1. Metabolic Disease

Metabolic Disease

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Metabolic Disease Related Products (1207):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-A0190
    Ceruletide 17650-98-5 99.96%
    Ceruletide, a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea, is a potent cholecystokinetic agent, and acts as a cholecystokinin receptor agonist.
    Ceruletide
  • HY-P0035
    Insulin(human) 11061-68-0
    Insulin(human) is a polypeptide hormone that regulates the level of glucose.
    Insulin(human)
  • HY-17386
    Rosiglitazone 122320-73-4 99.21%
    Rosiglitazone (BRL 49653) is a selective PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
    Rosiglitazone
  • HY-50202
    Etomoxir 124083-20-1 99.65%
    Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
    Etomoxir
  • HY-100116A
    Mitoquinone mesylate 845959-50-4 >98.0%
    Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant.
    Mitoquinone mesylate
  • HY-13443
    Exendin-4 141758-74-9 98.96%
    Exendin-4, a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM.
    Exendin-4
  • HY-10450
    Dapagliflozin 461432-26-8 99.96%
    Dapagliflozin (BMS-512148), a new type of drug used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine. Dapagliflozin induces HIF1 expression and attenuates renal IR injury.
    Dapagliflozin
  • HY-N0750
    Monocrotaline 315-22-0 >98.0%
    Monocrotaline is an pyrrolizidine alkaloid extracted from the seeds of the Crotalaria spectabilis plant to induce pulmonary hypertension in rodents.
    Monocrotaline
  • HY-P0014
    Liraglutide 204656-20-2 99.71%
    Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.
    Liraglutide
  • HY-15409
    Empagliflozin 864070-44-0 99.90%
    Empagliflozin is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.
    Empagliflozin
  • HY-50108
    GW 4064 278779-30-9 99.42%
    GW 4064 is a potent FXR agonist with EC50 of 65 nM.
    GW 4064
  • HY-100596
    AS1842856 836620-48-5 98.09%
    AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy. AS1842856 inhibits FoxO1 activity by suppressing the expression of SIRT1. AS1842856 only reduces the activity of FoxO1 by binding with it, without affecting its transcription and protein expression.
    AS1842856
  • HY-16901
    Firsocostat 1434635-54-7 98.61%
    Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.
    Firsocostat
  • HY-16737
    Elafibranor 923978-27-2 99.18%
    Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
    Elafibranor
  • HY-15145
    SRT 1720 Hydrochloride 2060259-60-9 99.92%
    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.
    SRT 1720 Hydrochloride
  • HY-P1156
    Insulin(cattle) 11070-73-8 98.60%
    Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells.
    Insulin(cattle)
  • HY-13992
    AP20187 195514-80-8 99.80%
    AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
    AP20187
  • HY-B0240
    Disulfiram 97-77-8 98.67%
    Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells[1-4].
    Disulfiram
  • HY-10838
    GW 501516 317318-70-0 99.27%
    GW 501516 is a PPARδ agonist with an EC50 of 1.1 nM.
    GW 501516
  • HY-15304
    Dynasore 304448-55-3 99.61%
    Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.
    Dynasore