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  3. A-3 hydrochloride

A-3 hydrochloride 

Cat. No.: HY-125957
Handling Instructions

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively.

For research use only. We do not sell to patients.

A-3 hydrochloride Chemical Structure

A-3 hydrochloride Chemical Structure

CAS No. : 78957-85-4

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Description

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively[1].

IC50 & Target[1]

CK1

80 μM (Ki)

CK2

5.1 μM (Ki)

PKC

47 μM (Ki)

PKA

4.3 μM (Ki)

In Vitro

A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM. A-3 is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1].

Molecular Weight

321.22

Formula

C₁₂H₁₄Cl₂N₂O₂S

CAS No.

78957-85-4

SMILES

O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

A-3A3A 3PKACasein KinaseCaMKPKCProtein kinase ACalmodulin-dependent protein kinasesCalmodulin-dependent kinasesProtein kinase CcaseinkinasecAMPMLC-kinasecalmodulininhibitorInhibitorinhibit

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A-3 hydrochloride
Cat. No.:
HY-125957
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