18:0-22:6 DG
Based on 1 Customer Validation
18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol (DG) that can interact with RasGRP (Ras guanine nucleotide-releasing protein) (Ki = 8.37 μM) and modulate the activation of MAP kinases (such as ERK1/ERK2), which play a crucial role in cellular signaling processes. 18:0-22:6 DG can also activate protein kinase C (PKC) isozyme. 18:0-22:6 DG can be used for research of cancer, immunology and metabolic disease.
For research use only. We do not sell to patients.
- Purity: 99%
- CAS No.: 65886-80-8
- Formula: C43H72O5
- Molecular Weight:669.03
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Storage:
Solution, -20°C, 2 years
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
ERK1 |
ERK2 |
PKCα |
PKC-βII |
PKCγ |
PKCδ |
PKCε |
PKCη |
PKCθ |
18:0-22:6 DG binds to RasGRP and promotes the conversion of Ras protein from the inactive state with GDP binding to the active state with GTP binding, thereby activating the phosphorylation of downstream ERK1/ERK2 and participating in cellular signal transduction[1].
18:0-22:6 DG (2-2000 mmol%) can activate multiple PKC enzymes, such as PKCα, βII, γ, δ, ε, η and θ[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 65886-80-8
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Appearance Liquid
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Molecular Weight 669.03
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Formula C43H72O5
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Color Colorless to light yellow
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SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O[C@@H](CO)COC(CCCCCCCCCCCCCCCCC)=O)=O
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Synonyms
1-Stearoyl-2-docosahexaenoyl-sn-glycerol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Madani S, et, al. Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. J Biol Chem. 2004 Jan 9;279(2):1176-83. [Content Brief]
[2]. Kamiya Y, et al. Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species. Biochem Biophys Rep. 2016 Jul 20;7:361-366. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
18:0-22:6 DG Related Classifications
HY-143212 Related Classifications
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