2. Screening Libraries
  3. Fragment Libraries

Fragment Libraries

Fragment-based drug discovery (FBDD) is a powerful method to develop potent small-molecule compounds starting from fragments binding weakly to targets. FBDD starts by screening libraries of low-molecular weight compounds (fragments) against the target of interest to identify ‘‘hits.’’ The identified hit is then grown into drug-like molecules through different strategies. Although FBDD cannot replace high-throughput screening (HTS) campaigns in drug discovery, it has some attractive advantages such as saving experimental cost, offering diverse hits, and exhibiting multiple ways to develop novel compounds.

Cat. No.
Name
Description
  • HY-L154 Cysteine Targeted Covalent Fragment Library Compound library containing fragments with various warheads targeting cysteine residue. 3148 compounds
    HY-L152 F-Fragments Library Unique F (fluorine)-containing compounds developed for fragment-based drug discovery. 4964 compounds
    HY-L032 Fragment Library Unique compounds developed for fragment-based drug discovery. 22447 compounds
    HY-L903 3D Diverse Fragment Library Unique 3D diversity fragment library: a new opportunity for fragment-based drug discovery (FBDD). 5196 compounds