61714-25-8
61714-25-8
Chemical Structure
W-5 hydrochloride
- CAS No.: 61714-25-8
- Formula:C16H23ClN2O2S
- Molecular Weight:342.88
IUPAC Name: N-(6-aminohexyl)naphthalene-1-sulfonamide hydrochloride
InChIKey: HOCSVIGHWPLMFC-UHFFFAOYSA-N
SMILES: O=S(C1=C2C=CC=CC2=CC=C1)(NCCCCCCN)=O.[H]Cl
Biological Activity: W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC50 value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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W-5 hydrochloride | 99.93% | W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC50 value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912). | ||||||||||||||||||||
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References
- [1]. Suzuki S, et al. Enhancement of the cAMP-induced apolipoprotein-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW 264 mouse macrophage cell line cells. J Cardiovasc Pharmacol. 2000 Nov;36(5):609-16. [Content Brief]
- [2]. Yokokura S, et al. Calmodulin antagonists induce cell cycle arrest and apoptosis in vitro and inhibit tumor growth in vivo in human multiple myeloma. BMC Cancer. 2014 Nov 26;14:882. [Content Brief]
