1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

mAChR

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Related Products (104):

Cat. No. Product Name Effect Purity
  • HY-B0726
    Pilocarpine Hydrochloride Agonist 99.92%
    Pilocarpine Hydrochloride is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
  • HY-N0296A
    Scopolamine hydrobromide Antagonist >98.0%
    Scopolamine hydrobromide is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM.
  • HY-B0394
    Atropine sulfate monohydrate Antagonist 99.62%
    Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist.
  • HY-A0012
    Darifenacin hydrobromide Antagonist
    Darifenacin HBr(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
  • HY-A0083
    Methacholine chloride Agonist >98.0%
    Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.
  • HY-B2146
    Scopolamine N-oxide hydrobromide Antagonist >98.0%
    Scopolamine N-oxide hydrobromide is an antagonist of the muscarinic acetylcholine.
  • HY-112209
    VU0467154 Agonist 98.78%
    VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.
  • HY-100154
    Darenzepine Inhibitor
    Darenzepine is a muscarinic receptor inhibitor extracted from patent US 20170095465 A1.
  • HY-B0489
    Arecoline hydrobromide Agonist >99.0%
    Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.
  • HY-B0406A
    Bethanechol chloride Agonist
    Bethanechol Chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
  • HY-12100
    Umeclidinium bromide Antagonist 99.72%
    Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
  • HY-16171
    Diphenmanil methylsulfate Antagonist 99.83%
    Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
  • HY-13410
    Xanomeline oxalate Agonist 98.63%
    Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist.
  • HY-B0520A
    Benztropine mesylate Inhibitor 98.92%
    Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.
  • HY-B0662
    Imidafenacin Inhibitor 98.38%
    Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).
  • HY-12980
    Batefenterol Antagonist 98.30%
    Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
  • HY-17037
    Pirenzepine dihydrochloride 99.60%
    Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.
  • HY-B0499A
    Otilonium bromide Inhibitor
    Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.
  • HY-A0016
    Dronedarone Inhibitor 99.49%
    Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.
  • HY-17465
    Glycopyrrolate Antagonist >98.0%
    Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.
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