1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38 MAPK Inhibitors

p38 MAPK Inhibitors

p38 MAPK

p38α

p38β

MAPK13

p38δ

p38γ

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

p38 MAPK p53 Inhibitors, Inhibitors, Agonists & Activators
Product Name p38 MAPK p38α p38β MAPK13 p38δ p38γ Purity
Adezmapimod
p38, IC50: 50 nM
 
p38β2, IC50: 500 nM
      99.96%
SB 202190  
p38α, IC50: 50 nM
p38β2, IC50: 100 nM
      99.89%
Doramapimod
p38 MAP kinase, Kd: 0.1 nM
p38α, IC50: 38 nM
p38β, IC50: 65 nM
 
p38δ, IC50: 520 nM
p38γ, IC50: 200 nM
99.98%
Adezmapimod hydrochloride
p38, IC50: 50 nM
 
p38β2, IC50: 500 nM
      99.71%
Muramyl dipeptide
p38 MAPK
          ≥98.0%
Ralimetinib dimesylate  
p38α MAPK, IC50: 5.3 nM
p38β MAPK, IC50: 3.2 nM
      99.91%
Diprovocim
p38 MAPK
          98.35%
Neflamapimod  
p38α, IC50: 10 nM
p38β, IC50: 220 nM
      99.32%
Naporafenib  
p38α, IC50: 2.1 μM
        99.72%
Exarafenib
p38 MAPK
          99.68%
Talmapimod  
p38α, IC50: 9 nM
p38β, IC50: 90 nM
      98.97%
Semapimod tetrahydrochloride
p38 MAPK
          98.43%
MAPK13-IN-1      
MAPK13 (p38δ), IC50: 620 nM
    98.93%
Skatole
p38
          99.96%
Tpl2 Kinase Inhibitor 1
p38, IC50: 180 μM
          99.22%
Esculin
p38 MAPK
          99.78%
TAK-715  
p38α, IC50: 7.1 nM
p38β, IC50: 200 nM
 
p38δ, IC50: >10 μM
p38γ, IC50: >10 μM
99.73%
Paris saponin VII
p38
          99.13%
BMS-582949 hydrochloride  
p38α MAPK, IC50: 13 nM
        98.29%
p38 MAPK-IN-1
p38 MAPK, IC50: 68 nM
          99.45%
UM-164  
p38α
p38β
      99.15%
Broussonin E
p38 MAPK
          98.18%
AMG-548 dihydrochloride  
p38α, Ki: 0.5 nM
dog p38α, Ki: 5.0 nM
p38β, Ki: 3.6 nM
 
p38δ, Ki: 2600 nM
p38γ, Ki: 4100 nM
99.85%
MKK7-COV-9
p38 MAP kinase
         
TA-01
p38 MAP kinase, IC50: 6.7 nM
          99.77%
Cornuside
p38 MAP kinase
          99.95%
MW-150  
p38α, Ki: 101 nM
        99.90%
Gossypetin
p38 MAP kinase
          99.82%
PF-05381941  
p38α, IC50: 186 nM
        99.75%
Rotundic acid
p38 MAPK
          99.41%
Isoliquiritin apioside
p38 MAPK
          99.87%
Dihydrocaffeic acid
p38 MAPK
          99.38%
NF-κB/MAPK-IN-1
p38
          98.42%
Pamapimod  
p38α, IC50: 14 nM
p38α, Ki: 1.3 nM
p38β, IC50: 480
p38β, Ki: 120 nM
      99.92%
EW-7195  
p38α, IC50: 1.5 μM
        99.20%
Ferulic acid methyl ester
p38
          99.95%
SJFα  
p38α, DC50: 7.16 nM
   
p38δ, DC50: 299 nM
  99.61%
SB 202190 hydrochloride  
p38α, IC50: 50 nM
p38β2, IC50: 100 nM
      99.66%
Emprumapimod  
p38α
        99.12%
SR-318  
p38α, IC50: 5 nM
p38β, IC50: 32 nM
      99.89%
p38α inhibitor 1  
p38α
        98.30%
R1487 Hydrochloride  
p38α, Kd: 0.2 nM
p38β, Kd: 29 nM
      99.33%
SM-7368
p38 MAP kinase
          99.90%
RWJ-67657  
p38α, IC50: 1 μM
p38β, IC50: 11 μM
      99.32%
SD-169  
p38α MAPK, IC50: 3.2 nM
p38β MAPK, IC50: 122 nM
      99.91%
Emprumapimod hydrochloride  
p38α
        ≥98.0%
Anti-inflammatory agent 35
p38 MAPK
          99.77%
N-​Feruloyloctopamine
p38 MAPK
          98.49%
JNJ-49095397  
p38α
     
p38γ
99.85%
p38α inhibitor 2  
p38α MAPK, pIC50: 9.6
        98.03%
AL 8697  
p38α, IC50: 6 nM
p38β, IC50: 82 nM
      99.83%
AMG-548  
p38α, Ki: 0.5 nM
dog p38α, Ki: 5.0 nM
p38β, Ki: 3.6 nM
 
p38δ, Ki: 2600 nM
p38γ, Ki: 4100 nM
≥99.0%
Ralimetinib  
p38α MAPK, IC50: 5.3 nM
p38β MAPK, IC50: 3.2 nM
     
SJFδ  
p38α, DC50: 46.17 nM
       
MW-150 hydrochloride  
p38α, Ki: 101 nM
       
MW-150 dihydrochloride dihydrate  
p38α, Ki: 101 nM
       
PF-03715455  
p38α, IC50: 0.88 nM
p38β, IC50: 23 nM
     
Talmapimod hydrochloride  
p38α, IC50: 9 nM
p38β, IC50: 90 nM
     
p38-α MAPK-IN-4  
p38α MAPK, IC50: 1.5 μM
       
p38 MAP Kinase Inhibitor IV  
p38α, IC50: 0.13 μM
p38β, IC50: 0.55 μM
 
p38δ, IC50: 8.63 μM
 
p38-α MAPK-IN-5  
p38α, IC50: 0.1 nM
p38β, IC50: 0.2 nM
 
p38δ, IC50: 4100 nM
p38γ, IC50: 944 nM
p38 MAPK-IN-3  
p38α MAPK
       
SB-284851-BT  
p38α, Kd: 0.47 nM
       
DCZ19931
p38 MAPK
         
Lucidone
p38 MAPK
         
AMG-548 hydrochloride  
p38α, Ki: 0.5 nM
dog p38α, Ki: 5.0 nM
p38β, Ki: 3.6 nM
 
p38δ, Ki: 2600 nM
p38γ, Ki: 4100 nM
CHMFL-ABL-053
p38, IC50: 62 nM
         
Semapimod
p38 MAPK
         
(aS)-PH-797804  
p38α, IC50: 26 nM
p38β, IC50: 102 nM
     
JNK3 inhibitor-5  
p38α, IC50: 215.8 nM
       
Balanophonin
p38
         
SB 220025
p38, IC50: 60 nM
         
p38 MAP Kinase Inhibitor III
p38 MAP kinase, IC50: 0.9 μM
         
SX 011  
p38α, IC50: 9 nM
p38β, IC50: 90 nM
 
p38δ, IC50: > 300,000 nM
p38γ, IC50: > 300,000 nM
BMS-582949  
p38α, IC50: 13 nM
       
p38 MAPK-IN-4
p38, IC50: 35 nM
         
Cudraflavone B
p38 MAP kinase
         
p38α inhibitor 4  
p38α, IC50: 1.2 μM
       
Sugiol
p38 MAPK