1. Metabolic Disease

Metabolic Disease

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Metabolic Disease Related Products (369):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13443
    Exendin-4 141758-74-9
    Exendin-4, a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM.
    Exendin-4
  • HY-17386
    Rosiglitazone 122320-73-4
    Rosiglitazone is a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, and is a blocker of TRPM2 and TRPM3 channels.
    Rosiglitazone
  • HY-50108
    GW 4064 278779-30-9
    GW 4064 is a potent FXR agonist with EC50 of 65 nM.
    GW 4064
  • HY-50202
    Etomoxir 124083-20-1
    Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
    Etomoxir
  • HY-50202A
    (R)-(+)-Etomoxir sodium salt 828934-41-4
    (R)-(+)-Etomoxir sodium salt is R-form of Etomoxir sodium salt. Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
    (R)-(+)-Etomoxir sodium salt
  • HY-14601
    Pioglitazone hydrochloride 112529-15-4
    Pioglitazone hydrochloride is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
    Pioglitazone hydrochloride
  • HY-B0131
    Prostaglandin E1 745-65-3
    Prostaglandin E1 (Alprostadil) is a prostaglandin, which is used in the treatment of erectile dysfunction and has vasodilatory properties.
    Prostaglandin E1
  • HY-15409
    Empagliflozin 864070-44-0
    Empagliflozin is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for hSGLT-2.
    Empagliflozin
  • HY-10450
    Dapagliflozin 461432-26-8
    Dapagliflozin is a new pharmacological therapy for type 2 diabetes, and inhibits sodium/glucose cotransporter 2 (SGLT2), which results in excretion of glucose into the urine.
    Dapagliflozin
  • HY-10451
    Canagliflozin 842133-18-0
    Canagliflozin is a selective SGLT2 inhibitor with IC50 of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively.
    Canagliflozin
  • HY-A0190
    Ceruletide 17650-98-5
    Ceruletide (Caerulein) is a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea. It is a potent cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts in humans and
    Ceruletide
  • HY-10838
    GW 501516 317318-70-0
    GW 501516 is a PPARδ agonist with an EC50 of 1.1 nM.
    GW 501516
  • HY-15848
    AdipoRon 924416-43-3
    AdipoRon is a novel AdipoR agonist, binding to both AdipoR1 (Kd=1.8 μM) and AdipoR2 (Kd=3.1 μM).
    AdipoRon
  • HY-14832
    PTC124 775304-57-9
    PTC124 targets nonsense mutations, which insert a termination codon in the middle of the CFTR gene.
    PTC124
  • HY-15145
    SRT 1720 Hydrochloride 1001645-58-4
    SRT 1720 (Hydrochloride) is a selective activator of human SIRT1 (EC1.5=0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5=37 μM; SIRT3: EC1.5 > 300 μM).
    SRT 1720 Hydrochloride
  • HY-15304
    Dynasore 304448-55-3
    Dynasore is an inhibitor of the GTPase activity of dynamin with an IC50 of 15 μM.
    Dynasore
  • HY-16737
    Elafibranor 923978-27-2
    Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively.
    Elafibranor
  • HY-B0285A
    Amiloride hydrochloride 2016-88-8
    Amiloride (hydrochloride) is a relatively selective inhibitor of the epithelial sodium channel (ENaC), used in the management of hypertension and congestive heart failure.
    Amiloride hydrochloride
  • HY-10007
    NPS-2143 284035-33-2
    NPS-2143 is a novel potent and selective antagonist of Ca2+ receptor with IC50 of 43 nM.
    NPS-2143
  • HY-10042
    Odanacatib 603139-19-1
    Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrates high selectivity versus off-target cathepsin B, L, S.
    Odanacatib