1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin
  3. Mertansine

Mertansine  (Synonyms: DM1; Maytansinoid DM1)

Cat. No.: HY-19792 Purity: 99.55%
COA Handling Instructions

Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).

For research use only. We do not sell to patients.

Mertansine Chemical Structure

Mertansine Chemical Structure

CAS No. : 139504-50-0

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2 mg USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 624 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1128 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 12 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Mertansine purchased from MCE. Usage Cited in: Biomaterials. 2022: 121913.

    Free Mertansine (DM1; 20 nM; 24 h) is able to induce apoptosis in NCI-H929 cells.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC)[1][2].

    IC50 & Target

    Maytansinoids

     

    In Vitro

    Mertansine is a strong antiproliferative chemotherapeutics toward over 60 types of cancer cell lines[3].
    Mertansine (0-1 μg/mL) shows antitumor activity in malignant B16F10 melanoma cells, and inhibits tumor cell growth by inhibiting mitosis when combined with DTX[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay

    Cell Line: Malignant B16F10 melanoma cells[3]
    Concentration: 0, 0.01, 0.1, and 1 μg/mL
    Incubation Time: 4 h
    Result: Showed antitumor activity in malignant B16F10 melanoma cells, with an IC50 of 0.092 μg/mL. Co-delivery of DTX and DM1, both of which inhibit tumor cell growth by inhibiting mitosis, is an effective strategy to achieve a combinatorial anticancer effect.
    In Vivo

    Mertansine (DM1) has a low maximum-tolerated dose (MTD) of 1 mg/kg[3]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    738.29

    Formula

    C35H48ClN3O10S

    CAS No.
    SMILES

    C[[email protected]]1([[email protected]@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([[email protected]](C)N(C)C(CCS)=O)=O)[[email protected]]([[email protected]@H]([[email protected]](OC4=O)([H])C[[email protected]]([[email protected]](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years

    *The compound is unstable in solutions, freshly prepared is recommended.

    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (84.66 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3545 mL 6.7724 mL 13.5448 mL
    5 mM 0.2709 mL 1.3545 mL 2.7090 mL
    10 mM 0.1354 mL 0.6772 mL 1.3545 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.17 mg/mL (2.94 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (2.82 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (2.82 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.80%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    Mertansine
    Cat. No.:
    HY-19792
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