1. Protein Tyrosine Kinase/RTK
    Neuronal Signaling
    GPCR/G Protein
  2. DYRK
    5-HT Receptor
  3. Harmine hydrochloride

Harmine hydrochloride (Synonyms: Telepathine hydrochloride)

Cat. No.: HY-N0737
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Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.

For research use only. We do not sell to patients.

Harmine hydrochloride Chemical Structure

Harmine hydrochloride Chemical Structure

CAS No. : 343-27-1

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Top Publications Citing Use of Products

    Harmine hydrochloride purchased from MCE. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267.

    Representative images showing the restoration effect of Harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg) is used as a positive control, and all data are shown as mean±SEM.
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    Description

    Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].

    IC50 & Target

    Ki: 397 nM (5-HT2A serotonin receptor)[1], DYRK1A[2]

    In Vitro

    Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM[2]. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine[3].

    In Vivo

    It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group[4].

    Molecular Weight

    248.71

    Formula

    C₁₃H₁₃ClN₂O

    CAS No.

    343-27-1

    SMILES

    CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    Keywords:

    HarmineTelepathineDYRK5-HT ReceptorDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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    Harmine hydrochloride
    Cat. No.:
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