1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

mAChR

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Related Products (73):

Cat. No. Product Name Effect Purity
  • HY-B0726
    Pilocarpine Hydrochloride Agonist
    Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
  • HY-N0296A
    Scopolamine hydrobromide Antagonist
    Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM.
  • HY-12100
    Umeclidinium bromide Inhibitor
    Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of GSK573719 for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
  • HY-13410
    Xanomeline oxalate Agonist
    Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist.
  • HY-16171
    Diphenmanil methylsulfate Antagonist
    Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
  • HY-100795
    (±)-Pirmenol Inhibitor
    Pirmenol inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.
  • HY-12980
    Batefenterol Antagonist
    Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
  • HY-100234
    DREADD agonist 21 Agonist
    DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist(EC50=1.7 nM).
  • HY-13204
    Biperiden Hydrochloride Inhibitor
    Biperiden(KL 373) Hcl is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
  • HY-B0394
    Atropine sulfate monohydrate Antagonist
    Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist.
  • HY-B0406A
    Bethanechol chloride Agonist
    Bethanechol Chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
  • HY-B0662
    Imidafenacin Inhibitor
    Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).
  • HY-A0083
    Methacholine chloride Agonist
    Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.
  • HY-A0016
    Dronedarone Inhibitor
    Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.
  • HY-76772
    Cevimeline hydrochloride hemihydrate Agonist
    Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
  • HY-13340
    VU0152100 Agonist
    VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.
  • HY-14562
    TBPB Agonist
    TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.
  • HY-17465
    Glycopyrrolate Antagonist
    Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.
  • HY-B0327
    Irsogladine Inhibitor
    Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
  • HY-B0499A
    Otilonium bromide Inhibitor
    Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.