2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Neurotrophic Factors
  5. Neurotrophins/NGF

Neurotrophins/NGF

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The neurotrophin family (Neurotrophins, NTs) is a family of structurally and functionally related peptides which regulates neural survival, development, function, and plasticity. In mammals, NTs consists of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5. Two additional members, NT-6 and NT-7 have been identified only in fish, but mammalian homologs have not yet been identified. NTs mediate their actions by binding to 2 classes of receptors, the tropomyosin receptor kinase (trk) family of receptor tyrosine kinases, and a member of the tumour necrosis factor (TNF)-α family of receptors, p75. NGF binds TrkA, BDNF and NT-4 bind TrkB, and NT-3 binds TrkA, TrkB, and TrkC. In addition, all NTs activate p75 with low affinity, enhancing the activation of Trk receptors. Through these, NTs activate many signaling pathways, including those mediated by ras and members of the cdc-42/ras/rho G protein families, and the MAP kinase, PI-3 kinase, and Jun kinase cascades.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7660
    Beta-NGF Protein, Human (HEK293)

    rHuBeta-NGF; Beta-Nerve Growth Factor; Beta-NGF;

    		Human HEK293
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (HEK293) is produced by HEK293 cells (S122-R239), with tag free.
  • HY-P73316
    Beta-NGF Protein, Human (CHO)

    Beta-NGF; Beta-Nerve Growth Factor; NGF; NGFB

    		Human CHO
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (CHO) is produced by CHO cells (S122-R239), with tag free.
  • HY-P73317
    Beta-NGF Protein, Mouse (CHO)

    Beta-NGF; Beta-Nerve Growth Factor; NGF; NGFB

    		Mouse CHO
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (CHO) is produced by CHO cells (S122-G241), with tag free.
  • HY-P700018AF
    Animal-Free Beta-NGF Protein, Human (His)

    β-Nerve Growth Factor; NGF-β

    		Human E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Human (His) is produced by E.coli (S122-A241), with C-terminal His-tag.
  • HY-P7116
    BDNF Protein, Human (CHO)

    rHuBDNF/Brain-derived neurotrophic factor; Abrineurin

    		Human CHO
    BDNF Protein, Human (CHO) is a neurotrophin binding to the high-affinity tropomyosin-related receptor kinase B (TrkB) receptor to regulate neurodevelopmental processes, including neuronal survival, neuronal differentiation, and synaptic plasticity.
  • HY-P7661
    Beta-NGF Protein, Mouse (120a.a)

    rMuBeta-NGF; Beta-nerve growth factor; Beta-NGF;

    		Mouse E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (120a.a) is produced by E.coli (S122-G241), with tag free.
  • HY-P70530
    Beta-NGF Protein, Mouse (110a.a)

    Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

    		Mouse E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (110a.a) is produced by E.coli (M130-R239), with tag free.
  • HY-P70449
    Beta-NGF Protein, Human (120a.a)

    Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

    		Human E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (120a.a) is produced by E.coli (S122-A241), with tag free.
  • HY-P700158AF
    Animal-Free BDNF Protein, Human/Mouse (His)

    rain-derived neurotrophic factor; BDNF; Abrineurin; ProBDNF

    		Human; Mouse E. coli
    Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. Animal-Free BDNF Protein, Human/Mouse (His) is an animal-free recombinant human/muose BDNF (H129-R247) with C-terminal His tag, which is produced in E.coli.
  • HY-P700162AF
    Animal-Free Beta-NGF Protein, Mouse (His)

    beta-NGF; beta-Nerve Growth Factor; NGF; NGFB

    		Mouse E. coli
    Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Mouse (His) is produced by E.coli (S122-G241), with C-terminal His-tag.
  • HY-P70530A
    Beta-NGF Protein, Mouse (110a.a, His)

    Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

    		Mouse E. coli
    Beta-NGF Protein, vital for developing and maintaining the nervous systems, engages NTRK1 and NGFR receptors, initiating signaling cascades regulating neuronal processes. The NGF precursor, proNGF, acts as a ligand for the SORCS2-NGFR receptor, activating pathways that impact RAC1/2, actin cytoskeleton, and neuronal growth. In vitro, proNGF induces neuronal apoptosis. Beta-NGF inhibits platelet glycoprotein VI proteolysis, binds lysophosphatidylinositol and lysophosphatidylserine, influencing mast cell histamine release. Its homodimer interacts with NTRK1, NGFR, and SORCS2, and proNGF binds to SORT1-NGFR, leading to NGF endocytosis. These interactions highlight Beta-NGF's multifaceted roles in cellular responses. Beta-NGF Protein, Mouse (110a.a, His) is the recombinant mouse-derived Beta-NGF protein, expressed by E. coli, with N-6*His labeled tag. The total length of Beta-NGF Protein, Mouse (110a.a, His) is 110 a.a., with molecular weight of ~12.0 kDa.
  • HY-P7116A
    BDNF Protein, Human

    rHuBDNF/Brain-derived neurotrophic factor; Abrineurin

    		Human E. coli
    Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Human is a recombinant human BDNF (H129-R247) without tag, which is produced in E.coli.
  • HY-P70456
    Neurotrophin-3 Protein, Human

    Neurotrophin-3; NT-3; HDNF; Nerve Growth Factor 2; NGF-2; Neurotrophic Factor; NTF3

    		Human E. coli
    Neurotrophin-3 Protein, Human is a recombinant Neurotrophin-3 protein expressed in E. coli system. Neurotrophin-3 is widely expressed in the nervous system. Neurotrophin-3 reduces cellular damage, improves neuronal regeneration in different models of lesions.
  • HY-P72489
    BDNF Protein, Human (R125A,R127A,R128A)

    Brain-derived neurotrophic factor; BDNF; Abrineurin; ProBDNF

    		Human E. coli
    Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Human (R125A,R127A,R128A) is a recombinant human BDNF (A19-R247) with R125A, R127A, R128A mutations, and without tag, which is produced in E.coli.
  • HY-P7272
    Neurotrophin-4 Protein, Human

    rHuNT-4; NT-5; NTF4; NTF5; NT4

    		Human E. coli
    NT-4 Protein, Human is a member of neurotrophins family, binding with two distinct receptors: TrkB, high affinity receptor and p75 low-affinity neurotrophin receptor (p75NTR).
  • HY-P7273
    NT-4 Protein, Mouse

    rMuNT-4; NT-5; NTF4; NTF5

    		Mouse E. coli
    NT-4 Protein, Mouse is a member of neurotrophins family, binding with two distinct receptors: TrkB, high affinity receptor and p75 low-affinity neurotrophin receptor (p75NTR).
  • HY-P74383
    BDNF Protein, Mouse (R129A, R130A, HEK293, His, Solution)

    Brain-derived neurotrophic factor; BDNF; ProBDNF

    		Mouse HEK293
    Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Mouse (R129A, R130A, HEK293, His) is a recombinant mouse BDNF (M1-R249, R129A, R130A) with C-terminal His tag, which is produced in HEK293.
  • HY-P72488
    pro-Beta-NGF Protein, Human (223a.a)

    Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB

    		Human E. coli
    Pro-Beta-NGF protein plays a crucial role in the development and maintenance of the nervous system by binding to NTRK1 and NGFR receptors. Immature NGF precursors act as ligands for the SORCS2-NGFR complex, triggering signaling pathways affecting RAC1/2, the actin cytoskeleton, and neuronal growth. pro-Beta-NGF Protein, Human (223a.a) is the recombinant human-derived pro-Beta-NGF protein, expressed by E. coli , with tag free. The total length of pro-Beta-NGF Protein, Human (223a.a) is 223 a.a., with molecular weight of ~30 kDa.
  • HY-P701335
    Neurotrophin-4 Protein, Human (His)

    rHuNT-4; NT-5; NTF4; NTF5; NT4

    		Human E. coli
    Neurotrophin-4 (NT-4) protein serves as a vital target-derived survival factor for peripheral sensory sympathetic neurons, emphasizing its crucial role in promoting their survival and maintenance. The specific and targeted actions of NT-4 underscore its significance as a neurotrophic factor in the intricate mechanisms governing the well-being of peripheral neurons within the sympathetic nervous system. Neurotrophin-4 Protein, Human (His) is the recombinant human-derived Neurotrophin-4 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Neurotrophin-4 Protein, Human (His) is 129 a.a., with molecular weight of 19 kDa.
  • HY-P72489Y
    BDNF Protein, Human (R125A, R127A, R128A, solution)

    Brain-derived neurotrophic factor; BDNF; Abrineurin; ProBDNF

    		Human E. coli
    Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Human (R125A,R127A,R128A) is a recombinant human BDNF (A19-R247) with R125A, R127A, R128A mutations, and without tag, which is produced in E.coli.
Cat. No. Product Name Effect Purity