B7-H3/CD276
B7-H3, formally the CD276 antigen, belongs to the B7 family of immune regulators and circulates predominantly as the 4Ig-B7-H3 splice variant with tandem IgV-IgC pairs. It is expressed on dendritic cells, monocytes and many non-hematopoietic tissues; protein levels in healthy organs are low, whereas frequent overexpression occurs in lung, prostate, ovarian and pediatric solid tumors. Functionally, B7-H3 is generally regarded as an inhibitory checkpoint that dampens T cell responses, although its receptor assignments remain less settled than for PD-L1. This tumor-restricted expression pattern has made CD276 one of the most actively pursued next-generation antibody, antibody-drug conjugate and CAR-T targets in oncology.
-
B7-H3/CD276 Recombinant Proteins (21)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- 1
- 2
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- 2
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
