2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. 5-HT Receptor
  5. 5-HT2 Receptor Isoform

5-HT2 Receptor

 

5-HT2 Receptor Related Products (186):

Cat. No. Product Name Effect Purity
  • HY-N0145
    Puerarin
    		Antagonist 99.42%
    Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
  • HY-N0737A
    Harmine
    		Inhibitor 99.93%
    Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities.
  • HY-19545A
    SCH-23390 hydrochloride
    		Agonist 99.91%
    SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively.
  • HY-14539
    Clozapine
    		Modulator 99.99%
    Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia.
  • HY-15780
    Brexpiprazole
    		Modulator 99.64%
    Brexpiprazole (OPC-34712), an atypical orally active antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively.
  • HY-14541
    Olanzapine
    		Antagonist 99.89%
    Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM).
  • HY-11018
    Risperidone
    		Inhibitor 98.01%
    Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
  • HY-14940
    Volinanserin
    		Antagonist 98.33%
    Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors.
  • HY-136109
    SEP-363856 hydrochloride
    		Agonist 99.78%
    SEP-363856 hydrochloride (SEP-856 hydrochloride), an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects.
  • HY-B0527A
    Amitriptyline hydrochloride
    		Inhibitor 99.56%
    Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively.
  • HY-14546
    Aripiprazole
    		Agonist 99.93%
    Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist.
  • HY-14557A
    Pimavanserin hemitartrate
    		Inhibitor 99.75%
    Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.
  • HY-13409
    SB 242084
    		Antagonist 99.84%
    SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier).
  • HY-10562
    Ketanserin
    		Antagonist 99.24%
    Ketanserin is a selective 5-HT2 receptor antagonist.
  • HY-14544
    Quetiapine
    		Agonist 99.96%
    Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor.
  • HY-14557
    Pimavanserin
    		Inhibitor 99.84%
    Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
  • HY-N0049
    Nuciferine
    		Modulator 99.46%
    Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
  • HY-10791
    Ritanserin
    		Antagonist 99.78%
    Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.
  • HY-10562A
    Ketanserin tartrate
    		Antagonist 99.99%
    Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist.
  • HY-14543
    Sertindole
    		Antagonist 99.75%
    Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist.