cell proliferation.
  • HY-19610
    alpha-Amanitin 99.79%
    alpha-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
  • HY-15162
    Monomethyl auristatin E 99.94%
    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
  • HY-13631D
    Dxd
    Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
  • HY-14519
    Methotrexate 99.75%
    Methotrexate is a traditional folate antagonist, with median IC50 of 78 nM for a 120 h drug exposure in a panel of six pediatric leukemia and lymphoma cell lines using the sulforhodamine B assay.
  • HY-32735
    Triptolide 99.83%
    Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM.
  • HY-16261
    INNO-206
    INNO-206 is a prodrug of the anticancer agent doxorubicin, which is released from albumin under acidic conditions.
  • HY-16560
    Campathecin 98.26%
    Campathecin is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM.
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin is a potent DNA-damaging cytotoxic agent.
  • HY-13062
    Daunorubicin Hydrochloride 99.64%
    Daunorubicin hydrochloride is a topoisomerase II inhibitor.
  • HY-15162A
    D8-MMAE 98.31%
    D8-MMAE is a deuterated form of MMAE, which is a microtubule-disrupting agent.
  • HY-13061
    Daun02 98.56%
    Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor.
  • HY-16700
    PNU-159682
    PNU-159682, a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a potent ADCs cytotoxin.
  • HY-15584
    Taltobulin 99.90%
    Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
  • HY-15579A
    MMAF Hydrochloride 98.96%
    MMAF hydrochloride is an antitubulin agent that inhibit cell division; inhibits H3397 cell growth with an IC50 of 105 nM.
  • HY-15739
    Ansamitocin P-3 >98.0%
    Ansamitocin P-3 is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.
  • HY-15581
    MMAD 99.92%
    MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).
  • HY-15583
    Auristatin F 98.35%
    Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.
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