1. Neuronal Signaling
    GPCR/G Protein
    Immunology/Inflammation
    Membrane Transporter/Ion Channel
    Protein Tyrosine Kinase/RTK
  2. Serotonin Transporter
    5-HT Receptor
    Histamine Receptor
    mAChR
    Adrenergic Receptor
    Sodium Channel
    Trk Receptor
  3. Amitriptyline hydrochloride

Amitriptyline hydrochloride 

Cat. No.: HY-B0527A Purity: 99.56%
Handling Instructions

Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.

For research use only. We do not sell to patients.

Amitriptyline hydrochloride Chemical Structure

Amitriptyline hydrochloride Chemical Structure

CAS No. : 549-18-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 96 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Amitriptyline hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

IC50 & Target[1][3]

5-HT1A Receptor

450 nM (IC50)

5-HT1B Receptor

40 nM (IC50)

5-HT2A Receptor

4 nM (IC50)

5-HT2B Receptor

40 nM (IC50)

5-HT2C Receptor

6 nM (IC50)

H1 Receptor

1.1 nM (IC50)

H3 receptor

1 μM (IC50)

H4 receptor

33.6 nM (IC50)

SERT

3.45 nM (Ki)

NET

13.3 nM (Ki)

DAT

2.58 μM (Ki)

Adrenergic receptor

24 nM (IC50)

muscarinic receptor

7.2 nM (IC50)

TrkA

 

TrkB

 

Clinical Trial
Molecular Weight

313.86

Formula

C₂₀H₂₄ClN

CAS No.

549-18-8

SMILES

CN(C)CC/C=C1C2=CC=CC=C2CCC3=C\1C=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (318.61 mM)

H2O : ≥ 50 mg/mL (159.31 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1861 mL 15.9307 mL 31.8613 mL
5 mM 0.6372 mL 3.1861 mL 6.3723 mL
10 mM 0.3186 mL 1.5931 mL 3.1861 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 120 mg/mL (382.34 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AmitriptylineSerotonin Transporter5-HT ReceptorHistamine ReceptormAChRAdrenergic ReceptorSodium ChannelTrk Receptor5-HTTSERTSLC6A4Serotonin Receptor5-hydroxytryptamine ReceptorMuscarinic acetylcholine receptorBeta ReceptorNa channelsNa+ channelsTropomyosin related kinase receptorneurotrophinsdepressionneuropathicpainneurologicpsychiatricdiseasesTrkA/TrkBheterodimerizationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Amitriptyline hydrochloride
Cat. No.:
HY-B0527A
Quantity:
MCE Japan Authorized Agent: