1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

mAChR

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Related Products (76):

Cat. No. Product Name Effect Purity
  • HY-B0726
    Pilocarpine Hydrochloride Agonist 99.63%
    Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
  • HY-N0296A
    Scopolamine hydrobromide Antagonist >98.0%
    Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM.
  • HY-13410
    Xanomeline oxalate Agonist 98.63%
    Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist.
  • HY-12100
    Umeclidinium bromide Inhibitor 99.72%
    Umeclidinium bromide is a novel mAChR antagonist.
  • HY-B0394
    Atropine sulfate monohydrate Antagonist 99.07%
    Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist.
  • HY-A0030
    Fesoterodine fumarate Antagonist
    Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.
  • HY-90010
    Tolterodine Tartrate Antagonist
    Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.
  • HY-13204
    Biperiden Hydrochloride Inhibitor
    Biperiden(KL 373) Hcl is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
  • HY-B0406A
    Bethanechol chloride Agonist
    Bethanechol Chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
  • HY-A0083
    Methacholine chloride Agonist >98.0%
    Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.
  • HY-B1208
    Carbamoylcholine chloride Agonist >98.0%
    Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.
  • HY-16171
    Diphenmanil methylsulfate Antagonist
    Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
  • HY-B0662
    Imidafenacin Inhibitor 99.30%
    Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).
  • HY-14562
    TBPB Agonist 99.62%
    TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.
  • HY-B0499A
    Otilonium bromide Inhibitor
    Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.
  • HY-17360
    Tiotropium Bromide Antagonist 99.84%
    Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
  • HY-B0520A
    Benztropine mesylate Inhibitor 98.59%
    Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.
  • HY-B0549A
    Flavoxate hydrochloride Antagonist 99.54%
    Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.
  • HY-76772
    Cevimeline hydrochloride hemihydrate Agonist >98.0%
    Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
  • HY-A0016
    Dronedarone Inhibitor 99.62%
    Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.