Neurotrophins/NGF
The neurotrophin family (Neurotrophins, NTs) is a family of structurally and functionally related peptides which regulates neural survival, development, function, and plasticity. In mammals, NTs consists of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5. Two additional members, NT-6 and NT-7 have been identified only in fish, but mammalian homologs have not yet been identified. NTs mediate their actions by binding to 2 classes of receptors, the tropomyosin receptor kinase (trk) family of receptor tyrosine kinases, and a member of the tumour necrosis factor (TNF)-α family of receptors, p75. NGF binds TrkA, BDNF and NT-4 bind TrkB, and NT-3 binds TrkA, TrkB, and TrkC. In addition, all NTs activate p75 with low affinity, enhancing the activation of Trk receptors. Through these, NTs activate many signaling pathways, including those mediated by ras and members of the cdc-42/ras/rho G protein families, and the MAP kinase, PI-3 kinase, and Jun kinase cascades.
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Neurotrophins/NGF Recombinant Proteins (25)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
