5-HT₄ Receptor

5-HT₄ Receptor Related Products (35):

By Type:	Pan (10) Selective (24)
By Effects:	Inhibitor (1) Agonists (22) Antagonists (11) Modulator (1)

Cat. No.	Product Name	Effect	Purity

HY-14149

Cisapride	Agonist	99.72%
Cisapride (R 51619) is an orally active 5-HT₄ receptor agonist with an EC₅₀ value of 140 nM.

HY-14153A

Tegaserod maleate	Agonist	99.75%
Tegaserod maleate (SDZ-HTF-919) is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist.

HY-B0189A

Mosapride citrate	Agonist	99.80%
Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.

HY-15574

Piboserod	Antagonist	99.12%
Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.

HY-14151

Prucalopride	Agonist	99.83%
Prucalopride is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pK_is of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively.

HY-101172

RS 23597-190	Antagonist
RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist.

HY-103152

GR 113808	Antagonist	99.96%
GR 113808 is a potent and highly selective 5-HT₄ receptor antagonist (pK_b= 8.8).

HY-12694

Prucalopride succinate	Agonist	99.83%
Prucalopride succinate is a selective, high affinity 5-HT4 receptor agonist with pKi of 8.6/8.1 for 5-HT4a/4b.

HY-14336A

SB 271046 Hydrochloride	Antagonist	98.64%
SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pK_i of 9.02, 8.55, and 8.81 for rat, pig and human, respectively.

HY-18137

PF-04995274	Agonist	99.95%
PF-04995274 is a potent, high-affinity, orally active and partial serotonin 4 receptor (5-HT₄R) agonist.

HY-10457

Velusetrag	Agonist	99.64%
Velusetrag (TD-5108) is an orally active, potent and selective agonist of serotonin 5-HT₄ receptor (5-HT4R), with a pK_i of 7.7.

HY-101343

RS 39604	Antagonist	≥98.0%
RS 39604 is a potent, selective, and orally active 5-HT₄ receptor antagonist with a pK_i of 9.1 in guinea pig striatal membranes.

HY-102057

Felcisetrag	Agonist	99.65%
Felcisetrag (TD-8954) is an orally active, potent and selective 5-HT₄ receptor agonist with gastrointestinal prokinetic properties.

HY-U00373

Revexepride	Agonist	99.84%
Revexepride is a highly selective 5-HT4 receptor agonist, and a potential inducer of CYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease.

HY-10457A

Velusetrag hydrochloride	Agonist
Velusetrag (TD-5108) hydrochloride is an orally active, potent and selective agonist of serotonin 5-HT₄ receptor (5-HT₄R), with a pK_i of 7.7.

HY-16729A

Relenopride hydrochloride	Agonist	99.13%
Relenopride (YKP10811) hydrochloride is a specific and selective 5-HT₄ receptor agonist (K_i=4.96 nM).

HY-116565

Usmarapride	Modulator	≥98.0%
Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT₄ receptor partial agonist (EC₅₀=44 nM).

HY-116565A

Usmarapride free base	Agonist	99.91%
Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT₄ receptor partial agonist (EC₅₀=44 nM).

HY-110094

BIMU 8	Agonist	≥99.0%
BIMU 8 is a potent and selective 5-HT4 agonist with EC₅₀s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.

HY-105201

Fabesetron	Antagonist
Fabesetron (FK1052) is an orally active 5-HT₃ receptor antagonist with 5-HT₄ receptor antagonistic activity.

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