1. Protein Tyrosine Kinase/RTK
    Neuronal Signaling
    GPCR/G Protein
  2. DYRK
    5-HT Receptor
  3. Harmine hydrochloride

Harmine hydrochloride (Synonyms: Telepathine hydrochloride)

Cat. No.: HY-N0737
Handling Instructions

Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.

For research use only. We do not sell to patients.

Harmine hydrochloride Chemical Structure

Harmine hydrochloride Chemical Structure

CAS No. : 343-27-1

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Top Publications Citing Use of Products

    Harmine hydrochloride purchased from MCE. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267.

    Representative images showing the restoration effect of Harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg) is used as a positive control, and all data are shown as mean±SEM.
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    Description

    Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].

    IC50 & Target[1]

    DYRK1A

     

    5-HT2A Receptor

    397 nM (Ki)

    In Vitro

    Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM[2]. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    248.71

    Formula

    C₁₃H₁₃ClN₂O

    CAS No.
    SMILES

    CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    HarmineTelepathineDYRK5-HT ReceptorDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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    Product Name:
    Harmine hydrochloride
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