1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    Drug-Linker Conjugates for ADC

Mertansine (Synonyms: DM1; Maytansinoid DM1)

Cat. No.: HY-19792 Purity: 98.74%
Handling Instructions

Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

For research use only. We do not sell to patients.

Mertansine Chemical Structure

Mertansine Chemical Structure

CAS No. : 139504-50-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
2 mg USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 624 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1128 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.33 mg/mL (112.87 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3545 mL 6.7724 mL 13.5448 mL
5 mM 0.2709 mL 1.3545 mL 2.7090 mL
10 mM 0.1354 mL 0.6772 mL 1.3545 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.17 mg/mL (2.94 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (2.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (2.94 mM); Clear solution

References
Molecular Weight

738.29

Formula

C₃₅H₄₈ClN₃O₁₀S

CAS No.

139504-50-0

SMILES

C[[email protected]]1([[email protected]@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([[email protected]](C)N(C)C(CCS)=O)=O)[[email protected]]([[email protected]@H]([[email protected]](OC4=O)([H])C[[email protected]]([[email protected]](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.74%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Mertansine
Cat. No.:
HY-19792
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Mertansine

Cat. No.: HY-19792