1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKCγ Inhibitors

PKCγ Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

PKCι

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Sorry. There is currently no product that acts on isoform PKCγ together.

Please try each isoform separately.

PKCγ Specific Inhibitors & Modulators
Product Name PKCγ PKC PKCα PKCβ PKCδ PKCε PKCη PKCζ PKCμ PKCγ Selectivity Purity
Go 6983
PKCγ, IC50: 6 nM
 
PKCα, IC50: 7 nM
PKCβ, IC50: 7 nM
PKCδ, IC50: 10 nM
   
PKCζ, IC50: 60 nM
PKCμ, IC50: 20000 nM
Pan Inhibitor 98.01%
Midostaurin
cPKC-γ, IC50: 24 nM
 
cPKC-α, IC50: 22 nM
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
nPKC-δ, IC50: 33 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 160 nM
aPKC-ζ, IC50: 465000 nM
  Pan Inhibitor ≥98.0%
Ruboxistaurin
PKCγ, IC50: 300 nM
 
PKCα, IC50: 360 nM
PKC-βI, IC50: 4.7 nM
PKC-βII, IC50: 5.9 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
    Pan Inhibitor 98.03%
Bisindolylmaleimide I
PKCγ, IC50: 20 nM
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
          Pan Inhibitor 98.14%
Rottlerin
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
 
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
  Pan Inhibitor ≥95.0%
Enzastaurin
PKCγ, IC50: 83 nM
 
PKCα, IC50: 39 nM
PKCβ, IC50: 6 nM
 
PKCε, IC50: 110 nM
      Pan Inhibitor 99.92%
Ingenol Mebutate
PKC-γ, Ki: 0.162 nM
 
PKC-α, Ki: 0.3 nM
PKC-β, Ki: 0.105 nM
PKC-δ, Ki: 0.376 nM
PKC-ε, Ki: 0.171 nM
      Pan Modulator 99.07%
Ro 31-8220 mesylate
PKC-γ, IC50: 27 nM
Rat Brain PKC, IC50: 23 nM
PKC-α, IC50: 5 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
 
PKC-ε, IC50: 24 nM
      Pan Inhibitor ≥98.0%
Ruboxistaurin hydrochloride
PKCγ, IC50: 300 nM
 
PKCα, IC50: 360 nM
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
    Pan Inhibitor 99.84%
HBDDE
PKCγ, IC50: 50 μM
 
PKCα, IC50: 43 μM
            Pan Inhibitor
Ro 32-0432 hydrochloride
PKCγ, IC50: 36.5 nM
 
PKCα, IC50: 9.3 nM
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 30 nM
 
PKCε, IC50: 108.3 nM
      Pan Inhibitor
Bisindolylmaleimide VIII acetate
PKC-γ, IC50: 213 nM
Rat Brain PKC, IC50: 158 nM
PKC-α, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
 
PKC-ε, IC50: 175 nM
      Pan Inhibitor