Signaling Pathway

mAChR

mAChR

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mAChRs (Muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. Muscarinic receptors were named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Inhibitors & Modulators (75)

Product Name Catalog No. Brief Description
(+)-Cevimeline hydrochloride hemihydrate

HY-76772A

Cevimeline hydrochloride hemihydrate, a  novel muscarinic receptor agonist,  is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

(-)-Cevimeline hydrochloride hemihydrate

HY-76772B

Cevimeline hydrochloride hemihydrate, a  novel muscarinic receptor agonist,  is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

(R)-5-Hydroxymethyl Tolterodine

HY-76569

(R)-5-Hydroxymethyl Tolterodine(PNU-200577; Desfesoterodine)  is a potent and selective muscarinic receptor antagonist with a Kb and a pA2 of 0.84 nM and 9.14, respectively.

Acetylcholine chloride

HY-B0282

Acetylcholine is a neurotransmitter that can induce the opening of calcium channels.

Aclidinium Bromide

HY-14144

Aclidinium Bromide(LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (COPD).

Anisodamine

HY-N0584

Anisodamine is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock, is also a naturally occurring tropane alkaloid found in some plants of the Solanaceae family.

Arecoline hydrobromide

HY-B0489

Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.

Atropine

HY-B1205

Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production during surgery.

Atropine sulfate

HY-B1205A

Atropine sulfate is a competitive muscarinic acetylcholine receptor antagonist.

Atropine sulfate monohydrate

HY-B0394

Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist.

Benzetimide hydrochloride

HY-B1547A

Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist.

Benztropine mesylate

HY-B0520A

Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.

Bethanechol

HY-B0406

Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors.

Bethanechol chloride

HY-B0406A

Bethanechol Chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.

Biperiden

HY-13204A

Biperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.

Biperiden Hydrochloride

HY-13204

Biperiden(KL 373) Hcl is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.

Camylofine

HY-B1230

Camylofin is an antimuscarinic, is a smooth muscle relaxant.

Carbamoylcholine chloride

HY-B1208

Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.

Cevimeline

HY-70020

Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.

Cevimeline hydrochloride

HY-70020B

Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.