1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

mAChR

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Related Products (105):

Cat. No. Product Name Effect Purity
  • HY-B0726
    Pilocarpine Hydrochloride Agonist 99.92%
    Pilocarpine Hydrochloride is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
  • HY-B1208
    Carbamoylcholine chloride Agonist >98.0%
    Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.
  • HY-N0296A
    Scopolamine hydrobromide Antagonist >98.0%
    Scopolamine hydrobromide is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM.
  • HY-B0394
    Atropine sulfate monohydrate Antagonist 99.62%
    Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist.
  • HY-A0012
    Darifenacin hydrobromide Antagonist
    Darifenacin HBr(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
  • HY-B2146
    Scopolamine N-oxide hydrobromide Antagonist >98.0%
    Scopolamine N-oxide hydrobromide is an antagonist of the muscarinic acetylcholine.
  • HY-112209
    VU0467154 Agonist
    VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.
  • HY-100154
    Darenzepine Inhibitor
    Darenzepine is a muscarinic receptor inhibitor extracted from patent US 20170095465 A1.
  • HY-A0083
    Methacholine chloride Agonist >98.0%
    Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.
  • HY-B0489
    Arecoline hydrobromide Agonist >99.0%
    Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.
  • HY-B0406A
    Bethanechol chloride Agonist
    Bethanechol Chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
  • HY-12100
    Umeclidinium bromide Antagonist 99.72%
    Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
  • HY-16171
    Diphenmanil methylsulfate Antagonist 99.83%
    Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
  • HY-13410
    Xanomeline oxalate Agonist 98.63%
    Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist.
  • HY-B0520A
    Benztropine mesylate Inhibitor 98.92%
    Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.
  • HY-13204
    Biperiden Hydrochloride Inhibitor >98.0%
    Biperiden(KL 373) Hcl is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
  • HY-B0499A
    Otilonium bromide Inhibitor
    Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.
  • HY-B0549A
    Flavoxate hydrochloride Antagonist >99.0%
    Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.
  • HY-A0016
    Dronedarone Inhibitor 99.62%
    Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.
  • HY-70020
    Cevimeline Agonist
    Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.
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