1. Neuronal Signaling
    GPCR/G Protein
    Autophagy
  2. 5-HT Receptor
    Autophagy

Harmine (Synonyms: Telepathine)

Cat. No.: HY-N0737A Purity: 99.58%
Handling Instructions

Harmine, a tricyclic b-carboline alkaloid that was originally isolated from seeds of Peganum harmala, has been reported to possess anxiolytic, behavioral effects.

For research use only. We do not sell to patients.

Harmine Chemical Structure

Harmine Chemical Structure

CAS No. : 442-51-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
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Estimated Time of Arrival: December 31
500 mg USD 60 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
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Customer Review

    Harmine purchased from MCE. Usage Cited in: Sci Rep. 2015 Aug 3;5:12728.

    Ganetespib decreases the DYRK1A protein level. 293T cells are transiently transfected with an expression vector for 3xFLAG-DYRK1A. At 24 h after transfection, the cells are treated with Ganetespib (100 nM) and collected 0 and 8 h after treatment. Total cell lysates are subjected to SDS-PAGE followed by Western blot analysis using antibodies against FLAG and GAPDH. In the control group (DMSO), expression of 3xFLAG-DYRK1A increases at 8 h compared to 0 h, and Ganetespib suppresses this increase of
    • Biological Activity

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    Description

    Harmine, a tricyclic b-carboline alkaloid that was originally isolated from seeds of Peganum harmala, has been reported to possess anxiolytic, behavioral effects. IC50 value: 1.47μM (EC50) and 337.10μM (CC50) [3]. Target: 5-HT2A In vitro: In the study, harmine negatively regulates HR but not NHEJ by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine [1]. In vivo: The present study demonstrated that administration of harmine significantly attenuated cerebral edema, and improved learning and memory ability [2].

    Clinical Trial
    References
    Molecular Weight

    212.25

    Formula

    C₁₃H₁₂N₂O

    CAS No.

    442-51-3

    SMILES

    CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO: 10 mg/mL

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

    Purity: 99.58%

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    Product Name:
    Harmine
    Cat. No.:
    HY-N0737A
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