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Cat. No.: HY-135439

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SB-203186

SB-203186 is a highly selective 5-HT₄ receptor antagonist. SB-203186 exhibits a potent competitive antagonistic effect, with its pK_B value being 8.3 in the isolated right atrium model of piglets. SB-203186 can dose-dependently shift the 5-HT-induced tachycardia curve to the right, and does not inhibit the maximum response. SB-203186 is an efficient 5-HT₄ antagonist in pig and human atria, but has no significant inhibitory effect in rat atria. SB-203186 can be used for the study of diseases such as arrhythmias and abnormal myocardial contraction.

For research use only. We do not sell to patients.

CAS No.: 135938-17-9
Formula: C₁₆H₂₀N₂O₂
Molecular Weight:272.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SB-203186 Chemical Structure

CAS No.: 135938-17-9

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

5-HT₄ Receptor

8.3 (pkB)

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 135938-17-9
Molecular Weight 272.34
Formula C₁₆H₂₀N₂O₂
SMILES

O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Medhurst AD, Kaumann AJ. Characterization of the 5‐HT4 receptor mediating tachycardia in piglet isolated right atrium. British journal of pharmacology. 1993 Nov;110(3):1023-30. [Content Brief]

[2]. Läer S, et al. Receptor mechanisms involved in the 5‐HT‐induced inotropic action in the rat isolated atrium. British journal of pharmacology. 1998 Mar;123(6):1182-8.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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