NT-4/5
NT-4/5 (NTF4) is the smallest and least redundant neurotrophin: it binds TrkB as a mature homodimer, sharing this receptor with BDNF but showing a broader tissue distribution and a strikingly milder knockout phenotype, since Ntf4-null mice lose only a small fraction of sensory neurons. NT-4 is expressed in brain, peripheral tissues and adipose, supports survival of motor, sensory and retinal ganglion neurons, and potentiates synaptic transmission. Rare heterozygous NTF4 variants have been reported in primary open-angle glaucoma. Recombinant NT-4/5 is used for TrkB activation assays, neuroprotection studies, retinal ganglion cell cultures and neurite outgrowth experiments.
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NT-4/5 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
