Fc Receptor-like Proteins
Fc receptor-like (FCRL) molecules, members of the immunoglobulin superfamily (IgSF), are preferentially expressed by B-cells and some T-cell subsets including CD4+ T-cells, CD8+ T-cells, NK cells, and dysfunctional population of CD4+ regulatory T-cells (Tregs). FCRLs have variable number of extracellular immunoglobulin-like domains and cytoplasmic activating ITAMs and/or inhibitory ITIMs. FCRLs share homology with conventional FcRs for IgG and IgE isotypes and are well-conserved between humans and nonhuman primates. FCRL1-5 could regulate different features of B-cell evolution such as development, differentiation, activation, antibody secretion and isotype switching.
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Fc Receptor-like Recombinant Proteins (12)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
