1. Metabolic Disease

Metabolic Disease

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Metabolic Disease Related Products (846):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-A0190
    Ceruletide 17650-98-5 99.96%
    Ceruletide, a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea, is a potent cholecystokinetic agent, and acts as a cholecystokinin receptor agonist.
    Ceruletide
  • HY-17386
    Rosiglitazone 122320-73-4 99.21%
    Rosiglitazone (BRL49653) is a potent thiazolidinedione insulin sensitizer. Rosiglitazone is a selective PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
    Rosiglitazone
  • HY-13443
    Exendin-4 141758-74-9 98.96%
    Exendin-4, a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. Sequence: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.
    Exendin-4
  • HY-50202
    Etomoxir 124083-20-1 99.40%
    Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
    Etomoxir
  • HY-P0035
    Insulin(human) 11061-68-0
    Insulin(human) is a peptide hormone that regulates the level of sugar (glucose) in the blood and that is produced by the beta cells of the pancreatic islets.
    Insulin(human)
  • HY-16737
    Elafibranor 923978-27-2 99.31%
    Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
    Elafibranor
  • HY-50108
    GW 4064 278779-30-9 99.42%
    GW 4064 is a potent FXR agonist with EC50 of 65 nM.
    GW 4064
  • HY-100116A
    Mitoquinone mesylate 845959-50-4 >98.0%
    Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant.
    Mitoquinone mesylate
  • HY-15409
    Empagliflozin 864070-44-0 99.91%
    Empagliflozin is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.
    Empagliflozin
  • HY-16901
    ND-630 1434635-54-7 98.72%
    ND-630 is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.
    ND-630
  • HY-13992
    AP20187 195514-80-8 99.80%
    AP20187 is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
    AP20187
  • HY-10838
    GW 501516 317318-70-0 99.26%
    GW 501516 is a PPARδ agonist with an EC50 of 1.1 nM.
    GW 501516
  • HY-10450
    Dapagliflozin 461432-26-8 99.89%
    Dapagliflozin (BMS-512148) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
    Dapagliflozin
  • HY-B0285A
    Amiloride hydrochloride 2016-88-8 >98.0%
    Amiloride (hydrochloride) is an epithelial sodium channel (ENaC) inhibitor and a competitive inhibitor of Urokinase-type plasminogen activator (uPA).
    Amiloride hydrochloride
  • HY-P0014
    Liraglutide 204656-20-2 99.96%
    Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.
    Liraglutide
  • HY-N0750
    Monocrotaline 315-22-0 >98.0%
    Monocrotaline is an pyrrolizidine alkaloid extracted from the seeds of the Crotalaria spectabilis plant to induce pulmonary hypertension in rodents.
    Monocrotaline
  • HY-15145
    SRT 1720 Hydrochloride 1001645-58-4 99.92%
    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities on SIRT2 and SIRT3 with EC1.5s of 37 μM and 300 μM, respectively.
    SRT 1720 Hydrochloride
  • HY-50202A
    (R)-(+)-Etomoxir sodium salt 828934-41-4 99.94%
    (R)-(+)-Etomoxir sodium salt is the R-form of Etomoxir sodium salt. Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
    (R)-(+)-Etomoxir sodium salt
  • HY-15304
    Dynasore 304448-55-3 99.61%
    Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.
    Dynasore
  • HY-10451
    Canagliflozin 842133-18-0 99.61%
    Canagliflozin is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively.
    Canagliflozin