Calmodulin

CaM; Calcium-modulated protein

Calmodulin (CaM), the member of EF-hand proteins superfamily, is a highly conserved eukaryotic Ca²⁺ sensor protein. Upon cellular stimulation, different mechanisms lead to transient intracellular increases in Ca²⁺ concentrations that initiate different protein activities. Most proteins are devoid of Ca²⁺ binding sites, requiring a mediator to respond to this cation. The ability to transmit conformational changes to a large and diverse array of proteins in response to Ca²⁺ oscillations, coordinating the activity of hundreds of proteins, makes calmodulin the most important Ca²⁺ signal transducer in eukaryotic cells. When Ca²⁺ binds to calmodulin it forms the Ca²⁺/calmodulin complex which then interacts with other proteins in the cell. These proteins are enzymes and effector proteins involved in a variety of cellular and physiological processes. The Ca²⁺/calmodulin complex can also regulate processes directly.

Calmodulin Related Products (24):

By Effects:	Inhibitors (9) Agonists (2) Antagonists (12)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-103319

Calmidazolium chloride	Antagonist	99.69%
Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC₅₀s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to calmodulin with a K_d of 3 nM.

HY-100912

W-7 hydrochloride	Antagonist	99.65%
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 µM, respectively. W-7 hydrochloride induces apoptosis and has antitumor activity.

HY-D0987

Stains-All		99.91%
Stains-All, a cationic carbocyanine dye, is a convenient probe to study the structural features of the individual calcium-binding sites of calmodulin (CaM) and related calcium-binding proteins (CaBP).

HY-P1077A

CALP1 TFA	Agonist	98.30%
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity.

HY-N7503

Psoralenoside	Inhibitor	99.84%
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H₁, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.

HY-N12405

Encecalinol	Inhibitor
Encecalinol, extracted from aerial parts of Ageratina grandifolia, is a potent inhibitor of calmodulin inhibitor.

HY-125412

Fasciculic acid B	Antagonist
Fasciculic acid B is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.

HY-N7733

Fasciculic acid A	Antagonist
Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.

HY-P1076A

CALP2 TFA	Antagonist	98.48%
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages.

HY-100913

W-7 isomer hydrochloride	Antagonist	99.50%
W-7 isomer hydrochloride is an isomer of W-7 hydrochloride (HY-100912). W-7 hydrochloride is a selective calmodulin antagonist.

HY-105118A

Zaldaride maleate	Antagonist	≥98.0%
Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC₅₀ of 3.3 nM. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na⁺, Ca²⁺ and K⁺ currents in PC12 cells and inhibits nAChR.

HY-N10772

Albanin A	Inhibitor
Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca²⁺/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.

HY-115745

Calmodulin antagonist-1	Antagonist	≥98.0%
Calmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca²⁺-phosphodiesterase (PDE) (IC₅₀=66 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca²⁺-PDE (IC₅₀=560 μM) in a competitive fashion with respect to cyclic GMP.

HY-P2471

Neurogranin (48-76), mouse	Inhibitor
Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca²⁺-CaM) pathway.

HY-100914

A-7 hydrochloride	Antagonist	99.09%
A-7 hydrochloride (Ophobolin A) is a calmodulin antagonist and can be used for the research of cancer.

HY-100263

Metofenazate	Inhibitor
Metofenazate is a selective calmodulin inhibitor.

HY-P1076

CALP2	Antagonist
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages.

HY-N10198

Acremonidin A	Inhibitor
Acremonidin A is a potent calmodulin (CaM) inhibitor found in Purpureocillium lilacinum. Acremonidin A binds to the human calmodulin (hCaM) biosensor hCaM M124C-mBBr, with K_d of 19.40 nM.

HY-P1805

Calmodulin Binding Peptide 1	Inhibitor
Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca²⁺ release .

HY-142087

Beauverolide Ja	Inhibitor
Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a K_d of 0.078 μM and a K_i of 0.39 μM for Ca²⁺-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea.

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