Cat. No.: HY-L268

Optogenetics Compound Library

100 Cited Publications

Customer Review

Based on 100 publication(s) in Google Scholar

Optogenetics and photopharmacology are emerging technologies that enable precise spatiotemporal control of biological processes. Optogenetics primarily employs genetically encoded light-sensitive proteins to modulate cellular activity in response to specific wavelengths of light, whereas photopharmacology utilizes photoswitchable compounds and photocaged molecules to achieve light-dependent control of molecular activity. These approaches provide valuable tools for investigating ion channel function, calcium signaling, downstream kinase cascades, neuronal excitability, and intracellular signal transduction. They have broad applications in neuroscience, synthetic biology, and the investigation of disease-associated mechanisms in neurological and psychiatric disorders.

The MCE Optogenetics Compound Library comprises 927 structurally defined small molecules, including modulators targeting ion channels, calcium signaling, and associated downstream neuronal signaling pathways. The library supports mechanistic studies of neuronal signaling, investigations of neuronal excitability and calcium dynamics, and preliminary screening of candidate compounds, providing chemical tools for optogenetics-related neuroscience research.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (100)
Documentation
Composition

Description & Advantages

• A unique collection of optogenetics-related compounds, including light-responsive molecules and modulators of ion channels, calcium signaling, and downstream neuronal signaling pathways, for optogenetics research and neuroscience drug discovery.

• Structurally diverse, bioactive, and cell permeable.

• More detailed compound information with structure, IC50, and other chemical & biological data.

• High purity and quality validated by NMR and LC/MS.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 927 optogenetics-related compounds supplied as pre-dissolved solutions or solid forms for optogenetics and neuroscience research.

Solution: 909 compounds supplied in 10 mM solution, 18 compounds supplied in 2 mM solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice