1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    Drug-Linker Conjugates for ADC

Mertansine (Synonyms: DM1; Maytansinoid DM1)

Cat. No.: HY-19792 Purity: 98.22%
Data Sheet SDS Handling Instructions

Mertansine is a tubulin inhibitor,inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).

For research use only. We do not sell to patients.
Mertansine Chemical Structure

Mertansine Chemical Structure

CAS No. : 139504-50-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO $143 In-stock
2 mg $55 In-stock
5 mg $88 In-stock
10 mg $150 In-stock
25 mg $300 In-stock
50 mg $520 In-stock
100 mg $940 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Mertansine is a tubulin inhibitor,inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC). In vitro: Maytansine is a potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at sub-nanomolar concentrations. Maytansine at a concentration of 100 nmol/L suppressed the growth and shortening rates by 35%, quantitatively similarly to the same concentration of vinblastine. maytansine inhibits the formation of a cross-link between Cys 12 and Cys 201

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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.3545 mL 6.7724 mL 13.5448 mL
5 mM 0.2709 mL 1.3545 mL 2.7090 mL
10 mM 0.1354 mL 0.6772 mL 1.3545 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

738.29

Formula

C₃₅H₄₈ClN₃O₁₀S

CAS No.

139504-50-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 83.33 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.22%

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Product Name:
Mertansine
Cat. No.:
HY-19792
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