1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin

ADC Cytotoxin

A cytotoxin is any substance which has a toxic effect on cells. Some common examples of cytotoxins include chemical agents and certain snake venoms. Cytotoxins typically attack only a specific type of cell or organ, rather than an entire body. Cells that have been affected by a cytotoxin can perish in several different ways. One is necrosis. In this form of cell death, the cells lose integrity in their membrane wall and collapse. Another type of possible cell death is apoptosis. This type of death is pre-programmed into the cell itself before the cytotoxin arrives. It is typically a beneficial property, as seen when cells in the fingers and toes of developing human babies undergo apoptosis, leading to the separation of digits. Chemotherapy as a treatment of cancer often relies on the ability of these agents to preferentially kill or damage cancer cells as opposed to healthy cells.

ADC Cytotoxin Related Products (36):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride Inhibitor 99.47%
    Doxorubicin hydrochloride is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
  • HY-13316
    Mitomycin C Inhibitor 98.51%
    Mitomycin C is a DNA-damaging agent and small-molecule inhibitor effectively sensitize cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL).
  • HY-B0015
    Paclitaxel Inhibitor 99.46%
    Paclitaxel is a potent anticancer agent known to promote microtubule (MT) assembly, inhibit MT depolymerization, and change MT dynamics required for mitosis and cell proliferation.
  • HY-15162
    Monomethyl auristatin E Inhibitor 99.76%
    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
  • HY-16261
    INNO-206 Inhibitor
    INNO-206 is a prodrug of the anticancer agent doxorubicin, which is released from albumin under acidic conditions.
  • HY-15579S
    D8-MMAF
    D8-MMAF is a deuterated form of MMAF, which is a microtubule disrupting agent.
  • HY-15581S
    D8-MMAD
    D8-MMAD is a deuterated form of MMAD, which is a microtubule disrupting agent.
  • HY-14519
    Methotrexate Antagonist 99.69%
    Methotrexate is a traditional folate antagonist, with median IC50 of 78 nM for a 120 h drug exposure in a panel of six pediatric leukemia and lymphoma cell lines using the sulforhodamine B assay.
  • HY-32735
    Triptolide Inhibitor 99.83%
    Triptolide is an inhibitor of heat shock factor (HSF1), inhibits HSP90-CDC37 binding and induces acetylation of HSP90, and also inhibits MDM2 expression in a dose-dependent manner with IC50 values range from 47 to 73 nM.
  • HY-19610
    alpha-Amanitin Inhibitor
    alpha-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.
  • HY-13062
    Daunorubicin Hydrochloride Inhibitor 99.64%
    Daunorubicin hydrochloride is a topoisomerase II inhibitor.
  • HY-19609
    Calicheamicin Inhibitor 98.44%
    Calicheamicin is a potent DNA-binding cytotoxic antibiotic.
  • HY-16560
    Campathecin Inhibitor 98.26%
    Campathecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor, with IC50 and IC70 of 50 nM and 0.225 μM in breast cancer cell line MDA-MB-231.
  • HY-13061
    Daun02 Inhibitor 98.56%
    Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor.
  • HY-16700
    PNU-159682 Inhibitor
    PNU-159682, a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, is a topoisomerase inhibitor and ADCs cytotoxin.
  • HY-15581
    MMAD Inhibitor 99.28%
    Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
  • HY-15739
    Ansamitocin P-3 Inhibitor
    Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29; Antibody drug conjugate cytotoxin.
  • HY-15162A
    D8-MMAE Inhibitor 98.31%
    D8-MMAE(D8-Monomethyl auristatin E; D8-Vedotin) is a deuterated form of MMAE.
  • HY-15579A
    MMAF Hydrochloride Inhibitor 98.96%
    MMAF hydrochloride is an antitubulin agent that inhibit cell division; inhibits H3397 cell growth with an IC50 of 105 nM.
  • HY-15580
    Dolastatin 10 Inhibitor
    Dolastatin 10(DLS 10;NSC 376128) is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly; Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE).